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Articles 11971 - 12000 of 240073
Full-Text Articles in Entire DC Network
Marine Viruses: Biogeochemical Implications And Potential Applications, Faiza A Fattouh, Sahar W.M. Hassan
Marine Viruses: Biogeochemical Implications And Potential Applications, Faiza A Fattouh, Sahar W.M. Hassan
Blue Economy
Viruses are the most plentiful microorganisms in the ecosystem and exhibit excessive diversity in relations to infection cycle, host specificity and size. Since the discovery of great viral distribution in marine ecosystems, the ecological significance of viruses to marine environment has become gradually evident. Lytic viruses trigger lysis of the host cell to give the new progeny and thus readdress nutrients from higher to lower trophic levels. Consequently, marine viruses exhibit direct or indirect influence on the capacity of carbon sequestration, exchange of gases in the ocean and biogeochemical cycles in addition to affecting microbial population dynamics. Marine viruses are …
Sustainable Agricultural Development In Nigeria: A Question Of Biotechnology, Environmental Conservation, Or Indigenous Knowledge?, Emmanuel O. Oritsejafor
Sustainable Agricultural Development In Nigeria: A Question Of Biotechnology, Environmental Conservation, Or Indigenous Knowledge?, Emmanuel O. Oritsejafor
Journal of African Policy Studies
Nigeria, like most developing countries, depends on agriculture primarily for subsistence and export revenues. However, Nigeria is confronted with food security challenges. Several factors have contributed to this problem, such as demographic trends, crude farming methods, deforestation, the oil boom and public policies that are not consistent with the socio-economic and political realities of the state.
Given these challenges, this inquiry will examine the socio-economic and environmental implications of recent recommendations by development agencies such as the United Nations Development Agency (UNDP), which has prescribed the use of biotechnology to address Africa's food security problems. This recommendation appears to be …
Advancing Faecalibacterium Prausnitzii Growth To Mitigate Psychological Stressors In Space, Alina Loseva, Lane Law
Advancing Faecalibacterium Prausnitzii Growth To Mitigate Psychological Stressors In Space, Alina Loseva, Lane Law
Utah Space Grant Consortium
Isolation and Confinement are two of the five main hazards of human spaceflight identified by NASA, leading to sleep loss, circadian desynchronization, and mental health issues such as depression and anxiety. These conditions can impair intestinal barrier function and decrease populations of butyrate-producing bacteria like Faecalibacterium prausnitzii, increasing the risk of stress-related brain disorders. Different fiber sources in diet can affect the growth and butyrate production of F. prausnitzii. This study reviews existing data on F. prausnitzii's fiber response and suggests new fiber combinations for testing, aiming to prevent reductions in F. prausnitzii populations and mitigate psychological disorders in astronauts, …
Nitrogen Form Determines Lettuce Yield In Continually Replanted Systems, Noah J. Langenfeld, Bruce Bugbee
Nitrogen Form Determines Lettuce Yield In Continually Replanted Systems, Noah J. Langenfeld, Bruce Bugbee
Utah Space Grant Consortium
Nitrogen (N) recycling is essential in closed root-zones for bioregenerative life support in crewed missions. Microorganisms recycle organic N forms from human waste into ammonium and nitrate for plant growth. We used lettuce as a model crop to examine yield under multiple N sources modelled from N recycling. Plants were grown in peat moss media adjusted to pH 6 or 7 for five repeated plantings in the same containers without replacing the media. A nutrient solution was used for both studies that contained N as either ammonium nitrate, ammonium, nitrate, urea, or microbial biomass from the N-fixing microorganism Azotobacter vinelandii …
Effect Of Rehabilitation Exercises And Antioxidants On Patients With Stable Heart Failure, Shimaa Mohamed Abu Zeid, Walid A. Ali
Effect Of Rehabilitation Exercises And Antioxidants On Patients With Stable Heart Failure, Shimaa Mohamed Abu Zeid, Walid A. Ali
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
The research aims to find out the effect of rehabilitation exercises and antioxidants in some physical and physiological abilities, free radicals and the degree of pain for patients with stable heart failure, and the research sample was selected randomly and whose ages ranged between 40–45 years and their number is 30 female patients with this disease, and the researcher used the experimental approach as the most appropriate approach to solve the research problem, as the sample was divided into two groups equal in number, each of which (15) patients (experimental and control), and the tribal tests were carried out after …
What Model For Language Planning In Education And Development?, Raymond Mopoho
What Model For Language Planning In Education And Development?, Raymond Mopoho
Journal of African Policy Studies
