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Associations Between Cardiovascular Disease And Utilization Of Dental Preventive And Periodontic Services, Amirhossein Fakhre Yaseri Apr 2025

Associations Between Cardiovascular Disease And Utilization Of Dental Preventive And Periodontic Services, Amirhossein Fakhre Yaseri

Theses and Dissertations

Cardiovascular disease (CVD), including coronary artery disease, heart failure, myocardial infarction, and stroke, remains a leading cause of global mortality, with approximately 20.5 million deaths in 2021. Despite advancements in medical science, CVD prevalence continues to rise, underscoring the need for preventive approaches and increased awareness. CVD is closely associated with oral diseases, and poor oral health is linked to worse cardiovascular outcomes. This study investigates the association between CVD and the utilization of dental preventive and periodontal services using data from the Dental Experience and Research Exchange (DERE) database, which aggregates clinical data from dental practices across the U.S. …


The Effects Of Acute Nutrient Intake On Raw Segmental Bioelectrical Impedance Values And Fluid Shifts In Premenopausal Women, Callie Unrein Apr 2025

The Effects Of Acute Nutrient Intake On Raw Segmental Bioelectrical Impedance Values And Fluid Shifts In Premenopausal Women, Callie Unrein

Theses and Dissertations

Background: Raw bioimpedance measures—impedance (Z), resistance (R), reactance (Xc), and phase angle (PhA)—are emerging tools to assess hydration, cellular integrity, and muscle quality. While multifrequency bioimpedance analysis (MF-BIA) can detect acute physiological shifts, its sensitivity to nutrient intake, especially across hormonal phases in women, remains underexplored. Purpose: This study investigated how essential amino acids (EAA), carbohydrates (CHO), and water (CON) influence postprandial segmental bioimpedance and fluid distribution in healthy women, and whether these responses vary by menstrual hormone phase. Methods: Twenty-two recreationally active women (18–40 years) underwent serial MF-BIA (InBody 970) assessments during high- and low-hormone phases, randomized to one …


Use Of Electrical Household Appliances And Risk Of All Types Of Tumours: A Case-Control Study, Shabana Noori, Abdul Aleem, Imrana Niaz Sultan, Afrasiab Khan Tareen, Hayat Ullah, Muhammad Waseem Khan Apr 2025

Use Of Electrical Household Appliances And Risk Of All Types Of Tumours: A Case-Control Study, Shabana Noori, Abdul Aleem, Imrana Niaz Sultan, Afrasiab Khan Tareen, Hayat Ullah, Muhammad Waseem Khan

Biological Engineering Student Research

Introduction: The use of electrical appliances using extremely low frequency (ELF) electromagnetic fields (EMF) has increased in the past few years. These ELF MF are reported to be linked to several adverse health effects. However, only a couple of studies have been conducted on the association between risk of tumours and use of electronic devices using low frequency (LF) EMF. Methods: We studied the use of common household electrical appliances and suspected risk of tumours in a multi-hospital-based case-control study. In total, 316 patients were included in the final analysis. Results: The study results showed a below unity risk for …


The Pharmaceutical Applications Of Poisonous Compounds Found In Datura Stramonium, Ruby M. Raffaldt Apr 2025

The Pharmaceutical Applications Of Poisonous Compounds Found In Datura Stramonium, Ruby M. Raffaldt

Senior Theses

Datura stramonium is a plant that is known for its toxicity. However, a facet of this plant’s noxious chemicals, namely its tropane alkaloids, can be used medicinally. The aim of this paper was to compile knowledge on the botanical, chemical, and medicinal properties of Datura stramonium L with a focus on atropine, scopolamine, and anisodamine; three tropane alkaloid compounds with the ability to be both a poison and a medicine. Information was compiled using pre-existing studies, articles, and literature reviews on D. stramonium. For each of the three alkaloids, their biosynthetic pathways, targets, administration, distribution, metabolism, and excretion were discussed. …


From Pregnancy To Postpartum: A Longitudinal Analysis Of Maternal Depressive Symptoms And Hemoglobin Concentration In Uttar Pradesh, India, Abdullah Nurus Salam Khan Apr 2025

