Digital Commons Network^™

Research Progress And Clinical Translation Potential Of Coronary Atherosclerosis Diagnostic Markers From A Genomic Perspective, Hanxiang Liu, Yuchen Zhang, Yueyan Zhao, Yuzhen Li, Xiaofeng Zhang, Lingyu Bao, Rongkai Yan, Yixin Yang, Huixian Zhou, Jinming Zhang, Siyuan Song

Children’s Nutrition Research Center Staff Publications

Objective: Coronary atherosclerosis (CAD) is characterized by arterial intima lipid deposition, chronic inflammation, and fibrous tissue proliferation, leading to arterial wall thickening and lumen narrowing. As the primary cause of coronary heart disease and acute coronary syndrome, CAD significantly impacts global health. Recent genetic studies have demonstrated CAD's polygenic and multifactorial nature, providing molecular insights for early diagnosis and risk assessment. This review analyzes recent advances in CAD-related genetic markers and evaluates their diagnostic potential, focusing on their applications in diagnosis and risk stratification within precision medicine.

Methods: We conducted a systematic review of CAD genomic studies from PubMed and …

In-Vitro Cholinesterase Inhibition Potential And Fatty Acid Profiling Of Lipids Obtained Via Direct Trans-Esterification From Sarcocephalus Latifolius (Sm.) Fruits And Leaves, Olubunmi Atolani, Joanna Adewara, Jude Onojah

Al-Bahir

Sarcocephalus latifolius (sm.) of the family, Rubiaceae, is an important plant used in folkloric medicine for the management of various disease conditions. An innovative green route was adopted for the direct characterization of the underutilized tropical plant which was profiled for the fatty acid composition and examined for the in vitro anti-cholinesterase potential. The fatty acid methyl esters obtained via direct methylation was characterized using Gas Chromatography-Mass Spectrometry, GC-FID/GC-MS. With donepezil hydrochloride as a reference, the cholinesterase enzyme inhibition capacity of the FAMEs was further assessed through standard assay. Four fatty acids were identified from the total ion chromatogram …

Rapid Weight Regain Is Not Linked To Success In Professional Ufc Fighters During Competition, Antonella V. Schwarz, Peter J. Byers, Lauren Stern, Gabriel J. Sanders, Tobin Silver, Jose Antonio, Corey Peacock

Internet Journal of Allied Health Sciences and Practice

Background: Although previous research has explored rapid weight loss (RWL) and rapid weight regain (RWRG) of Mixed Martial Arts (MMA) athletes, there is a lack of research analyzing this in fighters for the Ultimate Fighting Championship (UFC). There is also a lack of literature analyzing how RWRG in MMA athletes affects performance outcomes. Therefore, the purpose of this study was to compare official versus fight-night weigh-ins and whether the percentage change influenced winning or losing records in UFC athletes. Methods: Twenty-four official and fight-night weights were obtained utilizing the commission-calibrated scale. Paired Samples T-Tests were utilized to determine if official …

Examining The Impact Of An Education Intervention On Parents' Perceptions Of Sport Specialization, Lauren Schlacht Butler, Justin S. Disanti, Joseph J. Janosky, Jane S. Chung, James F. Russomano, Amanda M. Black, Shelly Fetchen Dicesaro, Eric Post, Jonathan A. Santana, Troy M. Smurawa, Tamara Valovich Mcleod

Internet Journal of Allied Health Sciences and Practice

PURPOSE: Several organizations have developed educational materials to provide stakeholders with information about the health risks of early sport specialization (ESS), though the impact of these efforts is not yet known. Therefore, the purpose of this study was to describe and assess the effect of an educational intervention on parental knowledge and perceptions of ESS. We hypothesized that a video-based educational intervention would increase parental knowledge and change perceptions of ESS. METHODS: Eighty-three parents of youth athletes completed a web-based survey. Participants were randomized into an intervention (ESS video) or control (concussion video) group. Each group completed a pre-and post-intervention …

A Quasi-Experimental Study Examining The Effects Of A Proprioceptive Rehabilitation Protocol For The Cervical Spine On Balance And Function Using A Laser Head Light In Older Community Dwelling Individuals, Vern M. Swanson Jr., M. Samuel Cheng, Leah Nof, Eric Shamus, Phd

