Digital Commons Network^™

Ecoimmunology Of Dirty Physella Acuta Snails, Kevin Arthur Mcquirk

Biology ETDs

Research on Physella acuta, an invasive freshwater snail, reveals insights into its parasitology, fitness, and molecular biology. Morphological and molecular analyses revealed two distinct mitogenomic lineages, local (B) and invasive (A) strains of native P. acuta, both having comparable trematode infection rates, suggesting that the low infection rates observed from A in invaded regions result from "enemy release" rather than immune incompatibility. Fitness assessments showed that while lineages A and B performed similarly under laboratory conditions, rewilding experiments revealed significantly higher fitness in lineage A. Transcriptomic profiling supported these differences, with A snails showing greater immune-related gene expression and …

Lifestyle Factors Contributing To Occupational Heat-Related Acute Kidney Injury, Jonathan Specht, Fabiano Amorim, Flavio De Castro Magalhaes, Zachary Mckenna, Zachary Schlader

Health, Exercise, and Sports Sciences ETDs

Workers worldwide are at risk for acute kidney injury due to hyperthermia and dehydration as a consequence of exertional heat stress. Limited research has explored the impact which lifestyle agents such as beverages, recreational drugs, and medications have on core temperature, hydration, and risk of acute kidney injury during physical work in the heat. To address this research gap, we explored the impact of three agents frequently used by construction workers on thermoregulation and markers of risk of acute kidney injury. First, we investigated the effect which ibuprofen ingestion has prior to one hour of running in the heat on …

Potential Of Legume Seeds From The Leguminosae Family As Material Source Of Food And Medicine : A Literature Review, Ni Made Ayu Gangga Dewi, Nina Dewi Oktaviyanti, Aurapa Sakulpanich, Kartini Kartini

Pharmaceutical Sciences and Research

Leguminosae, also known as Fabaceae, is the third largest plant family after Orchidaceae and Asteraceae. This review aimed to explore the potential of several legume species indigenous to Indonesia, from the Leguminosae family, as sources of food and medicine. The data used for the analysis were collected from various online databases such as PubMed, ScienceDirect, and Google Scholar. The results showed that there were 13 species of Leguminosae family plants found easily in Indonesia including Cajanus cajan, Canavalia ensiformis, Mucuna pruriens, Arachis hypogaea, Vigna subterranea, Glycine max, Phaseolus vulgaris, Phaseolus lunatus, Vigna radiata, Vigna unguiculata subsp. unguiculata, Vigna angularis, Vigna …

Microneedle-Based Lc-Ms/Ms Profiling Of Dermal Interstitial Fluid Reveals Early Lipid Dysregulation Contributing To Painful Neuropathy In Prediabetic And Type 2 Diabetic Rats, Srinivasa Rao Gadam

Biomedical Sciences ETDs

Painful diabetic neuropathy (PDN), a complication of type 1 and type 2 diabetes, also occurs in obesity and prediabetes, with dyslipidemia as a modifiable risk factor. The distal-to-proximal neuropathy pattern and length-dependent intraepidermal nerve fiber loss suggest peripheral contributions. We hypothesized that elevated neurotoxic lipid intermediates—diacylglycerols (DAG), free fatty acids (FFA), and acylcarnitines (CARs)—in the dermal interstitial fluid (ISF) drive metabolism-associated hyperalgesia in prediabetic and diabetic rats. Using a microneedle array (MIA) with LC-MS/MS, we profiled ISF and serum lipids from high-fat diet (HFD) and HFD + streptozotocin (STZ) rat models alongside Hargreaves testing. ISF lipid changes appeared earlier (weeks …

Comparing P62 And Lc3 As Autophagy Biomarkers: Insights Into Cellular Homeostasis, Riya Roychan

