Digital Commons Network^™

Metabolite Profiling Of Functional Fungi Strains Of Hericium Erinaceus & Cordyceps Militaris: Using Phenotypes, Untargeted Metabolomics By Mass Spectrometry And Cell-Based Assays, Julie Daoust

Oxford ICSB

Mushrooms have a long tradition of use as medicinal and functional ingredients however the lack of development in testing methods currently limits our ability to characterize these products. Selecting the right strain or processing method is currently challenging given the lack of commercially available analytical methods to detect or quantify secondary metabolites with therapeutic endpoints. Very little is known about the variability of these metabolites between strains of the same species and between identical strains grown in different conditions therefore an untargeted analytical method was needed to adequately assess impact of strain genetics and growing methods for M2 Ingredients cultures …

I Am A "Fruit Eater": Predicting Fruit And Vegetable Consumption With Approach Self-As-Doer Identities, Melisandra R. Mclaughlin, Abree A. Dieterman, Katelyn R. Kelley, Hannah B. Dunlavy, Ashley M. Lenarz

Research & Creative Achievement Day

The daily recommended intake of fruits and vegetables is 1.5-2 cups and 2-3 cups, respectively, but only one in 10 adults in the United States are meeting those recommendations (CDC, 2019). Research on the Theory of Planned Behavior (TPB) indicates healthy eating behaviors can be predicted by intentions and other components of the theory (McDermott et al., 2015). Likewise, the self-as-doer, an identity that aims to describe individuals in terms of doing a behavior, also predicts healthy eating. However, less research has explored how the orientation of a doer identity predicts fruit and vegetable consumption. Those with an approach doer …

Re-Discovery Of Fungi, Christopher Hobbs

Oxford ICSB

This will be a very concise overview of the laboratory and clinical work that has been published on the health and medical benefits of medicinal mushrooms and mycelium. Medicinal mushroom and mycelium-based products currently on the market will be critically reviewed, specifically focusing on identifying the 5 most important constituent groups intensive world-wide research has identified as providing the intended benefits of these products, and what leading companies as well as startups are doing to insure their products contain them in meaningful amounts.

Evaluation Of Botanical Extracts For Cytochrome P450 Inhibition Mediated Drug Interactions, Angela I. Calderón, Zarna Raichura, Kabre Heck, Jaewoo Choi, Mikah Brandes, Cody Neff, Claudia Maier, Amala Soumyanath, Robert Arnold

Oxford ICSB

There has been remarkable growth in consumption of botanical dietary supplements (BDS), making it important to understand the safety profile of BDS with respect to the pharmacokinetic properties for any potential of botanical-drug interactions. One such botanical interactions which has gained significant attention involves inhibition of cytochrome P450 (CYP450) enzymes by co-administered drugs. Our study involved examining two widely used botanicals, ashwagandha and açaí for any potential inhibition of CYP450. Four different ashwagandha extracts were tested, resulting in inhibition of CYP2B6 with IC50 < 100 µg/ml of extract and showed potential of time-dependent inhibition for CYP2C9 and CYP2D6 with an IC50 ~ 200 µg/ml of extract. In the case of açaí, seven different extracts were tested and only CYP2C9 was inhibited. The acidic methanol extract of açaí formulation showed an IC50 of 0.3 µg/ml of extract indicating potent inhibition of CYP2C9, while the methanol (IC50 ~ 91.75 µg/ml) & ethanol extracts of Mountain Rose açaí powder showed weak inhibitory effect with an IC50 < 100 µg/ml of extract for CYP2C9. The results reflect that both botanical extracts showed potential of CYP450 inhibition, suggesting that compounds in BDS can prolong the half-lives of medications leading to extended action or toxicity. Next step involves, testing subfractions of these extracts to identify the compounds responsible for the observed inhibition.