From Pregnancy To Postpartum: A Longitudinal Analysis Of Maternal Depressive Symptoms And Hemoglobin Concentration In Uttar Pradesh, India, Abdullah Nurus Salam Khan

Theses and Dissertations

Background: Perinatal depression and maternal anemia impact maternal health, pregnancy outcomes, and infant growth in low- and middle-income countries. This study examines the prevalence and risk factors of these conditions during pregnancy and postpartum in rural Uttar Pradesh, India. Methods: A prospective cohort study was conducted among 475 pregnant women recruited during early pregnancy (≤20 weeks gestation) and followed through late pregnancy (≥27 weeks) and postpartum (< 42 days of childbirth). The outcome variables were, i) depressive symptoms, assessed using the Edinburgh Postnatal Depression Scale (EPDS), and ii) hemoglobin concentrations, measured using HemoCue Hb 301 analyzer from capillary blood. Multivariable linear regression examined associations of the outcome variables with sociodemographic, obstetric, nutritional, interpersonal, and perinatal factors. Path analysis evaluated direct and indirect paths influencing postpartum hemoglobin. Results: Prevalence of probable depression (EPDS score≥13) peaked in early pregnancy (24%) and declined in late pregnancy (17%) and postpartum (4%). Mean hemoglobin declined from early (10.5 g/dL) to late pregnancy (9.7 g/dL), and partially recovering in postpartum (10.4 g/dL). Household food insecurity was associated with higher depressive symptoms during pregnancy and postpartum (early pregnancy:β=2.61, p=0.011; late pregnancy:β=2.84, p< 0.001; postpartum:β=1.40, p=0.023). Psychological intimate partner violence was associated with greater depressive symptoms in early pregnancy (β=3.19, p=0.001). Receiving more antenatal visits was associated with decrease in depressive symptoms in late pregnancy (β=-0.46, p=0.001) and hemoglobin at postpartum (β=-0.11, p=0.070). Consumption of more food groups was associated with increase in depressive symptoms (β=0.63, p=0.004) and hemoglobin in late pregnancy (β=0.10, p=0.026). Iron folic acid (IFA) consumption was associated with increase in hemoglobin in late pregnancy (β=0.01, p< 0.001) and postpartum (β=0.004, p=0.031). Experiencing postpartum health complications was associated with increase in depressive symptoms (β=0.41, p=0.013) and decrease in hemoglobin concentrations (β=-0.18, p=0.036). Antenatal hemoglobin concentrations mediated the associations of IFA supplementation and dietary diversity with postpartum concentrations. Conclusion: Perinatal depression was associated with socioeconomic vulnerabilities, food insecurity, and intimate partner violence, while hemoglobin concentrations were associated with maternal nutrition and perinatal care. Integrating mental health services and comprehensive nutrition interventions into antenatal and postpartum care can improve psychological and physical well-being of mothers during and after pregnancy.


The Role Of B Cells In Promoting Lipid Absorption By Promoting Lacteal Development, Kenny Johnson Apr 2025

The Role Of B Cells In Promoting Lipid Absorption By Promoting Lacteal Development, Kenny Johnson

Theses and Dissertations

The absorption of dietary lipids in the gut is necessary to maintain the metabolic tone of tissues. Inflammation in the gut can cause defects in lipid absorption, which can result in tissue wasting, otherwise known as cachexia. Cachexia is commonly observed in patients with inflammatory bowel disease and cancer patients. The underlying cause of cachexia is unknown, and there are currently no effective therapeutic options available to treat it. Lymphatic drainage in the small intestine (SI) is specialized to promote the transport of dietary lipids into circulation. Lacteals are blunt-ended lymphatic vessels localized to the central axes of villi in …


Evaluation Of A Comprehensive Set Of Normal Tissue Complication Probability Models For Patients With Head And Neck Cancer In An International Cohort, Suzanne P M De Vette, Maria I Van Rijn-Dekker, Lisa Van Den Bosch, Kylie Keijzer, Hendrike Neh, Hung Chu, Yan Li, Mark L Frederiks, Hans Paul Van Der Laan, Jolien Heukelom, Peter Van Luijk, Arjen Van Der Schaaf, Roel J H M Steenbakkers, Nanna M Sijtsema, Katherine A Hutcheson, Clifton D Fuller, Johannes A Langendijk, Amy C Moreno, Lisanne V Van Dijk Apr 2025

