Digital Commons Network^™

Skeletal Muscle Stem Cell Mitochondria Are Transferred To Muscle Fibers In Response To A Hypertrophic Stimulus, Jensen Goh, Julia G. Williams, Sarah E. Ogle, Jai K. Joshi, Logan N. Scott, Benjamin Burke, Alex R. Keeble, Nicholas T. Thomas, Christopher S. Fry, Ahmed Ismaeel, John J. Mccarthy

Physiology Faculty Publications

The fusion of skeletal muscle stem cell (MuSC) to myofibers during hypertrophy has exclusively focused on the transfer of the MuSC nucleus, leaving the fate of other MuSC organelles, such as mitochondria, largely unexplored. The objective of this study was to determine whether MuSCs transfer their mitochondria upon myofiber fusion in response to a hypertrophic stimulus. To achieve this goal, we specifically labeled MuSC mitochondria with Dendra2 fluorescence by crossing the MuSC-specific CreER (Pax7^CreER/CreER) mouse with the Rosa26-Dendra2 mouse to generate the Pax7-Dendra2 mouse. To induce the fusion of MuSC to myofibers, Pax7-Dendra2 mice underwent synergist ablation surgery …

Association Of Social Support And Burnout Among Undergraduate Medical And Health Sciences Students At A Malaysian University, Lee Jia Le, Farrah Asyiqin Mansor, Kayalvili R. Manogar,, Siti Khadijah Adam

Health Professions Education

Purpose: Medical and health sciences students are prone to burnout due to intense academic pressure and demanding schedule. Social support plays a vital role in mitigating burnout by providing emotional, informational, and practical assistance, which helps students navigate the challenges of their rigorous academic environment. The aim of this study was to determine the prevalence of burnout and the contributing factors among these students in a university in Malaysia. The association between social support and burnout among these students was also explored.

Method: A cross-sectional study was conducted among 459 undergraduate students in the Faculty of Medicine and Health Sciences, …

Hormonal Decay After Death: Evaluating Dhea-S As A Potential Molecular Marker For Postmortem Estimation, Marisa Lydia Novak

Graduate Student Theses, Dissertations, & Professional Papers

Post-mortem interval (PMI) estimation is a central component of forensic anthropological investigation, but traditional methods for estimating time since death lose accuracy after ~72 hours. Recent research indicates that some steroid hormones may undergo predictable degradation patterns after death, offering potential use as biochemical clocks for PMI estimation beyond this threshold. Dehydroepiandrosterone (DHEA), and its sulfate form (DHEA-S) are of particular interest due to their metabolic stability, systemic influence, and association with trauma. This study investigates whether DHEA-S hormonal degradation patterns correlate with time elapsed since death and body temperature, evaluating their potential as biochemical PMI markers. 160 mL of …

Estrogen Receptor-Mediated Effects Of Resveratrol On Muscle Function, David Ayi-Bonte

Open Access Master's Theses

Artemis missions are set to send the next man and the first woman back to the moon and enable long-term missions on the lunar surface. However, exposure to lunar gravity has significant physiological effects characterized by loss of muscle mass, weakness and decreased bone density. Nutraceutical countermeasures such as Resveratrol (RSV), a naturally occurring polyphenol, have been identified as promising strategies to preserve musculoskeletal health; however, its pleiotropic effect hinders our ability to identify the primary cellular pathways through which it delivers its benefits. Furthermore, its efficacy in simulated lunar gravity is unknown. Based on the benefits observed with RSV …

“Democracy,” Usa, Marc Edelman

Publications and Research

What does it mean to be an effective citizen in a democracy? Answering this question requires unpacking “democracy” and an analysis of institutions that systematically disempower and alienate citizens. This paper briefly examines the contributions of psychoanalysis to understanding democracy and authoritarianism. It scrutinizes U.S. governance institutions and points to democratic deficits and backsliding present even before Trump 1.0 and 2.0. These range from the Electoral College, the Senate, and the Supreme Court to the Federal Communications Commission. All contributed to institutionalizing minority rule and elite capture. Governance institutions failed to deliver what the American people tell opinion pollsters they …

Annual Report, Associated Charities, Memphis, 1932

Documents

Annual Report of the Associated Charities, Memphis, TN. It covers the year of 1932.