The implementation of language policies by African countries after independence was very similar to what prevailed in the colonial era in that its centerpiece was the promotion of European languages, to the exclusion of native languages. The official rationale for such policies was political and economic in nature: In a multiethnic context, imposing a foreign language would promote national unity and foster the acquisition of the technical know-how necessary for development. Such a policy was characterized by several weaknesses. In its implementation, for many years, the school system seemed content with being a graduate generating machine, with little attention being …
Nigeria, Globalization And The Development Of Underdevelopment In The Third World, Kema Lrogbe
Nigeria, Globalization And The Development Of Underdevelopment In The Third World, Kema Lrogbe
Journal of African Policy Studies
There are two contending opinions on the issue of globalization. There are some observers who believe that globalization has brought rapid prosperity to the underdeveloped countries while others argue that globalization serves the needs of the metropolitan countries at the expense of the peripheral countries. This paper posits that globalization is economic terrorism. Using a dependency theory to analyze the asymmetric relationships between the developed and the underdeveloped countries, the writer applies some economic indicators to highlight the widening gap between the two worlds. In doing so, it is argued that the socio-economic and political structure of the peripheral countries …
Assessing The Effectiveness Of A Nurse-Led Family-Focused Program On The Physical Health Domain Of Children With Congenital Heart Defects, Maha Abdul Hussein Mutasher Al-Barki, Wameedh Hamid Shaker Alzubeidi
Assessing The Effectiveness Of A Nurse-Led Family-Focused Program On The Physical Health Domain Of Children With Congenital Heart Defects, Maha Abdul Hussein Mutasher Al-Barki, Wameedh Hamid Shaker Alzubeidi
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Assessing the effectiveness of a nurse-led family-focused program on the physical health domain of children with congenital heart defects (CHDs) is a critical area of research. CHDs are among the most common congenital anomalies, affecting nearly 1 in 100 live births. physical activity plays an important role in overall health and recovery congenital heart disease. Quality of life educational include specific directions to increase level of physical activity, such as walking daily or exercising regularly. Objectives: This study aims to assess the effectiveness of a nurse-led family-focused program in improving the physical health outcomes of children with CHDs. Methods …
Evaluation Of Rbc Indices And Significance Of Mentzer Index For Differentiation Between Iron Deficiency Anemia And Beta Thalassemia Trait, Raghda Hameed Jasim, Rasha Hussain Aouda
Evaluation Of Rbc Indices And Significance Of Mentzer Index For Differentiation Between Iron Deficiency Anemia And Beta Thalassemia Trait, Raghda Hameed Jasim, Rasha Hussain Aouda
Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences
Background: Anemia is a global public health problem affecting developed and adversely affecting developing countries. About 1.62 billion peoples are affected worldwide, currently pregnant women are the most vulnerable population corresponding to 24.8%. Objective: To evaluate RBC indices and significance of Mentzer index for differentiation between Iron deficiency anemia and Beta thalassemia trait. Patients and methods: Cross sectional study was conducted in Babylon Maternity and Pediatrics Teaching Hospital for a period of 4 months. Data was collected prospectively after approval of the research proposal was gained, the study involved 114 patients that were referred to the Babylon Maternity and Pediatrics …
Patterns And Determinants Of Fertility In Addis Ababa, Ethiopia, 1974-1998, Asfaw Yitna
Patterns And Determinants Of Fertility In Addis Ababa, Ethiopia, 1974-1998, Asfaw Yitna
Journal of African Policy Studies
Addis Ababa, the capital city of Ethiopia, reported a surprisingly low TFR level of 1.8 births per woman in the year 1994. Such a low level has never been experienced by any other large African city. In this paper, we attempt to confirm the adjusted level fertility of 2.1 births per woman and thus the fertility decline reported by the Central Statistical Authority (CSA), and to explore the important demographics, socio-economic and proximate determinants of fertility decline of Addis Ababa from 1974 to 1998.
We use data from fertility surveys of 1990 and 1995, conducted in Addis Ababa by CSA, …
Ghanaian Women And Environmental Policy, Leonard Gadzekpo
Ghanaian Women And Environmental Policy, Leonard Gadzekpo
Journal of African Policy Studies
The article makes a case that environmental policy in Ghana, and indeed in Africa, is often formulated with the role of men in economic activities in mind. Such policy often ignores the vital role that women play in their economic activities undertaken by women have serious ramifications for the ecosystem. Therefore daily contact, use, and management of the environment. As such, various, the article places women in the center of environmental policy. It argues that the important role women play in African society, particularly their direct contact with environment through farming, should be taken into account when formulating environmental policy.
