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Around The Center, 1989 June, Advocate Health - Midwest Jun 2024

Around The Center, 1989 June, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, a patient letter, and features on reversing reimbursement denials and on pesticides.


Around The Center, 1992 June, Advocate Health - Midwest Jun 2024

Around The Center, 1992 June, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and photographs from the annual dinner dance and talent show.


Obesity Severity Among Adolescents Presenting For Initial Evaluation To An Adolescent Weight Loss Surgery Program, Maria Cuccia, Alicia Wheelington, Hallie Kaplan, Grayce O'Neil, Sarah Barlow, Faisal Qureshi Jun 2024

Obesity Severity Among Adolescents Presenting For Initial Evaluation To An Adolescent Weight Loss Surgery Program, Maria Cuccia, Alicia Wheelington, Hallie Kaplan, Grayce O'Neil, Sarah Barlow, Faisal Qureshi

2024

No abstract provided.


Central Thromboxane A2, Prostaglandin F2Α, Prostaglandin E, And Prostaglandin D Contribute To The Cardiovascular Effects Elicited By Nesfatin-1, Gökçen Güvenç Bayram, Murat Yalçin Jun 2024

Central Thromboxane A2, Prostaglandin F2Α, Prostaglandin E, And Prostaglandin D Contribute To The Cardiovascular Effects Elicited By Nesfatin-1, Gökçen Güvenç Bayram, Murat Yalçin

Turkish Journal of Medical Sciences

Background/aim: Our recent study revealed that the expression of lipoxygenase (LOX) and cyclooxygenase (COX) enzymes in the hypothalamus is activated by nesfatin-1, leading to the liberation of leukotrienes and prostaglandins (PG), respectively. Moreover, our prior report explained that intracerebroventricular (ICV) nesfatin-1 treatment triggers cardiovascular responses mediated by central LOX and COX enzymes. Building upon our prior reports, the present investigation sought to clarify the role of cardiovascularly active central COX products, such as thromboxane (TX) A2, PGF2α, PGE, and PGD, in orchestrating nesfatin-1-evoked reactions in mean arterial pressure (MAP) and heart rate (HR).Materials and methods: The Sprague Dawley rats, which …


From Australia To Nebraska: Researching Social Value, Marilyn R. Schlake, Cheryl A. Burkhart-Kriesel, Jean Ann Fischer, Michelle Krehbiel, Randy Saner Jun 2024

From Australia To Nebraska: Researching Social Value, Marilyn R. Schlake, Cheryl A. Burkhart-Kriesel, Jean Ann Fischer, Michelle Krehbiel, Randy Saner

Cornhusker Economics

Globally, there is a growing body of research on social capital through the lens of social value, or how the social connections translate into actions with tangible outcomes impacting livelihoods and well-being. In the United States, social value is a relatively new perspective that will add to the social capital discussion.


Structural Analysis Of The Female Reptile Reproductive System By Micro-Computed Tomography And Optical Coherence Tomography†, Bonnie K Kircher, Michaela A Mccown, Deirdre M Scully, Richard R Behringer, Irina V Larina Jun 2024

Structural Analysis Of The Female Reptile Reproductive System By Micro-Computed Tomography And Optical Coherence Tomography†, Bonnie K Kircher, Michaela A Mccown, Deirdre M Scully, Richard R Behringer, Irina V Larina

Faculty, Staff and Student Publications

Volumetric data provide unprecedented structural insight to the reproductive tract and add vital anatomical context to the relationships between organs. The morphology of the female reproductive tract in non-avian reptiles varies between species, corresponding to a broad range of reproductive modes and providing valuable insight to comparative investigations of reproductive anatomy. However, reproductive studies in reptilian models, such as the brown anole studied here, have historically relied on histological methods to understand the anatomy. While these methods are highly effective for characterizing the cell types present in each organ, histological methods lose the 3D relationships between images and leave the …


Social Stigma Of Obesity In Neil Labute’S Fat Pig, : Rafal Thair Abdul Qadir, . Marwa Ghazi Mohammed Jun 2024