Correspondence And Documents, Family Welfare Agency, Memphis, 1939

Documents

A grouping of correspondence and blank cards. The correspondence is to the Family Welfare Agency, Memphis, TN, on 1939 December 5 from the Family Welfare Association of America, New York, NY. They were asking the Family Welfare Agency in Memphis for feedback on cards that the agencies in membership with the Family Welfare Association of America were able to order. Included is the response from Leora L. Conner, General Secretary, of the Family Welfare Agency, Memphis, TN, on 1939 December 7.

Correspondence And Documents, Family Welfare Agency, Memphis, 1939

Documents

A grouping of documents including correspondence, blank forms, and blank cards. The correspondence is to the Family Welfare Agency, Memphis, TN, on 1939 October 25 and 1939 November 16, from the Family Welfare Association of America, New York, NY. They were asking the Family Welfare Agency in Memphis for feedback on forms and cards that the agencies in membership with the Family Welfare Association of America were able to order.

2024 Quality Assessment And Performance Improvement Strategy Update, Tennessee. Division Of Tenncare.

TennCare Additional Reports

No abstract provided.

Smart Goal-Setting On Behaviors To Enhance Intrinsic Motivation For Exercise: A Pilot Study With Orangetheory Fitness Participants, Adam Relitz

Williams Honors College, Honors Research Projects

Abstract

PURPOSE: Sustaining long-term motivation for exercise remains a challenge within health and fitness, particularly when extrinsic factors like weight loss dominate motivational strategies. This study investigates the role of behavioral SMART (Specific, Measurable, Achievable, Relevant, Time-bound) goal-setting in fostering intrinsic motivation, a self-driven form of engagement, among participants in a structured fitness program. The primary aim was to evaluate the effectiveness of a SMART goal-setting curriculum in promoting intrinsic motivation and behavior-based goals over external outcomes like losing weight. METHODS: Participants (N = 24) were recruited from a fitness challenge program and selected one behavioral SMART goal from a …

Indirect Calorimetry: The Effects Of Overfeeding And Underfeeding Mechanically Ventilated Patients, Hailee Schirm

Williams Honors College, Honors Research Projects

This research focuses on the effects of overfeeding and underfeeding mechanically ventilated patients in the ICU and how indirect calorimetry plays a role in improving patient outcomes. Research was pulled from eight peer reviewed sources written within the last ten years to support this statement. It includes multiple types of studies including but not limited to a retrospective cohort study, meta-analysis, review, and deterministic cost-sequences analysis. Indirect calorimetry measures carbon dioxide production and oxygen consumption to calculate energy expenditure and determine the number of calories needed to sustain one’s body. This allows us to determine the number of calories a …

Hip Strengthening In Female Collegiate Soccer Players: Effects Of Gluteus Medius Strengthening On Biodex Balance Scores, Caitlin Bruni, Morgan Shansky

Williams Honors College, Honors Research Projects

The purpose of this study is to examine the effects of gluteus medius (Gmed) strengthening program on single leg stability in collegiate female soccer players. Given the role of Gmed in stabilizing the hip, improving its strength may reduce lower extremity injury risk. Weakness in Gmed has been linked to conditions such as Anterior Cruciate Ligament (ACL) tears and Patellofemoral pain syndrome (PFPS). This study investigates whether an 8-week strength program improves single-leg stability, measured using the Biodex Balance System. Thirty-three female soccer players (18-23 years) from The University of Akron were recruited, with 22 completing the study. Participants underwent …

Critical Analysis Of Gestational Diabetes Risk Factors: A Systematic Review, Madison Keich, Madeleine Ray, Mia Ross

Williams Honors College, Honors Research Projects

Gestational Diabetes Mellitus (GDM) is a common complication of pregnancy that causes an increased blood sugar that can affect both the mother's and baby’s health. A variety of factors can increase the risk of developing the disease, including race, socioeconomic status, and prenatal education. Each of these factors contributes to the experience of one’s maternal care. Expecting mothers may not understand how significant GDM is, and its potential to result in negative outcomes. It is important to review these factors, acknowledge them, and help reduce health disparities caused by them. Nurses are vital to assessing and delivering patient education on …

