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White Clover Content In New Zealand Pastures Affects Milksolids Production, S` L. Harris, D A. Clark Jul 2024

White Clover Content In New Zealand Pastures Affects Milksolids Production, S` L. Harris, D A. Clark

IGC Proceedings (1977-2023)

As a preliminary experiment to measuring milksolids (fat plus protein) production of dairy cattle grazing swards containing different levels of white clover (Trifolium repens L.) nine Jersey and nine Friesian cattle housed indoors during late lactation and fed diets containing either 20, 50 or 80% white clover with the balance perennial ryegrass (Lolium perenne L.). During the first 10 day measurement period cows were fed ad libitum and during the second 10 days feeding was restricted to 75% of metabolisable energy requirement. Milk yields of cows fed 50 and 80% clover were 18% and 10% greater than for …


Pasture Species Effects On Animal Performance, T J. Fraser, S=J S. Rowarth, T L. Knight Jul 2024

Pasture Species Effects On Animal Performance, T J. Fraser, S=J S. Rowarth, T L. Knight

IGC Proceedings (1977-2023)

Increasing concerns about food quality have resulted in investigations into the effects of different forage species on animal production and carcass quality. Pure species plots of high-endophyte ryegrass (Lolium perenne L.), white clover (Trifolium repens L.), chicory (Cichorium intybus L.), plantain (Plantago lanceolata L.) or lotus (Lotus corniculatus L.) were established and lambs grazed the species for 120 days during summer. Pasture species influenced growth rate, hot carcass weight, GR, wool growth, faecal egg counts, adult nematodes at slaughter, and sheep meat odour and flavour. Lambs grazing white clover, lotus or chicory outperformed those grazing …


Effect Of Grazing Pressure And Supplemental Level On Weight Gain In Dairy Heifers, J M. Mieres, Y M. Acosta Jul 2024

Effect Of Grazing Pressure And Supplemental Level On Weight Gain In Dairy Heifers, J M. Mieres, Y M. Acosta

IGC Proceedings (1977-2023)

An experiment designed to assess the effect of two grazing pressures (GP, expressed as kg MS/100 kg LW) and four levels of supplement (0, 0.25, 0.50 and 0.75 expressed as kg/100 kg LW) fed to yearling heifers (212 kg) on live weight gain, was carried out at the Dairy Unit of INIA La Estanzuela (Uruguay). The experiment consisted of 8 treatments. Forty animals were used in the experiment, 5 per treatment, each animal being a replication of the treatment. The animals were blocked by weight in 5 blocks of 8 animals each, and then randomly assigned to the different treatments. …


Grazing Systems Research In The Falkland Islands, J A. Kerr Jul 2024

Grazing Systems Research In The Falkland Islands, J A. Kerr

IGC Proceedings (1977-2023)

Conceptual models of both the metabolisable energy (ME) balance of sheep in relation to the environment and the effects heavy grazing on vegetation and soils will form the basis for the development of a sustainable grazing system for wool production in the Falkland Islands. Research which integrates plant community ecology, agricultural meteorology, sheep energetics, grazing systems and socio-economics is described.


Wool Production From Annual Pastures Intensively Grazed By Wethers In Southern Western Australia, M W. Hyder, A N. Thompson, P T. Doyle, M Grimm, P J. Michael Jul 2024

Wool Production From Annual Pastures Intensively Grazed By Wethers In Southern Western Australia, M W. Hyder, A N. Thompson, P T. Doyle, M Grimm, P J. Michael

IGC Proceedings (1977-2023)

Intensively grazing annual pastures in southern Western Australia to target amounts of feed on offer increased the greasy wool production per hectare three-fold or more compared to production from a setstocked grazing regime. Feed on offer was maintained at 0.8, 1.1, 1.4, 2.0, 2.8 t DM/ha during spring and wool growth per hectare compared to that of sheep set-stocked at the district average of 8 sheep/ha. The role of intensive grazing as a tactic to increase production and profitability of wool producers in Mediterranean environments is discussed.