Screening Of Medicinal Herbs To Predict The Potential Perpetrators Of Herb-Drug Interaction, Ikhlas A. Khan, Amar G. Chittiboyina, Shabana Khan, Bill Gurley, Islam Husain

Oxford ICSB

Over time, the popularity and consumption of herbal medicine and its products like nutraceuticals, botanical drugs, and dietary supplements have increased immensely. Parallelly, several health issues associated with the overconsumption of these products have also been raised, which has attracted enormous attention. Herb-drug interaction (HDI) is a health issue caused by herbs or phytochemicals that modulate the homeostasis of drug-metabolizing enzymes (CYPs) and transporters, thus altering the pharmacokinetic of clinical drugs. To date, only a few medicinal herbs, such as Hypericum perforatum, Hydrastis canadensis, Glycyrrhiza glabra, and Camellia sinensis etc., were recognized as HDI perpetrators. However, many need to be …

New Natural Product Certified Reference Material Resources Supported By The Nih Office Of Dietary Supplements, Adam Kuszak, Zoe Ruan, Linda Smith, Sarah Ajaz, Uma Srennivasan, Sabrina Giddings, Daniel Beach, Pearse Mccarron, Stephen Wise

Oxford ICSB

The NIH Office of Dietary Supplements (ODS) Analytical Methods and Reference Materials (AMRM) Program supports the development of tools that promote and facilitate rigorous and reliable characterization of dietary supplement (DS) identity, composition, and purity, as well as assessments of authenticity and contamination of botanical and other natural product raw materials and finished products. AMRM goals are accomplished through development and validation of quantitative and qualitative methods, production of certified reference materials (CRMs), and support of dietary supplement focused laboratory quality assurance programs. Recent advances in DS analytical resources supported by AMRM include an expanded availability of CRM calibration solutions …

Community Health Assessments In Guatemala And Honduras, Grace Sibert

Liberty University Research Week

Community Health Assessments (CHAs) give health professionals necessary information to identify and provide care for community needs. The services provided by CHA’s are integral, especially in underdeveloped and rural communities. This research paper serves to discuss the outcomes and benefits of community health screenings performed in Hierba Buena, Chiquimula, a rural, mountainous community in Guatemala and three, underserved communities in Copan Ruinas, Honduras. The screenings were conducted by a team of faculty and graduate and undergraduate students from Liberty University, public health professionals, Iglesia Vida, a church in south Florida and Iglesia de las Americas. The team worked alongside a …

Glp-1 Receptor Antagonists Medicaid Utilization Trends And Obesity Rates In The Us, Faith Magwenzi

Liberty University Research Week

Approximately 42% of adults in the US today are classified as obese, an additional 30% categorized as overweight, and it is projected that half of the adult U.S. population will meet the criteria for obesity by 2030. Obesity is associated with negative health outcomes, compounded by substantial economic ramifications for affected individuals. Glucagon-like peptide-1 (GLP-1s) receptor agonists like Semaglutide and Tirzepatide have garnered attention as promising weight-loss treatments. However, their widespread adoption has been impeded by financial constraints to the healthcare system. Our study aims to explore the association between prescription rates and costs of GLP-1 medications and obesity trends …

The Sweet Lie, Rayah Smith

Liberty University Research Week

This presentation examines the treatment for a documentary about the scandal coverup of the sugar industry. The sugar industry is responsible for faulty research and information influencing the diet culture and overall health of America. The documentary starts by discussing the diet culture and health standards before the incorrect influences occurred. It will show different statists of food proportions and the overall health of America. Then the treatment shows the mood changing as the narrators will explain what the sugar industry did. They will explain how studies were done without the sponsorship of the sugar industry being disclosed and how …

Complementary Alternative Medicine (Cam) And Nausea And Vomiting During Pregnancy (Nvp) Across Diverse Demographics: Pilot Data Collection, Erin Chocklett

Liberty University Research Week

Current research explores the experiences and prevalence of nausea and vomiting among pregnant women, but much is still unknown about how women choose to treat NVP. A plethora of research, documents differences in experiences among pregnant women in the severity of NVP, and its outcomes on pregnancy and infant health. There are options considered alternative health treatments, that focus on more holistic and natural approaches for preventing and treating the symptoms of NVP. Previous work done by Dr. Linnaya Graf and Dr. Debra Blackett provides a comprehensive dive into the literature exploring the Perceptions of Using Complementary Alternative Medicine (CAM) …

