Digital Commons Network^™

Foreign Policy And International Power: The Effects Of The Us War In Afghanistan On India's Afghanistan Policy, Brian W. Storch

Browse all Theses and Dissertations

India’s compliance to the United States’ regional ambitions following the 2001 invasion of Afghanistan demonstrated a unique re-alignment that reversed India’s historic defiance of international powers pursued since its independence. Instead of resisting the United States or seeking to disengage from the Afghan conflict, India provided aid to the new regime but did not extend military assistance because of limits set by the United States to appease Pakistan. India complied and increased cooperation with the United States despite the disadvantages this compliance presented. It will be argued that the structure of the international system enforcing US hegemony primarily influenced India’s …

A Novel In-Vitro Approach To Investigate The Molecular Interaction Between Inhaled Particles And The Human Pulmonary Surfactant System, Bryan Mayville

Browse all Theses and Dissertations

The deployment of military personnel to austere environments poses significant pulmonary health risks from inhalation of particulates including sand, dust, pollution, and heavy machinery exhaust. When particles are less than 10 µm in diameter, they can penetrate deep within the alveoli and embed within the protective lung surfactant monolayer. Here, absorption of surfactant lipids to the particle surface disrupts the essential monolayer configuration needed to reduce surface tension and prevent atelectasis, thus leading to disease. Currently, there are no in vitro surfactant-producing lung cell models capable of studying the effects of inhaled particles on the human pulmonary surfactant system. A549 …

Exploring The Effects Of Choline Treatment On Dystrophic Phenotype, Brooklyn Morris

Browse all Theses and Dissertations

Duchenne Muscular Dystrophy (DMD) is a devastating progressive muscular disorder caused by a mutation in the dystrophin gene affecting approximately 1 in 3,500 males. However, despite its prevalence, there is currently no cure for this disease. Mutations in dystrophin lead to enhanced inflammation, fibrosis, cell death, development, and decreased skeletal muscle function. Phosphatidylcholine, synthesized by choline, is a major phospholipid that functions in maintaining and synthesizing cell membranes and has previously been found to be decreased in DMD patients. This led us to hypothesize that the dystrophic phenotype could be improved through treatment with choline. In this study, we used …

Development Of Sulfur-Based N-Heterocyclic Carbenes And Their Potential Energy Applications, Kalpana Sampath

Browse all Theses and Dissertations

N-heterocyclic carbenes (NHCs), a characteristic 5-membered ring structure, contain a carbene carbon and at least one nitrogen atom. The presence of nitrogen atoms in the cyclic structure has two effects on its electronic structure: it withdraws σ-electrons and donates π-electrons to the carbene carbon, significantly enhancing the electronic richness and stability of the carbene center. Incorporating heteroatoms like sulfur, oxygen, or phosphorus into the NHC framework has paved the way for advanced developments in their structural properties. The incorporation of additional aromatic ring/heteroatom into NHC offers novel pathways for functionalization, ultimately broadening its scope of potential applications. The primary goal …

Functionalized 1,4-Naphthoquinone-Annulated N-Heterocyclic Carbenes For Biomedical Applications, Dilsha Samanali Wickramasinghe

Browse all Theses and Dissertations

Gold has long been recognized for its medicinal applications, dating back centuries. The use of N-heterocyclic carbenes (NHCs), stable, tunable ligands, has revolutionized the development of metal complexes, particularly those involving gold. Among these, Au-NHC complexes have shown significant promise in treating various diseases, especially arthritis and cancer. More recently, our research has focused on synthesizing dual-targeting naphthoquinone-annulated NHC-based gold(I) complexes, which have demonstrated impressive therapeutic potential in cancer treatment. This emphasizes the growing importance of gold-based complexes in developing more selective and effective cancer therapies. By strategically tuning the electronic and steric properties of these complexes, we have explored …

Studies Of Selective And Reversible Inhibitors Of Calcium Entry In Immune Cells, Naga Lakshmi Gandi