The Plymouth Student Scientist

Autophagy is a fundamental cellular process that maintains homeostasis by the degradation of damaged organelles and proteins. It plays crucial roles in cellular remodelling, development, and disease progression. These roles apply to the study of neurodegenerative diseases which is heavily linked to the toxicity produced by unwarranted accumulation of cellular material. A key player in autophagy is LC3, which translocate to autophagosomal membranes during the process. Detecting fluorescently labelled LC3-II through immunofluorescence provides a valuable method for assessing autophagy levels in samples. In a similar premise p62, also known as sequestosome-1 (SQSTM-1), is an adaptor between LC3 and ubiquitinated substrates, …

Cocoa Polyphenols Alter The Fecal Microbiome Without Mitigating Colitis In Mice Fed Healthy Or Western Basal Diets, Eliza C. Stewart, Mohammed F. Almatani, Marcus Hayden, Giovanni Rompato, Jeremy Case, Samuel Rice, Korry J. Hintze, Abby D. Benninghoff

Animal, Dairy, and Veterinary Science Student Research

Background/Objectives: Chronic inflammation and Western-style diets elevate colorectal cancer (CRC) risk, particularly in individuals with colitis, a feature of inflammatory bowel disease (IBD). Diets rich in polyphenol-containing functional foods, such as cocoa, may reduce gut inflammation and modulate the gut microbiome. This study investigated the impact of cocoa polyphenol (CP) supplementation on inflammation and microbiome composition in mice with colitis, fed either a healthy or Western diet, before, during, and after the onset of disease. We hypothesized that CPs would attenuate inflammation and promote distinct shifts in the microbiome, especially in the context of a Western diet. Methods: …

But Who Is It For? Introducing A Framework For Critical Reflection On Design And Delivery Of Ethical Participatory Research, Hannah Gardiner, Clare Pettinger, Louise Hunt, Mary Hickson

School of Health Professions

Delivering ethical collaborative research is challenging, requiring disruption of assumptions, academic norms, and ways of working–including long-standing power dynamics. This article proposes a framework to support critical reflection on participatory practice; an adaptation of the wheel of consent. The adapted ‘ILBR’ framework explores the balance of who Initiates (makes requests/offers), does Labour (the action), gets Benefits, and takes on Risks (ILBR) in the conduct of research. This aims to support reflexive design and delivery of ethical participation, including a shift towards consent becoming an ongoing multi-way negotiation of agreements. Particularly it aims to support ‘interpersonal reflexivity’, and navigation of the …

Transforming Healthcare Virtually: A Comprehensive Exploration Of Artificial Intelligence In Telehealth Across Internal Medicine Subspecialties, Jassimran Singh, Aditi Agrawal

Internet Journal of Allied Health Sciences and Practice

This review provides a comprehensive exploration of the transformative role of artificial intelligence (AI) in revolutionizing telehealth within various subspecialties of internal medicine. The focus is on enhancing patient care, addressing healthcare challenges, and mitigating professional burnout through the real-time, data-driven insights offered by AI. The integration of AI in telehealth is examined across diverse medical fields such as cardiology, pulmonary medicine, gastroenterology, endocrinology, geriatrics, nephrology, neurology, and hematology-oncology. The research methodology employs a systematic literature review and analysis approach, utilizing academic databases such as PubMed, Scopus, and IEEE Xplore to identify relevant literature up to July 2023. Inclusion criteria …

Clinical Observation Of Oral-Motor Dysfunction In Joubert Syndrome: Case Series, Müberra Tanrıverdi, Gökhan Can Törpü

Internet Journal of Allied Health Sciences and Practice

Purpose: Joubert Syndrome (JS) is a rare autosomal recessive neurological disorder, characterized by hypotonia, ataxia, tremor, developmental delay. JS also presents with respiratory abnormalities, oculomotor apraxia, motor speech dysarthria, and various atypical dysmorphic features. Oral-motor dysfunction (OMD) is a notable concern in JS, manifesting as difficulties with sucking, swallowing, drooling, and prolonged meal times. Methods: This study investigates OMD in five JS cases evaluated by physiotherapists and assessed using the Oral-Motor Examination Tool (OMET). Results: The cases exhibited feeding-related stress symptoms such as gagging and reflux. OMET evaluations identified asymmetrical faces, puckered lips, open mouths, and lip biting, with normal …