Feminism, Children And Environmental Policy In Zimbabwe, Saliwe Kawewe
Feminism, Children And Environmental Policy In Zimbabwe, Saliwe Kawewe
Journal of African Policy Studies
This study utilizes a feminist perspective in demonstrating how gender intersects with socioeconomic forces of over a century of patriarchal environmental endeavors such as global modernization: imperialism and colonialism as conditions that have historically perpetuated environmental degradation in Zimbabwe as elsewhere in sub-Saharan Africa. The study examines how environmental policies of both pre and post independent Zimbabwe have had devastating consequences on the poor and marginalized, particularly women and girl children of this Third World in the nation. Additionally, the study proposes gender mainstreaming as a social networking model for socioeconomic and environmental sustainability through grassroots indigenous participation, capacity building, …
Public Policy And Social Welfare Programs In Zimbabwe: An Evaluation Of Esap, Robert Dibie, Saliwe M. Kawewe
Public Policy And Social Welfare Programs In Zimbabwe: An Evaluation Of Esap, Robert Dibie, Saliwe M. Kawewe
Journal of African Policy Studies
No abstract provided.
Can Anemia Be A Prognostic Indicator To Scope For Gastroesophageal Junction Adenocarcinoma?, Ryan Tam, Neha Narayanan, Evan Basha, Joel Thompson
Can Anemia Be A Prognostic Indicator To Scope For Gastroesophageal Junction Adenocarcinoma?, Ryan Tam, Neha Narayanan, Evan Basha, Joel Thompson
Advances in Clinical Medical Research and Healthcare Delivery
Gastroesophageal junction adenocarcinoma is a rapidly progressive disease that has a poor prognosis with a 5-year survival rate of 20%. It commonly presents with major symptoms of dysphagia and weight loss in addition to a long-standing history of reflux. As of now, screening for esophageal adenocarcinoma (EAC) is dependent on identifying risk factors which include a family history of Barrett’s esophagus and esophageal adenocarcinoma or patients with gastroesophageal reflux disease and at least one other risk factory for EAC such as age greater than 50 years, obesity or central adiposity, history of smoking, or male gender. Here, we present a …
Resolution Of Chronic Urticaria In A Vegan Patient With Vitamin B12 Supplementation: A Case Report, Auda H. Auda, Oluwasegun Shoewu, Ingrid Corredor, Ayrton Bangolo, Mohammad Jurri, John Sotiriadis, Iyad Baker
Resolution Of Chronic Urticaria In A Vegan Patient With Vitamin B12 Supplementation: A Case Report, Auda H. Auda, Oluwasegun Shoewu, Ingrid Corredor, Ayrton Bangolo, Mohammad Jurri, John Sotiriadis, Iyad Baker
Journal of Community Hospital Internal Medicine Perspectives
Background Chronic urticaria, characterized by persistent hives and pruritus lasting over six weeks, often presents diagnostic and therapeutic challenges. While its etiology is frequently idiopathic, associations with nutritional deficiencies, such as vitamin B12 deficiency, have been observed. Case Presentation A 24-year-old female with no significant medical history presented with chronic, treatment-resistant hives persisting for several years. Comprehensive evaluations, including allergy testing and autoimmune screenings, were unremarkable. Further investigation revealed a significant vitamin B12 deficiency (serum B12 level of 170 pg/mL), attributed to her long-standing vegan diet without supplementation. Initiation of vitamin B12 supplementation led to the gradual resolution of her …
Iron Deficiency—More Than Just Anemia: A Literature Review, Arianna S Moss, Zahra Pakbaz
Iron Deficiency—More Than Just Anemia: A Literature Review, Arianna S Moss, Zahra Pakbaz
Journal of Community Hospital Internal Medicine Perspectives
Iron deficiency (ID) is a global public health concern, as it can be a prodrome of gastrointestinal (GI) malignancies, exacerbate chronic conditions, and lead to an overall decreased quality of life. Despite being the most prevalent nutritional deficiency, it remains underdiagnosed by many healthcare professionals. Misconceptions regarding the clinical and laboratory manifestations of ID lead to delayed or missed diagnoses, contributing to poor patient outcomes. Though anemia is a commonly known consequence of ID, there are additional consequences that remain underrecognized by the medical community, including vague signs and symptoms, such as fatigue, depression, and abnormalities in white blood cell …
Dynamic Riskscapes For Prey: Disentangling The Impact Of Human And Cougar Presence On Deer Behavior Using Gps Smartphone Locations, Heather N. Abernathy, Mark A. Ditmer, David C. Stoner, Kent R. Hersey, Kathryn A. Schoenecker, Pat J. Jackson, Kristin N. Engebretsen, Julie K. Young, George Wittemyer