Milk Production From Ruzi Grass Alone, Ruzi Mixed With Leucaena And Ruzi Supplemented With Dolichos Lablab, S Tudsri, S Prasanpanich, S Swasdiphanich Jul 2024

Milk Production From Ruzi Grass Alone, Ruzi Mixed With Leucaena And Ruzi Supplemented With Dolichos Lablab, S Tudsri, S Prasanpanich, S Swasdiphanich

IGC Proceedings (1977-2023)

Three groups of dairy cattle were compared under different grazing managements viz. strip-grazed on pure ruzi grass (Brachiaria ruziziensis), strip-grazed on mixed pasture between ruzi and leucaena (Luecaena luecocephala) and strip-grazed on pure ruzi and supplemented with lablab (Lablab purpureus). The results showed that the animals that received the legumes through supplementary or mixed with the grass produced higher in daily milk yield (13.63 and 13.26 kg/cow) and fat percentage (4.7 and 4.5) than that of the pure grass alone (12.00 kg/cow for milk yield and 4.2 % for fat). This advantage was due …


Zea Mays Grazing In Cattle Production Systems, V Mundy, B E. Anderson, T L. Gompert, T L. Mader, C A. Shapiro Jul 2024

Zea Mays Grazing In Cattle Production Systems, V Mundy, B E. Anderson, T L. Gompert, T L. Mader, C A. Shapiro

IGC Proceedings (1977-2023)

Nebraska producers have used silage maize (Zea mays L.) hybrids as a grazed forage in dairy and beef production systems. In an onfarm case study, farmers and researchers collaborated to gather information on production practices, grazing management, and plant characteristics of grazing maize within three forage-based dairy and beef systems. Production practices were generally similar to conventional grain corn production, except that in one system maize was seeded directly into a suppressed grass sod. Milk production from grazing maize was 23 kg/day/animal, compared to 24 kg/day/ animal before using maize and 22 kg/day/animal after using maize. Average gain of …


Grazing Management Of Lotus In Eastern Australia: A Participatory Approach, M J. Blumenthal, J F. Ayers, Z Hochman Jul 2024

Grazing Management Of Lotus In Eastern Australia: A Participatory Approach, M J. Blumenthal, J F. Ayers, Z Hochman

IGC Proceedings (1977-2023)

Both Lotus uliginosus Schkukr and L. corniculatus L. require lenient grazing management for persistent production. However, grazing systems, where Lotus is adapted in eastern Australia are based on intermittent set stocking. Conflict between plant ecophysiology and the adverse influences of traditional grazing systems that limit the adoption of new grazing management technology have been addressed by a participatory (co-learning) research and development process. The approach taken involved the use of a facilitator who ran an initial meeting to involve stakeholders and subsequently established “colearning” groups and “co-learning” experimental sites. These sites are monitored, progress is reviewed, and knowledge is …


Tropical Forage Seed Production In Southeast Asia: Current Status And Prospects, C Phaikaew, L Guodao, A Abdullah, M Tuhulele, E Magboo, B Bouahom, W Stur Jul 2024

Tropical Forage Seed Production In Southeast Asia: Current Status And Prospects, C Phaikaew, L Guodao, A Abdullah, M Tuhulele, E Magboo, B Bouahom, W Stur

IGC Proceedings (1977-2023)

The demand for forage seed in southeast Asia has increased in recent years. More than 1,200 tons of seed were produced in Thailand in 1995 with smaller quantities of seed having been produced in China, Lao PDR, Malaysia, Philippines and Indonesia. Large quantities have been produced of Brachiaria ruziziensis, Stylosanthes hamata, Stylosanthes guianensis and Panicum maximum. There are good prospects to increase forage seed production and to develop trade between countries in the southeast Asian region. There is a need to increase seed production of widely adapted species, and expand production of forages for other purposes such as turf …


Office Of Equity And Inclusion Newsletter - July 2024, Office Of Equity And Inclusion, East Tennessee State University Jul 2024

Office Of Equity And Inclusion Newsletter - July 2024, Office Of Equity And Inclusion, East Tennessee State University

Office of Equity and Inclusion Newsletters

No abstract provided.


