Digital Commons Network^™

Expanded-Access Use Of Elamipretide In A Patient With Membrane Protein-Associated Neurodegeneration, Jorge Patino, Anna Haertling Clearman, Lindsey Miller, Mary Kay Koenig

Faculty, Staff and Student Publications

This case report presents a progressively declining 17-year-old patient with membrane protein-associated neurodegeneration who demonstrated symptomatic improvements in her dysarthria, dysphagia, and gait, and objective improvements in her 6-minute walk test and 5 times sit-to-stand test during elamipretide treatment.

Accuracy Of Energy And Nutrient Intake Estimation Versus Observed Intake Using 4 Technology-Assisted Dietary Assessment Methods: A Randomized Crossover Feeding Study, Clare Whitton, Clare E. Collins, Barbara A. Mullan, Megan E. Rollo, Satvinder S. Dhaliwal, Richard Norman, Carol J. Boushey, Edward J. Delp, Fengqing Zhu, Tracy A. Mccaffrey, Sharon I. Kirkpatrick, Christina M. Pollard, Janelle D. Healy, Amira Hassan, Shivangi Garg, Paul Atyeo, Syed Aqif Mukhtar, Deborah A. Kerr

Research outputs 2022 to 2026

Background:

Technology-assisted 24-h dietary recalls (24HRs) have been widely adopted in population nutrition surveillance. Evaluations of 24HRs inform improvements, but direct comparisons of 24HR methods for accuracy in reference to a measure of true intake are rarely undertaken in a single study population.

Objectives:

To compare the accuracy of energy and nutrient intake estimation of 4 technology-assisted dietary assessment methods relative to true intake across breakfast, lunch, and dinner.

Methods:

In a controlled feeding study with a crossover design, 152 participants [55% women; mean age 32 y, standard deviation (SD) 11; mean body mass index 26 kg/m2, SD 5] were …

The Relationship Between Diet, Depression, And Alzheimer's Disease: A Narrative Review, Hilal Salim Said Al Shamsi, Stephanie R. Rainey-Smith, Samantha L. Gardener, Hamid R. Sohrabi, Rodrigo Canovas, Ralph N. Martins, Warnakulasuriya Mary Ann Dipika Binosha Fernando

Research outputs 2022 to 2026

Purpose of Review: This narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD). Recent Findings: AD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, …

Identification Of Core Competencies For Exercise Oncology Professionals: A Delphi Study Of United States And Australian Participants, Mary A. Kennedy, Kelley Covington Wood, Anna Campbell, Melanie Potiaumpai, Christopher M. Wilson, Anna L. Schwartz, Jessica Gorzelitz, Maxime Caru, Kathryn H. Schmitz

Research outputs 2022 to 2026

Introduction: Integration of exercise into standard oncology care requires a highly skilled workforce of exercise professionals; however, competency requirements have not kept pace with advancements in the field. Therefore, the aim of this study was to obtain consensus on core competencies required for an exercise professional to be qualified to work with adults undergoing active cancer treatment. Materials and Methods: A three-round modified electronic Delphi process was used. In Round 1, an international group of 64 exercise oncology stakeholders (i.e., exercise oncology professionals (n = 29), clinical referrers (n = 21), and people with lived experience (n = 14)) responded …

Strong Marine Heatwaves Trigger Flowering In Seagrass, Catalina A. García-Escudero, Victoria Litsi-Mizan, Pavlos T. Efthymiadis, Vasilis Gerakaris, Oscar Serrano, Eugenia T. Apostolaki

Research outputs 2022 to 2026

In recent decades, the global intensification of marine heatwaves has impacted several ecosystems and species, including the endemic Mediterranean seagrass Posidonia oceanica. However, the scarcity of research in Eastern Mediterranean meadows, where historical and present thermal conditions differ from those of the Western Mediterranean, hampers our ability to draw comprehensive conclusions regarding the species' response to elevated sea temperatures. Here, we studied flowering patterns of P. oceanica meadows (3–15 m depth) of the Greek seas and assessed their potential association with marine heatwaves, while also examining the effects on plant growth associated with the transition from vegetative to sexual reproduction. …

