Digital Commons Network^™

St6galnac-I Regulates Tumor Cell Sialylation Via Nectin2/Muc5ac-Mediated Immunosuppression And Angiogenesis In Non-Small Cell Lung Cancer, Muthamil Iniyan Appadurai, Sanjib Chaudhary, Ashu Shah, Gopalakrishnan Natarajan, Zahraa W. Alsafwani, Parvez Khan, Dhananjay D. Shinde, Subodh M. Lele, Lynette M. Smith, Mohd W. Nasser, Surinder K. Batra, Apar Kishor Ganti, Imayavaramban Lakshmanan

Journal Articles: Biochemistry & Molecular Biology

Glycosylation controls immune evasion, tumor progression, and metastasis. However, how tumor cell sialylation regulates immune evasion remains poorly characterized. ST6GalNAc-I, a sialyltransferase that conjugates sialic acid to the glycans in glycoproteins, was overexpressed in an aggressive-type KPA (KrasG12D/+ Trp53R172H/+ Ad-Cre) lung adenocarcinoma (LUAD) model and patient samples. Proteomic and biochemical analysis indicated that ST6GalNAc-I mediated NECTIN2 sialylation in LUAD cells. ST6GalNAc-I-deficient tumor cells cocultured with T cells were more susceptible to T cell-mediated tumor cell killing, indicating a key role for NECTIN2 in T cell dysfunction. Mice injected with St6galnac-I-knockdown syngeneic cells showed reduced lung tumor incidence and Nectin2/Tigit-associated immunosuppression. …

The Effects Of Sugar Alcohols On The Growth Of Cariogenic Bacteria, Jake Sanders Boone

UNLV Theses, Dissertations, Professional Papers, and Capstones

The purpose of this study was to examine the potential of sugar alcohols, commonly used as sugar substitutes to reduce the activity of dental caries causing bacteria. Specifically, the sugar alcohols xylitol, erythritol, sorbitol, and mannitol were placed into the growth media of Streptococcus mutans and Lactobacillus acidophilus. The effects on their bacterial growth were observed. 10% xylitol, 10% erythritol, 10% sorbitol, 10% mannitol, 5% xylitol + 5% erythritol, and 3.3% erythritol + 3.3% xylitol + 3.3% sorbitol combinations were compared to the control groups for differences in bacterial growth. S. mutans samples were significantly inhibited by all groups except …

Clustering Of Internet Behaviors And Associated Mental Health Outcomes Among U.S. Adolescents, Aakansha Singh

UNLV Theses, Dissertations, Professional Papers, and Capstones

In recent years, the Internet has become an integral part of daily life, influencing education, work, and recreation. As of 2024, approximately two-thirds of the global population is online, with an estimated one-third of users under the age of 18. Given the potential long-term effects of excessive Internet use on health and well-being, adolescents represent a critical population for monitoring online behaviors. This study used baseline data from the SHARE project and conducted a latent class analysis (LCA) to identify patterns of Internet use among a sample of adolescents and the relationship of class membership with mental health outcomes, including …

Less Pain, More Game: Red Kinesiology Tape On Carpal Tunnel Syndrome And Occupational Performance In Fps Esports, Sarah Ashley Taing

UNLV Theses, Dissertations, Professional Papers, and Capstones

Esports encompasses competitive video gaming, requiring tactical, mental, and physical skills. It offers benefits like improved cognition and social inclusion but poses risks such as musculoskeletal disorders (MSD) from repetitive movements. Prolonged gaming can lead to Carpal Tunnel Syndrome (CTS), with symptom severity correlating with gaming duration (Bibi & Khan, 2019; Basuodan et al., 2023). Kinesiology tape (KT), a treatment used for decades, shows promise for pain relief and functional improvement (Kase et al., 2013). Developed in 1973 by Kase, KT increases circulation, reduces pain, and improves joint stability, though its effectiveness remains ambiguous. Additionally, the psychosocial impact of tape …

Specters Of Change: A Rhetorical And Qualitative Analysis Of Environmental Ghost Stories From Las Vegas Locals, Rachel J. Wuester

UNLV Theses, Dissertations, Professional Papers, and Capstones

This thesis explores “environmental ghost stories,” a term created to represent narratives that blend emotions and memories of ecological loss to make sense of environmental change. This project utilizes a mixed-methods approach that blends narrative theory, environmental rhetoric, and qualitative interviews to examine the narratives of chronic and acute changes experienced by long-term residents of Las Vegas, Nevada. Participants (N = 15) were required to have resided in the Las Vegas valley for a minimum of twenty years in order to have had the opportunity to witness both chronic and acute changes to their environment. Using a phronetic iterative approach …

Research And Reflections On Southeast Asian American Education And Advancement, Wayne E. Wright, Vikrant Chap, Phitsamay S. Uy, Chhany Sak-Humphry, Vichet Chhuon, Bryan Thao Worra

Purdue University Press Books

This book is in commemoration of the twentieth anniversary of the Journal of Southeast Asian American Education and Advancement (JSAAEA) and the fiftieth anniversary of Southeast Asian American refugee resettlement in the United States. Pivotal research articles, reviews, and creative works from past issues of JSAAEA have been selected for this volume to document the history and experiences of Cambodian, Laotian, Hmong, and Vietnamese Americans since initial refugee resettlement began in the United States in 1975, as well as the experiences of more recent Southeast Asian immigrant and refugee groups. Reviews of academic books, novels, memoirs, children’s books, and motion …

Exploring The Public Health Agency Of Canada’S And The Ontario Government’S Vaccine-Related Crisis Communication On X During The Covid-19 Pandemic, Sheraza Burney, Lori Donelle Phd, