Digital Commons Network^™

Elucidation Of Mismatch Repair Regulation By Abl1: Advantages/Disadvantages Of Tyrosine Kinase Inhibitor Treatment, Hannah Daniels

Theses and Dissertations--Toxicology and Cancer Biology

DNA mismatch repair (MMR) is a critical repair process necessary for not only repairing mispairs incorporated into the DNA during replication, but also for inducing apoptosis in response to certain types of DNA damage. MMR is required for maintaining genomic integrity and due to the importance of this pathway, any impairment of its function can lead to increased mutation frequency, which is well known to be a driving force of cancer development, progression, and resistance. Despite extensive studies involving the proteins involved in the MMR pathway, the regulation of those proteins remains relatively unknown. Regulation of MLH1, a protein necessary …

Acquired Treatment Resistance In Prostate Cancer Via The Production Of Radiation Derived Extracellular Vesicles Containing Mitochondrial Proteins, Caitlin Miller

Theses and Dissertations--Toxicology and Cancer Biology

Radiation treatment (RT) is one of the most commonly administered treatments for prostate cancer (PCa) patients, yet the recurrence of tumors after RT remains one of the significant challenges in the eradication of PCa. In addition to induction of DNA damage, ROS production, and cell death, we found that RT promotes Extracellular vesicle (EV) production in PCa cells, at least in part, through H₂O₂ production (Miller CE et al., Antioxidants 2022, PMID 36358489). Since we observed EV production upon RT, EVs and their contents could play a role(s) in cancer survival after RT. By using flow cytometry …

Understanding The Mechanism Of Ferroptosis Susceptibility Variation In Colorectal Cancer, Aziza Alshahrani

Theses and Dissertations--Toxicology and Cancer Biology

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Despite the use of chemotherapeutic agents, CRCs remains to be difficult to cure at least partially due to their intrinsic and/or acquired resistance to cell death inducers. Ferroptosis is a form of regulated cell death that caused by the accumulation of lipid peroxides. Studies have shown that dysregulation of ferroptotic pathways is associated with the development of resistance to various cancer treatment. Glutathione peroxidase 4 (GPX4) is a known target for inducing ferroptosis due to its critical role in detoxifying lipid hydroperoxides, and ferroptosis suppressor protein (FSP1) also …

Porcupine’S Role In The Enhancement Of Enzalutamide Efficacy In Drug Resistant Prostate Cancer, Katelyn Jones

Theses and Dissertations--Toxicology and Cancer Biology

Androgen receptor (AR) signaling continues to participate as a vital component of castration-resistant prostate cancer (CRPC). Subsequently, this has led to the development of Androgen Signaling Inhibitors (ASI), specifically Enzalutamide (ENZ), which is a direct inhibitor of AR, to clinically manage CRPC. Inevitably, ENZ treatment only provides improvement for approximately two months before advancing to an incurable form, ENZ-resistant CRPC. With PCa ranking as the second leading cause of cancer-related deaths in USA males, there is an urgency and necessity for the discovery and development of novel therapeutic approaches for CRPC. Wnt signaling has been extensively documented in its involvement …

Therapeutic Approaches And Novel Mechansims In Cancer Progression, Kendall Simpson

Theses and Dissertations--Toxicology and Cancer Biology

Prostate cancer (PCa) remains the most diagnosed cancer among men in the United States. There are various therapeutic routes that are implored to combat this fatal disease, and our work aims to increase the options made available to PCa patients. A combination treatment of Enzalutamide (Enz), an FDA approved drug for castration-resistant PCa patients, and Metformin, an FDA approved drug for type 2 diabetes, was utilized to enhance the efficacy of Enz in Enz-resistant PCa, both in vitro and in vivo. Thymic Lymphoma is one of the most common malignancies that can occur in various tissues and organs. Genomic stability …

Delineating Contributions Of Genotype And Lineage To Lung Cancer Therapy Response, Kassandra Jo Naughton

Theses and Dissertations--Toxicology and Cancer Biology

Non-small cell lung cancer (NSCLC) heterogeneity is a major challenge for determining effective treatment strategies. Adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs) are histologically and epigenetically distinct subtypes of NSCLC. Patients with ADC tumors harboring mutations in both KRAS and LKB1 (aka STK11) have lower survival rates than those with KRAS-only tumors. KRAS/LKB1 tumors are not only aggressive, but also respond poorly to immunotherapy. However, these data are limited to ADCs, and it is unclear if SCCs with this genotype are also resistant to immunotherapy. We developed a mouse model of Kras^mut/Lkb1^mut capable of producing …