Facets Of Neuroticism As Predictors Of Heart Rate Variability And Psychological Distress, Mikel Cressman Jul 2024

Facets Of Neuroticism As Predictors Of Heart Rate Variability And Psychological Distress, Mikel Cressman

Theses and Dissertations

Heart rate variability (HRV) and personality are related to both physical and mental health outcomes. Previous research has found a relationship between neuroticism and distress while the findings on the relationship between neuroticism and HRV are mixed. Studying the facets of neuroticism may provide a more nuanced view of the effects of personality on HRV and distress. Previous research has suggested that the vulnerability facet of neuroticism appears to be uniquely related to the cardiovascular response to stress. This study's first hypothesis is that individuals with higher scores on the vulnerability facet will have lower heart rate variability. The second …


Phytoplankton Community Dynamics In The Northern California Current System, Kristin E. Forgrave Jul 2024

Phytoplankton Community Dynamics In The Northern California Current System, Kristin E. Forgrave

Dissertations and Theses

The Northern California Current system is a productive coastal ecosystem encompassing a variety of temporal and spatial features. The photosynthetic microbial community plays a crucial role in supporting the rich ecosystem and its economically important fisheries. My research integrates data across location and two years to investigate the community composition of two major phytoplankton groups in this system: picocyanobacteria and photosynthetic picoeukaryotes (PPE). The abundances and sizes of the phytoplankton were measured using flow cytometry. I found PPE present at similar concentrations in both summer and winter seasons. Abundances of both PPE and picocyanobacteria were comparable in the winter, but …


Examining Teacher Attrition And The Contemporary Educator Shortage In The United States: A Quantitative Study Of Herzberg's Two-Factor Theory, Joycelyn Wesley Jul 2024

Examining Teacher Attrition And The Contemporary Educator Shortage In The United States: A Quantitative Study Of Herzberg's Two-Factor Theory, Joycelyn Wesley

Electronic Theses and Dissertations Archive

In many educational systems across the world, teacher attrition has become a major problem. As the student population in America continues to grow, one problem plaguing policymakers and school districts is staffing schools with quality educators. This national shortage of educators has been plaguing the United States for almost a decade. It brings one to question why there is such a shortage of qualified educators available to effectively instruct and academically prepare America’s youth. The main goal of this quantitative study is to investigate the reasons for teacher attrition in a large urban school district in the southeastern region of …


The Effects Of Torso-Borne Loads On Functional Movement Patterns, Kathryn S. Bell, Jasmine D. Brooks, Kara N. Radzak, Sean W. Mulvenon, Brian K. Schilling Jul 2024

The Effects Of Torso-Borne Loads On Functional Movement Patterns, Kathryn S. Bell, Jasmine D. Brooks, Kara N. Radzak, Sean W. Mulvenon, Brian K. Schilling

International Journal of Exercise Science

International Journal of Exercise Science 17(7): 975-984, 2024. Functional movement patterns are an important aspect of everyday life, and a growing area of interest for determining the risk of injury and performance ability. Police, military, and fire personnel often carry torso-borne loads that increase the demands on the body while performing occupational tasks. The purpose of this study was to compare movement screen results in both a loaded and unloaded condition to identify potential effects that torso-borne body armor load carriage may have on tactical performance. This provided objective data on the effects that external loads may have on functional …


Increasing Stroke Symptom Awareness In The Hispanic Community, Karina Barabash Jul 2024

Increasing Stroke Symptom Awareness In The Hispanic Community, Karina Barabash

DNP Projects

Ethnic and racial minorities are at higher risk for many health conditions including coronary artery disease and stroke (Mital et al., 2021). The Hispanic population specifically faces more risk factors, less knowledge of stroke symptoms, and higher probability of death and disability post stroke (Eisenstein et al., 2018). Unless this gap is addressed, ethnic and racial minority patients will continue to experience higher rates of death and disability from stroke, compared to non-Hispanic White patients. Therefore, the purpose of this project was to provide clinic-based stroke education in Spanish to Hispanic community members. The goal was to increase awareness of …


Broadcasters, Receivers, Functional Groups Of Metabolites, And The Link To Heart Failure By Revealing Metabolomic Network Connectivity, Azam Yazdani, Raul Mendez-Giraldez, Akram Yazdani, Rui-Sheng Wang, Daniel J Schaid, Sek Won Kong, M Reza Hadi, Ahmad Samiei, Esmat Samiei, Clemens Wittenbecher, Jessica Lasky-Su, Clary B Clish, Jochen D Muehlschlegel, Francesco Marotta, Joseph Loscalzo, Samia Mora, Daniel I Chasman, Martin G Larson, Sarah H Elsea Jul 2024

Broadcasters, Receivers, Functional Groups Of Metabolites, And The Link To Heart Failure By Revealing Metabolomic Network Connectivity, Azam Yazdani, Raul Mendez-Giraldez, Akram Yazdani, Rui-Sheng Wang, Daniel J Schaid, Sek Won Kong, M Reza Hadi, Ahmad Samiei, Esmat Samiei, Clemens Wittenbecher, Jessica Lasky-Su, Clary B Clish, Jochen D Muehlschlegel, Francesco Marotta, Joseph Loscalzo, Samia Mora, Daniel I Chasman, Martin G Larson, Sarah H Elsea

Faculty, Staff and Students Publications

Background and objective: Blood-based small molecule metabolites offer easy accessibility and hold significant potential for insights into health processes, the impact of lifestyle, and genetic variation on disease, enabling precise risk prevention. In a prospective study with records of heart failure (HF) incidence, we present metabolite profiling data from individuals without HF at baseline.

