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Biogenesis And Function Of Microglial Extracellular Vesicles In Neuroinflammation And Parkinson’S Disease, Karl E. Biggs Jan 2024

Biogenesis And Function Of Microglial Extracellular Vesicles In Neuroinflammation And Parkinson’S Disease, Karl E. Biggs

Dartmouth College Ph.D Dissertations

Microglia are subject to chronic proteinaceous and environmental stress during the progression of prevalent neurodegenerative diseases such as Parkinson’s Disease (PD). Chronic stress can activate the NLR family pyrin domain containing 3 (NLRP3) pattern recognition receptor resulting in the formation of the NLRP3 inflammasome, proinflammatory signaling, and pyroptotic cell death. A distinct subset of extracellular vesicles (EVs) are released from cells upon NLRP3 activation. We studied WT and Nlrp3-/- primary microglia exposed to bacterial stimulating agents and alpha synuclein preformed fibrils (αsyn PFFs), which model Parkinson’s disease and associated synucleinopathies. We identified the NLRP3-dependent release of the endosome fate …


Democratic Accountability And Tax Enforcement, Joshua D. Blank, Leigh Osofsky Jan 2024

Democratic Accountability And Tax Enforcement, Joshua D. Blank, Leigh Osofsky

Faculty Publications

One of the most powerful charges that can be leveled against the IRS is that it is targeting taxpayers. Charges of political targeting have dogged the IRS for over a century, including in major controversies such as the alleged Tea Party auditing scandal in 2013. Commentators and scholars have long critiqued the IRS for focusing audit resources on some of the lowest-income Americans. And, most recently, a group of researchers estimated that the IRS audits Black taxpayers at a 2.9 to 4.7 times greater rate, as compared to non-Black taxpayers. In response, legislators demanded action, there was widespread public consternation, …


Debt, Race, And Physical Mobility, Kate Sablosky Elengold Jan 2024

Debt, Race, And Physical Mobility, Kate Sablosky Elengold

Faculty Publications

Residents in every state in the United States can lose their driver’s license or car registration because they owe debt to the state. At least eleven million people across the United States suffer these debt-based driving restrictions at any given time. Because Americans overwhelmingly rely on personal automobiles for transportation, states, by controlling access to driver’s licenses and vehicle registrations, use debt policy to control where and how people travel. And because these laws disproportionately affect people of color, primarily Black people, this kind of regulation props up racial segregation in both location and opportunity. This Article’s first contribution is …


Rethinking Tax Information: The Case For Quarterly 1099s, Kathleen Delaney Thomas Jan 2024

Rethinking Tax Information: The Case For Quarterly 1099s, Kathleen Delaney Thomas

Faculty Publications

When an electricity provider wants customers to pay their bills monthly, it sends them a bill each month. Yet, this is not how the tax system works— at least not for independent contractors. Their taxes are due quarterly, but they receive a tax statement (Form 1099) only one time a year. It is up to the individual, then, to know when their taxes are due and how to pay them, and it is on that individual to estimate how much they owe each quarter. As a result, compliance for independent contractors—particularly for online platform workers—tends to be lacking. Failure to …


What Is In Your Tampon? Increasing Transparency In Menstrual Products, Elianna Spitzer Jan 2024

What Is In Your Tampon? Increasing Transparency In Menstrual Products, Elianna Spitzer

Seattle University Law Review

The average person who menstruates will bleed for an average of five days, every twenty-four to thirty-eight days, over several decades and could use thousands of disposable menstrual products in their lifetime. Menstrual products line retail shelves. They can be found in homes, bags, and bodies—but until 2021, manufacturers were not required to disclose the ingredients used to make these products to consumers at all. In fact, they still are not federally required to disclose menstrual product ingredients on product packaging. Instead, in recent years, changes to menstrual product labels have largely been the result of state legislation. In 2019, …


Sneakers, The Shoes That Talk The Talk And Walk The Walk: How Jack Daniel’S Properties, Inc. V. Vip Products Left Its Footprint On Trademark Law And The Sneaker Industry, Nitya Tolani Jan 2024

Sneakers, The Shoes That Talk The Talk And Walk The Walk: How Jack Daniel’S Properties, Inc. V. Vip Products Left Its Footprint On Trademark Law And The Sneaker Industry, Nitya Tolani