Evaluation Of A Comprehensive Set Of Normal Tissue Complication Probability Models For Patients With Head And Neck Cancer In An International Cohort, Suzanne P M De Vette, Maria I Van Rijn-Dekker, Lisa Van Den Bosch, Kylie Keijzer, Hendrike Neh, Hung Chu, Yan Li, Mark L Frederiks, Hans Paul Van Der Laan, Jolien Heukelom, Peter Van Luijk, Arjen Van Der Schaaf, Roel J H M Steenbakkers, Nanna M Sijtsema, Katherine A Hutcheson, Clifton D Fuller, Johannes A Langendijk, Amy C Moreno, Lisanne V Van Dijk

Faculty, Staff and Student Publications

Background/purpose: Normal tissue complication probability (NTCP) models can be used to guide radiation therapy (RT) decisions by estimating side-effect risks pretreatment to minimize (late) side-effects. Recently, a comprehensive individual toxicity risk (CITOR) profile of NTCP models addressing common side-effects in head and neck cancer (HNC) patients was developed. This study investigates the generalizability of these models in an international setting, with different treatment approaches and side-effect assessments, promoting their integration into more widespread clinical practice.

Materials/methods: From a prospective registry study, 407 HNC patients were included who were treated with definitive RT with or without systemic therapy between 2015 and …


Guidelines For The Management Of Pancreatic Cystic Lesions: Many Options, Too Few Solutions?, Yifan Wang, Michael P Kim Apr 2025

Guidelines For The Management Of Pancreatic Cystic Lesions: Many Options, Too Few Solutions?, Yifan Wang, Michael P Kim

Faculty, Staff and Student Publications

No abstract provided.


Nanosilica Supplementation In Tomato Increases Oviposition On Stems And Caterpillar Mortality In The Tomato Pinworm, Kokou R. Fiaboe, Fathiya M. Khamis, Xavier Cheseto, Abdullahi A. Yusuf, Baldwyn Torto Apr 2025

Nanosilica Supplementation In Tomato Increases Oviposition On Stems And Caterpillar Mortality In The Tomato Pinworm, Kokou R. Fiaboe, Fathiya M. Khamis, Xavier Cheseto, Abdullahi A. Yusuf, Baldwyn Torto

All Peer-Reviewed Publications

Silicon-induced responses play a key role in plant defense against herbivory, though the underlying mechanisms remain underexplored. In this study, we examined how mesoporous silica nanoparticles (MSNs) affect tomato (Solanum lycopersicum) defense against an invasive and highly destructive lepidopteran herbivore, the tomato pinworm (TPW), Phthorimaea absoluta. In tomato plants supplemented with MSN, prior exposure to TPW oviposition shifted subsequent egg-laying from a preference for leaves to an even distribution between stems and leaves. This shift was not observed in nonsilicon-supplemented plants. Prolonged oviposition triggered pigmentation in the basal cells of type I glandular trichomes on the stems of silicon-supplemented plants. …


Institute For Global Health And Development : Issue 10 - April 2025, Institute For Global Health And Development Apr 2025

Institute For Global Health And Development : Issue 10 - April 2025, Institute For Global Health And Development

IGHD Newsletters

  • Challenges and Opportunities for Poliovirus Eradication in Pakistan
  • IGHD Participates in Workshop on Societal Impacts of Extreme Heat
  • IGHD Participates in Roundtable in Pakistan’s Climate Prosperity Plan (CPP)
  • Dr. Zulfiqar Bhutta Receives International Pediatric Association Lifetime Achievement Award
  • Pakistan Urged to Make Bold Nutrition Pledges at N4G Summit 2025
  • Dr. Jai Das Speaks at AKDN Webinar on Climate Change and Community Health


Adolescent Sleep Health, Mental Health, And Cardiovascular Disease Risk In Adulthood, Prince Nii Ossah Addo Apr 2025

