Digital Commons Network^™

A Phenomenological Qualitative Study Of Adverse Childhood Experiences Among Adults With Autism Spectrum Disorder In Rural West Virginia, Kristen Shaylee Copenhaver

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe young adults’ experiences with high-functioning ASD and ACE in underserved regions of West Virginia. As ACEs are more prevalent in low-income and underserved communities, it can be essential to focus attention on the autism population and their recollection of the events that occurred, as well as the challenges they have experienced receiving treatment to adequately address their needs in West Virginia. The theory guiding this study was the theory of mind, coined by Premack and Woodruff; This theory focuses on the deficits in a person's mental state (Beaudoin et al., 2020), …

A Phenomenological Study Exploring The Covid-19 Mental Health Influences On Post-High School Students And Educators, Melvin J. Thomas

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore the influence of the COVID-19 pandemic on the mental health of post-high school students and educators located in the Northeastern Florida region of the United States. The theory guiding this study was Piaget’s theory on cognitive learning and development, as it assisted with highlighting the lived human experiences relating to the stages of cognitive development and mental health influences because of decreased physical and social interactions and changed learning environments. The qualitative method and the phenomenological design were used, which consisted of collecting data relating to the first-hand experiences of …

A Phenomenology Of The Importance Of Protection As It Relates To The Father And Daughter Relationship, Jared B. Reid

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to better understand the lived experience of a father’s relationship with his daughter(s) and how the central theme of protection impacts that relationship. Protection will be generally defined as a father’s ability to provide boundaries physically, spiritually, and emotionally around his family, created by safety and trust, in developing stability for healthy development. General research questions include but are not limited to, what necessitates a family to need protection. What is the impact on a daughter when the father does not protect her? The purpose of this phenomenological study is to investigate the …

Enriched Pathways In Gut Microbiome Predict Response To Immune Checkpoint Inhibitor Treatment Across Demographic Regions And Various Cancer Types, Xunhui Cai, Jennifer Y Cho, Lijun Chen, Yufeng Liu, Fenghu Ji, Katia Salgado, Siyi Ge, Dehua Yang, Hui Yu, Jianbo Shao, P Andrew Futreal, Boris Sepesi, Don Gibbons, Yaobing Chen, Guoping Wang, Chao Cheng, Meng Wu, Jianjun Zhang, Ansel Hsiao, Tian Xia

Faculty, Staff and Student Publications

Understanding the effect of gut microbiota function on immune checkpoint inhibitor (ICI) responses is urgently needed. Here, we integrated 821 fecal metagenomes from 12 datasets to identify differentially abundant genes and construct random forest models to predict ICI response. Gene markers demonstrated excellent predictive performance, with an average area under the curve (AUC) of 0.810. Pathway analyses revealed that quorum sensing (QS), ABC transporters, flagellar assembly, and amino acid biosynthesis pathways were enriched between responders (R) and non-responders (NRs) across 12 datasets. Furthermore,

Characterizing The Pathway Utilized By Enterolactone And Its Metabolic Precursor Matairesinol To Promote Glut4-Dependent Glucose Uptake In 3t3-L1 Adipocytes, Rochelle Miller, Heidi Bosch, Merritt Smith

Liberty University Research Week

Type-2 diabetes (T2D) is characterized by chronic insulin resistance and resultant fasting hyperglycemia. This is largely attributable to lifestyle factors like chronic over-nutrition, obesity, and excess abdominal adiposity. Research has shown an inverse association between habitual coffee consumption (both regular and decaffeinated) and T2D risk, suggesting that there may be protective effects elicited from certain chemical components of the beverage 1. Matairesinol (ML) is chemically classified as a lignan and is naturally occurring in coffee. It has been shown to inhibit the body weight gain and increase in fat mass commonly associated with high-fat diet-induced T2D2,3. ML and one of …

Community Health Assessments And Community Health Worker Training In Rural Guatemala, Grace Sibert

Liberty University Research Week

Public health plays a vital role in the health and well-being of communities, both within the United States and globally. In rural regions, particularly in Central America, addressing prevalent health issues such as hypertension, elevated blood glucose, anemia, and the promotion of sustainable care practices is of integral importance. Community Health Assessments (CHAs) serve as a critical tool for identifying and understanding local health needs, and Community Health Worker (CHW) training offers a sustainable solution to address these challenges. This research builds upon previous CHAs and CHW training initiatives in Guatemala and Honduras. Data collection involved structured questionnaires and biometric …

Meditation Or Medication: Comparing Meditation To Phosphatidylserine In The Reduction Of Salivary Cortisol In Collegiate Tennis Players Post Exercise, Elizabeth Hughes

