Digital Commons Network^™

Media Availability: Political Experts Comment On Significance Of New Hampshire Presidential Primary, Robbin Ray

Media Relations

No abstract provided.

Human Pluripotent Stem Cell Modeling Of Alveolar Type 2 Cell Dysfunction Caused By Abca3 Mutations, Yuliang L Sun, Erin E Hennessey, Hillary Heins, Ping Yang, Carlos Villacorta-Martin, Julian Kwan, Krithi Gopalan, Marianne James, Andrew Emili, F. Sessions Cole, Jennifer A. Wambach, Darrell N. Kotton

2020-Current year OA Pubs

Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial lung disease (chILD). Treatments for patients with pathological variants of ABCA3 mutations are limited, in part due to a lack of understanding of disease pathogenesis resulting from an inability to access primary AEC2s from affected children. Here, we report the generation of AEC2s from affected patient induced pluripotent stem cells (iPSCs) carrying homozygous versions of multiple ABCA3 mutations. We generated syngeneic CRISPR/Cas9 gene-corrected and uncorrected iPSCs and ABCA3-mutant knockin ABCA3:GFP …

Catalytic Isoforms Of Amp-Activated Protein Kinase Differentially Regulate Impdh Activity And Photoreceptor Neuron Function, Tae Jun Lee, Yo Sasaki, Philip A. Ruzycki, Norimitsu Ban, Joseph B. Lin, Hung-Ting Wu, Andrea Santeford, Rajendra S. Apte

2020-Current year OA Pubs

AMP-activated protein kinase (AMPK) plays a crucial role in maintaining ATP homeostasis in photoreceptor neurons. AMPK is a heterotrimeric protein consisting of α, β, and γ subunits. The independent functions of the 2 isoforms of the catalytic α subunit, PRKAA1 and PRKAA2, are uncharacterized in specialized neurons, such as photoreceptors. Here, we demonstrate in mice that rod photoreceptors lacking PRKAA2, but not PRKAA1, showed altered levels of cGMP, GTP, and ATP, suggesting isoform-specific regulation of photoreceptor metabolism. Furthermore, PRKAA2-deficient mice displayed visual functional deficits on electroretinography and photoreceptor outer segment structural abnormalities on transmission electron microscopy consistent with neuronal dysfunction, …

Susceptibility Of Toxoplasma Gondii To Autophagy In Human Cells Relies On Multiple Interacting Parasite Loci, Nicholas Rinkenberger, Alex Rosenberg, Joshua B Radke, Jaya Bhushan, Tadakimi Tomita, Louis M Weiss, L David Sibley

2020-Current year OA Pubs

Autophagy is a process used by cells to recycle organelles and macromolecules and to eliminate intracellular pathogens. Previous studies have shown that some stains of

2024.01.18 - Audit And Academic/Student Affairs, Enrollment, And Technology Committees Meeting Minutes, Northeastern Illinois University Board Of Trustees

Board of Trustees - 2024

Meeting materials for the NEIU Audit and Academic/Student Affairs, Enrollment and Technology Committees

Approved Programs 1-16-24, Angela Brock

Programs Committee (PC)

No abstract provided.

The Radical Potential Of Creating Communities Of Care Through Art, Rhoda Rosen, Amanda Leigh Davis

University of Miami International and Comparative Law Review

No abstract provided.

The Uneven Legal Geographies Of Nutrition Entitlement Programs In The United States. Realizing Or Hindering The Right To Food?, Joshua Lohnes, Mackenzie Steele

University of Miami International and Comparative Law Review

Unlike many countries across the world, the United States government does not formally recognize the Right to Food in law. However, it funds and administers nutrition entitlement programs that play a significant role in mitigating hunger and food insecurity across the country. Reflecting on the socio-political dynamics that shape the legal spaces of nutrition entitlement in different places, this Article explores the uneven geographies of the Right to Food in two other countries (South Africa and Ecuador) and then turns its focus to the United States. This Article offers an overview of the two most extensive nutrition entitlement programs (SNAP …