Adolescent Sleep Health, Mental Health, And Cardiovascular Disease Risk In Adulthood, Prince Nii Ossah Addo

Theses and Dissertations

Background: Insufficient sleep and poor sleep quality are major public health issues among adolescents in the United States (U.S.). Mental health and substance use challenges are also common among adolescents, particularly those with sleep problems. Although exposures in adolescence have been evidenced to significantly impact future health, little is known about how adolescent sleep health, mental health, and substance use influence future cardiovascular disease (CVD) risk. We, therefore, examined the association between sleep health in adolescence and CVD risk in adulthood and assessed whether the association is mediated by depressive symptoms and substance use in adolescents. Further, we explored the …


Child-Caregiver Relational Closeness And Child Mental Health In Nonparental Care Settings, Amanda Stafford Mcrell Apr 2025

Child-Caregiver Relational Closeness And Child Mental Health In Nonparental Care Settings, Amanda Stafford Mcrell

Theses and Dissertations

This dissertation examines child-caregiver relational closeness and child mental health within nonparental care systems in Low- and Middle-Income countries (LMICs). Five key factors impacting the well-being of orphaned, separated, and vulnerable children in LMICs are explored using the Positive Outcomes for Orphans (POFO) dataset: child maltreatment, social support, child-caregiver relationships, and nonparental care systems. First, I examined the relationship between maltreatment, social support, and mental well-being. Findings showed that maltreatment was associated with lower mental well-being, where social support (emotional support, tangible support, positive social support) was associated with greater mental well-being, even in the concurrent presence of maltreatment. Second, …


Literature Review Of Fuzzy Set Theory: Applications And Methodologies, Mohammed Jasim Mohammed Apr 2025

Literature Review Of Fuzzy Set Theory: Applications And Methodologies, Mohammed Jasim Mohammed

Journal of Economics and Administrative Sciences

This paper represents a comprehensive literature survey of the research published in the Journal of Economics and Administrative Sciences (JEAS) on applications and methodologies of fuzzy set theory. The review traced how fuzzy logic has been evolving in decision-making, optimization, and modeling uncertainties in published articles such as economics, management, and engineering. The categorization of fuzzy methodologies into various domains such as fuzzy linear programming, fuzzy regression, fuzzy control systems, and fuzzy multi-criteria decision-making relies heavily on the study of existing research. An analysis revealed an increasing trend of investigations highlighting the interplay of fuzzy logic with artificial intelligence, statistical …


Economic Importance Of Faw's Large Port And Its Role In Promoting Sustainable Development In Iraq, Rafeef Mahmoud Abd-Alstaar Ahmed, Hamdia Shaker Moslem Apr 2025

Economic Importance Of Faw's Large Port And Its Role In Promoting Sustainable Development In Iraq, Rafeef Mahmoud Abd-Alstaar Ahmed, Hamdia Shaker Moslem

Journal of Economics and Administrative Sciences

The paper studies the economic importance of Grand Faw Port and how that would help develop a more sustainable Iraq. It identifies Iraq's strategic location as the most critical point in the connection of East and West, thus elucidating how the port could build a more resilient economy, better trade efficiencies, and accompany long-term development frameworks. It also examines how the Development Road project affiliated with the port could boost diversification by improving transport infrastructure in Iraq. The study is deductive and descriptive in terms of approach: it assesses the impacts of the Grand Faw Port on the fortunes of …


The Effects Of Marketing On Societal Health, Carissa G. Holdridge Apr 2025

The Effects Of Marketing On Societal Health, Carissa G. Holdridge

Selected Honors Theses

In this thesis the significant health impacts which may be caused by the food additives which are allowed in our food are observed. Looking at the links between health issues such as Early Onset Colorectal Cancer and the correlation with the food additive Red 40. As well, looking at the adverse effect of brominated vegetable oil (BVO) and monosodium glutamate (MSG). The regulations on the food additives in the United States and other countries is concerning as it highlights the lack of importance placed on the health of Americans in relation to those of other countries. This thesis argues the …


Nh Learn Everywhere 4-H Livestock Science - Youth Planning Form, Unh Cooperative Extension Apr 2025

Nh Learn Everywhere 4-H Livestock Science - Youth Planning Form, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.