Benefits And Challenges Of Institutionalizing Peacebuilding And Activism In A Post-Liberal World, Clare Bath, Philip Gamaghelyan

School of Peace Studies: Faculty Scholarship

Peace and conflict studies is a normative field that seeks to reduce or eradicate violence. With multiple forms of violence plaguing human society, institutionalization of civil society has long been a tenet of liberal approaches to peace intended to enhance sustainability and policy impact of activism. Along with benefits, however, institutionalization brought with it a set of challenges, including cooptation by donors and competition among activists. The article builds on the analysis of 14 in-depth interviews, insights gathered from the “Rethinking Peace” workshop conducted in Mtsheka, Georgia in July 2022, and desk research on the risks and benefits of institutionalization …

Are Collective Joint Employers Of College Athletes? Empirical Analysis Of Nil Deals And School Policies, Michael H. Leroy

Marquette Sports Law Review

No abstract provided.

Possession And Control: Everyone Wants It, But No One Knows How To Get It, Peyton Phillips

Marquette Sports Law Review

No abstract provided.

Let Them Play: A Discussion Of Allowing United States Service Academy Graduates To Play Professional Sports, John M. Michalak

Marquette Sports Law Review

No abstract provided.

The Big Ten's Legal Duties And Risks: Protecting College Athletes Through The Voluntary Undertaking Doctrine In A Changing Landscape, Jeffrey F. Levine, Christian D. Hanna, Tiara Porterfield

Marquette Sports Law Review

No abstract provided.

Nil Necessitates Shared Medical Decision Making For College Athletes, Kathleen M. Boozang

Marquette Sports Law Review

No abstract provided.

Commercial Baseball Scouting Services: Broadcast Usage Fair Or Foul?, Ryan S. Monsevalles

Marquette Sports Law Review

No abstract provided.

Generating Climate Resilience Or Intensifying Vulnerabilities? A Feminist Poltitical Ecology Analysis Of Climate Resilient Agriculutre Projects In Sri Lanka’S Dry Zone, Nethmi Sachithma Perera Bathige

Theses and Dissertations--Geography

Conserving water for irrigation of crops has become a concern in the dry zone of Sri Lanka due to changes in climate patterns. In response, the United Nations Development Program (UNDP) has developed climate-resilient water management projects designed to build climate-resilience and water management practices among farmers. One such program called ‘Wew Gam Pubuduwa’ disseminates climate smart home gardening techniques, where women farmers receive sprinkler and drip irrigation systems, seeds and fertilizers, as well as training on water management methods. This study draws on a feminist political ecology framework to analyze the experiences of women home gardeners who …

Digital (Re)Production: Spatial Mediations Through Augmented Reality Landscapes In ‘Pokemon Go’, Brigitte Pulminar Perkins

Theses and Dissertations--Geography

Since 2016, the mobile augmented reality game Pokémon GO has renewed interest within communities by mediating spatial engagement using in-game markers that must be engaged with throughout physical urban landscapes. This thesis identifies factors that influence the spatial distribution of digital markers used by this game to help inform analyses of urban gamification, urban spatial distribution, and cultural knowledge production processes. Drawing specifically on theories of urban spatialization and digital media studies, I highlight features of physical and digital legacies of redlining within Lexington, KY that are reproduced via Pokémon GO. I argue that the urban racialized landscape of Lexington …

State Governance And Less-Skilled Migrant Workers In South Korea, Weejun Park

Theses and Dissertations--Geography

This dissertation examines the migration governance of South Korea with a focus on the immigration of less-skilled migrant workers. While geographers and broader social scientists have explored this topic, previous studies have two main foci: 1) individual immigrants and their activities; and 2) migration policy development. Despite these studies’ contribution to the scholarship, there seems to be a relative lack of interest in the South Korean state as a potentially crucial actor in governing less-skilled migrant workers. To address this gap, this dissertation draws upon (political) geography, related social sciences, and interdisciplinary fields such as border studies, migration studies, and …

The Role Of A Leader: Establishing Psychological Safety In The Church, Gaylen Sheree Pearl Jones