Prevent Phishy Business: Comparing California’S And The United Kingdom’S Age-Appropriate Design Code To Protect Youth From Cybersecurity Threats, Morgan Comite

University of Miami International and Comparative Law Review

Cybersecurity is the safeguarding of computer systems and networks against information disclosure, theft, or damage to users’ hardware, software, or electronic data, as well as disruption or misdirection of the services computers and networks provide. Knowing privacy would be breached due to the impact of COVID, in 2020, the United Kingdom got ahead of the game and passed rules/regulations requiring online services to protect children under the age of eighteen from scams, phishing, and security attacks. However, currently, the United States does not have a sufficient uniform privacy law governed to protect children under the age of eighteen from cybersecurity …

Protecting The Promise To The Families Of Tuskegee: Banning The Use Of Persuasive Ai In Obtaining Informed Consent For Commercial Drug Trials, Jennifer S. Bard

San Diego Law Review

This is the first article to call for a ban on the use of AI technology designed to influence human decision-making, “Persuasive AI,” for the purpose of recruiting or enrolling human participants in drug trials sponsored by commercial entities. It does so from a perspective of precaution, not fear. Advances in Artificial Technology that can assist human decision-making have tremendous potential for good. It makes the case for doing so based on both the substantial risk of harm to the decision-making process and the ineffectiveness of intermediate regulatory measures. This Article looks directly at Persuasive AI, a type of AI …

Annual Comprehensive Financial Report, Knox County, For The Year Ended June 30, 2024, Tennessee. Comptroller Of The Treasury.

Tennessee County Audit Reports

No abstract provided.

Tomato Seedling Performance In Commercial Organic Growing Media, Elizabeth Maynard, Wenjing Guan, Petrus Langenhoven, Lori A. Hoagland

Department of Horticulture & Landscape Architecture Faculty Publications

Healthy transplants are critical to productivity in the field. For certified organic production in the United States, seedlings must be grown in media that meet the standards of the US Department of Agriculture’s National Organic Program. Many commercial organic media options are available, they vary substantially in composition, and it is unknown to what extent this influences seedling performance. This project compared tomato (Solanum lycopersicum L.) seedling emergence and growth in seven commercially available media for organic production and evaluated posttransplant performance. Tomato seedlings were grown in greenhouses at Wanatah, West Lafayette, and Vincennes, IN, USA. Chemical characteristics of …

High Tunnel Broccoli Cultivar Evaluations, Lewis Jett

Midwest Vegetable Trial Reports

Broccoli is a potentially profitable crop for high tunnel production. Updated information on yield and quality of new cultivars is important for producers making planting decisions. This evaluation of 11 cultivars was conducted within a high tunnel in Fall 2023.

Ucc Minutes 1-16-24, Angela Brock

UCC Agendas/Minutes

No abstract provided.

Lifespace Patterns Of College Students High And Low In Personal Intelligence, John D. Mayer

UNH Personality Lab

Personal intelligence (PI) refers to the capacity to accurately reason about personality in oneself and other people. We hypothesize that people who are higher in personal intelligence differ from others in their relationships and behaviors. We conducted a series of theoretically-guided studies to examine how PI is associated with a person’s self-reported activities, interactions, situations, and group memberships: their lifespace. In two archival and three new studies of college students (Ns = 385, 358, 1186, 416, 696, respectively) we first identified 15 short, factor-based scales describing aspects of college students’ lifespace that are potentially relevant to personal intelligence. …

Knowledge, Attitudes, And Subjective Norms Associated With Covid-19 Vaccination Among Pregnant Women In Kenya: An Online Cross-Sectional Pilot Study Using Whatsapp, Sylvia Ayieko, Walter Jaoko, Rose Okoyo Opiyo, Elkanah Omenge Orang'o, Sarah E Messiah, Kimberly Baker, Christine Markham