A Model For Teaching Social Determinants Of Health In Doctor Of Physical Therapy Programs, Elise N. Bjork, Rupal M. Patel Pt, Phd, Rebecca Operacz, Deandrea B. Melvey, Luciano Garcia Iii

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to 1) describe the development and implementation of a novel educational module on social determinants of health (SDOH) for Doctor of Physical Therapy (DPT) students, and 2) to assess the effectiveness of the module on altering DPT students’ knowledge, attitudes, beliefs, and barriers in addressing SDOH. Methods: Drawing on current literature, content expert feedback, identity theory, and experiential learning theory, a two-hour module on SDOH was created and delivered at two universities. The Physical Therapy Social Determinants of Health Scale (PT-SDHS) was used to assess change in students’ knowledge, attitudes, beliefs, and barriers …

Enjoyment, Motivation, And Self-Efficacy Towards Physical Activity Among Physical Therapy Students, Lauren Butler, Amanda Thomas, Teresa Munecas, Erasmo Alvarez, David Capote, Alexa Almonte, Madeline Dawson, Jordan Hale, Mikayla Kerekes, Kaitlyn Mitchell, Mark D. Rossi

Internet Journal of Allied Health Sciences and Practice

Purpose: The purpose of this study was to determine physical therapy (PT) students’ participation in and attitudes toward physical activity (PA).

Methods An electronic survey assessed demographic, academic, and sports history. Student’s PA level was assessed with the Godin Leisure-Time Exercise Questionnaire (Godin); PA enjoyment was assessed using the Physical Activity Enjoyment Scale (PACES); motivation was assessed using 4 items from the Modified Behavioral Regulation in Exercise (BREQ 3); and self-efficacy towards PA was assessed with the Exercise Self-Efficacy Scale (ESES). Descriptive statistics, Pearson correlations, and independent t-tests with 95% Confidence Interval (95% CI) were used.

Results In total, 228 …

The Political Thought Of Plato And Aristotle, Ernest Barker Sir

Hannah Arendt Marginalia - All

New York : Dover Publication, 1959

Call #: JC72 .B26

Contains underlining

PDF Information: 10 pages – 3.5 MB

House Finches Lose Feeding Preferences During Infection: Behavioral Changes With Implications For Pathogen Spread, Francis Edward Tillman

Electronic Theses and Dissertations Archive

Foraging is a fundamental behavior that animals use to acquire food resources. Because these resources are critical for survival and reproduction, animals are often thought to forage optimally, maximizing resource intake per unit of time. While the foraging behaviors of healthy animals often align with such predictions, we know little about how or if these predictions hold true in sick animals. This is especially relevant when considering sickness behaviors, or changes in behavior that accompany infection and frequently include lethargy and anorexia, both of which may alter foraging decisions or ability. Because food resources often cause animals to aggregate, a …

Association Between Sociocultural Factors, Obesity, And Depression In The Hispanic/Latino Population, Maia Junco

Walden Dissertations and Doctoral Studies

The increasing prevalence of obesity and mental health disparities among Hispanic/Latino populations in the United States underscores the need to understand how sociocultural factors shape physical and psychological health. The purpose of this study was to examine how acculturation, diet quality, and fiber intake affect BMI and depressive symptoms over time. The study was guided by acculturation theory and the biopsychosocial model. The study used longitudinal secondary data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) with a sample of N=8,816, including adults who completed examination visits, 1 (2008–2011) and 2 (2014–2017). Path analysis was conducted to assess direct …

Considerations In Using Heart Rate-Based Physical Activity Estimates From Consumer Wearables In Individuals With Varying Weight Status., Denver M Y Brown, David Wing, Christopher D. Pfledderer, Peter Stoepker, Stuart J. Fairclough, Jordan A. Carlson