All Electronic Theses and Dissertations

Abuse is an intentional attempt to cause harm to others. Within any environment there is the possibility of abuse; abuse can be physical, sexual, psychological, and more. This project addressed the phenomena of psychological safety in the church to reduce psychological abuse. Psychological abuse, also referred to as emotional abuse, is a form of abuse that induces fear and intentionally affects one’s emotional health. Psychological safety in the church is a phenomenon that needs to be addressed. This project examined biblical and psychological resources to gain a better understanding on how to create psychologically safe environments that will discourage emotional …

A Mixed Methods Study Of Efficacy And Digital Learning Competencies For School Administrators In A Rural North Carolina District, Stephanie B. Harrell

Doctor of Education Dissertations

The purpose of this mixed methods research study was to determine the efficacy of digital learning competencies for school administrators in a rural eastern North Carolina district. The study had four research questions that were answered through a survey and a focus group. The survey had 44 quantitative items that participants chose from a 4-point Likert scale and two open-ended questions. A total of 20 administrators from District A completed the survey. A focus group with four participants was conducted following the closing of the survey to gain a better understanding of the results from the survey. Previous research in …

Cure Newsletter Volume 4 Issue 1, Department Of Oncology

Cancer Updates Research & Education (CURE) Archives

• Message from the Chair
• Conferences & Workshops
• Oncology Social Media
• Invited Talk Oncology
• Career Insight Session
• Guest Speakers
• Our Distinguished Faculty
• Celebrations
• Pink October
• Residents & Fellows
• Nursing
• Congratulation to Faculty
• Promotions
• Publications

Examining Implementation Of Science Of Reading Practices In North Carolina Public Schools, Brittany Ramsey Evans

Doctor of Education Dissertations

The purpose of this study was to examine teacher reactions to the adoption and implementation of the Science of Reading (SoR) in North Carolina public schools. In 2021, North Carolina mandated a shift in literacy instruction that started a change initiative beginning with a 2-year professional development for all PreK-5 public school teachers. As other states implement literacy movements aligned with SoR instruction, findings from this study may help them determine their best course of action. Using the theoretical foundation of change theory, I completed a mixed methods convergent parallel design study to explore the implementation process through the lens …

An Initial Investigation Of Measuring Change In Reading Proficiency During Letrs Implementation, Beverly Hart

Doctor of Education Dissertations

This study aimed to investigate the impact of LETRS professional development on reading proficiency. I used ANOVA tests to analyze third- through fifth-grade EOG assessment scores for changes in proficiency from 2021-2023. The results indicated a statistically significant change in the means for all grades. Third-grade results reflected the most impact from the professional development. The analysis also showed that the third-grade achievement gap had declined slightly. A dependent t test was conducted to ascertain any change in the growth index scores of schools. The test results showed no statistically significant change. The study's limitations include the lingering impact of …

A School-Wide Behavior Management Program Evaluation: Teacher Perceptions Of Gamification In The Alternative Setting, Christina J. Farnsworth

Doctor of Education Dissertations

The program evaluation provided an understanding of the effectiveness of gamification as a behavior management tool and its impact on student behaviors as perceived by teachers. The evaluation followed a sixth- through eighth-grade alternative public school whose vision is to provide a structured, safe, and motivating learning environment where students grow academically and behaviorally responsible. The two-phased mixed study allowed participants to share their perceptions and satisfaction with using gamification as an effective behavior management tool. The program evaluation took on the epistemological position that staff contributions significantly impact behaviors, dependent on the two constructs: (a) user attitude and (b) …

Creating Smiles With Digital Workflow And Matrix Transfer Technique In Customizing Personality-Based Smile Designing, Jahnavi Purna Gorripati, Surekha Godbole

International Arab Journal of Dentistry

Introduction: This report is a presentation of a clinical case that follows the Visagism concept for 2D planning and, CAD (Exo CAD) for 3D desiging along 3D printed diagnostic wax-up model for closure of anterior spacing.

Case presentation: A 24-year-old man presented with midline diastema and anterior spacing 11-13, 21-23 and wants a smile designed. This concern was solved following a smile design (VisagiSMile) planning digitally for diagnostic wax and printing a 3D model. The matrix transfer technique has been used to directly convey planned information from 3D-printed diagnostic wax-up to definitive restorations.