Browse all Theses and Dissertations

Calcium signaling is a crucial regulator in many cellular processes, from immune response modulation to gene expression and apoptosis. Here, I have investigated the dynamics of calcium entry pathways, namely, store-operated calcium entry and store-independent calcium entry using a variety of cell types such as Jurkat T cells, HEK-293 cells and murine macrophages. Using fluorescence calcium imaging and selective inhibitor compounds, I have investigated the contributions of Orai and related calcium channels to calcium entry in both immune and non-immune cell types. The results demonstrate the pharmacological modulation of store-operated and store-independent calcium entry, showing the ability of compounds such …

Investigating The Effects Of Human Astroviruses On Aquaporins And Tight Junction Proteins In Vitro, Makalia T. Robinson

Browse all Theses and Dissertations

Human Astroviruses (HAstV) are positive sense non-enveloped single stranded RNA viruses. HAstV is divided into classical (serotype 1-8) and non-classical (HAstVMLB 1-3 and HAstV-VA1-5) astroviruses. Classical HAstV is known to cause diarrhea in children, elderly, and immunocompromised patients. Additionally, the etiology of nonclassical HAstV remains unknown. However, recent studies have implicated non-classical HAstV closely associated with immunocompromised patients diagnosed neurological diseases like acute encephalitis. The mechanisms by which HAstV cause diarrhea is currently unknown. Aquaporins (AQPs) are integral membrane proteins that regulate the movement of water and small uncharged molecules across the cell membrane in response to osmotic gradients. Tight …

Repurposed Energy, Hannah Jacobs Wiseman, Alexandra Klass

Faculty Scholarship

Wildfires, weather extremes, and other conditions induced partially by climate change add urgency to the project of accelerating the clean energy transition from fossil fuels to zero-carbon energy infrastructure. Yet the hurdles to accomplishing such a massive industrial-scale transition are daunting. Indeed, large renewable energy generation projects regularly face denials or project-killing delays across the United States. This Article proposes a national policy to channel the bulk of new clean energy projects to targeted categories of both rural lands and urban, post-industrial lands that we define collectively as “repurposed energy” sites. Such lands will consist of marginal farmland, abandoned coal …

Transgender Students And The First Amendment, Dara Purvis

Faculty Scholarship

Suppose a transgender child experiences teasing and harassment from their classmates, whose hostile reactions interrupt the school day. School administrators tell the transgender child that, in order to allow educational activities to continue, they must dress in more gender-neutral clothing, ideally cionsistent with the sex they were assigned at birth. The student's parents protest, arguing that their child's clothing is speech that expresses their gender identity. The school points to Tinker v. Des Moines, allowing suppression of student speech where it creates a material disruption, as well as recent legislation characterizing discussion of gender identity as lewd and obscene. …

Research Priorities For Childhood Apraxia Of Speech: A Long View, Jenya Iuzzini-Seigel

Speech Pathology and Audiology Faculty Research and Publications

This article introduces the Journal of Speech, Language, and Hearing Research Special Issue: Selected Papers From the 2022 Apraxia Kids Research Symposium. The field of childhood apraxia of speech (CAS) has developed significantly in the past 15 years, with key improvements in understanding of basic biology including genetics, neuroscience, and computational modelling; development of diagnostic tools and methods; diversity of evidence-based interventions with increasingly rigorous experimental designs; and understanding of impacts beyond impairment-level measures. Papers in this special issue not only review and synthesize the some of the substantial progress to date but also present novel findings addressing critical research …

Msw Portfolio, Courtney R. Nucito

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio encapsulates my transformative journey through the realm of social work, detailing experiences, reflections, and insights gained throughout my academic and professional endeavors. Rooted in a commitment to social justice and ethical practice, my narrative unfolds through various roles and settings, each contributing to my growth as a compassionate and effective social work practitioner.