Effects Of Exercise On Cognitive Performance, Autumn Bailey

Williams Honors College, Honors Research Projects

This research project “Effects of Exercise on Cognitive Performance” will be conducted with the purpose of determining the relationship between exercise and cognitive performance. The relationship between injury and cognitive performance will also be investigated. In order to investigate these relationships 60 participants who are current students at the University of Akron will be asked to complete three cognitive assessments, one while at rest, one while riding an exercise bike, and one following the completion of exercise. The results of these three assessments will be compared to determine the relationship between cognitive performance in all three states. Participants will include …

Review Of Research On Relative Energy Deficiency In Sport (Red-S), Paige Mcmaster

Williams Honors College, Honors Research Projects

The following research article review serves to summarize and evaluate peer-reviewed research articles on the topic of Relative Energy Deficiency in Sport (RED-S). The paper will cover RED-S's effect on males versus females, endurance athletes versus non-endurance athletes, recreational athletes versus competitive athletes, and different age groups. Methodology includes strategically reviewing current literature and providing common themes or key points. The goal is to effectively summarize the subject of RED-S, provide in-depth understanding of the condition, and establish the need for education to prevent or reduce the incidence of RED-S.

The Social Construction Of Homelessness: A Qualitative Examination Of International Efforts To Address Homelessness, Chanel Swoope

Theses and Dissertations

Homelessness is a multi-layered worldwide issue, shaped by cultural, economic, and political factors. This qualitative case study compared two international non-profit organizations, Hope Haven in Paraguay and Safe Shelter Foundation in Finland, in their approaches to reducing homelessness. The research explores how institutional systems and sociocultural norms shape intervention by utilizing two theoretical frameworks, structural functionalism and social constructionism. The study included semi-structured interviews with twelve participants employed by the organizations, seven from Paraguay and five from Finland, and a review of archival program data. The interview and archival data were triangulated with deductive and inductive data analysis.

Findings revealed …

Exploring The Perceptions And Experiences Of School Building Leaders At Public Charter Schools And The Impact They Have On The Provision Of Physical Education In Charter School Settings, Nathaniel Bouie Jr.

Theses and Dissertations

This qualitative phenomenology study aimed to explore the perceptions of school principals regarding physical education (PE) and its impact on school programming. Semi-structured interviews were conducted with ten school principals in an urban charter school district in the United States. The interviews were transcribed, and data were analyzed using the phenomenological approach under the lens of teacher socialization.

The findings of the study revealed that physical education was perceived as an inferior subject compared to core subjects such as mathematics, science, and language arts. School leaders viewed PE as less important than other subjects and often reduced its instructional time …

A Systematic Review Of The Outcomes And Efficacy Of Complementary And Alternative Non-Pharmacological Interventions In Youth With Attention Deficit Hyperactivity Disorder, Kelly M. Kohler

Theses and Dissertations

A number of behavioral and pharmacological treatments have been widely accepted as evidenced-based approaches to treating symptoms of attention-deficit hyperactivity disorder (ADHD) in children and adolescents. While pharmacological approaches are safe and effective at managing symptoms, a large subset of caregivers do not have access to medication, refuse it, or find it ineffective, necessitating the need for non-pharmacological treatments. Such behavioral interventions are also generally effective approaches to symptom management and reducing the functional impairment of ADHD and may even demonstrate better parent satisfaction than medication alone. However, these interventions are often difficult to access and burdensome to implement, especially …

The Role Of Fruiting Bodies In Protecting A Community Of Myxococcus Xanthus Spores From The Environment, Dave Lall

Wayne State University Dissertations

Environmental microorganisms have evolved a variety of strategies to survive fluctuations in environmental conditions, including the production of biofilms and differentiation into spores. Myxococcus xanthus are ubiquitous soil bacteria that produce starvation-induced multicellular fruiting bodies filled with environmentally resistant spores (a specialized biofilm). Isolated spores have been shown to be more resistant than vegetative cells to heat, ultraviolet radiation, and desiccation. The evolutionary advantage of producing spores inside of fruiting bodies is not clear. Here, we examine a hypothesis that the fruiting body provides additional protection from environmental insults. We developed a high-throughput method to compare the recovery (outgrowth) of …