Internet Journal of Allied Health Sciences and Practice

Purpose: Falls continue to be a major health issue when considering health risks for older individuals. The multi-factorial nature of falls in older adults leads to an overwhelming number of causal factors. Cervical joint position sense and joint position error could be additional factors that could influence the fall risk of older individuals. This research examined the effects of a proprioceptive rehabilitation protocol for the cervical spine using a laser head set in older community dwelling individuals. Methods: Sixty (60) subjects were purposively assigned into an experimental and a control group. Control group subjects were given a general lower extremity …

Strategies For Optimizing Female Athlete Health: A Multidisciplinary Approach To Mitigate Stress Fractures And Minimize Missed Participation In Collegiate Sports, Natalie B. Allen, Melissa R. Penkalski, Shannon M. Hauschildt, Kristin A. Paloncy-Patel

Internet Journal of Allied Health Sciences and Practice

Background: If not recognized early, low energy availability, along with overtraining, may result in stress fractures and significant time lost from sports participation for athletes at any level. Objective/Aim: The multidisciplinary collegiate medical team plays a key role in early identification of Female Athlete Triad (Triad) and Relative Energy Density in Sport (RED-S). To help with early identification, which may in turn lead to fewer stress fractures and less time missed from sports participation, this study’s objective was to implement the use of the 2014 Female Athlete Triad Cumulative Risk Assessment (FACTRA) and test early identification. The first …

Impact Of An Education Session On Improving Female Collegiate Athletes’ Comfort With Women’S Health Topics, Pauline Skowron, Ramandeep Kaur, S. Andrew Cage, Carly Wadle, Laurel Trail, Lynzi K. Warner, Brandon J. Warner

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to assess the effectiveness of a face-to-face education session on women’s health topics to improve comfort among college female athletes when discussing women’s health topics with coaches, athletic trainers, and primary care physicians. A secondary purpose was to assess the effectiveness of the education session on college female athletes’ perceived knowledge of topics related to women’s health. Methods: A total of 44 female collegiate student athletes competing at an NCAA Division II institution consented to and participated in this study as a convenience sample (age= 20 ± 1 years). Immediately prior to the …

Congenital Rickets, Melissa Intriago

Mako: NSU Undergraduate Student Journal

No abstract provided.

How Did Covid-19 Impact Physiology Research Globally? – Lessons Learned And Future Recommendations, Jeet Patel, Santanu De

Mako: NSU Undergraduate Student Journal

The Coronavirus Infectious Disease 2019 (COVID-19) pandemic caused massive changes in the medical field across the globe. As the whole world moved from in-person to remote activities, students found themselves in a predicament where they were compelled towards schooling and work online from home. This would mean that all projects, research, tests, and meetings were conducted over Zoom or other online meeting platforms. Laboratories were shut down or only a limited number of people were allowed to enter to conduct the necessary research. This paper discusses how the COVID-19 pandemic affected research process and experiments within various aspects of the …

Big Data Management Within Multi-Objective Optimization Modeling For Sustainable Food Production, Breanna Paige Modica

Walden Dissertations and Doctoral Studies

Producing enough food to feed a growing human population without further degrading the environment through unsustainable natural resource use is a global issue. The purpose of this quantitative nonexperimental study was to examine the extent to which big data management of environmental impact sources, assessment methods, and allocation methods in multi-objective optimization (MOO) modeling affect the consistency and predictability of sustainable food animal feed management practices at the farm level. Representation theory, the theory of effective use of information systems, the dynamic capabilities view, and the natural resource-based view were used to describe the necessity of accurately representing and managing …

Perceptions And Practices Of Imaging Personnel And Physicians Regarding The Use Of Brain Mri For Dementia Diagnosis In Uganda, Stephen E. Jones, Martha Sajatovic

Faculty Scholarship

Introduction Diagnosing dementia remains challenging in low-income settings due to limited diagnostic options and the absence of definitive biomarkers. The use of brain MRI in the diagnosis of dementia is infrequent in Uganda, and even when it is used, subtle findings like mild regional atrophy are often overlooked, despite being crucial for imaging diagnosis. Objective The purpose of this study was to explore the perceptions and practices of imaging personnel and physicians regarding the use of brain MRI as a diagnostic approach for dementia in Uganda. Methods This was an exploratory qualitative study involving radiologists, technologists, senior house officers and …