Manuscripts, Articles, Book Chapters and Other Papers

Although moderate-to-vigorous physical activity (MVPA) is a widely used construct in physical activity (PA) research, the lack of standardized assessment methods- particularly with the growing use of consumer-grade wearable activity trackers- poses challenges for comparability. Consumer-grade devices tend to rely on heart rate (HR)-based estimation methods to classify PA intensity, which contrasts with traditional research-grade accelerometers that use count- or raw-acceleration metrics. Comparability issues are particularly salient across individuals with varying weight status. In this commentary, we discuss systematic discrepancies between HR-based (relative intensity) and acceleration-based (absolute intensity) classifications of MVPA among individuals with differing weight statuses. Using Fitbit data …

Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Bacteria-mediated cancer therapy represents a novel and promising strategy for targeted drug delivery to solid tumors. Multiple studies have demonstrated that various Bifidobacterium species can selectively colonize the hypoxic microenvironments characteristic of solid tumors. Leveraging this property, Bifidobacterium has been explored as a delivery vector for a range of anti-cancer approaches such as immunotherapy, nanoformulated chemotherapeutics, and gene therapy. Notably, anti-angiogenic genes such as endostatin and tumstatin have been successfully delivered to colorectal tumors using Bifidobacterium infantis and Bifidobacterium longum, respectively. Additionally, Bifidobacterium bifidum has been employed to transport doxorubicin and paclitaxel nanoparticles to breast and lung tumor sites. …

Engineered Bifidobacterium Strains Colonization At Tumor Sites: A Novel Approach To The Delivery Of Cancer Treatments, Rhea Amonkar, Ashley Ann Uy, Pablo Ramirez, Harina Patel, Jae Jin Jeong, Nicole Oyinade Shoyele, Vidhi Vaghela, Ashakumary Lakshmikuttyamma

College of Pharmacy Faculty Papers

Bacteria-mediated cancer therapy represents a novel and promising strategy for targeted drug delivery to solid tumors. Multiple studies have demonstrated that various Bifidobacterium species can selectively colonize the hypoxic microenvironments characteristic of solid tumors. Leveraging this property, Bifidobacterium has been explored as a delivery vector for a range of anti-cancer approaches such as immunotherapy, nanoformulated chemothera- peutics, and gene therapy. Notably, anti-angiogenic genes such as endostatin and tumstatin have been successfully delivered to colorectal tumors using Bifidobacterium infantis and Bifidobacterium longum, respectively. Additionally, Bifidobacterium bifidum has been employed to transport doxorubicin and paclitaxel nanoparticles to breast and lung tumor …

2025 Deerfield Fair 4-H Building Project Premium Book, Extension

UNH Cooperative Extension

No abstract provided.

Early Developmental Crime Prevention And Social Impact Over The Life Course, Brandon C. Welsh, Heather L. Paterson, Michael Rocque, David P. Farrington

All Faculty Scholarship

Preventing the development of criminal potential in young people is an important component of broader crime reduction strategies. A key feature of developmental crime prevention is a comprehensive effort to improve the life chances of at-risk children and families, and there is evidence that doing so improves long-term life-course outcomes like physical health, mental health, education, and employment. We assess available research evidence from 12 high-quality studies of developmental crime prevention initiatives and find that extensive use of multimodal interventions helps to foster cumulative protection over the life course, that there are significant improvements in other outcomes over the life …

Rna Sequencing Reveals Inflammatory And Metabolic Changes In The Lung And Brain After Carbon Black And Naphthalene Whole Body Inhalation Exposure In A Rodent Model Of Military Burn Pit Exposures, Allison M. Haaning, Brian J. Sandri, Henry L. Wyneken, William T. Goldsmith, Joshua P. Nixon, Timothy R. Nurkiewicz, Chris H. Wendt, Paul Barach, Janeen H. Trembley, Tammy A. Butterick