The Barriers To Adult Play In Graduate Students, Rosalind Nolde, Sabrina Solis, Catherine Salomon, T Monelli

Occupational Therapy | MSOT Capstone Projects

The purpose of this study is to expand the knowledge of barriers to play for graduate students. The research question asked, what are the barriers to play experienced by graduate students? Play is a complex term that is unique to the individual. Although subjective, existing literature gives suggestions as to what play can mean or feel like to the individual participating. Brown (2009), notes that the definition of play should be experienced rather than defined as it is distinctive to each individual. Van Vleet and Feeney (2015) describe play as being the purpose of amusement, fun or to have energetic, …

Addressing The Occupational Needs Of College Students, Amanda Lam, Ashley Keates, Marissa Heirich, Noreen Pervaiz, Albert Andrew Mendoza

Occupational Therapy | MSOT Capstone Projects

The Dominican Occupational Therapy (OT) Coaching project was led by a team of five master's level OT students in collaboration with the Integrative Coaching (IC) team at Dominican University of California. Aligned with the Occupational Therapy Practice Framework 4th edition (2020), the project supported various aspects of student wellness, such as academics, healthy lifestyles, stress management, sleep hygiene, and time management. In the fall of 2022, the team conducted a comprehensive literature review and needs assessment of Dominican's Student Success Center (SSC), actively engaged in SSC and IC meetings, and delivered an educational presentation on OT to SSC staff. The …

Using A Career Research Project In The Introductory Communication Course To Develop Agency, Self-Efficacy, Self-Determination, And Adaptability In Career Exploration, Stephen A. Klien, John Elmer, Patrick J. Rottinghaus

Journal of Communication Pedagogy

Helping students make connections between the disciplinary study of communication and the development of student agency in career exploration can be an important part of the mission of the introductory course in communication. This study incorporates social cognitive career theory to examine the effects of a semester-long communication career awareness research project as an intervention in an introductory communication course at a large public university in the Midwest. Survey data from 83 undergraduate students were analyzed to measure perceptions of self-efficacy, perceived competence, autonomy support, and adaptability for career exploration. The results of paired samples t-tests found significant gains on …

Intergenerational Connections: Us College Students’ Attitudes And Expectations Toward Older Adults And Aging In An Online Critical Community Engagement Project, Sandra L. Faulkner, Madison Pollino, Jaclyn Shetterly, Wendy K. Watson

Journal of Communication Pedagogy

We present a critically focused, semester-long community engagement project entitled Intergenerational Connections as a form of critical interpersonal and family communication pedagogy (CIFCP). The project utilized Zoom to connect small groups of undergraduate students in the US enrolled in a course on relational communication with older adults in a long-term care facility to dialogue about close relationships. We were interested in how dialogue across generations maintained or altered students’ attitudes and expectations about communicating with older adults and analyzed student reflections before, during, and after the dialogues using a turning point analysis. The study was framed using Social Identity Theory …

Journal Of Communication Pedagogy, Complete Volume, 2024

Journal of Communication Pedagogy

No abstract provided.

Applying X-Ray Fluorescence With Monte Carlo Methods For Analysis Of Surface Defects On Coated Zr4, James Tyler Cahill

Theses and Dissertations

Chromium-coated Zircaloy-4 cladding represents a novel solution for creating nuclear cladding that has passive safety features. This and related developments aimed at improving nuclear safety are broadly categorized as accident-tolerant fuel and cladding. However, implementing this material presents practical challenges such as the vulnerability that cladding has to surface damage such as fretting wear. This research aims to determine if the pre-existing technique of X-ray fluorescence analysis is applicable for detecting these defects on the surface of the cladding. This was done by developing Monte Carlo N-Particle Transport models of a handheld device, the XL-5, alongside experimental measurements using this …

Friends In Law Places- The Role For Medical-Legal Partnerships In Reshaping The Rural Bar And Bedside, Michael Sobol

South Dakota Law Review

No abstract provided.

Lest We Be Lemmings, Claire Wright

Faculty Articles

Lest We Be Lemmings concerns global warming, which is the most grave threat facing humanity today. In this article, I first: (1) discuss how the U.S. Congress and the U.S. Executive Branch, for decades, have been aware of the existence of global warming and its main cause – the burning of fossil fuels and emission of CO₂ - but have consistently failed to regulate the fossil fuel industry, reduce the lucrative subsidies that they provide to the fossil fuel industry, and hold the fossil fuel industry responsible for global warming; (2) explain how the fossil fuel industry, for decades, …

Municipal Abortion Bans: When Local Control Clashes With State Power, Laura D. Hermer

American University Journal of Gender, Social Policy & the Law

Anti-abortion activists are using different strategies in different states. Some focus on restricting zoning for abortion clinics. Others address the licensure of abortion providers. Some purport to create a cause of action for private individuals to sue neighbors and others in their municipality who get an abortion. Still, others seek to enforce the federal Comstock Act, alleging that it prohibits the mailing of abortifacients and preempts state abortion law to the contrary.