Effects Of Laccase And Transglutaminase On The Physicochemical And Functional Properties Of Hybrid Lupin And Whey Protein Powder, Teguh Santoso, Thao M. Ho, Geerththana Vinothsankar, Kirsi Jouppila, Tony Chen, Adrian Owens, Masoumeh Pourseyed Lazarjani, Mustafa M. Farouk, Michelle L. Colgrave, Don Otter, Rothman Kam, Thao T. Le

Research outputs 2022 to 2026

Plant-based protein is considered a sustainable protein source and has increased in demand recently. However, products containing plant-based proteins require further modification to achieve the desired functionalities akin to those present in animal protein products. This study aimed to investigate the effects of enzymes as cross-linking reagents on the physicochemical and functional properties of hybrid plant- and animal-based proteins in which lupin and whey proteins were chosen as representatives, respectively. They were hybridised through enzymatic cross-linking using two laccases (laccase R, derived from Rhus vernicifera and laccase T, derived from Trametes versicolor) and transglutaminase (TG). The cross-linking experiments were conducted …

University Of San Diego Magazine 75th Anniversary 2024, University Of San Diego

University of San Diego Magazine (1992- )

Forging Community; Celebrating Impact; Aesthetic Aspirations; From Grassroots to the Vatican; Lighting the Way Forward; Decade of Discovery; The Stories Within; Those at Our Core; Aiming for Excellence; Twice as Nice; A Simple Yet Grand Vision

Hiv Estimation Using Population-Based Surveys With Non-Response: A Partial Identification Approach, Oyelola A. Adegboye, Tomoki Fujii, Denis H. Y. Leung, Siyu Li

Research Collection School Of Economics

HIV estimation using data from the demographic and health surveys (DHS) is limited by the presence of non-response and test refusals. Conventional adjustments such as imputation require the data to be missing at random. Methods that use instrumental variables allow the possibility that prevalence is different between the respondents and non-respondents, but their performance depends critically on the validity of the instrument. Using Manski's partial identification approach, we form instrumental variable bounds for HIV prevalence from a pool of candidate instruments. Our method does not require all candidate instruments to be valid. We use a simulation study to evaluate and …

Expanding Time Covered For Medical Nutrition Therapy: A Need For Clear Reporting On The Intensity Of Nutrition Interventions, Rosa K. Hand

Faculty Scholarship

Medical Nutrition Therapy (MNT) is an evidence-based health care service that helps people improve their food and nutrition habits to positively influence health outcomes and quality of life, and is part of a suite of complementary interventions that can be implemented for effective disease prevention and management. However, the dose (ie, length and number of sessions) of MNT that is covered by health care payers in outpatient settings is highly variable and may not be adequate to achieve the desired clinical outcomes and cost savings. Interest in improving access to adequate doses of MNT provided by registered dietitian nutritionists (RDNs), …

Optimal Fat-Modified Diet Duration For The Treatment Of Postoperative Chylothorax In Children, Melissa M. Winder, Stephanie Schwartz, Jason R. Buckley, Kristi L. Fogg, Megan Matiasek, Alissa Lyman, Alisa Tortorich, Kathy Holmes, Deborah U. Frank, Mandy Nasworthy, Piyagarnt E. Vichayavilas, Rebecca A. Bertrandt, Cam Kasmai, Jill C. Kuester, Tia T. Raymond, Lawrence E. Greiten, Ron W. Reeder, David K. Bailly

College of Nursing Faculty Research and Publications

Background

Dietary modification is the mainstay of treatment for postoperative cyclothorax in children. However, optimal fat-modified diet (FMD) duration to prevent recurrence is unknown. Our aim was to determine the association between FMD duration and chylothorax recurrence.

Methods

Retrospective cohort study conducted across 6 pediatric cardiac intensive care units within the United States. Patients aged < 18 years who developed chylothorax within 30 days after cardiac surgery between January 2020 and April 2022 were included. Patients with a Fontan palliation, who died, or were lost to follow-up or within 30 days of resuming a regular diet were excluded. FMD duration was defined as the first day of a FMD when chest tube output was < 10 mL/kg/d without increasing until the resumption of a regular diet. Patients were classified into 3 groups (< 3 weeks, 3-5 weeks, >5 weeks) based on FMD duration.