Economic Impact And Clinical Benefits Of Clinical Pharmacy Interventions: A Six-Year Multi-Center Study Using An Innovative Medication Management Tool, Watheq M. Alsetohy, Kareem A. El-Fass, Seif El Hadidi, Mohammad F. Zaitoun, Osama Badary, Kareem Ali, Ahmed Ezz-Elden, Mohamed R. Ibrahim, Bahaa S. Makhlouf, Asmaa Hamdy, Noha S. El Baghdady, Maha Gamal Eldien, Sherif Allama, Amr A. Alashkar, Ahmed Seyam, Nanees Adel, Ahmed R. N. Ibrahim, Hany V. Zaki

Pharmacy

Background

Increasing healthcare costs, particularly in Low- and Middle-Income Countries (LMICs) like Egypt, highlight the need for rational economic strategies. Clinical pharmacy interventions offer potential benefits by reducing drug therapy problems and associated costs, thereby supporting healthcare system sustainability.

Objective

This study evaluates the economic impact and clinical benefits of clinical pharmacy interventions in four tertiary hospitals in Egypt by implementing an innovative tool for medication management, focusing on cost avoidance and return on investment (ROI), while accounting for case severity and drug therapy problem (DTP) resolution.

Methods

Utilizing a digital tool, cost avoidance was assessed by considering the severity …

Big Data Management Within Multi-Objective Optimization Modeling For Sustainable Food Production, Breanna Paige Modica

Walden Dissertations and Doctoral Studies

Producing enough food to feed a growing human population without further degrading the environment through unsustainable natural resource use is a global issue. The purpose of this quantitative nonexperimental study was to examine the extent to which big data management of environmental impact sources, assessment methods, and allocation methods in multi-objective optimization (MOO) modeling affect the consistency and predictability of sustainable food animal feed management practices at the farm level. Representation theory, the theory of effective use of information systems, the dynamic capabilities view, and the natural resource-based view were used to describe the necessity of accurately representing and managing …

Dysregulated Klf4 Expression Plays A Pivotal Role In The Pathogenesis Of Pancreatic Intraductal Papillary Mucinous Neoplasms, Xiangsheng Zuo, Liang Wang, Yi Liu, Huamin Wang, Margarete Hafley, Mihai Gagea, Ru Chen, Yun Xiong, Sheng Pan, Imad Shureiqi, Robert S Bresalier, Daoyan Wei

Faculty, Staff and Student Publications

No abstract provided.

Light-Dark Shift Promotes Colon Carcinogenesis Through Accelerated Colon Aging, Deepak Sharma, Phillip A Engen, Abu Osman, Darbaz Adnan, Maliha Shaikh, Mostafa K Abdel-Reheem, Ankur Naqib, Stefan J Green, Bruce Hamaker, Christopher B Forsyth, Lin Cheng, Ali Keshavarzian, Khashayarsha Khazaie, Faraz Bishehsari

Faculty, Staff and Student Publications

Colorectal cancer (CRC) is the third most common cancer worldwide, with rising prevalence among younger adults. Several lifestyle factors, particularly disruptions in circadian rhythms by light-dark (LD) shifts, are known to increase CRC risk. Epidemiological studies previously showed LD-shifts are associated with increased risk of CRC. To explore the mechanisms and interactions between LD-shift and intestinal aging, we investigated how the combination of LD-shifts and aging impacts colon carcinogenesis development. Our data showed that LD-shifts and aging increased colon tumorigenesis. Notably, LD-shift accelerated intestinal aging by altering aging-related pathways, such as intestinal barrier damage, accompanied by dysbiotic changes in the …

Recommendations For Interdisciplinary Research Collaboration For Early Career Dissemination And Implementation Researchers: A Multi-Phase Study, Hannah G Lane, Sallie D Allgood, Julie Schexnayder, Hayden B Bosworth, Ana A Baumann, Allison A Lewinski

2020-Current year OA Pubs

INTRODUCTION: Dissemination and implementation (D&I) scientists are key members of collaborative, interdisciplinary clinical and translational research teams. Yet, early career D&I researchers (ECRs) have few guidelines for cultivating productive research collaborations. We developed recommendations for ECRs in D&I when serving as collaborators or co-investigators.