This Article evaluates the likely success of each of these strategies in two states in which they are currently being tried: Nebraska and New Mexico. Part I will …

Hydrologic Pathways Of A Northern Hardwood Catchment In The Great Lakes Basin Using End Member Mixing Analysis, Cory C. Burkwald

Dissertations, Master's Theses and Master's Reports

This study investigated the seasonality of hydrologic pathways, the role of wetlands in streamflow generation, and how hydrologic pathways affect the export of nutrients by streamflow in the Sturgeon River using endmember mixing analysis. The results indicated that streamflow consists of three main components: shallow subsurface water from wetland soils, shallow groundwater, and surface runoff from precipitation. Snowmelt plays a dominating role in regulating stream water chemistry (~80% volume at peak) during the snowmelt season and likely also after that. Wetland soils store snowmelt, together with rainwater though the fraction is unknown, and then gradually release through summer in the …

“Not Much Of A Job”: Everyday Life And Labor At Camp Au Train, Josef T. Iwanicki

Dissertations, Master's Theses and Master's Reports

In this thesis, I use data from Camp Au Train, a Civilian Conservation Corp camp in Michigan’s Hiawatha National Forest, as a case study to connect the everyday life of enrollees with dominant government narratives while including a focus on labor and the capitalist crisis of the Great Depression. Using the vantage point of work, play, study, and health, I integrate archaeological, historic, and photographic evidence to show contradictions between the enrollees’ real lived experience and the dominant perspectives of the CCC ‘authorities’ who organized their lives. I argue that to interpret these contradictions, the CCC needs to be connected …

Data Driven And Machine Learning Based Modeling And Predictive Control Of Combustion At Reactivity Controlled Compression Ignition Engines, Behrouz Khoshbakht Irdmousa

Dissertations, Master's Theses and Master's Reports

Reactivity Controlled Compression Ignition (RCCI) engines operates has capacity to provide higher thermal efficiency, lower particular matter (PM), and lower oxides of nitrogen (NOx) emissions compared to conventional diesel combustion (CDC) operation. Achieving these benefits is difficult since real-time optimal control of RCCI engines is challenging during transient operation. To overcome these challenges, data-driven machine learning based control-oriented models are developed in this study. These models are developed based on Linear Parameter-Varying (LPV) modeling approach and input-output based Kernelized Canonical Correlation Analysis (KCCA) approach. The developed dynamic models are used to predict combustion timing (CA50), indicated mean effective pressure (IMEP), …

Exploring The Molecular Pathways Of Cell Death Induced By Pde3 Modulators, Aqsa Ahsan

Dissertations, Master's Theses and Master's Reports

Metabolic dysregulation, a critical hallmark of cancer, predisposes potential vulnerabilities for the development of targeted therapy. LKB1, a pivotal metabolic regulator and tumor suppressor, is often lost in many cancers. Our laboratory has unveiled that LKB1 suppresses phosphodiesterases (PDEs), and PDE3 modulators can selectively eradicate LKB1-deficient tumor cells. Through metabolic gene sgRNA library screening, Sarcolipin, an inhibitor of Sarcoendoplasmic Reticulum Calcium ATPase (SERCA), emerged as essential for cell death in this context. However, the precise molecular mechanisms by which PDE3 modulators exert their effects remain elusive. This study aims to uncover these mechanisms via RNA-Seq profiling and differential gene analysis, …

Confronting The Wildfire Crisis: Understanding Equity And Decision-Making In Wildfire Management Strategies, Katherine Huerta Sanchez