Social Stigma Of Obesity In Neil Labute’S Fat Pig, : Rafal Thair Abdul Qadir, . Marwa Ghazi Mohammed

Uruk Journal of Human Sciences

Beauty standards are often influenced by social values ​​and cultural norms. What is considered to be beautiful has evolved over time and varies across cultures. These standards play a significant role in individuals' perceptions and behaviors about beauty. In addition, society places strong pressure on women to follow unrealistic beauty ideals. In today’s society, being slim is the ideal that women should follow. On the other hand, obese women are subjected to frequent judgments based on their weight and appearance. The constant exposure to social judgments and negative comments about their bodies can lead them to have body dissatisfaction, low …


Associations Between Circadian Alignment And Cognitive Functioning In A Nationally Representative Sample Of Older Adults, Sophie Leahy, Qian Xiao, Chris Ho Ching Yeung, Mariana G Figueiro Jun 2024

Associations Between Circadian Alignment And Cognitive Functioning In A Nationally Representative Sample Of Older Adults, Sophie Leahy, Qian Xiao, Chris Ho Ching Yeung, Mariana G Figueiro

Faculty, Staff and Student Publications

Proper alignment of activity-rest and light-dark patterns allows for healthy bodily functions to occur at optimal times of the day. Disruptions to this alignment may cause poor sleep as well as physical, mental, and cognitive problems. The purpose of this cross-sectional study was to determine if poorer circadian alignment was associated with decreased cognitive functioning among older (> 60 years) participants in the National Health and Nutrition Examination Survey. We utilized actigraphy-based rest-activity and dark-light measurements to calculate phasor magnitude (strength of circadian alignment coupling) and phasor angle (phase difference between activity-rest and light-dark cycles). Multiple linear regression models were …


Implications Of The Net Zero Transition Scenarios On Sdg Indicators: Linking Global Energy System, Cge And Atmospheric Source-Receptor Models, Maksym Chepeliev, George Giannakidis, Amit Kanudia, Dominique Van Der Mensbrugghe Jun 2024

Implications Of The Net Zero Transition Scenarios On Sdg Indicators: Linking Global Energy System, Cge And Atmospheric Source-Receptor Models, Maksym Chepeliev, George Giannakidis, Amit Kanudia, Dominique Van Der Mensbrugghe

Department of Agricultural Economics Faculty Publications

This study contributes to a better understanding of synergies and trade-offs between climate mitigation and sustainable development goals, covering 17 indicators across various SDGs. Our assessment employs a multi-model framework, which includes a global computable general equilibrium model (ENVISAGE), an energy system model (KINESYS) and an atmospheric source-receptor model (TM5-FASST). This combination of modeling tools allows us to provide a detailed representation of the energy-related SDG indicators while accounting for their interactions with climate mitigation and socio-economic dimensions. We find that out of 17 analyzed SDG indicators, seven experience co-benefits from implementing mitigation efforts (including improved environmental footprints, energy efficiency …


Self-Determination Towards Regular Exercise Relates To Quality Of Life In Female College Students With At Least One Child, Toby Khung Chilai Roylance Jun 2024

Self-Determination Towards Regular Exercise Relates To Quality Of Life In Female College Students With At Least One Child, Toby Khung Chilai Roylance

Theses and Dissertations

Inspired by one of my daughters, Rachel Tam, and her journeys through motherhood while pursuing an MBA at Brigham Young University, this study was conceived from observing her struggle to balance academic responsibilities, motherhood, being a wife, and prenatal care. Her experience highlighted the significance of self-directed physical activity (PA) for young mothers pursuing higher education in a religious institution. This study explores the dynamics of PA, motivation, and well-being among 264 college-attending mothers from Brigham Young University Provo and BYU-Pathway Worldwide. These participants were selected from an online survey pool of over 1,500 female student respondents. All mothers in …