Seattle University Law Review

As the fashion industry—including the sneaker industry housed within it—continues to go through the motions of collectively flocking out, and then collectively flocking again to the newest innovations in the world of wearables, the landscape of laws to protect and promote those innovations expands as well, mainly in the area of intellectual property law. Although copyright, trademark, and patent law can cover innovations in the fashion industry, this Note centers its analysis on trademark law. Trademark law has been through notable change in recent years because of the United States Supreme Court’s 2023 decision in Jack Daniel’s Properties, Inc. v. …


Organizational Ghosts: How “Ghostly Encounters” Enable Former Leaders To Influence Current Organizational Members, Jeffrey S. Bednar, Jacob A. Brown Jan 2024

Organizational Ghosts: How “Ghostly Encounters” Enable Former Leaders To Influence Current Organizational Members, Jeffrey S. Bednar, Jacob A. Brown

Faculty Publications

Leadership research has assumed that leader group prototypicality enhances leadership influence during a leader’s tenure. Other leadership research has also assumed that leaders, especially founders, can transformtheir leadership influence into a legacy thatwill survive death and departure from the organization and continue to impact followers. However, to understand the historically embedded nature of leadership influence, it is critical to unpack how specific leaders can become group prototypes and influence followers after their departure. We address this opportunity by examining organizational ghosts—former organizational members who become the ideal prototype of an organization’s values and identity. Drawing on qualitative data from an …


Virtual Gaming, Actual Damage: Video Game Design That Intentionally And Successfully Addicts Users Constitutes Civil Battery, Allison Caffarone Jan 2024

Virtual Gaming, Actual Damage: Video Game Design That Intentionally And Successfully Addicts Users Constitutes Civil Battery, Allison Caffarone

Hofstra Law Faculty Scholarship

In recent years, there has been increased academic interest in both the neurological effects of compulsive gaming and the potential tort liability of game developers who scientifically engineer games in order to addict users. Scholars from various disciplines are currently debating the scope and potential solutions to the problems associated with Gaming Disorder, now a globally recognized illness. This article contributes to this discussion by offering a multidisciplinary analysis of the scope of video game addiction, its neurological bases, and its relation to the legal rights and responsibilities of victims and game developers. In addition, this article explores the practical …


Challenging Medicine: Ivermectin Cases, Medical Futility Cases And The Patient-Physician Relationship, Janet L. Dolgin Jan 2024

Challenging Medicine: Ivermectin Cases, Medical Futility Cases And The Patient-Physician Relationship, Janet L. Dolgin

Hofstra Law Faculty Scholarship

No abstract provided.


Defense Lawyering In The Progressive Prosecution Era, Jenny Roberts Jan 2024

Defense Lawyering In The Progressive Prosecution Era, Jenny Roberts

Hofstra Law Faculty Scholarship

The movement to elect so-called "progressive prosecutors" is relatively new, but there is a robust literature analyzing it from a number of angles. Scholars consider how to define "progressive prosecution," look at the movement through a racial justice lens, and examine it in the context of rural spaces, deportation, and the pandemic. One essay even offers a "progressive prosecutor's handbook." But what of the defense lawyer representing clients in a progressive prosecution jurisdiction? With the election of the new prosecutor, things may

have shifted from a highly-charged, adversarial relationship with a harsh law-and-order office to something quite different. Defenders in …


A Memory Efficient Deep Recurrent Q-Learning Approach For Autonomous Wildfire Surveillance, Jeremy A. Cantor Jan 2024

A Memory Efficient Deep Recurrent Q-Learning Approach For Autonomous Wildfire Surveillance, Jeremy A. Cantor

UNF Graduate Theses and Dissertations

Previous literature demonstrates that autonomous UAVs (unmanned aerial vehicles) have the po- tential to be utilized for wildfire surveillance. This advanced technology empowers firefighters by providing them with critical information, thereby facilitating more informed decision-making processes. This thesis applies deep Q-learning techniques to the problem of control policy design under the objective that the UAVs collectively identify the maximum number of locations that are under fire, assuming the UAVs can share their observations. The prohibitively large state space underlying the control policy motivates a neural network approximation, but prior work used only convolutional layers to extract spatial fire information from …


Fostering Multiliteracies And Engagement With Multimodal Texts In The Secondary English Language Arts Classroom, Amanda J. Hargis Jan 2024

Fostering Multiliteracies And Engagement With Multimodal Texts In The Secondary English Language Arts Classroom, Amanda J. Hargis

Graduate Research Papers

This study underscores the potential of multimodal texts to enhance student engagement and understanding in high school English Language Arts classrooms. While student preferences for different text formats varied, challenges remain in how to connect classic literature to contemporary students. However, the integration of multimodal resources can offer valuable opportunities for enriching the learning experience. Future research and continued adoption of culturally sustaining pedagogies in instructional practices will be key to maximizing the benefits of multimodal texts in diverse educational settings.