Dynamic Riskscapes For Prey: Disentangling The Impact Of Human And Cougar Presence On Deer Behavior Using Gps Smartphone Locations, Heather N. Abernathy, Mark A. Ditmer, David C. Stoner, Kent R. Hersey, Kathryn A. Schoenecker, Pat J. Jackson, Kristin N. Engebretsen, Julie K. Young, George Wittemyer
Wildland Resources Faculty Publications
Prey species adjust their behavior along human-use gradients by balancing risks from predators and humans. During hunting seasons, prey often exhibit strong antipredator responses to humans but may develop tolerance in suburban areas to exploit human-mediated resources. Additionally, areas with high human activity may offer reduced predation risk if apex predators avoid such locations. This study examined mule deer Odocoileus hemionus behavioral responses to risks from humans and their primary predators, cougars Puma concolor, contextualized by differences in risk levels between study sites, individual risk exposure, and human habituation. We framed our investigation using three non-mutually exclusive hypotheses: (H1) …
Dairy And Food Science Student Newsletter, May 5, 2025, Department Of Dairy And Food Science
Dairy And Food Science Student Newsletter, May 5, 2025, Department Of Dairy And Food Science
Dairy and Food Science Student Newsletter
No abstract provided.
An Adaptive Paradox: Improvised Drama Therapy And Dialectical Behavior For Eating Disorders In Teens, Krystany Taylor
An Adaptive Paradox: Improvised Drama Therapy And Dialectical Behavior For Eating Disorders In Teens, Krystany Taylor
Expressive Therapies Theses
The complexity of treating eating disorders compels professionals to investigate collaborative and integrative approaches to address psychological rigidity and emotional aversion in affected individuals. Mindfulness within Dialectical Behavior Therapy (DBT) and improvisational theater techniques may contribute to advancing emotional flexibility. This thesis study explored spontaneity in expressive therapy and gauged budding adaptive skills related to emotion regulation in minors with eating disorders. At a behavioral health center in Southern California, I held a dual role as a group facilitator and trainee drama therapist; I therein joined DBT and improvised drama therapy methods into a group treatment setting for ages 14 …
Adolescents And Addictions: An Expressive Arts Therapy Prevention Intervention In India – Development Of A Method, Ravtesh Kaur
Adolescents And Addictions: An Expressive Arts Therapy Prevention Intervention In India – Development Of A Method, Ravtesh Kaur
Expressive Therapies Theses
This thesis aims to propose an expressive arts therapy prevention intervention for substance use among adolescents in India. Adolescence is a period defined by many physiological and psychological changes and is considered to be a time of high-risk for the initiation of substance use. The prevalence of substance use amongst Indian adolescents is growing every year, with most adolescents engaging in frequent use of alcohol, tobacco, cannabis, and inhalants. This thesis intends to develop and implement an expressive arts therapy prevention intervention for adolescents. The current research was conducted in a private school in Punjab, India with 50 students of …
Cumulative Lifespan Stress And Inflammation Are Associated With Black-White Racial Disparities In Mortality Among Americans, Isaiah Spears
Cumulative Lifespan Stress And Inflammation Are Associated With Black-White Racial Disparities In Mortality Among Americans, Isaiah Spears
Arts & Sciences Graduate Student Theses and Dissertations
Black Americans disproportionately experience higher rates of health challenges and mortality compared to White Americans, yet the mechanisms underlying these disparities remain inadequately understood. Prominent theoretical models highlight stress and resulting allostatic load as putative mechanisms through which these Black-White racial disparities emerge; however, empirical data supporting such models with regard to mortality remains sparse. The current study examined the potential role of cumulative stress exposure across the life span and elevated levels of C-Reactive Protein, a biomarker of inflammation, in contributing to the longstanding increased mortality risk among Black relative to White Americans. Data were drawn from the Saint …
Dust To Dream, Brenda Meloto De Oliveira
Dust To Dream, Brenda Meloto De Oliveira
Bachelor of Architecture Theses - 5th Year
This thesis explores the design and implementation of a holistic housing initiative to address the needs of economically disadvantaged populations in Sertão do Moxotó, Pernambuco. Situated in an arid region with limited resources, the project provides not only shelter but also community spaces, educational opportunities, and essential services to improve local living standards.