Liberty University Research Week

Background: Cortisol is increased in the body in response to the reception of stress input, such as exercise or an emotional event. When this occurs, the hypothalamic-pituitary-adrenal (HPA) axis directs the adrenal cortex to release cortisol, thus raising cortisol levels.1 Phosphatidylserine (PS) is a glycerophospholipid made in the body that is a part of the cell membrane.2,3 PS reduces cortisol levels in the body.3 Meditation is a “consistent self-care practice…that allows for developing loving awareness of current thoughts and feelings.”4(p.37) Sadimi et al 4 used mindfulness meditation and found cortisol reductions were high. Meditation (MED) has not been compared to …

Global Trends In Sugar-Sweetened Beverages Consumption And Impact To Chronic Diseases In North America: A Retrospective Longitudinal Analysis (1990 – 2021), Ginika Muomah

Liberty University Research Week

Introduction: Sugar-sweetened beverages (SSBs) are a primary source of added sugars in global diets, strongly linked to adverse health outcomes, including obesity, type 2 diabetes, and cardiovascular diseases. Despite extensive research, excessive sugar intake remains a significant public health issue. This study aims to evaluate the association between SSB intake and the prevalence of chronic diseases across World Bank regions. Methods: A retrospective longitudinal analysis was conducted using Global Burden of Disease (GBD) data from the Institute for Health Metrics and Evaluation (IHME) from 1990 to 2021. This dataset includes information from 204 countries, categorized into seven World Bank regions. …

A Comparative Analysis Of Memory Loss And Cognitive Decline In The Workplace: U.S. And The Role Of Hr, Chidubem Xerona Nnajiofor

Liberty University Research Week

As the U.S. workforce continues to age, HR professionals face the growing challenge of addressing cognitive health in the workplace. Cognitive decline, including conditions such as dementia and memory loss, can impact employee productivity, engagement, and overall well-being. HR departments play a critical role in fostering a work environment that supports cognitive health through strategic initiatives. Workplace wellness programs, cognitive enrichment activities, and nutrition-focused policies have shown potential in maintaining cognitive function and prolonging employees' ability to contribute effectively to their organizations. This study explores how HR strategies can incorporate cognitive health initiatives to create supportive and sustainable work environments. …

Global Trends In Sugar-Sweetened Beverages Consumption And Its Impact On Chronic Diseases: A Retrospective Longitudinal Analysis In North America (1990-2021), Ginika Muomah

Liberty University Research Week

Hypothesis: Higher consumption of high sugar-sweetened beverages (SSBs) is associated with a significant increase in the prevalence of chronic diseases across World Bank regions. Introduction: Sugar-sweetened beverages (SSBs) are a primary source of added sugar in the global diet and have been strongly linked to adverse health outcomes. Despite decades of research, excessive sugar intake remains a critical public health concern, contributing to the risking burden of chronic diseases. This study aims to evaluate the association between SSB intake and the prevalence of various chronic diseases across World Bank regions. Methods: We conducted a retrospective longitudinal analysis using the Global …

Investigating The Spatial Distribution Of Food Insecurity And Its Associated Factors Across Mississippi Counties, Elizabeth C. Swindell, Riley Morgan, Dylan Barker, Ruaa Al Juboori

Journal of Public Health in the Deep South

Background: Mississippi has one of the highest rates of food insecurity in the United States, with many counties experiencing significant disparities in access to healthy food. Therefore, understanding the spatial distribution of these disparities is essential for developing targeted interventions.

Purpose: This study aims to investigate the spatial distribution of food insecurity and its associated social and health factors across Mississippi counties to identify areas in need of intervention.

Methods: Cross sectional study was conducted using publicly available datasets to examine food insecurity and its associated factors at the county level. Pearson correlations and bivariate Moran’s I were used to …

Book Of Abstracts: 2025 Honors College Research Symposium, Honors College, North Carolina Agricultural And Technical State University

2025 Honors College Research Symposium

This booklet contains the collection of research abstracts presented at the 2025 Honors College Research Symposium, held on April 17, 2025, at North Carolina Agricultural and Technical State University. The symposium highlights original undergraduate research across disciplines including science, engineering, humanities, health, education, business, and agriculture. The publication documents the scholarly contributions of Honors students through both oral and poster presentations.