METHODS: We employed a consensus-building approach: (1) group discussions to identify 3 areas of interest: "Marketing yourself" (describing your value to non-D&I collaborators), "Collaboration considerations

RESULTS: Forty-four D&I researchers completed the first survey, 12 of whom attended one of three focus groups. Twenty-nine D&I researchers completed the second survey (

CONCLUSIONS: Research collaborations are essential in …

Food Marketing To Youth, Marlene Schwartz, Dale Kunkel, Sarah Delucia

Communication Research Trends

No abstract provided.

A Comparative Study Of Leadership Styles Of U.S. Olympic Swimming Head Coaches, Stephanie Barnes

Masters Theses

The role of leadership is paramount in successful sport coaching. The current study explored the realm of coaching in swimming to gain a deeper understanding of the unique and diverse leadership styles of U.S. Olympic Head Swimming Coaches. This study employed a qualitative phenomenological research design using a case study approach with two specific cases. Purposeful sampling was utilized to investigate two former U.S. Olympic Head Swimming Coaches with a combined 80 years of elite professional swim coach experience. Through semi-structured interviews and detailed questions, meaningful insight was gained into coaching practices, athlete interactions, and self-perceived effectiveness. Data analysis utilizing …

Hiv Associated Epigenetic Trends And Chronic Diseases: Insights Into The Hidden Burden Of Chronic Infection, Courtney G. Wallace, Zachary Capriotti, Zachary Klase

Kimmel Cancer Center Faculty Papers

Human Immunodeficiency Virus (HIV) remains a major health challenge despite dramatic advances in treatment and prevention. People living with HIV (PLWH) continue to experience high rates of non-AIDS comorbidities, including cardiovascular, renal, pulmonary, oncologic, and neurocognitive disorders. These conditions persist under viral suppression, underscoring the lasting biological impact of infection. Epigenetic dysregulation has emerged as a key driver of these outcomes. HIV integration, viral proteins, chronic inflammation, and ART exposure have all been reported to alter DNA methylation, histone modifications, transcription factor networks, and noncoding RNA regulation. These changes extend beyond infected cells, reprogramming uninfected immune and tissue compartments. Long-lived …

Improving Cooking Skills, Lifestyle Behaviors, And Clinical Outcomes For Adults At Risk For Cardiometabolic Disease: Protocol For A Randomized Teaching Kitchen Multisite Trial (Tk-Mt), Jennifer Massa, Candace Sapp, Kate Janisch, Mopelola A Adeyemo, Auden Mcclure, Natalia I Heredia, Deanna M Hoelscher, Tannaz Moin, Shaista Malik, Wendelin Slusser, David M Eisenberg

Faculty, Staff and Student Publications

BACKGROUND/OBJECTIVES: This protocol describes a study to investigate the feasibility and preliminary efficacy of a novel Teaching Kitchen Multisite Trial (TK-MT) for adults with cardiometabolic abnormalities. The TK-MT protocol describes a hybrid lifestyle intervention combining in-person and virtual instruction in culinary skills, nutrition education, movement, and mindfulness with community support and behavior change strategies. This 18-month-long randomized controlled trial aims to evaluate the feasibility of implementing a 12-month, 24 class program, assess preliminary study efficacy, and identify barriers and facilitators to implementation.

METHODS: The intervention program includes 16 weeks of intensive hands-on culinary and lifestyle education classes followed by eight …

Current Status Of Hemodialysis In Iraq, Ismael Ismael, Anas Khalaf, Dalia Ali, Ali Al Saedi

Iraqi National Journal of Medicine

Background: The progressive and permanent damage associated with chronic kidney disease (CKD) makes it a major global health concern. Hemodialysis (HD) is a vital renal replacement therapy; however, its prevalence and adequacy remain understudied in Iraq. Aim: This study aims to assess the current situation of HD in Iraq, focusing on the prevalence and causes of CKD. Patients and Methods: This cross-sectional study included all Iraqi cities and examined patients receiving HD from January 1 to December 31, 2023. Data was collected through a structured questionnaire at governorate centers across Iraq. Results: A total of 10,721 HD patients from various …

A Phenomenological Study Exploring The Lived Experiences Of Former Adult Drug Users’ Sobriety Journey After Graduating From A Faith-Based/Spiritual Drug And Alcohol Recovery Program, Laurine Voltaire