Environmental Pollution And Early-Life Metabolic Programming, Lisa Koshko

Wayne State University Dissertations

Substantial evidence demonstrates that parental pollutant exposures can induce harmful health effects in the offspring, including the predisposition to Type II Diabetes. As rates of Type II Diabetes continue to rise in younger populations, a crucial gap lies in understanding the role of parental influence in the etiology of later-life metabolic disease. Therefore, the central goal of this work was to determine how early life exposure to smoking level benzene, an endocrine-disrupting air pollutant, affects the metabolic health of offspring, and to identify potential developmental mechanisms involved in disease susceptibility. This goal was achieved using two models of early life …

Proceedings Of The Tenth Annual Indiana Stem Education Conference: Generational Advances Through Stem Education, William S. Walker Iii, Lynn A. Bryan, S Selcen Guzey

Indiana STEM Education Conference

The Proceedings of the Tenth Annual Indiana STEM Education Conference are edited by the Center for Advancing the Teaching and Learning of STEM (CATALYST, https://www.education.purdue.edu/catalyst/) at Purdue University. The theme for the 2025 conference is Generational Advances through STEM Education. This year’s conference provides opportunities to learn about effective STEM education strategies, curriculum, and resources to engage students by considering the advances and impact of STEM.

Providing Safe Gastric Feedings In Pediatric Patients On High Flow Nasal Cannula Respiratory Support, Olivia Joyce Chan

Yale School of Nursing Digital Theses

Purpose: HFNC is used to manage pediatric respiratory distress, but concerns aboutgastric air insufflation and aspiration risk lead to delayed feedings. There is no standardized practice guiding gastric feedings in children on HFNC. This project developed and implemented a decision tree to guide clinical decision-making for gastric feedings for children on HFNC. Methods: A HFNC feeding safety decision tree was developed following literature review and implemented in a Pediatric Intensive Care Unit (PICU). The primary outcome evaluated HFNC flow rates when starting gastric feeds. Secondary outcomes include adverse events (AEs), physiologic distress, and PICU/hospital LOS. Data were analyzed using Chi-Square …

Legal Barriers To Maternal Healthcare Equity, Ashley Keith

Akron Law Faculty Publications

In examining contemporary maternal healthcare inequity in clinical care delivery, we must study the critical role played by the legal institutions in creating and perpetuating this problem. Comprehensive systems within the United States require legal advocacy and judicial enforcement to take shape and maintain their structural integrity. Healthcare in this country is no different. Legal institutions helped form and further, both intentionally and inadvertently, the racial disparities that we currently battle. Legal history plays an integral role in understanding why racial disparities in maternal mortality persist. One way for legal professionals to contribute to the ongoing efforts to achieve maternal …

The Central Role For Troponin C Amino-Terminal ⍺-Helix In Vertebrate Thin Filiment Ca²⁺-Activation, Yun Shi, Lauren A. Blackwell, Ryan K. Schroy, B. Max Cleland, Cristina M. Risi, Michelle S. Parvatiyar, Jose R. Pinto, Vitold E. Galkin, P. Bryant Chase

Department of Biomedical and Translational Sciences Faculty Publications

Troponin C (TnC) is the Ca²⁺-sensing subunit of troponin that is responsible for activating thin filaments in striated muscle, and, in turn, for regulating the systolic and diastolic contractile function of cardiac muscle. The secondary structure of vertebrate TnC is mainly composed of α-helices, with nine helices named sequentially, starting from the amino terminus, from N to A–H. The N-helix is a 12-residue-long α-helix located at the extreme amino terminus of the protein and is the only helical structure that does not participate in forming Ca²⁺-binding EF-hands. Evolutionarily, the N-helix is found only in TnC from mammalian species and most …

Reduced Slow Wave Sleep Is Associated With Increased Risk Of Short Stature In Children: A Cross-Sectional Study, Zhaohua Chen, Yuan Shi, Fei Lei, Xujun Feng, Lu Tan, Taomei Li, Junying Zhou, Yuanfeng Sun, Jiamin Liao, Yun Li, Zhoulong Yu, Jian Jiao, Yanyan Wang, Larry D. Sanford, Michael V. Vitiello, Ye Zhang, Rong Ren, Xiangdong Tang

Department of Biomedical and Translational Sciences Faculty Publications

Objective: Although growth hormone was shown to be specifically released during slow wave sleep (SWS), no population-based evidence has demonstrated the association between sleep quality and childhood height. To address this gap, our study aims to investigate the relationship between SWS and height of children.