The region’s history of resilience is reflected in its vernacular architecture, which uses materials like adobe, rammed earth, and thatch—offering sustainable, climate-adapted solutions. Yet, basic amenities remain out of reach for many. Community-led initiatives, non-monetary systems, and vocational training help bridge these gaps and empower individuals to …
Seas Of Lemongrass: A Political Ecology Perspective On Urban Agriculture And Immigrant Food Security In The Twin Cities, Minnesota, Reece V. Mckee
Seas Of Lemongrass: A Political Ecology Perspective On Urban Agriculture And Immigrant Food Security In The Twin Cities, Minnesota, Reece V. Mckee
Geography Honors Projects
Urban agriculture (UA) frequently employs organic, polycultural and agroecological techniques in order to farm suboptimal urban land with limited resources. However, less scholarly attention has been paid to its actual impacts on the eating patterns of marginalized groups like immigrants, which is important to study for political debates about the expansion and purpose of UA. In this study, I examined how different forms of UA affect food security and dietary diversity for immigrants in the Twin Cities, Minnesota. Using dietary surveys, food access questionnaires, and informal conversations, I determined that a simplistic definition of food security focused only on overall …
Eos Wellness Center: Rethinking Inpatient Mental Health Facility Design, Emily Simms
Eos Wellness Center: Rethinking Inpatient Mental Health Facility Design, Emily Simms
Bachelor of Architecture Theses - 5th Year
The design of mental health facilities significantly impacts patient outcomes, especially for individuals with depression. Environmental factors such as lighting, thermal comfort, and access to nature influence mental health. This research explores how architectural design can reduce self-harm incidents and enhance recovery outcomes for patients with depression. The project hypothesizes that synchronizing light patterns and thermal comfort with patients’ circadian rhythms will reduce self-harm incidents and improve recovery. The problem established in the research is that disruptions to circadian rhythms increase the risk of depression, PTSD, and anxiety by 30% (Burns et al., 2022). Suicide is also the second leading …
Rescue Of The First Mitochondrial Membrane Carrier, The Mpic, By Tat-Mediated Protein Replacement Treatment, Samar Zabit, Orly Melloul, Michal Lichtenstein, Erin L. Seifert, Haya Lorberboum-Galski
Rescue Of The First Mitochondrial Membrane Carrier, The Mpic, By Tat-Mediated Protein Replacement Treatment, Samar Zabit, Orly Melloul, Michal Lichtenstein, Erin L. Seifert, Haya Lorberboum-Galski
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
The mitochondrial phosphate carrier (mPiC), encoded by the nuclear gene SLC25A3, is synthesized with an N-terminus mitochondrial targeting sequence (MTS), enabling its import into the mitochondria. mPiC imports inorganic phosphate (Pi) into the mitochondrial matrix for ATP production and other matrix phosphorylation reactions, as well as regulates mitochondrial Ca2+ uptake and buffering of matrix Ca2+. PiC also imports copper (Cu), crucial to COX subunit holoenzyme assembly. Variants in SLC25A3 exist and lead to mPiC deficiency (MPCD), cause a rare autosomal recessive disease with no current cure; patients with MPCD usually die within the first …
Examining Food Choice Determinants In Ncaa Division Iii Athlete Participants Representing Multiple Sports, Olivia Towne
Examining Food Choice Determinants In Ncaa Division Iii Athlete Participants Representing Multiple Sports, Olivia Towne
Theses
Objective: To examine determinants of food choice among NCAA Division III athletes using the Athlete Food Choice Questionnaire (AFCQ), focusing on gender, sport type, and seasonal status. Participants: 72 NCAA Division III athletes from 13 sports at a private northeastern university participated in an online survey during Fall 2024. Methods: Participants completed the 32-item AFCQ assessing nine food choice factors. Independent t-tests and Pearson’s correlations were used to compare factor scores by gender, sport type, seasonal status, and team success. Results: Performance, Sensory Appeal, and Food Values and Beliefs emerged as the most influential factors in food choice, while Weight …
Healthcare Use: Impact Of Race And Insurance Status On Influenza In The Bronx, Miselie Charite
Healthcare Use: Impact Of Race And Insurance Status On Influenza In The Bronx, Miselie Charite