Fungal Infections In People Who Use Drugs, Jose Portugal Gonzales, Luis Ostrosky-Zeichner Apr 2025

Fungal Infections In People Who Use Drugs, Jose Portugal Gonzales, Luis Ostrosky-Zeichner

Faculty, Staff and Student Publications

Illicit drug use in the United States continues to rise, alongside an increasing number of severe infections associated with drug use. Surveillance studies report that 28%–34% of candidemia cases are linked to intravenous drug use, with Candida albicans being the most commonly isolated species, followed by Candida parapsilosis and Candida glabrata. Marijuana use is associated with lung infections caused by Aspergillus and the Mucorales, showing a 3.5-fold increased risk of mold infections and a 2.2-fold increased risk for other fungal infections. Intravenous drug use also presents a recognized risk factor for Aspergillus and Mucorales infections. Additionally, substances like …


Higher Dietary Nitrate Intake Is Associated With Lower Likelihood Of First Clinical Diagnosis Of Central Nervous System Demyelination In Australian Women, Hajar Mazahery, Lucinda J. Black, Alison Daly, Maja Banjac, Catherine P. Bondonno, Liezhou Zhong, Lauren C. Blekkenhorst, Jonathan M. Hodgson, Eleanor Dunlop Apr 2025

Higher Dietary Nitrate Intake Is Associated With Lower Likelihood Of First Clinical Diagnosis Of Central Nervous System Demyelination In Australian Women, Hajar Mazahery, Lucinda J. Black, Alison Daly, Maja Banjac, Catherine P. Bondonno, Liezhou Zhong, Lauren C. Blekkenhorst, Jonathan M. Hodgson, Eleanor Dunlop

Research outputs 2022 to 2026

Dietary nitrate is a precursor to nitric oxide, for which plausible mechanisms exist for both beneficial and detrimental influences in first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to the diagnosis of multiple sclerosis (MS). Whether dietary nitrate has any role in FCD onset is unclear. We tested associations between nitrate intake from food sources (plant, vegetable, animal, processed meat, and unprocessed meat) and likelihood of FCD. We used data from the Ausimmune Study (264 cases, 474 controls) and logistic regression with full propensity score matching. In females, higher nitrate intake from plant-based foods (odds ratio …


Shaping Effective Food Action Groups: Participant Perspectives On Structure And Stakeholder Involvement In Regional And Remote Western Australia, Stephanie L. Godrich, Sarah Goodwin, Jess Doe, Melissa Stoneham, Amanda Devine Apr 2025

Shaping Effective Food Action Groups: Participant Perspectives On Structure And Stakeholder Involvement In Regional And Remote Western Australia, Stephanie L. Godrich, Sarah Goodwin, Jess Doe, Melissa Stoneham, Amanda Devine

Research outputs 2022 to 2026

Issue Addressed: Food systems strongly influence food security outcomes. Food Action Groups (often termed Food Policy Councils/Coalitions/Networks internationally) offer a co-ordinated and collaborative approach to local food system issues. Their organisational structure and stakeholder membership significantly impact their focus and impact. Therefore, it is imperative to understanding community member and food system stakeholders' perspectives on how regional and remote Australian Food Action Groups should be structured to maximise their impact on local food systems, and identify the most appropriate stakeholders to facilitate and drive their action. Methods: A qualitative study using focus groups, was conducted in regional and remote townships …


Early Childhood Educator Preparation, Exposure, And Perspectives Of Autism Spectrum Disorder In Preschool Hispanic Populations, Karla C. Vidaurri, Ruth Crutchfield, Jessica R. Stewart Apr 2025

Early Childhood Educator Preparation, Exposure, And Perspectives Of Autism Spectrum Disorder In Preschool Hispanic Populations, Karla C. Vidaurri, Ruth Crutchfield, Jessica R. Stewart

Communication Sciences & Disorders Faculty Publications

Purpose: With an increase in prevalence of autism spectrum disorder (ASD) and the Hispanic population, there is a crucial demand for early identification and servicing of individuals with ASD. Early childhood educators are one profession in the position to identify and provide services to individuals with ASD at an early age. The aim of this study was to explore early educators’ preparation, exposure, and perspectives of ASD specific to preschool Hispanic populations.