Methods: We uncovered the interconnectivity of metabolites using data-driven and causal networks augmented with polygenic factors. Exploring the networks, we identified metabolite broadcasters, receivers, mediators, and subnetworks corresponding to functional classes of metabolites, and provided insights into the link between metabolomic architecture and regulation in health. …


Mhealth Intervention For Elevated Blood Pressure Among College Students: Single-Arm Intervention Study, Dieu-My T. Tran, Catherine E. Dingley, Roger Bonilla Jul 2024

Mhealth Intervention For Elevated Blood Pressure Among College Students: Single-Arm Intervention Study, Dieu-My T. Tran, Catherine E. Dingley, Roger Bonilla

Nursing Faculty Research

Background: Current evidence reveals a growing pattern of hypertension among young adults, significantly increasing their risk for cardiovascular disease later in life. Young adults, particularly those of college age, often develop risk factors related to lifestyle choices in diet, exercise, and alcohol consumption. Developing useful interventions that can assist with screening and possible behavioral modifications that are suitable and appealing to college-aged young adults could help with early identification and intervention for hypertension. Recent studies indicate mobile health (mHealth) apps are acceptable and effective for communication and message delivery among this population.

Objective: The purpose of this study was to …


Quaking Aspen In A High-Use Recreation Area: Challenges Of People, Ungulates, And Sodium On Landscape Resilience, Georgie Corkery, Anna B. Miller, Paul C. Rogers Jul 2024

Quaking Aspen In A High-Use Recreation Area: Challenges Of People, Ungulates, And Sodium On Landscape Resilience, Georgie Corkery, Anna B. Miller, Paul C. Rogers

Environment and Society Student Research

Quaking aspen (Populus tremuloides Michx.) landscapes are valued for their biodiversity, water retention, fire mitigation, aesthetics, and recreation opportunities. Across North America, some aspen populations are experiencing population declined as they face uninhibited ungulate browsing, drought, fire suppression, insects, disease, and inappropriate management. Increased human development and recreational use within aspen landscapes can serve as additive stressors, though there is a dearth of literature examining these elements. At a popular recreational area in Utah, USA, identifying the cause of apparent decline within a larger aspen community is complicated by development upstream and recreation-related activities. We sought to (1) assess …


Clinical Metabolomics Investigation Of Rheumatoid Arthritis Patients Receiving Ayurvedic Whole System Intervention, Sanjeev Rastogi, Ankita Verma, Rimjhim Trivedi, Anuj Shukla, Dinesh Kumar Jul 2024

Clinical Metabolomics Investigation Of Rheumatoid Arthritis Patients Receiving Ayurvedic Whole System Intervention, Sanjeev Rastogi, Ankita Verma, Rimjhim Trivedi, Anuj Shukla, Dinesh Kumar

Faculty, Staff and Student Publications

BACKGROUND: Arthritis is a common clinical condition seen in Ayurveda clinics. Clinical trials have reported Ayurvedic interventions to be of benefits in many arthritic conditions including Rheumatoid Arthritis (RA). No mechanistic details however are available about how such interventions on their own or as a combination of whole system Ayurveda might be working.

OBJECTIVE: The study aims to evaluate simultaneously the clinical outcome of Ayurveda whole system (AWS) intervention in RA patients and identifying the serum metabolic signatures which could be useful for diagnosing the disease and monitoring treatment response.