Rest-Dependent Downregulation Of Von Hippel-Lindau Tumor Suppressor Promotes Autophagy In Shh-Medulloblastoma, Ashutosh Singh, Donghang Cheng, Jyothishmathi Swaminathan, Yanwen Yang, Yan Zheng, Nancy Gordon, Vidya Gopalakrishnan Jun 2024

Rest-Dependent Downregulation Of Von Hippel-Lindau Tumor Suppressor Promotes Autophagy In Shh-Medulloblastoma, Ashutosh Singh, Donghang Cheng, Jyothishmathi Swaminathan, Yanwen Yang, Yan Zheng, Nancy Gordon, Vidya Gopalakrishnan

Faculty, Staff and Student Publications

The RE1 silencing transcription factor (REST) is a driver of sonic hedgehog (SHH) medulloblastoma genesis. Our previous studies showed that REST enhances cell proliferation, metastasis and vascular growth and blocks neuronal differentiation to drive progression of SHH medulloblastoma tumors. Here, we demonstrate that REST promotes autophagy, a pathway that is found to be significantly enriched in human medulloblastoma tumors relative to normal cerebella. In SHH medulloblastoma tumor xenografts, REST elevation is strongly correlated with increased expression of the hypoxia-inducible factor 1-alpha (HIF1α)-a positive regulator of autophagy, and with reduced expression of the von Hippel-Lindau (VHL) tumor suppressor protein - a …


Unraveling The Nexus: Social Spending, Development, And Breaking The Cycle Of Poverty, Yasmin Shehata Jun 2024

Unraveling The Nexus: Social Spending, Development, And Breaking The Cycle Of Poverty, Yasmin Shehata

Theses and Dissertations

This study examines the role of development, as indicated by the Human Development Index (HDI), in shaping the connection between social public spending on health, education, and social protection and poverty in terms of the poverty headcount ratio at $3.65/day (2017 PPP). Empirical analysis is used to this end, employing a panel dataset of 68 countries at varied stages of development over the period 1995-2021. The empirical model is estimated using the Fixed Effects Two-stage Least Squares (2SLS). It is also re-estimated using the Instrumental Variable Generalized Method of Moments (IV-GMM) and Limited Information Maximum Likelihood (LIML) to test the …


Unlocking Prosperity: The Role Of Icts In Alleviating Poverty In Middle East And Africa, Yousra Elnemr Jun 2024

Unlocking Prosperity: The Role Of Icts In Alleviating Poverty In Middle East And Africa, Yousra Elnemr

Theses and Dissertations

Most countries in the Middle East and Africa region (MEA) have recently witnessed digital improvements despite the increase in poverty rates. This thesis investigates the potential relationship of Information and Communication Technologies and poverty reduction using annual unbalanced panel data for 21 MENA countries and 48 Sub Saharan African (SSA) countries from 1990 to 2022. By focusing on two primary ICT indicators representing ICT usage and access—internet penetration and mobile subscriptions— our research applies Fixed-Effects Two Stage Least Square (2SLS) economic model to explore their relationship with the poverty headcount ratio at the $2.15 per day international poverty line. The …


How Do The Entrepreneurial Motivations And Struggles Of Egyptian Women Entrepreneurs Challenge Existing Perspectives?, Salma Sherif Jun 2024

How Do The Entrepreneurial Motivations And Struggles Of Egyptian Women Entrepreneurs Challenge Existing Perspectives?, Salma Sherif

Theses and Dissertations

This paper examines ten profiles of Egyptian women entrepreneurs and compares their perspectives to the widespread and main arguments in the existing literature reviewed on the topic; mainly their entrepreneurial motivation and challenges. The paper reveals similarities and contradictions, and introduces different angles to perceiving both aspects. The researcher concludes that contextualizing entrepreneurial motivations can, therefore, disclose deeper dimensions to the subject matter, and as for the challenges, it can change their relative importance. For the primary data collection, the paper follows a non-probability sampling approach by applying a purposive sampling technique. Semi-structured, in-depth interviews were conducted accordingly. The women …