Time To Tickle The Taste Buds, Victoria Maclean

Liberty University Research Week

The CHEM 497 Special Topics in Chemistry: Kitchen Chemistry course was designed for students to learn, engage, reason with, and practice foundational scientific principles in a familiar setting – food in the kitchen. The process of cooking involves transforming the qualities of ingredients and how they combine to form new textures, flavors, and tastes. According to our survey, taste is the most important factor when determining how appealing a certain food product is. Thus, finding a compound to alter the taste and perception of food could prove very useful. The Miracle Fruit Berry (MFB) is not sweet in and of …

Morphology Of Trematodes In Gadwall Ducks (Mareca Strepera) Found In The Mississippi Valley: Parasitology Class Project, Annika N. Lensch, Ethan B. Gjervik, Mckenna A. Baker, Elizabeth K. Haumont, Mivang Xiong

Research & Creative Achievement Day

Gadwall ducks (Mareca strepera) are commonly found in lakes, ponds, and marshes west of the Mississippi River in summer months. A Gadwall duck is considered a dabbler duck which feeds on aquatic plants floating on the water's surface occasionally feeding on insects, crustaceans (crayfish, crabs), and small fish. Trematodes are a commonly found parasite in the gastrointestinal tract of many species of ducks. The ducks used in this study were legally collected and donated by hunters from Buffalo City, Wisconsin along the Mississippi River. This study will focus on identifying trematodes found within Gadwall ducks such as Echinostoma, Zygocotyle, and …

Silent Cycles: Unveiling 19th-Century Perspectives On Menstruation, Women's Agency, And Societal Transformations, Anna Bennethum

Campus Research Month

In the 19th century, menstruation was a topic often vieled in silence and misinformation. Nonetheless, it is pivotal in discussions on women's agency and societal shifts. This paper explores 19th-century medical perceptions, the dissemination of reproductive knowledge through women's publications, and a case study of Adventist health publications. Through primary source analysis, this paper reveals how access to medical knowledge empowered women, especially in pursuing higher education. Additionally, examination of Adventist health publications showcases alternative remedies to menstrual disorders, granting women control over their reproductive health. This study illuminates the intersection of menstruation, women's agency, and societal change, emphasizing the …

Perceptions And Practices Of Self-Care, Genesis Sanchez, Amber Bowes, Kilah Runnels, Sophia Cirigliano

Campus Research Month

No abstract provided.

Faith Community Nursing Case Study: Share Grant Procurement During The Covid-19 Epidemic, Deborah J. Ziebarth, Deborah Fell-Carlson, Marcy Shanks

International Journal of Faith Community Nursing

A group of faith community nurses (FCNs) in rural Oregon joined together to form the Faith Community Health Network (FCHN). They applied for and received a grant to provide care coordination services to the residents of Lebanon and the greater Linn County. This case study is used to present the FCHN’s journey from coalition to a funded non-profit during the COVID-19 pandemic and the grant, “Rebuilding the Bridge Between Healthcare and Faith Communities” they received from the Intercommunity Health Network Coordinated Care Organization. The grant’s intent was to support the FCNs to expand their network, document electronically, and provide care …

Psychological Science: Who’S Really In Charge? Popular Media’S Influences On Food Behavior, Chakuen W. Rambang, Amilya Bryant, Benjamin Ramer, Delvin Porter

[Archive] Belmont University Research Symposium (BURS)

With mass media, consumption being very accessible, many individuals are being impacted in their daily lives. Mass media influences have had the opportunity to persuade people in their daily choices such as nutritional behaviors. With different nutritional trends on the rise, the presentation of popular media applications, such as TikTok, may have correlations to how individuals react to different trends regarding nutrition. Many videos on the platform have different algorithms that persuade their viewers to partake in different trends. In addition to popular media possibly having the impact of changing an individual's behavior, the overall understanding of nutrition may play …

Rebuilding Lives: Exploring The Advantages Of Occupational Therapy In A Community-Based Resource Center For Homeless Veterans, Melanie Clampitt

MOT Student Capstones

Current research demonstrates that homeless veterans continue to face unmet needs through ineffective government programs. Although community-based veterans resource centers have been established to address these gaps, they are often overwhelmed by the number of homeless veterans seeking assistance. The occupational therapy (OT) profession is uniquely positioned to address these challenges by utilizing interventions that enhance occupational performance and participation, 3 improving homeless veterans' overall quality of life. However, these programs are frequently overlooked due to a need for more awareness among resource center staff and community stakeholders regarding the benefits of OT. An extensive review of scholarly articles was …