Faculty, Staff and Student Publications

COVID-19 vaccination during pregnancy has been recommended, but the perceptions related to uptake remain unexplored. This pilot study aimed to explore how perceptions influence COVID-19 vaccine uptake among a sample of 115 pregnant women in Kenya, recruited via WhatsApp. Data were collected using an adapted online questionnaire between May and October 2022. Logistic analyses assessed the relationship between COVID-19 vaccination uptake and the Theory of Reasoned Action (TRA) constructs: attitudes and subjective norms. COVID-19 vaccination coverage was 73%, with vaccine hesitancy estimated at 41.4% among the unvaccinated group. Most participants had completed college education and had good knowledge of COVID-19 …

Revamping Green Securitization Frameworks In The Eu, Samuel Pinson

University of Miami International and Comparative Law Review

Sustainable finance and green investments have grown from a trend to a dominant investment strategy throughout asset classes globally, and the EU is no exception. The EU published its Green New Deal and Sustainable Finance Strategy as roadmaps toward a more sustainable and equitable future. The twin reports contain comprehensive plans and initiatives to make sustainable finance more accessible through effective regulation. Stemming from those initiatives were various regulatory frameworks such as the EU Taxonomy, the Corporate Sustainability Reporting Directive, the Sustainable Finance Disclosure Regulation, and the EU Green Bond Standard. The regulations above are aimed at everything from public …

Between Religion And Politics: The Case Of The Islamic Movement In Israel, Suheir Abu Oksa Daoud

Political Science

The power of the “moderate” branch of the Islamic Movement (Alharaka al-Islamiyya, subsequently referred to as IM) Southern Faction (IMSF) in Israel stems from its ability to adapt to different situations, reconcile with the complex reality of being an indigenous minority in a state that defines itself a “Jewish state”, and operate within the state structure accepting democratic processes that have long been debated to clash with Islamism. Besides being represented in the Israeli Knesset since 1996, the culmination of this adaptation was the joining of the movement to the short-lived Zionist coalition government on 2 June 2021 (the government …

Ndls Communicator: Week Of 01.16.24, Notre Dame Law School

NDLS Communicator

The Latest News

• Marcus Cole was a guest on the IBJ News podcast: "Off the Record."
• The podcast features interviews with IBJ Media's Indiana 250, a list of the state’s most influential and impactful leaders across business, philanthropy, the arts, government and not-for-profits.
• Mary Ellen O'Connell provided her views in a Forever Wars article about South Africa's compelling case under the Genocide Convention in the International Court of Justice against Israel.
• Carter Snead was a featured presenter this week at the 2024 Congreso Futuro conference at the CEINA Cultural Center at the Metro University of Chile.
• Nicole Garnett wrote, "Time …

Turning Fake Data Into Fake News: Ai Training Set As A Trojan Horse Of Misinformation, Bill Tomlinson, Donald J. Patterson, Andrew W. Torrance

San Diego Law Review

Generative artificial intelligence (AI) offers tremendous benefits to society. However, these benefits must be carefully weighed against the societal damage AI can also cause. Dangers posed by inaccurate training sets have been raised by many authors. These include racial discrimination, sexual bias, and other pernicious forms of misinformation. One remedy to such problems is to ensure that training sets used to teach AI models are correct and that the data upon which they rely are accurate. An assumption behind this correction is that data inaccuracies are inadvertent mistakes. However, a darker possibility exists: the deliberate seeding of training sets with …

Residential Metals Abatement Program Investigation Summary Report (Non-Residential Parcels – Indoor Dust) East Middle School, Environmental Resource Management (Erm)

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Gene Editing Of Pigs To Control Influenza A Virus Infections, Taeyong Kwon, Bianca L. Artiaga, Chester D. Mcdowell, Kristin M. Whitworth, Kevin D. Wells, Randall S. Prather, Gustavo Delhon, Mark Cigan, Stephen N. White, Jamie Retallick, Natasha N. Gaudreault, Igor Morozov, Juergen A. Richt