Apoe Genotype Distribution In A Mexican Population: A Comparative Study And Its Implications For Alzheimer’S And Cardiovascular Disease, Carlos Perezcano, Andrea Sánchez, Josué Nava, Christian Rosete

Human Biology Open Access Pre-Prints

The apolipoprotein E (APOE) ε4 allele is a major genetic risk factor for Alzheimer’s disease (AD) and cardiovascular risk (CVD). This study analyzes the distribution of APOE alleles in 143 patients from a Mexican population based in Mexico City. The ε3 allele was the most prevalent (82.9%) followed by ε4 (12.5%) and ε2 (4.5%). Notably, the APOE 3/4 genotype, associated with increased risk for AD and CVD, was observed in 21% of the cohort, while the APOE 4/4 genotype, representing the highest genetic risk for both conditions, was rare (2.1%). The APOE 2/2 genotype, linked to type III …

Gc Minutes Apr 17, 2025, Graduate Council

Graduate Council Minutes

No abstract provided.

Comparison Of Total Oxidative State, Total Antioxidative State , Serum Paraoxonase Activity, And Thiol Levels Before And After 6 Months Of Treatment In Patients With Multiple Sclerosis Who Have Been Recently Started On New Therapy Agents, Emel Başar, Hasan Bayindir, Hati̇ce Ferhan Kömürcü, Ebru Bi̇lge Di̇ri̇k, Ömer Anlar, Özcan Erel

Turkish Journal of Medical Sciences

Background/aim: The objective of this study was to establish the oxidative stress determiners as a total oxidative state (TOS), total antioxidative state (TAS), paraoxonase (PON) activity, oxidative stress index (OSI), and thiol/disulfide levels before and after 6 months of immunomodulator therapy in patients who were diagnosed according to the revised McDonald Criteria.

Materials and methods: Thirty-nine patients were included in our study who were diagnosed according to the revised McDonald Criteria, approved to participate in the study, and had been treated in the neurology inpatient clinic or presented in the neurology outpatient clinic of Ankara Yıldırım Beyazıt University Atatürk Training …

Evaluation Of Clinical Features And Treatment Modality Of Pediatric Patients With Steven Johnson Syndrome/Toxic Epidermal Necrolysis: A Single-Center Experience, Funda Ayteki̇n Güveni̇r, Vi̇ldan Seli̇n Çayhan, Selman Kürşat Balci, Ragip Dere, Hati̇ce Irmak Çeli̇k, Serhat Emeksi̇z, Ahmet Selmanoğlu, Zeynep Şengül Emeksi̇z, Emrah Şenel, Emi̇ne Di̇bek Misirlioğlu

Turkish Journal of Medical Sciences

Background/aim: Steven Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but life-threatening severe cutaneous drug hypersensitivity reactions. The aim of our study was to evaluate the clinical features of pediatric patients diagnosed with SJS, TEN or SJS/TEN overlap and to examine treatment modalities.

Materials and methods: Patients aged 0–18 years who were followed up with SJS, TEN or SJS/TEN overlap at Ankara Bilkent City Hospital between August 2019 and January 2024 were retrospectively analyzed.

Results: Twelve patients who met the inclusion criteria were included in the study. Five of the patients had SJS, four had SJS/TEN overlap, and …

The Effects Of Liraglutide On Expressions Of Insulin Secretion And Beta Cell Survive Associated Gpcr Genes In Pancreatic Beta Cells, Meli̇kenur Türkol, Türker Bi̇lgen

Turkish Journal of Medical Sciences

Background/aim: Liraglutide as a long-acting glucagon-like peptide drug has anti-hyperglycemic and antiobesity effects. G protein-coupled receptors (GPCRs) are well- known drug target molecules that conduct critical signaling pathways related with diseases. Research has confirmed the role of many GPCRs genes in the regulation of pancreatic beta cell functions and insulin secretion. Liraglutide dependent expressional changes in GPCR genes may let us determine new drug targets.

Materials and methods: Therefore, we investigated the changes in expression of GPR75, GPR56, GLP1R, M3R, and CB1R genes, which are the GPCR family members, in response to liraglutide treatment in the NIT-1 mouse pancreatic beta …

The Impact Of Diet On Preeclampsia: An Observational Study Of Nutritional Influence, Trinity G. Moye, Alyssa Cunningham

Department of Nutrition Student Projects

Preeclampsia is a pregnancy-specific condition typically diagnosed after 20 weeks of gestation in women with no prior history of hypertension. Characterized by high blood pressure, proteinuria, thrombocytopenia, increased liver enzymes, and affecting the arteries carrying blood to the placenta, preeclampsia affects the health of both the mother and the fetus. Preeclampsia is disproportionately prevalent in certain populations, specifically among Black women, with various factors contributing to the higher susceptibility including socioeconomic status, education, and health distrust. These factors have been historically structured against Black women in American society. This study aims to reveal how dietary habits can play a role …