College of Population Health Faculty Papers

Military personnel deployed to Iraq and Afghanistan were exposed to emissions from open-air burn pits, where plastics, metals, and medical waste were incinerated. These exposures have been linked to deployment-related respiratory diseases (DRRD) and may also impact neurological health via the lung-brain axis. To investigate molecular mechanisms, adult male rats were exposed to filtered air, naphthalene (a representative volatile organic compound), or a combination of naphthalene and carbon black (surrogate for particulate matter; CBN) via whole-body inhalation (six hours/day, three consecutive days). Lung, brain, and plasma samples were collected 24 h after the final exposure. Pro-inflammatory biomarkers were assessed using …

Combination Of Irreversible Electroporation And Clostridium Novyi-Nt Bacterial Therapy For Colorectal Liver Metastasis, Zigeng Zhang, Guangbo Yu, Qiaoming Hou, Farideh Amirrad, Sha Webster, Surya M. Nauli, Jianhua Yu, Vahid Yaghmai, Aydin Eresen, Zhuoli Zhang

Pharmacy Faculty Articles and Research

Colorectal liver metastasis (CRLM) poses a significant challenge in oncology due to its high incidence and poor prognosis in unresectable cases. Current treatments, including surgical resection, systemic chemotherapy, and liver-directed therapies, often fail to effectively target hypoxic tumor regions, which are inherently more resistant to these interventions. This review examines the potential of a novel therapeutic strategy combining irreversible electroporation (IRE) ablation and Clostridium novyi-nontoxic (C. novyi-NT) bacterial therapy. IRE is a non-thermal tumor ablation technique that uses high-voltage electric pulses to create permanent nanopores in cell membranes, leading to cell death while preserving surrounding structures, and …

Demystifying The Nuances Of The Lipid Patient: A Guide For Primary Care Providers, Merle Myerson, Kyle Gillett, James O'Hara, Richard Potter, Neil Skolnik

Abington Jefferson Health Papers

Atherosclerosis, a major cause of mortality and morbidity in the United States (US), is driven by complex factors, including the cumulative burden of low-density lipoprotein cholesterol (LDL-C) and other atherogenic lipids and lipoproteins. Lipid management in US primary care aims to prevent atherosclerotic cardiovascular disease (ASCVD) events through screening and LDL-C lowering to risk-based goals. However, lipid screening and ASCVD treatment is often inadequate, with few patients meeting LDL-C goals in clinical practice. Primary care providers have a vital role in identifying patients most at risk of ASCVD to prevent ASCVD events and improve patient outcomes. There are multiple different …

Rnai Knockdown Screen Reveals Genes Required For Non-Professional Phagocytosis In Drosophila Melanogaster, Elinor Romaguera

Summer Research Internship Program

No abstract provided.

Intersecting Risks: Food Insecurity, Cigarette Smoking, Rurality And Colorectal Cancer Diagnosis In The U.S., Tessa Peterson

Summer Research Internship Program

No abstract provided.

Contributions Of Occupational Therapy In Sport Provider Training Using A Health-Promoting Environment For Positive Youth Development, Jennifer Papenfuse Otd, Otr/L, Chc, Camille Skubik-Peplaski Phd, Otr/L, Faota, Shirley P. O'Brien Phd, Otr/L, Faota

Student Journal of Occupational Therapy

Rising youth public health disparities can be attributed to the social determinants of health that influence health and wellness. Youth sport providers can be influential in creating healthier environments that facilitate positive youth development and social emotional learning, thus positively impacting life-long health behaviors choices and public health. The purpose of this study was to explore the impact of an education module developed by an occupational therapist on sport’s providers perceptions of their capacity to implement positive youth development programming and to create a health-promoting environment.