School of Veterinary and Biomedical Sciences: Faculty Publications

Proteolytic activation of the hemagglutinin (HA) glycoprotein by host cellular proteases is pivotal for influenza A virus (IAV) infectivity. Highly pathogenic avian influenza viruses possess the multibasic cleavage site of the HA which is cleaved by ubiquitous proteases, such as furin; in contrast, the monobasic HA motif is recognized and activated by trypsin-like proteases, such as the transmembrane serine protease 2 (TMPRSS2). Here, we aimed to determine the effects of TMPRSS2 on the replication of pandemic H1N1 and H3N2 subtype IAVs in the natural host, the pig. The use of the CRISPR/Cas 9 system led to the establishment of homozygous …

Computer Self-Efficacy, Computer Anxiety And Information Retrieval Skills As Correlate Of Electronic Library Use Among Lis Undergraduates In Southern Nigeria Universities., Lucky O. Akpojotor

Library Philosophy and Practice (e-journal)

The study examined computer self-efficacy, computer anxiety and information retrieval skills as correlate of electronic library use among library and information science undergraduates in universities in Southern Nigeria. One research question guided the study while one hypothesis was tested at 0.05 level of significance. The correlational research design was adopted for the study. The population of the study was 10,345 library and information science (LIS) undergraduates from ten federal, seventeen state and eight private universities in Southern Nigeria. The study explores purposive and quota sampling technique to determine the sample size which arrived at 1, 006 used for the study. …

Host Ip3r Channels Are Dispensable For Rotavirus Ca2+ Signaling But Critical For Intercellular Ca2+ Waves That Prime Uninfected Cells For Rapid Virus Spread, Jacob L Perry, Francesca J Scribano, John T Gebert, Kristen A Engevik, Jenna M Ellis, Joseph M Hyser

Faculty, Staff and Students Publications

Many viruses exploit host Ca2+ signaling to facilitate their replication; however, little is known about how Ca2+ signals from different host and viral channels contribute to the overall dysregulation of Ca2+ signaling or promote virus replication. Using cells lacking IP3R, a host ER Ca2+ channel, we delineated intracellular Ca2+ signals within virus-infected cells and intercellular Ca2+ waves (ICWs), which increased Ca2+ signaling in neighboring, uninfected cells. In infected cells, IP3R was dispensable for rotavirus-induced Ca2+ signaling and replication, suggesting the rotavirus NSP4 viroporin supplies these signals. However, IP3R-mediated ICWs increase rotavirus replication kinetics and spread, indicating that the Ca2+ signals …

Expanded T Lymphocytes In The Cerebrospinal Fluid Of Multiple Sclerosis Patients Are Specific For Epstein-Barr-Virus-Infected B Cells, Assaf Gottlieb, H Phuong T Pham, Jerome G Saltarrelli, J William Lindsey

Faculty, Staff and Student Publications

Epstein-Barr virus (EBV) infection has long been associated with multiple sclerosis (MS), but the role of EBV in the pathogenesis of MS is not clear. Our hypothesis is that a major fraction of the expanded clones of T lymphocytes in the cerebrospinal fluid (CSF) are specific for autologous EBV-infected B cells. We obtained blood and CSF samples from eight relapsing-remitting patients in the process of diagnosis. We stimulated cells from the blood with autologous EBV-infected lymphoblastoid cell lines (LCL), EBV, varicella zoster virus, influenza, and candida and sorted the responding cells with flow cytometry after 6 d. We sequenced the …

Metabolomic Rewiring Promotes Endocrine Therapy Resistance In Breast Cancer, Songyeon Ahn, Jun Hyoung Park, Sandra L Grimm, Danthasinghe Waduge Badrajee Piyarathna, Tagari Samanta, Vasanta Putluri, Dereck Mezquita, Suzanne A W Fuqua, Nagireddy Putluri, Cristian Coarfa, Benny Abraham Kaipparettu