Results

A total of 105 patients were included: < 3 weeks (n = 61) 3-5 weeks (n = 18), and >5 weeks (n = 26). Demographic, surgical, and hospitalization characteristics were not different across groups. In the >5 weeks group, chest tube duration was longer compared with the < 3 weeks and 3-5 weeks groups (median, 17.5 days [interquartile range, 9-31] vs 10 and 10.5 days; P = .04). …

A Guide To Understanding Big Data For The Nurse Scientist: A Discursive Paper, Henry Ofori Duah, Samantha J. Boch, Sara Arter, Nichole Nidey, Joshua Lambert

College of Nursing Faculty Research and Publications

Big data refers to extremely large data generated at high volume, velocity, variety, and veracity. The nurse scientist is uniquely positioned to leverage big data to suggest novel hypotheses on patient care and the healthcare system. The purpose of this paper is to provide an introductory guide to understanding the use and capability of big data for nurse scientists. Herein, we discuss the practical, ethical, social, and educational implications of using big data in nursing research. Some practical challenges with the use of big data include data accessibility, data quality, missing data, variable data standards, fragmentation of health data, and …

Cholesterol-Dependent Lxr Transcription Factor Activity Represses Pronociceptive Effects Of Estrogen In Sensory Neurons And Pain Induced By Myelin Basic Protein Fragments, Swathi K Hullugundi, Jennifer Dolkas, Andrei V Chernov, Tony L Yaksh, Kelly A Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y Strongin, Patrick M Dougherty, Yan Li, Oswal Quehenberger, Aaron Armando, Veronica I Shubayev

Faculty, Staff and Student Publications

BACKGROUND: A bioactive myelin basic protein (MBP) fragment, comprising MBP

METHODS: In male and female normal and post-CCI rat sciatic nerves, we assessed: (i) cholesterol precursor and metabolite levels by lipidomics; (ii) MBP

RESULTS: CCI regulated LXRα ligand and receptor levels in nerves of both sexes, with cholesterol precursors, desmosterol and 7-DHC, and oxysterol elevated in females relative to males. MBP

CONCLUSION: The injury-released bioactive MBP fragments induce pronociceptive changes by selective inactivation of nuclear transcription factors, including LXRα. By Ncoa1 sequestration, bioactive MBP fragments render LXRα function to counteract pronociceptive activity of estrogen/ESR1 in sensory neurons. This effect of …

Epigenetic Developmental Mechanisms Underlying Sex Differences In Cancer, Joshua B. Rubin, Tamara Abou-Antoun, Joseph E. Ippolito, Lorida Llaci, Camryn T. Marquez, Jason P. Wong, Lihua Yang

2020-Current year OA Pubs

Cancer risk is modulated by hereditary and somatic mutations, exposures, age, sex, and gender. The mechanisms by which sex and gender work alone and in combination with other cancer risk factors remain underexplored. In general, cancers that occur in both the male and female sexes occur more commonly in XY compared with XX individuals, regardless of genetic ancestry, geographic location, and age. Moreover, XY individuals are less frequently cured of their cancers, highlighting the need for a greater understanding of sex and gender effects in oncology. This will be necessary for optimal laboratory and clinical cancer investigations. To that end, …

Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation In Melanoma: Impact Of Antibiotic Preconditioning On Microbiome And Immunity, Isabella C Glitza, Yongwoo David Seo, Christine N Spencer, Jennifer R Wortman, Elizabeth M Burton, Farah A Alayli, Christopher P Loo, Shikha Gautam, Ashish Damania, Julie Densmore, Justin Fairchild, Christopher R Cabanski, Matthew C Wong, Christine B Peterson, Brian Weiner, Nathan Hicks, John Aunins, Christopher Mcchalicher, Emily Walsh, Michael T Tetzlaff, Omid Hamid, Patrick A Ott, Genevieve M Boland, Ryan J Sullivan, Kenneth F Grossmann, Nadim J Ajami, Theresa Lavallee, Matthew R Henn, Hussein A Tawbi, Jennifer A Wargo

Faculty, Staff and Student Publications

Gut-microbiota modulation shows promise in improving immune-checkpoint blockade (ICB) response; however, precision biomarker-driven, placebo-controlled trials are lacking. We performed a multicenter, randomized placebo-controlled, biomarker-stratified phase I trial in patients with ICB-naïve metastatic melanoma using SER-401, an orally delivered Firmicutesenriched spore formulation. Fecal microbiota signatures were characterized at baseline; patients were stratified by high versus low Ruminococcaceae abundance prior to randomization to the SER-401 arm (oral vancomycin-preconditioning/SER-401 alone/nivolumab + SER-401), versus the placebo arm [placebo antibiotic/placebo microbiome modulation (PMM)/nivolumab + PMM (NCT03817125)]. Analysis of 14 accrued patients demonstrated that treatment with SER-401 + nivolumab was safe, with an overall response rate …