The Result Of Her Experiment: Evelyn De Morgan's Spiritualist Message Of A Hopeful Death, Mary Daylin Paul

Theses and Dissertations

The late Victorian artist Evelyn De Morgan's paintings have been analyzed and interpreted through the lens of her many stylistic influences by past critics and current art historians. This thesis seeks to restore 19th-century Spiritualism as the central influence on the subject matter and style of De Morgan's paintings. This is particularly true of works concerned with the struggles of mortal life and the moment of death, based on her anonymously published text The Result of an Experiment. Victorian mourning rituals, Spiritualism, and the writings of Swedenborg served to draw out the specific Spiritualist symbols within De Morgan's paintings. A …

April 18, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Accurate Measurement Of Field Size Is Essential For Analysis Of Smallholder Survey Data, Rica Joy Flor, Shen Yuan, Gonzalo Rizzo, Fahmuddin Agus, Anny Ruth P. Pame, Akhara Ouk, Rathmuny Then, Sokheng Keo, Virender Kumar, Particio Grassini

Department of Agronomy and Horticulture: Faculty Publications

Context: Agronomic surveys play a vital role in identifying on-farm yield constraints and opportunities to increase productivity, input-use efficiency, and farmer profit. These surveys typically rely on farmer-reported data, where crop yield and applied inputs per hectare are estimated based on farmer-reported total harvested output and applied inputs per field and associated field size. At question is how accurate field size is, which is vital in the case of smallholders as small inaccuracies can lead to large biases in estimated yield and inputs.

Objectives: The goals of this study are to assess current approaches to determine field size …

Association Between Handgrip Strength And Muscle Mass In Children 6 To 10 Years Old, Samantha Velázquez Villalobos

Theses and Dissertations

Measuring body composition in children is important due to the rise of childhood obesity and changes that occur during pre-pubertal years. Sarcopenia, defined as a muscle mass loss and function, is increasingly recognized in pediatric populations, particularly in childhood obesity. Therefore, it is necessary to have measurements which not only provide an overall picture of body composition, but that can distinguish between muscle and fat mass. Methods of body composition such as Dual Energy X-ray Absorptiometry (DEXA) provide accurate assessments of body composition, but they are resource-intensive and impractical for routine monitoring in clinical or community settings. To address this, …

Family Medicine’S Role In Addressing The Intersections Of Redlining And Climate Change, Daryl O. Traylor, Eboni E. Anderson, Brianna Clark, Alex M. Smith, Cooper K. Allenbrand

Journal of Sustainable Social Impact

Redlining, the practice of discriminating against specific neighborhoods based on race and socioeconomic status, leads to persistent environmental hazards and socioeconomic inequalities that have lasting adverse health effects on their populations. Health disparities are further exacerbated through the concentration of environmental hazards, as well as the escalating impact of climate change, which poses an increased risk of respiratory illness, cardiovascular disease, mental health issues, heat-related illness, infectious diseases, food insecurity, and socioeconomic difficulties in redline neighborhoods.

This paper examines the interplay of redlining, climate change, and health disparities, with an emphasis on the enduring consequences for these marginalized communities. Through …

April 18, 2024, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Direct Hyperbilirubinemia And Infant Characteristics In A Newborn Intensive Care Population, Maritza Chavez, Holly Kastendieck, Jessie R. Maxwell, Dawn Novak

2024 Pediatric Research Forum Session

Background: Direct hyperbilirubinemia is frequently encountered in the NICU and is always a pathologic condition. It is exceedingly difficult to distinguish between common causes of direct hyperbilirubinemia based on laboratory work-up alone. Through retrospective chart review we aim to better establish the incidence of risk factors and progression of direct hyperbilirubinemia in the NICU, with the goal of streamlining the secondary evaluation.