Method: A survey methodology was implemented to explore early childhood educators’ preparation, exposure, and perspectives of ASD. The anonymous survey consisted of 23 questions and statements that explored …


Development Of A Self-Management Tool For Individuals With Seizure Clusters: Trial Design And Methodological Report, Molly Mcvoy, Eytan Hirsch, Luisa Londono, Kari Colón-Zimmermann, Jin Seok Cho, Martha Sajatovic Apr 2025

Development Of A Self-Management Tool For Individuals With Seizure Clusters: Trial Design And Methodological Report, Molly Mcvoy, Eytan Hirsch, Luisa Londono, Kari Colón-Zimmermann, Jin Seok Cho, Martha Sajatovic

Faculty Scholarship

Background: Despite advances in anti-seizure medications (ASMs) for people with epilepsy (PWE), adverse outcomes, negative health events (NHEs), and breakthrough seizures remain common. Rescue medication (RM) can better manage repetitive seizures, but barriers to RM use persist. Self-management for PWE and a history of NHEs (SMART) is an evidence-based epilepsy self-management program aimed at reducing barriers and maximizing facilitators to self-care in high-risk PWE. Methods: This 2-phase, ongoing clinical trial adapts SMART to integrate RM support for PWE with repetitive seizures. Phase 1, now completed, used input from an advisory board (AB) of PWE, caregivers, and clinicians to adapt the …


The Impact Of Equine-Assisted Services Through An Occupational Therapy Lens, Caitlyn Espinosa Apr 2025

The Impact Of Equine-Assisted Services Through An Occupational Therapy Lens, Caitlyn Espinosa

Capstone Projects

The topic of this capstone project is the role of occupational therapy in Equine-Assisted Services. This field is currently dominated by physical therapy because occupational therapists report a lack of knowledge and training involving this unique treatment strategy. Another common issue for equine-assisted programs is funding because insurance often denies coverage for these unique and expensive services. Therefore, objectives for this project include development of three educational visuals, submission of three grant proposals, completion of two continuing education opportunities, and service provision. Results of this project include educational visuals on (1) the basics of Equine-Assisted Services, (2) the impact of …


Promoting Mental Wellness In Emergency Medical Service Students, Providers, And Their Support Systems Through Occupational Therapy, Morgan Gutzman Apr 2025

Promoting Mental Wellness In Emergency Medical Service Students, Providers, And Their Support Systems Through Occupational Therapy, Morgan Gutzman

Capstone Projects

Emergency medical service (EMS) students and providers work in high-stakes and high-stress environments with limited education on how to manage the psychological toll of the job. Research shows that EMS providers have a higher prevalence of mental health struggles and suicide than the general population, which demonstrates the strong need for awareness, education, intervention, and stigma reduction. Occupational therapy (OT) is very capable of supporting this population through mental wellness education and awareness, occupational balance, and trauma-informed self-care strategies. One goal of this capstone project was to create and disseminate multimedia resources for EMS students, providers, and their support systems. …


Project Gender Nutriscope: Methods Of A Mixed Methods, Community-Engaged Study Design To Explore The Nutritional Needs Of Transgender And Gender-Diverse Youth And Young Adults., Heather E Schier, Krithika Chetty, Shivakriti Induri, Liam Gallagher, Miriam Knopp, Julie Kennel, Whitney Linsenmeyer, Avery M Anderson, Matthew Adkins, Irene E Hatsu, Janna D Stephens, Carolyn Gunther Apr 2025

Project Gender Nutriscope: Methods Of A Mixed Methods, Community-Engaged Study Design To Explore The Nutritional Needs Of Transgender And Gender-Diverse Youth And Young Adults., Heather E Schier, Krithika Chetty, Shivakriti Induri, Liam Gallagher, Miriam Knopp, Julie Kennel, Whitney Linsenmeyer, Avery M Anderson, Matthew Adkins, Irene E Hatsu, Janna D Stephens, Carolyn Gunther

Ambulatory and Primary Care Articles

OBJECTIVE: Despite growing evidence of distinct nutrition-related experiences and disparities, transgender and gender-diverse (TGD) youth and young adults are an underrepresented population in nutrition research. This paper describes the methods and study design from Project Gender NutriScope, a study that will explore the nutritional needs of TGD youth and young adults.