The Effect Of Student Discussion Groups On Music Preference, Abby Steffen Jan 2024

The Effect Of Student Discussion Groups On Music Preference, Abby Steffen

Graduate Research Papers

The purpose of this study was to explore the effect of three different listening conditions on how students rate their preference of musical genre. The preferences of the students could then be analyzed and incorporated into daily teaching. The participants were fifth-grade students of the researcher. Students (N = 44) were divided into three groups: Listening Only, Small Group Discussion and Teacher Info. Students in the Listening Only group listened to a playlist of music representing ten genres and rated each genre on a scale from 1(I don’t like it) to 5 (I like it a lot). Students in the …


Front Matter - Table Of Contents - Preface Jan 2024

Front Matter - Table Of Contents - Preface

Iowa Journal of Communication

No abstract provided.


Environmental Information Avoidance Motives On A U.S. Campus, Mary Beth Deline, Laura N. Rickard, Jared V. Worwood, Pei Geng, Elisabeth Reed Jan 2024

Environmental Information Avoidance Motives On A U.S. Campus, Mary Beth Deline, Laura N. Rickard, Jared V. Worwood, Pei Geng, Elisabeth Reed

Iowa Journal of Communication

Although communication, broadly, is often identified as a key factor across campus sustainability initiatives, few studies have examined specific information behaviors that can affect reception of such efforts. We therefore seek to characterize motives for a key communication barrier to campus sustainability efforts: environmental information avoidance (IA), and to investigate whether these motives differ in relation to known or unknown information. This exploratory study thematically analyzed answers from an open-ended question on a questionnaire with faculty, staff and students on a U.S. university campus. We identified six environmental IA motives, ranging from information overload to efficacy constraints. Correlational analysis found …


Book Review: From Thought To Action: Developing A Social Justice Orientation, Joy L. Daggs Jan 2024

Book Review: From Thought To Action: Developing A Social Justice Orientation, Joy L. Daggs

Iowa Journal of Communication

In the second edition of From Thought to Action: Developing a Social Justice Orientation, Sanford helps to provide a framework for students’ first exposure to allyship and activism. In the preface of the book, Sanford (2024) articulates the three major purposes of the book, which include helping new allies, “a) focus on common humanity, b) feel less isolated on their social justice journey, c) figure out how to move from thought to action, either individually or collectively.” (p. xiv) The book could be used to supplement a course on Intercultural Communication, encouraging students to take their knowledge to collaborate with …


The Human Health Effects Of Harmful Algal Blooms In Florida: The Importance Of High Resolution Data, Andrew Bechard, Corey Lang Jan 2024

The Human Health Effects Of Harmful Algal Blooms In Florida: The Importance Of High Resolution Data, Andrew Bechard, Corey Lang

Environmental and Natural Resource Economics Faculty Publications

Harmful algal blooms (HABs) have been found to cause increases in healthcare visits for a variety of illnesses to humans if exposure and contact is sufficient. We use a more comprehensive dataset than previously implemented in prior literature to better isolate visits by healthcare facility type and proximity to bloom. Using a difference-in-differences model, our results suggest HABs cause an increase of 23.67 healthcare admissions per zip code per month across four HAB-related diagnoses. This impact is a 3,000% increase over baseline non-bloom times and an increase in monthly healthcare costs of about $250,000 for the entire impacted area. Our …


"Guarding The Sanctity Of Choice And Privacy": Data Privacy And Abortion–The Next Frontier Of The Fourth Amendment, Ryan S. Houser Jan 2024

"Guarding The Sanctity Of Choice And Privacy": Data Privacy And Abortion–The Next Frontier Of The Fourth Amendment, Ryan S. Houser