Correlations Of Physical And Psychological Health In Parents Of Individuals With Autism Spectrum Disorder, Norah L. Johnson, Abir K. Bekhet, Emily Zint, June Wang, Sylvia Peña, Amy V. Van Hecke, Mauricio Garnier-Villarreal, Alexander V. Ng

College of Nursing Faculty Research and Publications

Background: Individuals with autism spectrum disorder (ASD) have social communication difficulties and restricted, repetitive, and/or sensory behaviors or interests. The prevalence of ASD is now 1 in 36 individuals. Parents of individuals with ASD face challenges that can affect their physical and psychological wellbeing.

Objective: With the long-term goal to tailor an exercise program, the purpose of this study was 2-fold: (1) establish the baseline physical and mental health of parents of individuals with ASD and (2) estimate the relationship of physiologic variables with psychological variables of health for parents of individuals with ASD.

Methods: This descriptive, cross-sectional study (N …

Religiosity, Dietary Acculturation, And Obesity Among Immigrants To The United States, Samira Rahman

Electronic Theses and Dissertations Archive

Obesity, influenced by lifestyle choices, has risen sharply worldwide and is linked to diabetes, cancers, and cardiovascular diseases. Among U.S. immigrants, obesity risk often increases with acculturation to American practices. However, religious involvement and maintaining the origincountry diet may protect against obesity. Using 2003 New Immigrant Survey data, this study examines the relationship between religion and obesity among immigrants to the United States. Results show significant variations: Jewish immigrants have the highest obesity risk, while Buddhist immigrants have the lowest, due to cultural and dietary practices. Longer U.S. residence and older age correlate with higher obesity rates. The findings emphasize …

Antenatal Care Utilisation And Receipt Of Its Components In Nigeria: Assessing Disparities Between Rural And Urban Areas—A Nationwide Population-Based Study, Emmanuel O. Adewuyi, Asa Auta, Mary I. Adewuyi, Aaron Akpu Philip, Victory Olutuase, Yun Zhao, Vishnu Khanal

Research outputs 2022 to 2026

Introduction Antenatal care (ANC) is crucial for positive pregnancy outcomes, but it is underutilised in Nigeria, suggesting unmet needs, and potentially contributing to the country’s high burden of maternal and neonatal mortalities. This study comprehensively assesses ANC utilisation and receipt of its components in Nigeria, focusing on disparities between rural and urban areas. Methods We used the data disaggregation approach to analyse the Nigeria Demographic and Health Survey 2018. We estimated ANC utilisation, assessed the receipt of ANC components, and identified factors associated with eight or more (≥ 8) ANC contacts nationally and across rural and urban residences. Results Nationwide, …

Exercise And Diet Support In Breast And Prostate Cancer Survivors: Findings From Focus Groups, Jack Dalla Via, Christopher R. Andrew, Brenton J. Baguley, Nina Stewart, Jonathan M. Hodgson, Joshua R. Lewis, Mandy Stanley, Mary A. Kennedy

Research outputs 2022 to 2026

Purpose: Cancer survival is improving, making optimal management of long-term treatment-related adverse effects increasingly important. Exercise and a healthy diet are beneficial and regularly recommended in cancer survivorship guidelines; however, few cancer survivors meet these recommendations so there is a need to explore why. This study aimed to understand experiences receiving exercise and diet support among Australian breast and prostate cancer survivors during and following treatment, and to explore what support they would like to receive. Methods: Adults who completed active treatment for breast or prostate cancer were recruited via a private cancer care centre. Using a qualitative descriptive study …

Transforming Place-Based Management Within Watersheds In Fiji: The Watershed Interventions For Systems Health Project, Stacy D. Jupiter, Aaron P. Jenkins, Joel Negin, Shylett Anthony, Ponipate Baleinamau, Rachel Devi, Sikeli Gavidi, Alice Latinne, Kini Koto Mailautoka, Sangeeta Mangubhai, Kelera Naivalu, Timoci Naivalulevu, Vilisi Naivalulevu, Nabeela Nasim, Sikeli Naucunivanua, Sarah Nelson, Ingrid Qauqau, Anaseini Ratu, Mereia Ravoka, Jacqueline Thomas, Andrew Tukana, Paul Van Nimwegen, Ama Wakwella, Amelia Wenger, Donald Wilson, Pierre Horwitz