DESIGN: Parallel convergent cross-sectional mixed methods; community-engaged.

SETTING: A purposive sample will be recruited in a Midwest city through clinics, youth organizations, and a large state university.

PARTICIPANTS: Transgender and gender-diverse youth and young adults aged 13-24 years.

INTERVENTION: Findings from this formative study will be used to inform …


Navigating Food Insecurity: Families’ Coping Strategies, Challenges, And Insights For Educators, Ndũcũ Ngũgĩ Apr 2025

Navigating Food Insecurity: Families’ Coping Strategies, Challenges, And Insights For Educators, Ndũcũ Ngũgĩ

Theses & Dissertations

Food is essential for life. It fuels growth, well-being, and stability. Yet, food insecurity -uncertain or inadequate access to sufficient food- remains a jarring reality for millions. In the U.S. alone, 47 million people, including 14 million children, experience food insecurity despite government efforts. Addressing this crisis is essential for public health, socioeconomic progress, and societal welfare. This narrative study’s main objective was to understand the lived experiences of food-insecure families by examining how they navigate the challenges they face, their inventive coping mechanisms, and the insights they can provide for educators. While research has shown the adverse effects of …


Trifluridine/Tipiracil And Oxaliplatin As Induction Chemotherapy In Resectable Esophageal And Gastroesophageal Junction Adenocarcinoma: A Phase Ii Study, Sarbajit Mukherjee Apr 2025

Trifluridine/Tipiracil And Oxaliplatin As Induction Chemotherapy In Resectable Esophageal And Gastroesophageal Junction Adenocarcinoma: A Phase Ii Study, Sarbajit Mukherjee

All Publications

Background: Preoperative chemoradiation (CRT) followed by surgery for localized esophageal and gastroesophageal junction adenocarcinoma (EGAC) is a standard of care with a pathologic complete response (pCR) rate of 20%. We evaluated a novel combination of trifluridine/tipiracil with oxaliplatin as induction chemotherapy (IC) followed by CRT.

Methods: We enrolled patients with potentially resectable localized EGAC (T3, T4aN0, or node-positive disease) in this open-label, single-arm, multicenter, Phase II trial between January 2020 and October 2022. Patients received three cycles of IC with trifluridine/tipiracil and oxaliplatin and then underwent concurrent CRT with weekly carboplatin and paclitaxel followed by surgery. The primary objective was …


Development Of Flexible Lactate-Specific Molecularly Imprinted Polymers Based On Laser-Induced Graphene Electrochemical Biosensors For Disease Diagnosis, Christopher Animashaun Apr 2025

Development Of Flexible Lactate-Specific Molecularly Imprinted Polymers Based On Laser-Induced Graphene Electrochemical Biosensors For Disease Diagnosis, Christopher Animashaun

Biomedical Engineering Theses & Dissertations

Lactate is a critical biomarker linked to conditions such as sepsis, ischemia, cancer, and heart failure. Current lactate detection methods remain invasive, costly, and unsuitable for real-time, continuous monitoring. This study presents the development of a flexible, non-enzymatic electrochemical biosensor based on laser-induced graphene (LIG) electrodes modified with gold nanoparticles (AuNPs) and molecularly imprinted polymers (MIPs) for highly selective and sensitive lactate measurement. The integration of AuNPs enhanced surface conductivity and provided nanoscale heterogeneity, facilitating superior signal amplification. The optimized LIG/AuNP/MIP sensor achieved an extensive dynamic detection range from 0.1 μM to 1000 μM, with an outstanding detection limit of …


Historic Bedrocks Of Volunteer Recruitment: Collaboration Between The Peace Corps And Higher Education Partners, Melanie Elizabeth Graham Apr 2025

Historic Bedrocks Of Volunteer Recruitment: Collaboration Between The Peace Corps And Higher Education Partners, Melanie Elizabeth Graham