The Impact Of The Mediterranean Diet And Low-Glycemic Diet On Fertility In Women Of Childbearing Age With Pcos, Samantha Cicardo, Kayla Le, Carly Traynor

Department of Nutrition Student Projects

Endocrine disorder Polycystic Ovarian Syndrome (PCOS) is an imbalance of reproductive hormones in women, primarily treated with medications such as hormonal birth control and metformin. However, long-term use of medications can have adverse effects as it masks the symptoms of PCOS rather than treat it. Women of childbearing age who are diagnosed with PCOS often are diagnosed with infertility. This proposed research study aims to look at the holistic approach to evaluate how the Low-Glycemic Index (GI) diet and the Mediterranean diet (MD) can impact individuals with PCOS. The primary objective of this study is to assess the impact of …

The Impact Of An Iron-Rich Diet On Fatigue In Menstruating Women With Non-Anemic Iron Deficiency, Meagan Seraydar, Lauren Latimer, Sam Miragliatto

Department of Nutrition Student Projects

Fatigue without diagnosed anemia is prevalent in menstruating women, with iron deficiency being a potential contributor. While iron supplementation is a standard intervention, dietary sources of iron may offer a sustainable alternative. This study aims to assess the impact of an iron-rich diet on fatigue levels in menstruating women. A 12-week randomized controlled trial (RCT) will be conducted, assigning participants to either an iron-rich diet group or a control group following their usual diet without specific iron recommendations. Fatigue will be measured using the Fatigue Severity Scale (FSS) at baseline, six weeks, and twelve weeks, alongside iron status biomarkers, including …

The Impact Of Aspartame On Mood Regulation: Examining Neurophysiological Effects In Individuals With Anxiety, Kyra Triepke, Valentina Guzman Cortes, Mateus Ismael Ribeiro

Department of Nutrition Student Projects

Despite being widely used as sugar alternatives, artificial sweeteners (AS), especially aspartame, remains debated regarding their potential effects on mental health. While some studies suggest aspartame has no discernible impact on stress, anxiety, or cognitive performance, others indicate that it may affect serotonin pathways and contribute to mood disorders. Given these contradictory findings, further research is needed to clarify aspartame’s effect on mood regulation. This study aims to evaluate the impact of aspartame on stress-related biomarkers and mood modulation, focusing on individuals with anxiety. A controlled experimental design will be used, in which participants with anxiety will be randomly assigned …

Student Perceptions On Career Decision Making Skills In Relation To The Covid-19 Pandemic, Emily G. Oliver

Honors College Theses

The Covid-19 pandemic had major ramifications on all areas of the professional world as well. As mandatory quarantines and shutdowns were implemented, the negative effects were widespread and everyone was impacted. People from all different career fields faced unforeseen circumstances that caused anxiety about their income and workplace stability. With all of these changes in the world, students who were in high school and first years of college still had to make a decision about their future and what they wanted to do for an occupation one day. This study aims to evaluate the impact of the Covid-19 pandemic on …

Dietary Patterns And Their Effects On C-Reactive Protein Regarding Female Reproductive Disorders, Mckenzie Moe

Theses and Dissertations

Objectives: Chronic inflammation, as indicated by elevated C-reactive protein (CRP), plays a critical role in women’s reproductive health disorders. CRP is one of the most common biomarkers of inflammation. Dietary components, lifestyle factors, and women’s reproductive health disorders are major components that influence the levels of CRP within the body. Other influential factors include injury, infection, and illness. The purpose of this review is to explore the findings of literature available on nutrition interventions for CRP levels in consideration of women's reproductive disorders.

Methods: This narrative review examines the works of 15 articles, including 10 cross-sectional and five longitudinal designs. …

The Role Of Almonds In Exercise Recovery And Athletic Performance, Kathryn M. Trochman

Theses and Dissertations

Objectives: During exercise, many trained athletes and physically active adults experience symptoms of exercise-induced muscle damage (EIMD). The effects of EIMD can cause limitations in athletic performance and increased duration of exercise recovery. Nutritional interventions have shown results in improving the duration of recovery. However, there are few studies completed on common food items. This review aims to examine the role of almonds in exercise recovery and athletic performance. Methods: A literature search was conducted utilizing Google Scholar, PubMed, CINAHL Ultimate, and reference hand searching. The search parameters included the dietary intervention of almonds for trained athletes and physically active …

2025 April 17 - From My Notepads Newsletter, Office Of The President, East Tennessee State University, Brian Noland

From My Notepads: A Newsletter from President Brian Noland

No abstract provided.