Research outputs 2022 to 2026

Watersheds offer opportunities for place-based interventions to transform systems health via preventative versus reactive approaches to management that achieve multiple co-benefits for public and environmental health. The Watershed Interventions for Systems Health in Fiji (WISH Fiji) project embraced participatory knowledge co-production and action-oriented research to identify risks to public and ecosystem health, prioritize interventions to address risks, and monitor responses of the system to interventions. We used screening filters and local knowledge to collaboratively identify five watersheds for action with high prior incidence of water-related diseases (Fiji’s “three plagues” of leptospirosis, typhoid and dengue) and high risk to downstream environmental …

Comparing Goldin And The Philippines: Analyzing The Research Efforts In Women And Labor Economics Using Basic Text Mining Techniques, Arianna Liza Ortillan

Angelo King Institute for Economic and Business Studies (AKI)

No abstract provided.

Abc Efflux Transporters And Solute Carriers In The Early Developing Brain Of A Marsupial Monodelphis Domestica (South American Gray Short-Tailed Opossum), Yifan Huang, Katarzyna M. Dziegielewska, Mark D. Habgood, Fiona Qiu, Ana C. Leandro, Paul D. Callaghan, Joanne E. Curran, John L. Vandeberg, Norman R. Saunders

School of Medicine Publications

This study used a marsupial Monodelphis domestica, which is born very immature and most of its development is postnatal without placental protection. RNA-sequencing (RNA-Seq) was used to identify the expression of influx and efflux transporters (ATP-binding cassettes [ABCs] and solute carriers [SLCs]) and metabolizing enzymes in brains of newborn to juvenile Monodelphis. Results were compared to published data in the developing eutherian rat. To test the functionality of these transporters at similar ages, the entry of paracetamol (acetaminophen) into the brain and cerebrospinal fluid (CSF) was measured using liquid scintillation counting following a single administration of the drug along with …

Genetic Correlations Between Liver Fat Content, Metabolic Health, And Adiposity Distribution In The Fels Longitudinal Study, Ariana L. Garza, Miryoung Lee, John Blangero, Cici X. Bauer, Stefan A. Czerwinski, Audrey C. Choh

School of Medicine Publications

Highlights

• Steatosis and all other related phenotypes examined were significantly heritable.

• Liver fat showed significant genetic correlation with various phenotypes.

• The strongest genetic correlation of liver fat was with insulin resistance.

• Glucose homeostasis phenotypes were also genetically correlated to adiposity traits.

Abstract

Background and aims

Hepatic steatosis is known to be heritable, but its genetic basis is mostly uncharacterized. Steatosis is associated with metabolic and adiposity features; recent studies hypothesize that shared genetic effects between these traits could account for some of the unexplained heritability. This study aimed to quantify these genetic associations in a family-based sample of non-Hispanic white …

2024 Deerfield Fair 4-H Building Premium Book, Extension

UNH Cooperative Extension

No abstract provided.

2024 Deerfield Fair 4-H Animal Shows Premium Book, Extension

UNH Cooperative Extension

No abstract provided.

Medical Practice As Rhetorical Art Functional Medicine’S Therapeutic Partnership, Cristina Elena De León-Menjivar

English Theses & Dissertations

The current rates of provider burnout are at an all-time high, and our healthcare system is currently seeing numerous providers leave the system. The U.S. Surgeon General has deemed burnout rates at crisis levels, creating an exigency for research and work to help ameliorate this issue. One main issue at the heart of provider burnout is the idea of meaning and purpose in one’s professional life, and Functional Medicine methodology argues that it provides the means by which it can mitigate burnout while improving professional fulfillment and joy through deeper connections with patients. Their methodology is rooted in a concept …

Examining The Physical Activity Experiences Of Blind And Visually Impaired Women, Lindsay E. Ball

Human Movement Studies & Special Education Theses & Dissertations

Substantial research has indicated that blind and visually impaired adults often do not meet physical activity guidelines, and therefore, are not experiencing the numerous affordances of physical activity participation. However, those who report meeting physical activity guidelines express higher rates of health-related quality of life. Largely, the research examining the physical activity behaviors and perspectives of blind and visually impaired adults have been survey studies leaving a rich description of their physical activity experiences unexplored. The overall aim of this project was to engage with blind or visually impaired women to understand their experiences accessing and participating in physical activity, …