Conclusions: In this day …

The Impact Of The Science Of Reading Required Training On The Reading Proficiency Levels Of Third-Grade African American Male Students, Tonya Campbell

Doctor of Education Dissertations

Proficiency in reading is an essential skill for achieving success in the modern era, and African American students have struggled with reading due to insufficient support during literacy instruction. Through the implementation of the Science of Reading™ course, this research aimed to examine the effect of the Language Essentials for Teachers of Reading and Spelling (LETRS™) curriculum on the success of African American third-grade males based on the South Carolina College- and Career-Ready (SC READY™) summative assessments and Northwest Academic Evaluation Measures of Academic Progress (NWEA MAP™) data. This study followed the year before LETRS™ was introduced (2019), the 2 …

A Mixed Methods Study Of An Alternative Educational Program For At-Risk Students In South Carolina, Lucia K. Jacobs

Doctor of Education Dissertations

This research study focused on the theories that support and underpin the Nine Characteristics of High-Performing Schools. Much of the data presented about high-performing schools lack data about schools that are nontraditional; the nontraditional school, otherwise known as an alternative school or alternative learning placement, supports students who fail to thrive in the traditional school setting. The study employed a sequential explanatory mixed methods design. This design utilized an initial quantitative phase of data collection and analysis, followed by a qualitative phase of data collection and analysis. The purpose of the qualitative phase was to gain further insight regarding the …

Increasing Parent Engagement At The Middle School Level Using A Team Approach In An Urban, Title I School In Upstate South Carolina, Jaime Szalach Talkington

Doctor of Education Dissertations

Parent engagement declines when students are in middle school. A Title I school implemented a group text team approach to improve authentic dialogue among school staff and families and included the student as an active participant in the equation. Strategically scheduled between progress reports and report cards, students were responsible for taking a picture of their current grades and sending it in a group text to their parents, teachers, and administrators. The administrator responded to the group text with the current newsletter to keep all stakeholders informed. There was a significant improvement in satisfaction of parent engagement by participants who …

Forecast La: Thinking About The Future, Thomas And Dorothy Leavey Center For The Study Of Los Angeles

StudyLA Data Briefs

ABOUT THIS STUDY

The 2024 Angeleno Poll conducted by StudyLA involved telephone sessions, online, and face-to-face surveys with 2,011 adults living in Los Angeles County. The survey was conducted in English, Spanish, Mandarin, and Korean. Respondents were asked a range of questions on various issues like policing, housing, climate change, and so on to gauge what Angelenos think about these crucial issues facing our society at present.

ABOUT THIS REPORT

Survey results are presented in two sections: (1) toplines, or total responses for each question and (2) crosstabs, or all questions crossed by major demographics. The following report presents data …

(Meta-)Physical Artworks: Digital Augmentation In Art Observation, Macy A. Toppan

Dartmouth College Master’s Theses

Augmented art— the subgenre of art that incorporates physical and digital artwork— is a rapidly growing field driven by advancing technology and a new generation for whom that tech is a given. Yet the presence of media like augmented and virtual reality in exhibition remains a controversial subject. Rather than focusing on the many theoretical debates about whether digital pieces can qualify as "good" art, we study it in practice through the eyes of the casual art observer. This paper highlights the audience in a within-participant study that asked viewers to take in a physical sculpture intentionally built with virtual …

Potential Advantages And Disadvantages Of Case Study As Methodological Approach In Streetscape Research, Ferdy Sabono, Indah Widiastuti, Iwan Sudradjat

NAKHARA (Journal of Environmental Design and Planning)

In recent decades, streetscape research has advanced quickly in tandem with societal understanding of the impact of urban environmental quality on aesthetic satisfaction and urban dwellers' well-being. The case study method is one of the methodological approaches that has grown in popularity in streetscape research. However, no researchers have yet conducted a comprehensive investigation into the efficacy of case studies when used in streetscape research. Based on the experiences and findings of other researchers using case studies as their research design, this study explores the potential advantages and drawbacks of using case studies in streetscape research. The study uses the …

Study Of Antibiotics Resistance And Biofilm Formation Of Staphylococcus Aureus, Lamyaa Khalid Muhammed, Ali Jaffar Saleem

Al-Nisour Journal for Medical Sciences

The aim of this study is to assess the biofilm-production rates in clinical S. aureus isolates and to correlate between multidrug resistance and their biofilm-forming capacity. One hundred ninety (190) clinical specimens were collected from different clinical sources (wounds, burns, urine, ear and blood) in Diyala province, during the period from September 15/ 2022 to December 15/ 2022. The isolates were diagnosed morphologically, microscopically, biochemically and confirmed by 16SrRNA detection. All isolates were investigated for antibiotic sensitivity, using the disc diffusion method. The isolates under test showed a high resistance 100% to OX, while the rates of resistance ranged from …