Feasibility Of Oil Palm Agroforestry System: Evaluating The Application Of Oil Palm Ash For Enhancing Cherry Tomato (Solanum Lycopersicum. Var. Nancy Rz) Production Using Brackish Water., Ime Joseph Bassey Jun 2024

Feasibility Of Oil Palm Agroforestry System: Evaluating The Application Of Oil Palm Ash For Enhancing Cherry Tomato (Solanum Lycopersicum. Var. Nancy Rz) Production Using Brackish Water., Ime Joseph Bassey

Theses and Dissertations

Monoculture systems of oil palm production are ravaging the world’s tropical forests, causing deforestation and biodiversity loss, which contribute to climate change at an uncontrollable pace. Oil palm agroforestry systems (AFSs), one of the strategies of regenerative agriculture, have proven to reverse the unfavorable effects of the oil palm monoculture systems. A sustainable means of soil fertilization and irrigation must be explored to improve the feasibility of oil palm AFSs. This study evaluates the impact of the application of oil palm ash and brackish irrigation on cherry tomato production. The experiment was conducted in a hydroponic system using a 2*4 …


The Inflammatory Exposome Of Major Depressive Disorder In An Egyptian Sample, Reem Deif Jun 2024

The Inflammatory Exposome Of Major Depressive Disorder In An Egyptian Sample, Reem Deif

Theses and Dissertations

Major depressive disorder (MDD) has been recognized as a global public health concern affect-ing the lives of 264 million people with increasing prevalence worldwide. Inspired by the expo-somic research, this study aims to investigate the dynamic and complex interplay between dif-ferent demographic, lifestyle, environmental factors and bimolecular factors that are potentially involved in the pathology of MDD in a sample of Egyptian adults living in Cairo. This is in an attempt to acknowledge the biological underpinnings of MDD without underestimating the role of environmental influences. The context of Egypt provides richness to the current study given the national transition from …


Water Quality Assessment, Eutrophication, And Pollution Index In Lake Edku (Nile Delta Of Egypt), Mohamed A. Okbah, Mahmoud S. Ibrahim, Tarek O. Said, Mohammed E.M. Nassar, Maie I. El-Gammal Jun 2024

Water Quality Assessment, Eutrophication, And Pollution Index In Lake Edku (Nile Delta Of Egypt), Mohamed A. Okbah, Mahmoud S. Ibrahim, Tarek O. Said, Mohammed E.M. Nassar, Maie I. El-Gammal

Blue Economy

Lake Edku is one of the most important lakes in the northern Nile Delta of Egypt. Studying the physicochemical characteristics and nutrient salts is essential for assessing water quality. pH recorded values fell within internationally permitted limits; the temperature was suitable for the growth of fish and living organisms. Electrical conductivity indicates a source of fresh water; salinity indicates that the lake water is brackish; Total Dissolved Solids (TDS) refers to most of the fresh water in the lake. Solid particulate matter occurred within the permissible limits according to WHO, and DO, and some results exceeded the permissible limit. However, …


Survey Evidence In Trademark Actions, Ioana Vasiu And Lucian Vasiu Jun 2024

Survey Evidence In Trademark Actions, Ioana Vasiu And Lucian Vasiu

DePaul Business & Commercial Law Journal

No abstract provided.


A Systematic Review On Umbilical Cord As An Effective And Cost-Beneficial Alternative For Stem Cell Therapy, Ashley Janelle R. Barcelona, Frances Claire A. Chin, Hanna Leila S. Manalo Jun 2024

A Systematic Review On Umbilical Cord As An Effective And Cost-Beneficial Alternative For Stem Cell Therapy, Ashley Janelle R. Barcelona, Frances Claire A. Chin, Hanna Leila S. Manalo

DLSU Senior High School Research Congress

The high cost and limited accessibility of bone marrow-derived stem cell therapy pose substantial challenges to its widespread adaptation. In contrast, the umbilical cord, often discarded as biomedical waste, offers a promising and cost-effective source of stem cells with therapeutic potential. This study aims to investigate the potential cost savings and medical benefits that could be derived from using umbilical cord stem cells as an alternative to bone marrow in stem cell therapy. The study conducted a comparative analysis systematically reviewing existing research using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. The study compared the procedures, …