MATERIAL AND METHODS: RA patients (n = 37) simultaneously diagnosed …


Association Analysis Of The Oprm1 Polymorphism Gene And Personality Traits Among A Cohort Of Professional Athletes., Remigiusz Recław, Agnieszka Boroń, Krzysztof Chmielowiec, Jolanta Chmielowiec, Katarzyna Prabucka, Milena Lachowicz, Łukasz Zadroga, Przemysław Guła, Maciej Brożyna, Anna Grzywacz Jul 2024

Association Analysis Of The Oprm1 Polymorphism Gene And Personality Traits Among A Cohort Of Professional Athletes., Remigiusz Recław, Agnieszka Boroń, Krzysztof Chmielowiec, Jolanta Chmielowiec, Katarzyna Prabucka, Milena Lachowicz, Łukasz Zadroga, Przemysław Guła, Maciej Brożyna, Anna Grzywacz

Baltic Journal of Health and Physical Activity

In sports research, genetic studies linked to the traits of the temperament, in addition to medical examinations and other physiological and biochemical tests, would enrich the scope of possibilities and successes that a competitor can accomplish. This could be beneficial for the protection of both mental and physical health. The study group comprised 391 male volunteers. Out of these, 222 sports subjects and 186 were non-addicted. The temperament and character questionnaire (TCI-R) was used to determine personality traits such as novelty seeking, harm avoidance, reward addiction and perseverance, as well as self-direction, cooperation and self-transcendence. Genotyping OPRM1 rs1799971 was carried …


Associations Between Total, Free And Bioavailable 25-Hydroxyvitamin D Forms With Adiponectin And Irisin In Maternal-Neonatal Pairs At Birth From Greece, Tarek Ziad Arabi, Hana M.A. Fakhoury, Hani Tamim, Rene F. Chun, Martin Hewison, Fatme Alanouti, Stefan Pilz, Cedric Annweiler, Georgios Tzimagiorgis, Costas Haitoglou, Spyridon N. Karras Jul 2024

Associations Between Total, Free And Bioavailable 25-Hydroxyvitamin D Forms With Adiponectin And Irisin In Maternal-Neonatal Pairs At Birth From Greece, Tarek Ziad Arabi, Hana M.A. Fakhoury, Hani Tamim, Rene F. Chun, Martin Hewison, Fatme Alanouti, Stefan Pilz, Cedric Annweiler, Georgios Tzimagiorgis, Costas Haitoglou, Spyridon N. Karras

All Works

Background: Apart from the well-established skeletal effects, vitamin D has been explored as a secretagogue influencing various adipokines, including adiponectin and irisin. Recent evidence suggests that specific forms of 25-Hydroxyvitamin D (25(OHD), such as free and bioavailable 25(OH)D, may provide more accurate measurements of vitamin D status. The relationship between vitamin D status and serum irisin and adiponectin concentrations remains largely unexplored, particularly during pregnancy. Methods: We analyzed data from 67 healthy maternal-neonatal pairs from Northern Greece at birth. Biochemical and hormonal tests were conducted on each maternal-neonatal pair. The vitamin D forms were estimated using validated mathematical models. Subsequently, …


The Effect Of Chronic Exercise On The Self-Perceived Mental Well-Being Of College Students, Joshua Hardy Jul 2024

The Effect Of Chronic Exercise On The Self-Perceived Mental Well-Being Of College Students, Joshua Hardy

Research Papers

No abstract provided.


Malposition Of Percutaneous Endoscopic Gastrostomy (Peg) Tube Through The Transverse Colon: A Novel Approach To Conservative Management, Joel Calafell Jul 2024

Malposition Of Percutaneous Endoscopic Gastrostomy (Peg) Tube Through The Transverse Colon: A Novel Approach To Conservative Management, Joel Calafell

All Publications

Percutaneous endoscopic gastrostomy (PEG) is a common technique for enteral nutrition support. Complications range from skin injuries and leakage to more severe intraabdominal pathologies. This case report describes a patient with invasive right lateral pharyngeal wall squamous cell carcinoma who developed a gastrocolocutaneous fistula following PEG tube malpositioning in the transverse colon performed at an outside institution. Based on the patient's comorbidities and the associated high-risk nature of the surgery, a transverse colectomy and partial gastrectomy to resect the malpositioned tube followed by a new PEG tube was deemed invasive and would likely have a poor clinical outcome. Instead, the …


Impact Of Sociodemographic Status And Sex On Chronic Rhinosinusitis And Olfaction In People With Cystic Fibrosis., Ethan J. Han, Christine M. Liu, Jakob L. Fischer, Jess C. Mace, Karolin Markarian, Jeremiah A. Alt, Todd E. Bodner, Naweed I. Chowdhury, Patricia H. Eshaghian, Yuqing A. Gao, Multiple Additional Authors Jul 2024