Methods: A retrospective chart review was conducted for neonates admitted to the University of New Mexico Hospital NICU from February 1^st, 2019, through February 1^st, 2022 who had a direct hyperbilirubinemia level of .5 …

Computational Fluid Dynamics Analysis And Empirical Evaluation Of Carboxymethylcellulose/Alginate 3d Bioprinting Inks For Screw-Based Microextrusion, Sungmin Lee, Minjae Son, Juo Lee, Iksong Bun, Jin-Woo Kim, Jungsil Kim, Hoon Seonwoo

Biological and Agricultural Engineering Faculty Publications and Presentations

Three-dimensional microextrusion bioprinting technology uses pneumatics, pistons, or screws to transfer and extrude bioinks containing biomaterials and cells to print biological tissues and organs. Computational fluid dynamics (CFD) analysis can simulate the flow characteristics of bioinks in a control volume, and the effect on cell viability can be predicted by calculating the physical quantities. In this study, we developed an analysis system to predict the effect of a screw-based dispenser system (SDS) on cell viability in bioinks through rheological and CFD analyses. Furthermore, carboxymethylcellulose/alginate-based bioinks were used for the empirical evaluation of high-viscous bioinks. The viscosity of bioinks was determined …

Validity Of Self-Reported Weight And Height Among Female Young Adults In The United Arab Emirates, Dalia Haroun, Aseel Ehsanallah

All Works

Self-reported weight and height serve as important metrics in estimating overweight and obesity prevalence within epidemiological studies, primarily due to their cost and time efficiency. However, the accuracy and reliability of these self-reported measures remain controversial, with conflicting reports emerging from different regions. This study aims to compare self-reported weight and height with measured values among young female adults in the United Arab Emirates. A cross-sectional study of 131 female university students aged 17-27 reported their weight and height on a self-administered questionnaire and on the same day had their height and weight measured. Body Mass Index (BMI) values of …

Cocoa Polyphenols Modulate The Fecal Microbiome In A Mouse Model Of Colitis, Independent Of Basal Diet And Colon Inflammation, Abby D. Benninghoff

Browse all Datasets

Chronic inflammation increases the risk of developing multiple chronic diseases, including cancer. The risk of developing colorectal cancer (CRC) specifically is increased in individuals who suffer from colitis, a characteristic of Inflammatory Bowel Disease (IBD). Diet is another risk factor for developing CRC, particularly an inflammation-promoting Western-type diet. Thus, supplementing a Western diet with functional foods containing anti-inflammatory polyphenols is a potential approach to decreasing CRC risk by reducing gut inflammation and altering gut microbiome profile. This study aimed to determine the effects of cocoa polyphenol (CP) supplementation on inflammation status and microbiome profile before, during, and after colitis when …

Session E Overview Of The U.S. Cosmetics Regulatory Framework, Jannavi Srinivasan

Oxford ICSB

Cosmetic products in the U.S. has been regulated by the Food and Drug Administration (FDA) according to the Federal Food, Drug, and Cosmetic Act which has provided for FDA’s regulation of cosmetics since 1938. The Modernization of Cosmetics Regulation Act (MoCRA), enacted in December of 2022, significantly expanded and reformed regulations overseeing cosmetics in the U.S. Included in MoCRA among other provisions, are facility registration and product listing, reporting of serious adverse events, and a requirement that FDA propose a rule for good manufacturing practices. This presentation will provide an overview of cosmetics regulations including the major provisions of MoCRA …

Cracking A Back Is Not Rehabilitation: A Comparative Analysis Of Chiropractic Vs. Physical Therapy, Lauren M. Radack

Student Scholar Showcase

There is an increasingly common belief among the general public that chiropractic care is more successful in treating injuries than physical therapy. Research shows that chiropractic care cannot be compared to physical therapy due to their different skill sets, knowledge of treatment, and applications; therefore, one modality cannot be determined better than the other. While the two domains are incomparable, individuals continue to feel pressured to select between chiropractic care and physical Therapy. Analyzing the influence of the false claims and misinformation that surrounds rehabilitation services, the belief that physical therapy treatment is able to be replaced by chiropractic treatment …

Artificial Intelligence, Human Cognition, And Human Rights: Employee Infantilization And Organized Immaturity With Bossware Platforms, Jo Ann Oravec

Midwest Ethics Symposium

No abstract provided.