Refined Sugar Consumption And Its Association With The Academic Performance Of Dlsu-Is Grade 12 Stem Students, Johna King, Juliana Milan J. Carpio, Jiana Fhem P. Retrita, Sophia Louise A. Traspe Jun 2024

Refined Sugar Consumption And Its Association With The Academic Performance Of Dlsu-Is Grade 12 Stem Students, Johna King, Juliana Milan J. Carpio, Jiana Fhem P. Retrita, Sophia Louise A. Traspe

DLSU Senior High School Research Congress

The study examines DLSU-IS Grade 12 STEM students’ refined sugar intake and academic performance for the first trimester of the academic year 2023–2024. The study aims to determine if a significant correlation exists between the consumption of foods containing refined sugar and the students’ academic performance. The study analyzes Grade 12 STEM students’ data using quantitative methods such as descriptive statistics and the Pearson correlation coefficient to investigate the relationship and possible correlation between the two variables. Student survey results showed that cookies or biscuits were the most popular processed foods high in refined sugar (71.8%) that they consume, followed …


Influence Of Green Versus Conventional Colored Buns On The Perceived Healthiness Of Banana Heart Burgers Among Grades Four To Six Students At La Salle College Antipolo, Joby Keren Dg. Parrocha, Brielle Angela M. Toledo, Kilua Angelo G. Daloma, Jason Angelo A. Alarcos, Alfonso Barron R. Espiritu, Cassandra Maze Guinevere D. Garvida Jun 2024

Influence Of Green Versus Conventional Colored Buns On The Perceived Healthiness Of Banana Heart Burgers Among Grades Four To Six Students At La Salle College Antipolo, Joby Keren Dg. Parrocha, Brielle Angela M. Toledo, Kilua Angelo G. Daloma, Jason Angelo A. Alarcos, Alfonso Barron R. Espiritu, Cassandra Maze Guinevere D. Garvida

DLSU Senior High School Research Congress

This study investigated the influence of bun color on the perceived healthiness of banana heart burgers among grades four to six students at La Salle College Antipolo. Employing a quantitative experimental design, 30 participants were exposed to burgers with either green or conventional-colored buns. Data gathered through a structured survey were analyzed using frequency distributions and an Independent Samples T-Test. Results indicated that while the color green was overwhelmingly associated with healthiness (93.3%), changes in bun color did not significantly influence the perceived healthiness of the burgers (p = 0.784). Consequently, the study supports the null hypothesis, suggesting that visual …


The Correlation Between Students’ Academic Workload And Salivary Ph Levels, Yves Zidane J. Biscocho, Lorenzo Miguel S. Carpio, Giovanni Paolo C. Salceda Jun 2024

The Correlation Between Students’ Academic Workload And Salivary Ph Levels, Yves Zidane J. Biscocho, Lorenzo Miguel S. Carpio, Giovanni Paolo C. Salceda

DLSU Senior High School Research Congress

Stress has been known to have negative and positive effects on humans. Studies have shown that academic stress, which comes from overwhelming academic demands, causes various negative effects on the well-being of students. Salivary cortisol levels can also be a predictor of academic stress. Concurrently, salivary pH levels are affected by changes in the salivary cortisol, and it can be inferred that salivary pH levels can predict the increase in academic workloads. To prove this relationship between students’ academic workloads and salivary pH levels, the researchers conducted a study utilizing a prospective research design. The data was collected from sixteen …


Influence Of Green Versus Conventional Colored Buns On The Perceived Healthiness Of Banana Heart Burgers Among Grades Four To Six Students At La Salle College Antipolo, Joby Keren Dg. Parrocha, Brielle Angela M. Toledo, Kilua Angelo G. Daloma, Jason Angelo A. Alarcos, Alfonso Barron R. Espiritu, Cassandra Maze Guinevere D. Garvida Jun 2024