Educational Leadership & Workforce Development Theses & Dissertations

In this study I investigate the collaboration between the United States Peace Corps and their higher education partnership institutions, focusing on Peace Corps Prep Programs (PCPP) which aim to recruit, prepare, and retain diverse Peace Corps Volunteers. The inquiry examines the purpose, structure, and process of these collaborations to uncover successes and shortcomings, shedding light on the underlying mechanisms that contribute to effectiveness or hinder progress. A mixed-method, multiple case study methodology, integrating surveys and individual interviews that parallel The Wilder Collaboration Factors Inventory, facilitates an in-depth examination of the intricate dynamics and multifaceted experiences within the collaborative partnerships. By …


Linear Growth During Treatment With A Simplified, Combined Protocol: Secondary Analyses Of Severely Wasted Children 6-59 Months In The Compas Cluster Randomized Controlled Trial, Grace Heymsfield, Kevin Stephenson, Zachary Tausanovitch, André Briend, Marko Kerac, Heather Stobaugh, Jeanette Bailey, Suvi T Kangas Apr 2025

Linear Growth During Treatment With A Simplified, Combined Protocol: Secondary Analyses Of Severely Wasted Children 6-59 Months In The Compas Cluster Randomized Controlled Trial, Grace Heymsfield, Kevin Stephenson, Zachary Tausanovitch, André Briend, Marko Kerac, Heather Stobaugh, Jeanette Bailey, Suvi T Kangas

2020-Current year OA Pubs

A simplified, combined protocol treats children with moderate acute malnutrition (MAM), defined by mid-upper arm circumference (MUAC) of <  125 and ≥ 115 mm and no oedema, with 1 daily sachet of ready-to-use therapeutic food (RUTF) and those with severe acute malnutrition (SAM), defined by MUAC <  115 mm and/or oedema, with two daily sachets of RUTF. This protocol was previously shown to result in non-inferior recovery compared to standard treatment that used higher, weight-based RUTF dosing among children with SAM and ready-to-use supplementary food (RUSF) for MAM in a cluster-based randomised controlled trial in Kenya and South Sudan. We conducted a secondary analysis of this trial to compare linear growth among children admitted with MUAC <  115 mm. Linear and ponderal growth were calculated from admission to discharge and visualised using aggregate growth curves. HAZ change adjusted for admission characteristics was negative across the course of treatment but similar across arms [-0.21 ± 0.18 SE in the standard arm, -0.24 ± 0.18 SE in simplified; difference (95% confidence interval) 0.03 (-0.12, 0.18)]. The unadjusted mean ± SE linear growth velocity from admission to discharge was 1.8 ± 0.7 mm/week in the standard arm compared to 1.7 ± 0.7 mm/week in the simplified arm [difference = 0.09 (-0.36, 0.53)] and similar in adjusted analysis. MUAC and weight gain velocities were not significantly different by treatment arm. Reducing the RUTF dose prescribed to children during SAM treatment does not appear to affect linear growth or other growth velocities during treatment.


An Integrative Review Of The Use Of The Individual And Family Self-Management Theory In Research, Wendy S. Bauer, Rachel F. Schiffman, Julie L. Ellis, Jeanne M. Erickson, Michele Polfuss, Murad H. Taani, Kathleen J. Sawin Apr 2025

An Integrative Review Of The Use Of The Individual And Family Self-Management Theory In Research, Wendy S. Bauer, Rachel F. Schiffman, Julie L. Ellis, Jeanne M. Erickson, Michele Polfuss, Murad H. Taani, Kathleen J. Sawin

College of Nursing Faculty Research and Publications

The extent of the application of the Individual and Family Self-Management Theory (IFSMT) in research has yet to be determined. The purpose of this analysis was to review the use of the IFSMT in published research and evaluate posited constructs and relationships. Dimensions and categories of the IFSMT and the interrelationships were generally supported in the 77 articles reviewed. A majority focused on self-management of chronic conditions in the adult population. More research on the strength, direction, and interaction of relationships is needed. Defining and exploring social constructs, including race, ethnicity, and gender, should be prioritized in future IFSMT research.