Seg-Swin: A Dual-Attention Transformer Model For Advanced Amd Classification And Lesion Detection Using Color Fundus Imaging, Niveen Nasr El-Den, Mohamed Elsharkawy, Ibrahim Saleh, Ali H. Mahmoud, Mohammed Ghazal, Ashraf Khalil, Ashraf Sewelam, Hani Mahdi, Ayman El-Baz

All Works

Age-related macular degeneration (AMD) is a prevalent retinal disorder in the elderly, often leading to significant vision impairment. The diagnosis of AMD is confirmed through various medical imaging modalities, with color fundus photography (CFP) being a primary tool. The detection and staging of AMD-severity depend on several factors, including the number and size of drusen, the presence of pigmentary changes, geographic atrophy, and neovascularization, all of which are identifiable through CFP. In this study, we introduce an innovative dual-vision transformer-based network designed to automatically detect AMD and classify its severity into either dry AMD or wet AMD using CFP. Early …

A Prospective Study For The Examination Of Peripheral Blood Smear Samples In Pediatric Population Using Artificial Intelligence, Eli̇f Habi̇be Akteki̇n, Mert Burkay Çöteli̇, Ayşe Erbay, Nalan Yazici

Turkish Journal of Medical Sciences

Background/aim: Peripheral blood smear (PBS) and bone marrow aspiration are gold standards of manual microscopy diagnostics for blood cell disorders. Nowadays, data-driven artificial intelligence (AI) techniques open new perspectives in digital hematology. This study proposes an AI learning technique for the classification of blood cells over PBS samples while increasing the sensitivity and specificity rates of the experts as a decision support system of a prediagnostic tool.

Materials and methods: The methodology of this study comprises three steps for the creation of an effective learning technique for blood cell disorders. First is the digitization of PBS samples in 100x optical-digital …

Procedural And Patient-Related Factors Play Differential Roles In The Postdural Puncture Headache, Ece Yanik, Doğa Vuralli, Tuğba Tunç

Turkish Journal of Medical Sciences

Background/aim: The incidence of postdural puncture headache varies depending on the multifactorial nature of the risk factors. Patient-related and procedure-related risk factors are still controversial. In this prospective observational study, we aimed to evaluate the risk factors for postdural puncture headache, the effect of previous headache features on the development of postdural puncture headache, and the risk factors for the immediate or delayed postdural puncture headache.

Materials and methods: We prospectively analyzed 116 patients who underwent lumbar puncture for diagnostic or therapeutic purposes. All clinical and laboratory findings, previous headache history, and the features and information related to the lumbar …

Benzyl Alcohol Improves Ang Ii-Induced Vascular And Renal Injury, Qi Hua, Zhenyu Gu

Turkish Journal of Medical Sciences

Background/aim: The etiology of hypertension in pediatric populations is complex and multifactorial, with metabolic abnormalitiesplaying a fundamental role in the pathogenesis of the condition. This study investigates the therapeutic effects of Benzyl alcohol (BA),identified through metabolomics analysis of pediatric hypertension serum, on Angiotensin II (Ang II)-induced vascular and renalinjury in murine models.

Materials and methods: Male C57BL/6 mice were used to establish a vascular remodeling model by continuous 4-week Ang II infusionusing a subcutaneous osmotic pump. Bioinformatics was used to identify target metabolites. The tail artery, common carotid arterydiastolic, and systolic pressures in mice were determined with a blood pressure …

Lipid Dysregulation In Sebaceous Gland Disorders And The Impact Of Sphingolipid Metabolism On Acne Pathogenesis, Kaitlyn Miner, Ryan Murphy, Samantha Steiss, Mckenzie Burian, Hannah Welp, Alexandra Loperfito, Ashley O'Malley, Radhika Misra, Kelly Frasier

Student Publications

Lipid dysregulation within sebaceous glands is a critical factor underlying the pathogenesis of sebaceous gland disorders, particularly acne vulgaris. Sebaceous glands synthesize and secrete a complex mixture of lipids, including triglycerides, wax esters, free fatty acids, and sphingolipids, which contribute to skin barrier function and microbial homeostasis. Dysregulated lipid production, characterized by increased sebum secretion and altered lipid composition, has been implicated in promoting Cutibacterium acnes proliferation, hyperkeratinization, and inflammation, key processes in acne pathogenesis. Recent research highlights the pivotal role of sphingolipid metabolism, particularly ceramides, in modulating sebaceous gland activity and skin inflammation. Ceramide deficiencies in acne-prone skin contribute …