Digital Commons Network^™

Ultra-Rapid Electrophilic Cysteine Arylation Using Pyridinium Salts, Bradley M. Lipka

Open Access Dissertations

Small molecule-based bioconjugation enables in vitro and in vivo functionalization of proteins and peptides, significantly expanding the chemical space of biomacromolecules. Among these transformations, nucleophilic aromatic substitution (S_NAr) of cysteine residues is a widely employed strategy for protein bioconjugation.

Although many reagents facilitate cysteine arylation, they are disadvantageous in two crucial aspects - limited synthetic modularity and undesired hydrophobicity. First, conventional cysteine arylating reagents are frequently activated by multiple electron-withdrawing groups (EWGs) on a single aromatic ring, leaving few synthetic handles to derivatize the reagents for advanced applications. Second, these labeling reagents are generally hydrophobic in nature and …

Synthesis And Evaluation Of Anti-Hiv Activity Of Fatty Acyl Conjugates Of Tenofovir Alefanamide, Muhammad Sajid, Naglaa Salem El-Sayed, Louise A. Ouattara, Amita Verma, Gustavo F. Doncel, Keykavous Parang, M. Iqbal Choudhary, Hina Siddiqui

CONRAD Publications

The activity of nucleoside and nucleotide analogs as antiviral agents requires phosphorylation by intracellular enzymes. Phosphate-substituted analogs have low bioavailability due to the presence of ionizable negatively-charged groups. To circumvent this limitation, several prodrug approaches have been proposed and developed. Herein, we hypothesized that the conjugation of anti-HIV fatty acids with the nucleotide tenofovir alafenamide (TAF) (1) could improve the anti-HIV activity of the nucleotide. Several fatty acyl amide conjugates of TAF were synthesized and evaluated in comparative studies with TAF. The synthesized compounds were evaluated as racemic mixtures for anti-HIV activity in vitro in a single-round HIV-1 infection assay …

Environmentally Friendly Chelation For Enhanced Algal Biomass Deashing, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

High ash content in algal biomass limits its suitability for biofuel production by reducing combustion efficiency and increasing fouling. This study presents a green deashing strategy using nitrilotriacetic acid (NTA) and deionized (DI) water to purify Scenedesmus algae, which was selected for its high ash removal potential. The optimized sequential treatment (DI, NTA chelation, and DI+NTA treatment at 90–130 °C) achieved up to 83.07% ash removal, reducing ash content from 15.2% to 3.8%. Elevated temperatures enhanced the removal of calcium, magnesium, and potassium, while heavy metals like lead and copper were reduced below detection limits. CHN analysis confirmed minimal …

Data Injustice In Global Justice, Asaf Lubin, Cherry Tang

Articles by Maurer Faculty

In May 2020, the United Nations Secretary-General unveiled a sweeping “Data Strategy for Action by Everyone, Everywhere,” seeking to unlock the UN’s “full data potential.” The International Criminal Court’s Office of the Prosecutor followed suit, declaring in 2023 its intent to acquire advanced cyber forensic tools so as to hold the “widest range of digital evidence globally.” Across international institutions, data-driven governance has become the norm, with humanitarian agencies and tribunals transforming into “data hubs and information clearinghouses.” This Article critiques the unfettered datafication of global justice by international courts and organizations. These entities have aggressively expanded their data-driven operations …

Climate Prosecution As Climate Regulation, Cindy J. Cho

Articles by Maurer Faculty

Last term, the Supreme Court weakened the federal government’s ability to regulate. Three new decisions—and one landmark case from the previous term—will affect everything from drug approvals to overtime pay to national security. One issue stands out as a political flashpoint that will prove particularly difficult to address via regulation in the wake of this term: climate change. Given the unlikelihood of congressional climate action any time soon, those concerned about the risks of a warming planet will no doubt be looking for alternatives to regulation. Private and state civil lawsuits against polluters reflect an important legal tradition that must …

Sources Of Influence In Marriage And Parenting For Interfaith Couples, William D. Stanford, Justin J. Hendricks, Ted G. Futris, Loren D. Marks, David C. Dollahite

Faculty Publications

Interfaith marriages are increasingly common, yet research on their family dynamics and sources of influence in family functioning remains limited. Relatedly, although research highlights religion’s influence on family processes, most studies only include same-faith couples. Subsequently, we qualitatively explored the experiences of 32 happily married interfaith couples, examining their sources of guidance in marriage and parenting, reasons for rejecting influences, and the role of religion in their family functioning. We identified one theme of rejecting outside influence and five key themes/sources of influence: one another/themselves, family, friends, media/professionals, and spiritual sources. Findings emphasize similarities between interfaith couples and American families …

"She's Such A Nice Girl": Exploring The Literacy And Identity Formation Practices Of Black Girls In White, Appalachian Communities, Tamicah Tierra Owens

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study examines the experiences and stories of two Black girls in predominantly White Appalachian communities, focusing on the language and literacy practices they employ to navigate and make sense of their Black feminine identities. It focuses on how literacy and language skills acquired from spending quality time with their mothers, engaging in various spaces with friends, and engaging in interest-driven traditional media and/or social media helped them to analyze their communities’ and the larger landscapes’ discourses around race and gender to create and modify their desired identities. This qualitative study employs narrative case study to center the lived experiences …

Public Constitutional Ai, Gilad Abiri

Georgia Law Review

We are increasingly subjected to the power of AI authorities. Machine learning models now underpin algorithmic markets, determine whose speech is amplified or restricted, shape government decisions ranging from resource allocation to predictive policing, and influence our access to information on critical issues such as voting and public health. As AI decisions become inescapable, entering domains such as healthcare, education, and law, we must confront a vital question: How can we ensure that AI systems, which increasingly regulate our lives and make decisions that shape our societies, have the authority and legitimacy necessary for effective governance?