Effects Of Ordered Eating On Various Postprandial Measures, Brian K. Ferguson

Human Movement Studies & Special Education Theses & Dissertations

Postprandial glucose (PPG) is an indicator of acute and chronic overall health, and aberrations in glucose, insulin, and other postprandial (PP) markers are common in obesity and cardiometabolic disorders. Chronically elevated glucose can lead to a number of health problems such as type 2 diabetes mellitus. Additionally, PPG responses can impact substrate utilization responses to exercise, which may have implications for both healthy and diseased populations. One potentially simple lifestyle modification to alter PPG and related markers is to change the order in which foods are consumed within meals. The purpose of this dissertation was to further explore the impact …

A Landscape Evaluation Of Caffeine Citrate Availability And Use In Newborn Care Across Five Low- And Middle-Income Countries, Osayame Ekhaguere, Olufunke Bolaji, Helen Nabwera, Andrew Storey, Nicholas Embleton, Stephen Allen, Zelalem Demeke, Olufunke Fasawe, Betty Wariari, Mansharan Seth

Centre of Excellence in Women and Child Health

Apnoea of prematurity (AOP) is a common complication among preterm infants (< 37 weeks gestation), globally. However, access to caffeine citrate (CC) that is a proven safe and effective treatment in high-income countries is largely unavailable in low- and-middle income countries, where most preterm infants are born. Therefore, the overall aim of this study was to describe the demand, policies, and supply factors affecting the availability and clinical use of CC in LMICs. A mixed methods approach was used to collect data from diverse settings in LMICs including Ethiopia, Kenya, Nigeria, South Africa, and India. Qualitative semi-structured interviews and focus group discussions were conducted with 107 different health care providers, and 21 policymakers and other stakeholders from industry. Additional data was collected using standard questionnaires. A thematic framework approach was used to analyze the qualitative data and descriptive statistics were used to summarize the quantitative data. The findings indicate that there is variation in in-country policies on the use of CC in the prevention and treatment of AOP and its availability across the LMICs. As a result, the knowledge and experience of using CC also varied with clinicians in Ethiopia having no experience of using it while those in India have greater knowledge and experience of using it. This, in turn, influenced the demand, and our findings show that only 29% of eligible preterm infants are receiving CC in these countries. There is an urgent need to address the multilevel barriers to accessing CC for managing AOP in Africa. These include cost, lack of national policies, and, therefore, lack of demand stemming from its clinical equivalency with aminophylline. Practical ways to reduce the cost of CC in LMICs could potentially increase its availability and use.

Establishing Marine Protected Areas In The Southern Ocean, Lessons For The Bbnj Agreement, Nengye Liu

Research Collection Yong Pung How School Of Law

This paper first gives a brief overview of the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR)’s struggle to establish Antarctic Marine Protected Areas (MPAs). The paper then addresses the question: what lessons can countries learn from CCAMLR's experience in establishing high seas MPAs under the Biodiversity in Areas Beyond National Jurisdiction (BBNJ) Agreement? The paper finds that the final text of the BBNJ Agreement did largely reflect CCAMLR's experience when it comes to MPAs. This is particularly so with respect to 1) clarification of the relationship between conservation and use; 2) the interpretation and application of a …

Application Of Clavien-Dindo Classification System In The Early Complications Of Radical Cystectomy In Al-Yarmook Teaching Hospital, Ahmed Abbass Al-Sadie, Saad Al-Sammarraie, Taha Kadhum

Iraqi Postgraduate Medical Journal

BACKGROUND: The most effective treatment for muscle-invasive bladder cancer and non-muscle invasive bladder cancer with highest risk of progression, is Radical cystectomy and urinary diversion. This operation carries                  a high risk of complications of multiple types that can affect not only the urinary system but also other systems. OBJECTIVE: This study analyzes the early complications (within 30 days) of Radical Cystectomy and urinary diversion, using a standardized classification system i.e. Clavien-Dindo classification system. PATIENTS AND METHODS: This is a combined retrospective and prospective study analyzing the early complications of RC.                    We review the early (30 days) post-operative period retrospectively for …