Methods: We analyzed polysomnography data and z-scores for height in 2527 suspected obstructive sleep apnea (OSA) children (537 non-OSA children and 1990 OSA children) collected over the past 16 years. Different grades of z-scores for height and SWS were classified by the quartile method, and the lowest z-scores for height quartile defined short stature as …

Phenotype Specific Nuclear Lamina Remodeling In Hipsc Derived Cardiomyocytes Bearing Tnnt2 Sarcomeric Variants, Isabella Leite Coscarella, Olalekan H. Usman, Lili Wang, Maicon Landim-Vieira, Lillian Wirstiuk, Amber N. Brown, Diego A. R. Zorio, Brian K. Washburn, Cynthia Vied, Bjorn C. Knollmann, Christopher Solís, Vitold E. Galkin, P. Bryant Chase, J. Travis Hinson, Jerome Irianto, Jose Renato Pinto

Department of Biomedical and Translational Sciences Faculty Publications

[Summary] Cardiomyocytes endure physical stress from the myocardium environment while generating their own mechanical strains. The force generated by sarcomeres is transmitted both longitudinally to adjacent sarcomeres and laterally to the cytoskeleton via intermediate filaments. This mechanical stimulus impacts other organelles, including the nucleus, thus playing a vital role in sensing and signaling nuclear adaptations. However, there is limited understanding of how changes in cardiac contractility affect nuclear mechanics. Here, we sought to investigate the effects of hyper- and hypo-contractility in nuclei of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) bearing TNNT2 pathogenic variants associated with hypertrophic (HCM) or dilated …

Countries As Laboratories: Reflections On Sierra Leone’S Amended Anti-Human Trafficking Law, Andrea L. Dennis

Scholarly Works

Sierra Leone’s improved anti-trafficking laws align with global norms, but enforcement remains weak due to socio-economic realities and Western deterrence mismatches, limiting effective prosecution despite recent legislative reforms.

The Hidden Cost Of Venture Capital, Emilie Aguirre

Faculty Scholarship

Founders, employees, consumers, and even funders increasingly expect businesses to pursue social goals alongside financial performance. Yet even the most committed firms have found it difficult to maintain social performance over time. Scholars in economics, management, and law have put forth several explanations for this “mission drift,” including inappropriate governance, poor management, lack of genuine commitment, and threat of takeovers. Puzzlingly, research to date primarily focuses on later-stage firms, even though the events and decisions that take place in a firm’s early stages can critically impact retention of its social performance.

Drawing from over five years of qualitative field research …

Association Of Socio-Demographic Factors, Perinatal Characteristics, And Hospital Maternity Practices With Breastfeeding Outcomes In The Uae, Zainab Taha, Farid El Ktaibi, Rafiq Hijazi

All Works

Breastfeeding (BF) rates remain suboptimal in the United Arab Emirates (UAE), despite global and national efforts. This study examined the association of socio-demographic factors, perinatal characteristics, and hospital maternity practices with breastfeeding outcomes in the UAE. In this cross-sectional study, 1,815 participating mothers with children below the age of 2 answered structured questions related to socioeconomics, hospital practices, and BF. Multivariate analysis showed that a non-Emirati nationality and vaginal birth were significantly associated with higher initiation rates (AOR = 6.19, 95% CI 1.96–19.54 and AOR = 2.65, 95% CI 1.35–5.21, respectively), timely initiation (AOR = 0.48, 95%CI 0.35–0.66, respectively), longer …

Edible Algae Reduce Blood Pressure In Humans: A Systematic Review And Meta-Analysis Of Randomised Controlled Trials, Patricia Casas-Agustench, Sandra Mínguez, Zoe Brookes, Raul Bescos

School of Health Professions

BACKGROUND: Edible algae contain bioactive compounds such as peptides, fucoidan, polyphenols, potassium, omega-3 fatty acids, and antioxidants that may benefit cardiovascular health, particularly in lowering blood pressure (BP) regulation. Certain species, including Nori and Kelp, are also rich in inorganic nitrate, known for its BP-lowering effects. However, the relationship between algae consumption and hypertension remains controversial. This study evaluated the effects of edible algae on BP in humans, considering factors such as algae type, format, dosage, intervention duration, health status, and baseline BP.

METHODS: A systematic search of Medline-Pubmed, Scopus and Cochrane databases was conducted through December 2024. Randomised controlled …