Influence Of Green Versus Conventional Colored Buns On The Perceived Healthiness Of Banana Heart Burgers Among Grades Four To Six Students At La Salle College Antipolo, Joby Keren Dg. Parrocha, Brielle Angela M. Toledo, Kilua Angelo G. Daloma, Jason Angelo A. Alarcos, Alfonso Barron R. Espiritu, Cassandra Maze Guinevere D. Garvida

DLSU Senior High School Research Congress

This study investigated the influence of bun color on the perceived healthiness of banana heart burgers among grades four to six students at La Salle College Antipolo. Employing a quantitative experimental design, 30 participants were exposed to burgers with either green or conventional-colored buns. Data gathered through a structured survey were analyzed using frequency distributions and an Independent Samples T-Test. Results indicated that while the color green was overwhelmingly associated with healthiness (93.3%), changes in bun color did not significantly influence the perceived healthiness of the burgers (p = 0.784). Consequently, the study supports the null hypothesis, suggesting that visual …


Noda News October 2007 Jun 2024

Noda News October 2007

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.


Differences In Perceived Energy And Macronutrient Requirements Across Divisions In Ncaa Athletes, K. Michelle Singleton, Andrew Jagim, Jamie Mcallister-Deitrick, Marcos Daou, Chad M. Kerksick Jun 2024

Differences In Perceived Energy And Macronutrient Requirements Across Divisions In Ncaa Athletes, K. Michelle Singleton, Andrew Jagim, Jamie Mcallister-Deitrick, Marcos Daou, Chad M. Kerksick

Faculty Scholarship

Background

Sports nutrition is an impactful component to sports performance. The purpose of the current study was to investigate the sports nutrition knowledge of National Collegiate Athletic Association collegiate athletes and assess self-reported perceived requirements for energy and macronutrient intake. A secondary aim was to evaluate the awareness of physical and emotional perceptions associated with mindful eating.

Methods

Participants included NCAA Division I (DI, n = 45), II (DII, n = 31), and III (DIII, n = 47) athletes. Athletes completed a validated questionnaire designed to assess sports nutrition knowledge and were asked questions about their perceived dietary energy and …


Differences In Perceived Energy And Macronutrient Requirements Across Divisions In Ncaa Athletes, K. Michelle Singleton, Andrew R. Jagim, Jamie Mcallister-Deitrick, Marcos Daou, Chad M. Kerksick Jun 2024

Differences In Perceived Energy And Macronutrient Requirements Across Divisions In Ncaa Athletes, K. Michelle Singleton, Andrew R. Jagim, Jamie Mcallister-Deitrick, Marcos Daou, Chad M. Kerksick

Kinesiology

Background: Sports nutrition is an impactful component to sports performance. The purpose of the current study was to investigate the sports nutrition knowledge of National Collegiate Athletic Association collegiate athletes and assess self-reported perceived requirements for energy and macronutrient intake. A secondary aim was to evaluate the awareness of physical and emotional perceptions associated with mindful eating. Methods: Participants included NCAA Division I (DI, n = 45), II (DII, n = 31), and III (DIII, n = 47) athletes. Athletes completed a validated questionnaire designed to assess sports nutrition knowledge and were asked questions about their perceived dietary energy and …


Incorporating Citizen-Generated Data Into Large Language Models, Jagadeesh Vadapalli, Srishti Gupta, Bishwa Karki, Chun-Hua Tsai Jun 2024

Incorporating Citizen-Generated Data Into Large Language Models, Jagadeesh Vadapalli, Srishti Gupta, Bishwa Karki, Chun-Hua Tsai

Information Systems and Quantitative Analysis Faculty Publications

This study investigates the use of citizen-generated data to optimize a large language model (LLM) chatbot that gives nutrition advice. By actively participating in the data collection and annotation process from FDA-approved websites, citizens provided insightful information that was essential for improving the model and addressing biases. The study highlights the difficulties in gathering and annotating data, especially in situations where nuances matter, such as pregnancy nutrition. The results show that the use of citizen-generated data improves the efficacy and efficiency of data collection procedures, providing a practical viewpoint and encouraging community involvement. In addition to guaranteeing data quality, the …