Impact Of Sociodemographic Status And Sex On Chronic Rhinosinusitis And Olfaction In People With Cystic Fibrosis., Ethan J. Han, Christine M. Liu, Jakob L. Fischer, Jess C. Mace, Karolin Markarian, Jeremiah A. Alt, Todd E. Bodner, Naweed I. Chowdhury, Patricia H. Eshaghian, Yuqing A. Gao, Multiple Additional Authors

Psychology Faculty Publications and Presentations

Sociodemographic status (SDS) including race/ethnicity and socioeconomic status as approximated by education, income, and insurance status impact pulmonary disease in people with cystic fibrosis (PwCF). The relationship between SDS and chronic rhinosinusitis (CRS) remains understudied.


Reported Incidence Of Infections Caused By Pathogens Transmitted Commonly Through Food: Impact Of Increased Use Of Culture-Independent Diagnostic Tests - Foodborne Diseases Active Surveillance Network, 1996-2023, Hazel J. Shah, Rachel H. Jervis, Katie Wymore, Tamara Rissman, Bethany Laclair, Michelle M. Boyle, Kirk Smith, Sarah Lathrop, Suzanne Mcguire, Rosalie Trevejo, Marcy Mcmillian, Stic Harris, Joanna Zablotsky Kufel, Kennedy Houck, Carey E. Lau, Carey J. Devine, Dave Boxrud, Daniel L. Weller Jul 2024

Reported Incidence Of Infections Caused By Pathogens Transmitted Commonly Through Food: Impact Of Increased Use Of Culture-Independent Diagnostic Tests - Foodborne Diseases Active Surveillance Network, 1996-2023, Hazel J. Shah, Rachel H. Jervis, Katie Wymore, Tamara Rissman, Bethany Laclair, Michelle M. Boyle, Kirk Smith, Sarah Lathrop, Suzanne Mcguire, Rosalie Trevejo, Marcy Mcmillian, Stic Harris, Joanna Zablotsky Kufel, Kennedy Houck, Carey E. Lau, Carey J. Devine, Dave Boxrud, Daniel L. Weller

Pathology Research and Scholarship

Reducing foodborne disease incidence is a public health priority. This report summarizes preliminary 2023 Foodborne Diseases Active Surveillance Network (FoodNet) data and highlights efforts to increase the representativeness of FoodNet. During 2023, incidences of domestically acquired campylobacteriosis, Shiga toxin-producing Escherichia coli infection, yersiniosis, vibriosis, and cyclosporiasis increased, whereas those of listeriosis, salmonellosis, and shigellosis remained stable compared with incidences during 2016-2018, the baseline used for tracking progress towards federal disease reduction goals. During 2023, the incidence and percentage of infections diagnosed by culture-independent diagnostic tests (CIDTs) reported to FoodNet continued to increase, and the percentage of cases that yielded an …


What Constitutes Adequate Control Of High Blood Pressure? Current Considerations, Donald E. Casey, Alexander J. Blood, Stephen D. Persell, Daniel Pohlman, Jeff D. Williamson Jul 2024

What Constitutes Adequate Control Of High Blood Pressure? Current Considerations, Donald E. Casey, Alexander J. Blood, Stephen D. Persell, Daniel Pohlman, Jeff D. Williamson

College of Population Health Faculty Papers

An estimated 45% of adult Americans currently have high blood pressure (HBP). Effective blood pressure (BP) control is essential for preventing major adverse events from cardiovascular and other vascular-related diseases, such as chronic kidney disease, stroke and dementia. A large and growing number of medical professional societies, health care organizations, and governmental agencies have now endorsed a clinical practice guideline-based target for adequate control of HBP to a systolic BP of less than 130 mm Hg. However, adequate BP control to this goal has been recently estimated to be as low as 30%. The first and most important steps to …


Hur Controls Glutaminase Rna Metabolism, Douglas Adamoski, Larissa M Dos Reis, Ana Carolina Paschoalini Mafra, Felipe Corrêa-Da-Silva, Pedro Manoel Mendes De Moraes-Vieira, Ioana Berindan-Neagoe, George A Calin, Sandra Martha Gomes Dias Jul 2024

Hur Controls Glutaminase Rna Metabolism, Douglas Adamoski, Larissa M Dos Reis, Ana Carolina Paschoalini Mafra, Felipe Corrêa-Da-Silva, Pedro Manoel Mendes De Moraes-Vieira, Ioana Berindan-Neagoe, George A Calin, Sandra Martha Gomes Dias