Dissertations, Master's Theses and Master's Reports

This study investigates how fuel managers incorporate equity and social vulnerability considerations into wildfire fuel reduction treatments on National Forest land and explores the resulting impact on the implementation of wildfire risk reduction policies. Through interviews, managers revealed differing perspectives on prioritizing social vulnerability characteristics and challenges such as insufficient information and resources to inform equitable fuel treatment decisions. These findings illuminate the complexities of integrating considerations of social vulnerability into decision-making processes for wildfire management at the wildland-urban interface, suggesting potential divergence from nationally supported policies aimed at equitably implementing wildfire risk reduction measures. The study findings underscore the …

Restoration Is Repairing Relationships: Bridging Indigenous And Western Sciences To Assess The Socio-Ecological Restoration Of Wild Rice (Zizania Palustris) On Keweenaw Bay Indian Community Homelands, Cassandra M. Reed-Vandam

Dissertations, Master's Theses and Master's Reports

Manoomin (wild rice, Zizania palustris) is an ecologically and culturally significant plant relative for the Keweenaw Bay Indian Community (KBIC). Historically, manoomin was present across much of the Great Lakes, however, their presence has declined since the early 1900s and, by 1990, virtually disappeared within KBIC homelands. Employing ethnography, surveys, focus groups, and conversations with Ojibwa knowledge holders, this research defined successful manoomin restoration for KBIC and developed socio-ecological attributes and indicators to assess restoration presented in the Medicine Wheel Framework for Manoomin Restoration. Surface water, sediment, and pore water samples at six different manoomin sites were analyzed to …

Discontinuous Galerkin Methods For Compressible Miscible Displacements And Applications In Reservoir Simulation, Yue Kang

Dissertations, Master's Theses and Master's Reports

This dissertation contains research on discontinuous Galerkin (DG) methods applied to the system of compressible miscible displacements, which is widely adopted to model surfactant flooding in enhanced oil recovery (EOR) techniques. In most scenarios, DG methods can effectively simulate problems in miscible displacements.
However, if the problem setting is complex, the oscillations in the numerical results can be detrimental, with severe overshoots leading to nonphysical numerical approximations. The first way to address this issue is to apply the bound-preserving
technique. Therefore, we adopt a bound-preserving Discontinuous Galerkin method
with a Second-order Implicit Pressure Explicit Concentration (SIPEC) time marching
method to …

Anaerobic Reductive Bioleaching Of Manganese Ores, Neha Sharma

Dissertations, Master's Theses and Master's Reports

Manganese extraction by biological methods is a green and economical way to produce manganese from low as well as high grade manganese ores. This is especially important for US ores, which are primarily either small in extent, low-grade with a high iron content, or both. They are therefore not suitable for conventional mining, which is very capital-intensive and requires a large up-front investment and are therefore imported at high costs. The goal is therefore to develop a process that can be applied at small scales, with minimal startup costs, and low equipment and labor requirements. It is also critical to …

Recovering Access Control Via Disk Forensics On Low-Level Flash Memory, Caleb J. Rother

Dissertations, Master's Theses and Master's Reports

In the history of access control, nearly every system designed has relied on the operating system (OS) to enforce the access control protocols. However, if the OS (and specifically root access) is compromised, there are few if any solutions that can get users back into their system efficiently. In this work, we have proposed a novel approach that allows secure and efficient rollback of file access control after an adversary compromises the OS and corrupts the access control metadata. Our key observation is that the underlying flash memory typically performs out-of-place updates. Taking advantage of this unique feature, we can …

Novel Analytical Approaches For The Study Of Energy And Nutrient Flow In Streams, Michelle Catherine Kelly

Dissertations, Master's Theses and Master's Reports

This dissertation applied novel modeling, experimental and statistical approaches to overcome the challenges of measuring and analyzing energy and nutrient cycling in streams through 3 studies: (1) determining the predictors of respiration and denitrification in streams across the United States, (2) simultaneous estimation of denitrification and nitrogen (N) fixation rates, and (3) the impact of C lability metrics on the interpretation of C degradation in DOM incubation experiments. In the first study, I used predictive modeling approaches to show that respiration and denitrification were positively correlated across the landscape but were predicted by factors at different spatial scales. Denitrification rates …