A qualitative descriptive approach was used in this study allowing for purposive sampling, inductive …

Relationship Between Participation In Employee Wellness Programs And Health-Related Quality Of Life Among Health Care Workers, Ana Williams

Walden Dissertations and Doctoral Studies

Employee wellness programs are available in many health care organizations but remain underutilized by health care workers. Low employee participation in these wellness programs can negatively impact employees’ health-related quality of life (HRQoL), which, in turn, may adversely influence patient care and overall health outcomes. Despite this, little is known about which factors, such as perceived barriers and benefits, job category, or work shift, are associated with participation. This study addressed that gap by exploring how these variables relate to employee engagement in wellness programs and their potential impact on HRQoL. Guided by the health belief model, this study examined …

Cocoa Polyphenols Modulate The Mouse Gut Microbiome In A Site-Specific Manner, Abby D. Benninghoff

Browse all Datasets

Background/Objectives: Dietary modulation of the gut microbiome is a promising strategy for mitigating gastrointestinal diseases, such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Cocoa powder is rich in polyphenols, including (-)-epicatechin and (+)-catechin, which have been associated with beneficial effects on gut health and microbiome modulation. Importantly, changes in the bacterial populations associated with the gut mucosal layer may have different health impacts compared to changes in cecal or fecal microbiomes. This study investigated the effects of cocoa polyphenol supplementation on microbiome composition across the cecal, fecal, and mucosal compartments in a mouse model of colitis. Methods: …

The Relationship Between Hand Grip Strength And Cognitive Function In Middle-Aged And Elderly People In China: A Cross-Sectional Analysis Based On Charls Data, Haiwei Li, Jing Zhang, Peipei Cheng, Liwei Guo, Xuemei Sui M.D., M.P.H., Ph.D.

Faculty Publications

This study explores the relationship between hand grip strength (HGS) and cognitive function in China’s middle-aged and elderly population. We employed a cross-sectional design using data from 4535 participants aged ≥ 45 years from the 2015 China Health and Retirement Longitudinal Study national dataset. The relationships between HGS and various dimensions of cognitive function, as well as the association between HGS and cognitive impairment, were investigated using ordinary least squares regression models and logistic regression models. Dose–response relationships between HGS and cognitive impairment were modeled using restricted cubic spline curves. Subgroup and sensitivity analyses were performed to assess the robustness …

Autism Spectrum Disorder: A Review Of Genomic Risk Factors, Diagnostic And Pharmacotherapeutic Strategies, Zohor Azher

Saudi Toxicology Journal

Autism Spectrum Disorder (ASD) is a multifactorial neurodevelopmental condition characterized by impairments in social communication and delayed language development, repetitive behaviors, and sensory processing abnormalities. The genetic background of ASD remains incompletely understood due to significant genetic heterogeneity and complexity. This review aims to present current insights into the genetic landscape of ASD, focusing on both common and rare genomic variations. We describe candidate genes associated with ASD, as they are involved in synaptic function and neuronal signaling, making these findings potential therapeutic targets. This review emphasizes the importance of integrating comprehensive clinical assessments with advanced genetic investigations to enhance …

Epigenetic Profiling Of Cell-Free Dna In Cerebrospinal Fluid: A Novel Biomarker Approach For Metabolic Brain Diseases, Kyle Sporn, Rahul Kumar, Kiran Marla, Puja Ravi, Swapna Vaja, Phani Paladugu, Nasif Zaman, Alireza Tavakkoli

SKMC Student Presentations and Publications

Due to their clinical heterogeneity, nonspecific symptoms, and the limitations of existing biomarkers and imaging modalities, metabolic brain diseases (MBDs), such as mitochondrial encephalopathies, lysosomal storage disorders, and glucose metabolism syndromes, pose significant diagnostic challenges. This review examines the growing potential of cell-free DNA (cfDNA) derived from cerebrospinal fluid (CSF) epigenetic profiling as a dynamic, cell-type-specific, minimally invasive biomarker approach for MBD diagnosis and monitoring. We review important technological platforms and their use in identifying CNS-specific DNA methylation patterns indicative of neuronal injury, neuroinflammation, and metabolic reprogramming, including cfMeDIP-seq, enzymatic methyl sequencing (EM-seq), and targeted bisulfite sequencing. By synthesizing current …