To secure AI legitimacy, …

Surveillance As Retaliation, Daiquiri J. Steele

Georgia Law Review

Employers have a myriad of technologies at their disposal to help them surveil their employees, and they deploy these technologies for several reasons. Some of these reasons—e.g., monitoring time and attendance, ensuring compliance with occupational safety standards, protecting against certain data disclosure, etc.—are legitimate. Others are not. Chief among the illegitimate reasons is monitoring employees in retaliation for reporting alleged employer misconduct internally or externally. Just as terminating, demoting, or transferring an employee constitutes an adverse action for retaliation claims, subjecting an employee to surveillance because the employee has engaged in protected activity is also an adverse action. Courts and …

Protecting “Learned Hands”: Table Saw Injuries, The Sawstop Saga, And How Our Design Defect Doctrine Is Disincentivizing Safety, Tanner P. Samples

Georgia Law Review

The American judicial system has been grappling with the grisly realities of industrial carnage for over one hundred years. From Justice Cardozo’s storied expansion of manufacturer liability to the regulatory explosion of the 1960s, our nation has struggled to balance the personal freedom of consumers with the dangers of modern machinery. The winding morass of products liability law has afforded plaintiffs some degree of protection from the wily manufacturer, but most would agree that advancements in safety technology have prevented more consumer harm than any tort claim or cause of action.

Despite the unquestionable utility of safety advancements, analysis of …

Penneast Pipeline And The Policy Implications Of The Private Use Of Eminent Domain, Emily C. Wood

Georgia Law Review

This Note considers the modern implications of the takings power in light of PennEast Pipeline Co. v. New Jersey, a 2021 U.S. Supreme Court decision holding that states do not have the right to exercise state sovereign immunity against private parties holding congressionally delegated authority. Against current environmental conditions and recent takings power history, this Note then examines the delegation power of Congress and the public policy implications of the present administrative scheme—as compared to the typical exercise of the federal eminent domain power. Finally, this Note argues that the current administrative scheme ultimately removes important decisions impacting local …

Suffolk University Academic Catalog, College Of Arts And Sciences And School Of Management, 2025-2026, Suffolk University

College of Arts and Sciences and Sawyer Business School Academic Catalogs

This catalog contains information for the day, evening, and graduate programs.

Using Advanced Machine Learning To Evaluate The Spatial And Temporal Patterns Of Human–Bear Interactions In Maryland, Usa, Katherine A. Kurth, Jonathan K. Trudeau

Human–Wildlife Interactions

American black bears (Ursus americanus) are highly adaptable to human-dominated areas, which can lead to interactions with humans. Managing these interactions is a priority for many wildlife agencies in North America. Climate-induced shortages in natural food can exacerbate human–bear interactions, as bears are driven to seek alternative food sources in human-dominated areas. However, few studies have investigated the impact of climate or weather on the frequency and severity of human–bear interactions. In Maryland, USA, no research has examined the anthropogenic or environmental factors contributing to human–bear interactions, even though reported interactions have consistently increased since the 1990s. Our …

Annual Report, Fiscal Year 2025, Tennessee. Department Of Correction

Annual Reports

This document is the annual report for the Tennessee Department of Correction during the fiscal year.

Forward Progress: The Rooney Rule And Its Post-Sffa Relevance, N. Jeremi Duru

Scholarly Articles in Law Reviews & Journals

In 2003, the National Football League (NFL), which had long struggled with racial inequity both on and off the field, implemented a policy known as the Rooney Rule, requiring that any league club searching for a head coach interview at least one person of color before making a hire. In the over two decades since, employers of all sorts seeking to increase opportunities for people of color and women have adopted a form of the Rule. Indeed, it has gained traction from coast to coast. Hundreds of American employers utilize the Rooney Rule or a policy derived therefrom. In the …

Criminalizing Ecocide: An Opportunity To Embed The Inseparability Of Humans From Nature Into The Law, Rebecca Hamilton

Scholarly Articles in Law Reviews & Journals

Amid widespread acknowledgment that we live on a planet in peril, the term “ecocide” packs a powerful rhetorical punch. Extant regulatory approaches to environmental protection feel insufficient in the face of the triple threat of climate change, pollution, and biodiversity loss. International criminal prosecution for ecocide, by contrast, promises to meet the moment, and a recent proposal to introduce ecocide into the canon of core international crimes is gaining traction. Assuming the push to criminalize ecocide continues to gain momentum, this Article argues that the primary (and perhaps, sole) benefit that international criminal law can offer in this context is …