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to investigate the lived experiences of former adult drug users and their sobriety journeys after graduating from a variety of faith-based or spiritual drug and alcohol recovery programs. The research included a systematic review and narrative synthesis of existing literature on faith-based and spiritual recovery programs to address the gap concerning the lived experiences of former users and an evaluation of the strategies and techniques vital for facilitating recovery. The guiding theoretical framework CHIME-D delineated the essential definitive characteristics such as connectedness, hope, identity, meaning of life, empowerment, and overcoming difficulties that …

Synesis As A Framework To Enable Safety Interventions In Complex Healthcare Environments, Aarti Bavare, Tiffany Wrenn, Anne Lam, Jamie Cargill, Lauren Salinas, Itode Idowu, Asma Razavi, Venessa Lynn Pinto, Eric Williams

Faculty, Staff and Students Publications

BACKGROUND: Despite wide adoption in the healthcare of safety event report (SER) systems, there is a paucity of unified structures for prompt analysis and action while retaining reporter confidentiality. We used a synesis framework to change siloed reviews of safety reports to a comprehensive appraisal of quality, safety, productivity and reliability to facilitate interventions.

METHODS: After a needs assessment survey, we launched serial plan-do-study-act cycles to (1) enhance teams' ability to access SERs, (2) facilitate regular multidisciplinary review of SERs to identify actionable opportunities, (3) allocate action priority using failure mode and effects analysis, and (4) launch actions and summarise …

Associations Between Deficit Accumulation Frailty And Baseline Markers Of Lifestyle In The Us Pointer Trial, Mark A Espeland, Yitbarek N Demesie, Kayloni Olson, Samuel N Lockhart, Sarah E Tomaszewski Farias, Maryjo L Cleveland, Christy C Tangney, Lucia Crivelli, Heather M Snyder, Michele K York, Laura D Baker, Rachel A Whitmer, Rena R Wing, Katelyn R Garcia, Kathryn E Callahan

Faculty, Staff and Students Publications

BACKGROUND: Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty index developed by the U.S. POINTER clinical trial team of investigators and assess its cross-sectional associations with sociodemographic factors and markers chosen to be representative of behaviors targeted by the trial's multidomain interventions.

METHODS: We draw baseline data from the 2 111 volunteers enrolled in U.S. POINTER who were ages 60-79 years and at increased risk for cognitive decline. Frailty components were grouped into 9 domains. Associations that frailty index scores …

Keeping Kids Safe At Meals: Preventing And Responding To Choking, Mia Dustin, Savannah Daines, Stacy Bevan, Palak Gupta, Mateja R. Savoie-Roskos

All Current Publications

Introducing solid foods is an exciting developmental milestone, but it can also raise concerns about choking for parents and caregivers. Choking occurs when an object, such as food or a toy, blocks a child’s airway and prevents air from moving in and out of the lungs. This fact sheet offers practical guidance on how to prevent food-related choking, recognize the signs of a choking emergency, and what to do if a child is choking.

Sex Differences In Response To Diet Enriched With Glutathione Precursors In The Aging Heart, Aude Angelini, Grecia Garcia Marquez, Anna Malovannaya, Marta L Fiorotto, Alexander Saltzman, Antrix Jain, Joann Trial, George E Taffet, Katarzyna A Cieslik

Faculty, Staff and Students Publications

Common features of the aging heart are dysregulated metabolism, inflammation, and fibrosis. Elevated oxidative stress is another hallmark of cardiac aging that can exacerbate each of these conditions. We hypothesize that by increasing natural antioxidant levels (glutathione), we will improve cardiac function. Twenty-one-month-old mice were fed glycine and N-acetyl cysteine (GlyNAC; glutathione precursors)-supplemented or control diets for 12 weeks. Heart function was monitored longitudinally, and the exercise performance was determined at the end of the study. We found that the GlyNAC diet was beneficial for old male but not old female mice, leading to an increase of Ndufb8 expression (a …

Gatekeeping Theory From Social Fields To Social Networks, David Deiuliis

Communication Research Trends

No abstract provided.

Eng 4801-001 Integrating The English Language, Elizabeth Tacke

Spring 2025

No abstract provided.

Eng 4903z-600 Young Adult Literature, Niall Nance-Carroll

Spring 2025

No abstract provided.

Eng 1002g-015 College Composition Ii, Glen Davis

Spring 2025

No abstract provided.