Northwestern Journal of Technology and Intellectual Property

In the wake of the Dobbs decision, a seismic shift reverberates through the landscape of reproductive rights. As investigations into private healthcare decisions surge, states wield increasingly sophisticated tools to probe into the private lives of pregnant individuals, igniting a contentious debate on privacy and data security. The United States is entering a looming era where internet search histories, emails, text messages, and GPS data become ammunition in the arsenal of state-led investigations. Dubbed as “dragnet criminal surveillance tools,” these tactics will unleash a torrent of prosecutions, raising profound questions about the sanctity of personal information in the digital age. …


Staying A Jane Doe Post Dobbs And Roe: The Risk Modern Technology Poses With Archaic Abortion Restrictions, Grace E. Marino Jan 2024

Staying A Jane Doe Post Dobbs And Roe: The Risk Modern Technology Poses With Archaic Abortion Restrictions, Grace E. Marino

Northwestern Journal of Technology and Intellectual Property

Dobbs v. Jackson Women’s Health Organization sent shockwaves across the nation, overturning years of precedent and marking a pivotal moment as Roe v. Wade receded from current legal standing. This consequential abortion case immediately ignited controversy, prompting states to swiftly enact laws prohibiting abortion. Beyond the immediate implications for the health and safety of those seeking abortions, the new legal landscape poses additional risks. Since the era when abortion was last illegal, rapid technological advancements have transformed the American societal landscape, resulting in daily surveillance of its citizens. The convergence of technological progress, societal dependence on technology, and the absence …


A Tort For The Digital Age: False Light Invasion Of Privacy Reconsidered, John C.P. Goldberg, Benjamin C. Zipursky Jan 2024

A Tort For The Digital Age: False Light Invasion Of Privacy Reconsidered, John C.P. Goldberg, Benjamin C. Zipursky

Faculty Scholarship

In his famous 1960 article, William Prosser identified four privacy torts: Disclosure of Private Facts, False Light Invasion of Privacy, Appropriation of Likeness, and Intrusion Upon Seclusion. Although each was recognized in the Second Torts Restatement and by various courts, the false light tort seems to have foundered. Indeed, starting in the late 1980s, prominent courts rejected it and many academics have expressed grave misgivings about it. Often interpreted as a kind of ‘defamation lite,’ the tort seems to its critics an ill-defined wrong that clever lawyers invoke to evade important limitations on defamation liability.

Drawing from case law and …


Designing Equitable Media Literacy Interventions For Critical Youth Agency, Bobby Foster, Paul Mihailidis, Patrick R. Johnson, Shannon Burth, Melissa Tully, Srividya Ramasubramanian, Emily Riewestahl Jan 2024

Designing Equitable Media Literacy Interventions For Critical Youth Agency, Bobby Foster, Paul Mihailidis, Patrick R. Johnson, Shannon Burth, Melissa Tully, Srividya Ramasubramanian, Emily Riewestahl

Journalism Faculty Publications and Presentations

In recent years, young people engaged in political discourse and civic action online. U.S.-based social movements centered on equity issues, such as Black Lives Matter, Dreamers, and March for Our Lives, engaged young people in shaping and publicizing the goals of these movements through digital platforms. Increasingly in communities at the margins, young Americans need digital and media literacy skills to supplement contentious education restrictions within the United States, as with many state bills curtailing the teaching of LGBTQIA+ histories and critical race theory. With these considerations in mind, our team conducted a national study of impactful media literacy in …


Students' Perceptions Of Effects Of Tiktok On Academic Performance: A Case Study At Southern Illinois University, Stellah Nakiranda Jan 2024

Students' Perceptions Of Effects Of Tiktok On Academic Performance: A Case Study At Southern Illinois University, Stellah Nakiranda

Research Papers

No abstract provided.


Advancements In Ai-Driven Education: Transforming Learning And Training With Intelligent Technologies, Sharon L. Burton Jan 2024

Advancements In Ai-Driven Education: Transforming Learning And Training With Intelligent Technologies, Sharon L. Burton

Publications

This article examines the transformative role of Artificial Intelligence (AI) in higher education, focusing on its integration in learning methodologies and its impact on student engagement and outcomes. Recent research underscores the increasing use of AI in education, where it is reshaping teaching and learning dynamics by facilitating personalized and effective learning experiences. Applying Literature review, the study further explores AI's role in enhancing independent learning abilities and student satisfaction, with intelligent learning tools proving crucial in improving user contentment and intent to use. Additionally, it considers the ethical and risk management aspects of AI in education, including data governance …


A Growing And Maturing Field, Jonte Bernhard, Shannon Chance, Tinne De Laet, Kristina Edström Jan 2024