Faculty, Staff and Student Publications

Glutaminase (GLS) is directly related to cell growth and tumor progression, making it a target for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) influences mRNA stability and alternative splicing. Overexpression of ELAVL1 is common in several cancers, including breast cancer. Here we show that HuR regulates GLS mRNA alternative splicing and isoform translation/stability in breast cancer. Elevated ELAVL1 expression correlates with high levels of the glutaminase isoforms C (GAC) and kidney-type (KGA), which are associated with poor patient prognosis. Knocking down ELAVL1 reduces KGA and increases GAC levels, enhances glutamine anaplerosis into the TCA cycle, and …


Antitumor Effects Of Resveratrol Opposing Mechanisms Of Helicobacter Pylori In Gastric Cancer, Daniela Trautmann, Francesca Suazo, Keila Torres, Layla Simón Jul 2024

Antitumor Effects Of Resveratrol Opposing Mechanisms Of Helicobacter Pylori In Gastric Cancer, Daniela Trautmann, Francesca Suazo, Keila Torres, Layla Simón

Faculty, Staff and Student Publications

Gastric cancer is an aggressive and multifactorial disease. Helicobacter pylori (H. pylori) is identified as a significant etiological factor in gastric cancer. Although only a fraction of patients infected with H. pylori progresses to gastric cancer, bacterial infection is critical in the pathology and development of this malignancy. The pathogenic mechanisms of this bacterium involve the disruption of the gastric epithelial barrier and the induction of chronic inflammation, oxidative stress, angiogenesis and metastasis. Adherence molecules, virulence (CagA and VacA) and colonization (urease) factors are important in its pathogenicity. On the other hand, resveratrol is a natural polyphenol with …


Urban-Rural Disparities In Food Insecurity And Weight Status Among Children In The United States, Jayna M Dave, Tzuan A Chen, Alexandra N Castro, Mamie A White, Elizabeth A Onugha, Sloane Zimmerman, Debbe Thompson Jul 2024

Urban-Rural Disparities In Food Insecurity And Weight Status Among Children In The United States, Jayna M Dave, Tzuan A Chen, Alexandra N Castro, Mamie A White, Elizabeth A Onugha, Sloane Zimmerman, Debbe Thompson

Children’s Nutrition Research Center Staff Publications

Place of residence (urban versus rural) is a contextual determinant of health that has received less attention in the food insecurity literature. The purpose of this study was to assess the urban–rural disparity in the prevalence of food insecurity and weight status among US children. Using data from the National Health and Nutrition Examination Survey (NHANES) 2013–2016 with three age groups of children (2–5, 6–11, and 12–17 years old), the associations of weight status and child and household food security status by urban–rural residence were examined using Rao–Scott Chi-square tests. Statistical significance was set at p < 0.05. Children living in urban areas were significantly more likely to experience household food insecurity (29.15%) compared to their rural counterparts (19.10%), among those aged 6–11 years. The associations between children’s weight status and child and household food security status were significant for children living in urban areas overall and different age groups but not for children living in rural areas. These trends were more pronounced in older age groups. Given the link between food insecurity and higher obesity rates, particularly among urban children, this study highlights the importance of incorporating food security interventions into future obesity prevention programs.


Comorbidity Of Disordered Eating And Depression: Examining Intersectional Inequities And Cardiometabolic Health Consequences Across The Life Course, Franklin Hunter Mcguire Jul 2024

Comorbidity Of Disordered Eating And Depression: Examining Intersectional Inequities And Cardiometabolic Health Consequences Across The Life Course, Franklin Hunter Mcguire

Brown School Graduate Student Theses and Dissertations

Traditional epidemiologic research has often neglected the degree to which interlocking systems of oppression may (1) describe the distribution of population health inequities and (2) moderate health exposure-outcome associations. Grounded in an intersectional framework, this three-aim dissertation used an intersectional multilevel modeling approach (i.e., intersectional MAIHDA) and US nationally representative data to answer a series of intersectionality-informed research questions relevant to disordered eating, depression, and cardiometabolic health. With data from the National Health and Nutrition Examination Survey, Aim 1 quantified the population distribution of weight loss-oriented disordered eating behaviors (DEBs) among US adults across intersectional groups defined by race/ethnicity, sex/gender, …