Walden Dissertations and Doctoral Studies
Underuse of healthcare services by Blacks, who receive fewer influenza vaccinations than Whites in New York, has resulted in elevated health complications and increased healthcare costs. The purpose of this quantitative correlational study was to determine if there is an association between race and insurance status with length of inpatient stay and total charges. Theoretical frameworks were the Quality, Cost, and Health Model and the Institute for Healthcare Improvement Triple Aim framework. Using a dataset from the New York State Planning and Research Cooperative System with a sample size of 3,137 cases, findings showed significant disparities during analysis. Regression analysis …
Experience Of Coparents/Partners Of African American Mothers Participating In Breastfeeding Education, Samantha Hickson
Experience Of Coparents/Partners Of African American Mothers Participating In Breastfeeding Education, Samantha Hickson
Walden Dissertations and Doctoral Studies
Coparents and partners of African American mothers are critical in the initiation and continuation of breastfeeding and influence a woman’s decision to breastfeed. The purpose of this qualitative study was to explore the experience of coparents/partners of African American mothers participating in breastfeeding education and its impact on the support they provide. Bandura’s social cognitive theory provided the theoretical foundation for this study. Data were collected via semi-structured interviews with 11 participants. Data analysis followed the traditional seven steps of interpretative phenomenological analysis. Findings showed that while coparents and partners of African American breastfeeding mothers found breastfeeding education to be …
Protocol For A Randomized Controlled Trial To Determine If Biomarkers Predict Response To A Pediatric Chronic Pain Symptom Management Program, Rona L Levy, Tasha B Murphy, Margaret M Heitkemper, Miranda A L Van Tilburg, Ann R Mcmeans, Jocelyn Chang, Cynthia Boutte, Katherine Lamparyk, Bruno P Chumpitazi, Robert J Shulman
Protocol For A Randomized Controlled Trial To Determine If Biomarkers Predict Response To A Pediatric Chronic Pain Symptom Management Program, Rona L Levy, Tasha B Murphy, Margaret M Heitkemper, Miranda A L Van Tilburg, Ann R Mcmeans, Jocelyn Chang, Cynthia Boutte, Katherine Lamparyk, Bruno P Chumpitazi, Robert J Shulman
Faculty, Staff and Students Publications
Background/Objectives: Disorders of gut-brain interaction (DGBI), characterized by chronic abdominal pain and significant disability, affect 15-20% of children and adults and continue into adulthood in ~60% of cases. Costs for adults reach USD 30 billion per year, yet effective management strategies are elusive. Studies support using cognitive behavioral therapy (CBT), but abdominal pain only improves in ~40% of patients. Dietary management (low FODMAP diet; LFD) has also shown promise but it is effective in only a similar percentage of patients. Studies suggest that biologic factors (biomarkers) contribute to CBT response. Similarly, gut microbiome composition appears to influence abdominal pain …
Protocol For A Randomized Controlled Trial To Determine If Biomarkers Predict Response To A Pediatric Chronic Pain Symptom Management Program, Rona L Levy, Tasha B Murphy, Margaret M Heitkemper, Miranda A L Van Tilburg, Ann R Mcmeans, Jocelyn Chang, Cynthia Boutte, Katherine Lamparyk, Bruno P Chumpitazi, Robert J Shulman
Protocol For A Randomized Controlled Trial To Determine If Biomarkers Predict Response To A Pediatric Chronic Pain Symptom Management Program, Rona L Levy, Tasha B Murphy, Margaret M Heitkemper, Miranda A L Van Tilburg, Ann R Mcmeans, Jocelyn Chang, Cynthia Boutte, Katherine Lamparyk, Bruno P Chumpitazi, Robert J Shulman
Children’s Nutrition Research Center Staff Publications
Background/Objectives: Disorders of gut-brain interaction (DGBI), characterized by chronic abdominal pain and significant disability, affect 15-20% of children and adults and continue into adulthood in ~60% of cases. Costs for adults reach USD 30 billion per year, yet effective management strategies are elusive. Studies support using cognitive behavioral therapy (CBT), but abdominal pain only improves in ~40% of patients. Dietary management (low FODMAP diet; LFD) has also shown promise but it is effective in only a similar percentage of patients. Studies suggest that biologic factors (biomarkers) contribute to CBT response. Similarly, gut microbiome composition appears to influence abdominal pain …