A Growing And Maturing Field, Jonte Bernhard, Shannon Chance, Tinne De Laet, Kristina Edström

Research Outputs: 2025-Present

The 8th SEFI Doctoral Symposium in Engineering Education Research, held at the campus of EPFL on Sunday, September 1st, preceded the SEFI 2024 Annual Conference. In all, 31 Ph.D. researchers attended. They came to share and further probe their Ph.D. research topics and study plans and to strengthen and extend their professional networks. During this full and intense day, 22 established scholars provided the Ph.D. researchers with personal feedback and ideas regarding their research. Highlights, according to the Ph.D. student participants, were the welcome and sense of support and belonging they experienced from the engineering education research …


Lecanemab: A Second In Class Therapy For The Management Of Early Alzheimer's Disease., Connie H Yoon, Corey Groff, Olivia Criss Jan 2024

Lecanemab: A Second In Class Therapy For The Management Of Early Alzheimer's Disease., Connie H Yoon, Corey Groff, Olivia Criss

Pharmacy Articles

The Food and Drug Administration granted traditional approval of lecanemab for the treatment of Alzheimer's disease (AD). Lecanemab is a humanized anti-amyloid monoclonal antibody directed towards Aβ protofibrils. Lecanemab is the only drug that targets Aβ soluble protofibrils and has shown statistical differences in mild AD or mild cognitive impairment. In its landmark phase III trial, lecanemab was shown to slow the progression of clinical decline, and a reduction in amyloid protein accumulation. The difference in mean CDR-SOB score improvement between the treatment and placebo groups was -0.45, of which the clinical significance could be argued. Amyloid burden was also …


2024 Cheshire County Ac Agenda & Minutes, Diane Dugray Jan 2024

2024 Cheshire County Ac Agenda & Minutes, Diane Dugray

Advisory Council

No abstract provided.


Displaced Worker Angst And Far Right Populism, Thomas E. Lambert Jan 2024

Displaced Worker Angst And Far Right Populism, Thomas E. Lambert

Faculty and Staff Scholarship

Background

Nothing causes more anguish and frustration than downward social mobility such as that experienced by less-educated workers and especially by displaced workers. Those who lose economic status lose more than income because they become so socially isolated that they are further frustrated through loneliness (Case and Deaton 2020). Hanna Arendt points out that lonely men are susceptible to authoritarian influence (1973, p. 475).

There is yet another aspect to the downward social mobility of low skilled men, namely that they are losing ground not only relative to social norms but also relative to the wages of low-skilled women. In …


Opening And Closing Remarks From The 2024 Watson Conference On Rhetoric And Composition, Andrea Olinger Jan 2024

Opening And Closing Remarks From The 2024 Watson Conference On Rhetoric And Composition, Andrea Olinger

Faculty and Staff Scholarship

This document contains the opening and closing remarks of the Watson Director, Andrea Olinger, which she delivered during the 2024 Watson Conference on Rhetoric and Composition, “Create, Connect, Reflect: Launching Collaborations and (Re)building Community in Our Fields.” It also contains the 2024 Watson Conference Commitments.


Exploring Post Quantum Cryptography With Quantum Key Distribution For Sustainable Mobile Network Architecture Design, Sanzida Hoque, Abdullah Aydeger, Engin Zeydan Jan 2024

Exploring Post Quantum Cryptography With Quantum Key Distribution For Sustainable Mobile Network Architecture Design, Sanzida Hoque, Abdullah Aydeger, Engin Zeydan

Electrical Engineering and Computer Science Faculty Publications

The proliferation of mobile networks and their increasing importance to modern life, combined with the emerging threat of quantum computing, present new challenges and opportunities for cybersecurity. This paper addresses the complexity of protecting these critical infrastructures against future quantum attacks while considering operational sustainability. We begin with an overview of the current landscape, identify the main vulnerabilities in mobile networks, and evaluate existing security solutions with new post-quantum cryptography (PQC) methods. We then present a quantum-secure architecture with PQC and Quantum Key Distribution (QKD) tailored explicitly for sustainable mobile networks and illustrate its applicability with several use cases that …


Iowa Journal Of Communication, Volume 56, Number 1, Fall 2024 [Download Entire Issue] Jan 2024

Iowa Journal Of Communication, Volume 56, Number 1, Fall 2024 [Download Entire Issue]

Iowa Journal of Communication

No abstract provided.