Faculty, Staff and Students Publications

Approximately one-third of endocrine-treated women with estrogen receptor-alpha positive (ER+) breast cancers (BC) are at risk of recurrence due to intrinsic or acquired resistance. Thus, it is vital to understand the mechanisms underlying endocrine therapy resistance in ER+ BC to improve patient treatment. Mitochondrial fatty acid β-oxidation (FAO) has been shown to be a major metabolic pathway in triple-negative BC (TNBC) that can activate Src signaling. Here, we found metabolic reprogramming that increases FAO in ER+ BC as a mechanism of resistance to endocrine therapy. A metabolically relevant, integrated gene signature was derived from transcriptomic, metabolomic, and lipidomic analyses in …

The Respiratory Enzyme Complex Rnf Is Vital For Metabolic Adaptation And Virulence In Fusobacterium Nucleatum, Timmie A Britton, Chenggang Wu, Yi-Wei Chen, Dana Franklin, Yimin Chen, Martha I Camacho, Truc T Luong, Asis Das, Hung Ton-That

Faculty, Staff and Student Publications

The Gram-negative oral pathobiont Fusobacterium nucleatum can traverse to extra-oral sites such as placenta and colon, promoting adverse pregnancy outcomes and colorectal cancer, respectively. How this anaerobe sustains many metabolically changing environments enabling its virulence potential remains unclear. Informed by our genome-wide transposon mutagenesis, we report here that the highly conserved Rhodobacter nitrogen-fixation (Rnf) complex, encoded by the rnfCDGEAB gene cluster, is key to fusobacterial metabolic adaptation and virulence. Genetic disruption of the Rnf complex via non-polar, in-frame deletion of rnfC (ΔrnfC) abrogates polymicrobial interaction (or coaggregation) associated with adhesin RadD and biofilm formation. The defect in coaggregation …

In-Patient Evolution Of A High-Persister Escherichia Coli Strain With Reduced In Vivo Antibiotic Susceptibility, Joshua B Parsons, Ashelyn E Sidders, Amanda Z Velez, Blake M Hanson, Michelle Angeles-Solano, Felicia Ruffin, Sarah E Rowe, Cesar A Arias, Vance G Fowler, Joshua T Thaden, Brian P Conlon

Faculty, Staff and Student Publications

Gram-negative bacterial bloodstream infections (GNB-BSI) are common and frequently lethal. Despite appropriate antibiotic treatment, relapse of GNB-BSI with the same bacterial strain is common and associated with poor clinical outcomes and high healthcare costs. The role of persister cells, which are sub-populations of bacteria that survive for prolonged periods in the presence of bactericidal antibiotics, in relapse of GNB-BSI is unclear. Using a cohort of patients with relapsed GNB-BSI, we aimed to determine how the pathogen evolves within the patient between the initial and subsequent episodes of GNB-BSI and how these changes impact persistence. Using

Resolving Acne With Optimized Adapalene Microspongeal Gel, In Vivo And Clinical Evaluations, Rania Yehia, Dalia Attia, M. M. Elmazar

Pharmacy

In our pursuit of enhancing acne treatment while minimizing side effects, we developed tailored Adapalene microsponges (MS) optimized using a Box–Behnken design 33. The independent variables, Eudragit RS100 percentage in the polymer mixture, organic phase volume, and drug to polymer percentage, were explored. The optimized formulation exhibited remarkable characteristics, with a 98.3% ± 1.6 production yield, 97.3% ± 1.64 entrapment efficiency, and a particle size of 31.8 ± 1.1 μm. Notably, it achieved a 24 h cumulative drug release of 75.1% ± 1.4. To delve deeper into its efficacy, we evaluated the optimized microspongeal-gel in vitro, in vivo, and clinically. …

Is Limit, Shubham Dubey Visa, Ishani Basu Visa, Surbhi Sharma Visa

Defensive Publications Series

The present disclosure relates to Installment Solutions (IS limit). Particularly, the present disclosure provides a system and method for splitting the existing card limit of a cardholder into a regular and Installment Solutions (IS limit) and defining plans for IS limit. The method further comprises issuing a virtual sub-PAN for IS limit and push provision to eligible merchant apps; and at the time of checkout, selecting sub-PAN as payment mode by the cardholder, where all transactions under the sub-PAN are aggregated during the billing cycle and split into EMIs based on pre-defined plan.