Non-Transgenic Guinea Pig Strains Exhibit Divergent Age-Related Changes In Hippocampal Mitochondrial Respiration, Maureen A. Walsh, Amanda S. Latham, Qian Zhang, Robert A. Jacobs, Robert V. Musci, Thomas J. Larocca, Julie A. Moreno, Kelly S. Santangelo, Karyn L. Hamilton Jun 2024

Non-Transgenic Guinea Pig Strains Exhibit Divergent Age-Related Changes In Hippocampal Mitochondrial Respiration, Maureen A. Walsh, Amanda S. Latham, Qian Zhang, Robert A. Jacobs, Robert V. Musci, Thomas J. Larocca, Julie A. Moreno, Kelly S. Santangelo, Karyn L. Hamilton

Health and Human Sciences Faculty Works

Aim: Alzheimer’s disease (AD) is the most common form of dementia. However, while 150+ animal models of AD exist, drug translation from preclinical models to humans for treatment usually fails. One factor contributing to low translation is likely the absence of neurodegenerative models that also encompass the multi-morbidities of human aging. We previously demonstrated that, in comparison to the PigmEnTed (PET) guinea pig strain which models “typical” brain aging, the Hartley strain develops hallmarks of AD like aging humans. Hartleys also exhibit age-related impairments in cartilage and skeletal muscle. Impaired mitochondrial respiration is one driver of both cellular aging and …


Limited Nerve Regeneration Across Acellular Nerve Allografts (Anas) Coincides With Changes In Blood Vessel Morphology And The Development Of A Pro-Inflammatory Microenvironment, Jesús A Acevedo Cintrón, Daniel A Hunter, Lauren Schellhardt, Deng Pan, Susan E Mackinnon, Matthew D Wood Jun 2024

Limited Nerve Regeneration Across Acellular Nerve Allografts (Anas) Coincides With Changes In Blood Vessel Morphology And The Development Of A Pro-Inflammatory Microenvironment, Jesús A Acevedo Cintrón, Daniel A Hunter, Lauren Schellhardt, Deng Pan, Susan E Mackinnon, Matthew D Wood

2020-Current year OA Pubs

The use of acellular nerve allografts (ANAs) to reconstruct long nerve gaps (>3 cm) is associated with limited axon regeneration. To understand why ANA length might limit regeneration, we focused on identifying differences in the regenerative and vascular microenvironment that develop within ANAs based on their length. A rat sciatic nerve gap model was repaired with either short (2 cm) or long (4 cm) ANAs, and histomorphometry was used to measure myelinated axon regeneration and blood vessel morphology at various timepoints (2-, 4- and 8-weeks). Both groups demonstrated robust axonal regeneration within the proximal graft region, which continued across …


Role Of Ethanolamine Utilization And Bacterial Microcompartment Formation In Listeria Monocytogenes Intracellular Infection, Ayan Chatterjee, Karan Gautam Kaval, Danielle A Garsin Jun 2024

Role Of Ethanolamine Utilization And Bacterial Microcompartment Formation In Listeria Monocytogenes Intracellular Infection, Ayan Chatterjee, Karan Gautam Kaval, Danielle A Garsin

Faculty, Staff and Student Publications

Ethanolamine (EA) affects the colonization and pathogenicity of certain human bacterial pathogens in the gastrointestinal tract. However, EA can also affect the intracellular survival and replication of host cell invasive bacteria such as Listeria monocytogenes (LMO) and Salmonella enterica serovar Typhimurium (S. Typhimurium). The EA utilization (eut) genes can be categorized as regulatory, enzymatic, or structural, and previous work in LMO showed that loss of genes encoding functions for the enzymatic breakdown of EA inhibited LMO intracellular replication. In this work, we sought to further characterize the role of EA utilization during LMO infection of host …