Digital Evidence: Facilitating What And For Whom?, Rebecca Hamilton, Adebayo Okeowo

Scholarly Articles in Law Reviews & Journals

The emergence of user-generated evidence has revolutionized how atrocities and human rights violations are documented globally. Since 2011, when Syrian human rights defenders began documenting atrocities on their smartphones, a professional field has emerged around the collection, authentication, and preservation of digital evidence. However, this professionalization has created unintended consequences, as expertise and verification power shifted away from frontline communities to Global North institutions. This Article examines this tension through two case studies: the Rohingya Genocide Archive, and Nigeria's #EndSARS movement. These examples demonstrate both the power of locally-informed evidence collection and the challenges when verification skills remain concentrated among …

Educational Behavioral Strategies For Students Who Have Encountered Adverse Childhood Experiences, Andrea J. Sullivan

Theses, Dissertations and Capstones

Adverse childhood experiences (ACEs) affect approximately 1 in 4 children in the United States, often resulting in behavioral and developmental challenges within school settings. This qualitative case study applied Thomas et al.’s (2019) trauma-informed framework to examine the extent to which 15 Title I elementary teachers in a rural West Virginia district implemented evidence-based practices to address trauma-related behaviors. Using semi-structured virtual interviews and a peer-reviewed protocol, data were thematically analyzed across key domains including trauma screening, interdisciplinary collaboration, positive behavior intervention systems (PBIS), cognitive-behavioral strategies, restorative practices, multitiered systems of support (MTSS), social emotional learning (SEL), and family engagement. …

A New Chapter: Therapeutic Jurisprudence And The Path To Financial Rehabilitation In Bankruptcy Law, Karni Perlman, Itay Krayden

UIC Law Review

No abstract provided.

Uncharted Success: Expanding Metrics For Community Court Impact, Tamar Ben-Dror, Hadar Dancig-Rosenberg, Tali Gal

UIC Law Review

No abstract provided.

The End Of Prison Gerrymandering: Has Illinois Done Enough To End Prison Gerrymandering By 2030?, Isabel Beebe

UIC Law Review

No abstract provided.

The Right To Be Heard, Skylar Nafziger

UIC Law Review

No abstract provided.

Barefoot Justice For Pro Se Litigants In Immigration Proceedings, Sabrina Rivera

UIC Law Review

No abstract provided.

Pure//Evil Part One: How Evil Is Popularized As Truth In The Marketplace Of Ideas, Joshua J. Schroeder

UIC Law Review

No abstract provided.

Supervised Injection Sites After Safehouse: The Case For A Federal Policy Of Non-Enforcement And Research-Based Operation, Sebastian Rozpadek

UIC Law Review

No abstract provided.

Concerning The Creation Of Tax Incentives To Support The Film Festival Industry, Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

“Hope Is The Only Thing We Have”: Same-Sex Marriage In Hindu Traditions And The Modern Indian Legal System, Ruth Vanita

Global Humanities and Religions Faculty Publications

No abstract provided.

Characterization Of The Slc7a5/Slc3a2 Amino Acid Transporter In Human Pleural Mesothelial Cells, Ann Francis

Biotechnology Theses

The SLC7A5/SLC3A2 amino acid transporter moves essential amino acids, such as leucine, phenylalanine, and tryptophan, across the cellular plasma membrane. SLC7A5 overexpression was identified in diverse cancers, suggesting a role in tumorigenesis and cancer cell proliferation. However, the role of SLC7A5/SLC3A2 in other aggressive cellular phenotypes, including mesothelial mesenchymal transition (MesoMT), remains unexplored. RNA sequencing analyses identified SLC7A5 as one of three highly upregulated SLCs in mesothelial cell derived myofibroblasts. This sodium independent transporter exhibits a high affinity for branched chain amino acids such as leucine; however, what role, if any, this channel plays in MesoMT is unclear. SLC7A5 knockdown …

Activist Directors: The Evolution Of Hedge Fund Activism In The S&P 500, Anna Christie

Connecticut Law Review

The prevailing rhetoric associated with hedge fund activism is almost universally negative. This Article provides new evidence of activist hedge fund behavior that contradicts this dominant narrative. The principal argument of the Article is that the conventional picture of hedge fund activism requires updating to account for the phenomenon of activist board representation.

This Article makes two general contributions to academic and policy debates on hedge fund activism. First, it analyzes original, hand-collected data on all activist hedge fund campaigns at S&P 500 companies from 2010 to 2019. Currently, there is continued reliance on empirical studies of hedge fund activism …

On “Self” Care, Suzanne A. Kim

Connecticut Law Review

The dominant answer to popular calls for self care in everyday discourse is a thriving eleven billion dollar industry. The self care economy encompasses workplace wellness programs, consumer goods and services, and entrepreneurship. This infrastructure revolves around commercial consumers and providers and advances through conceptions of health and well-being centered on individuals.

Despite their prevalence, the concept and provision of self care have gone underexamined in legal critiques of societal underinvestment in care. This Article fills this gap by exploring the social construction of the dominant contemporary conception of self care in the United States, one that continues to be …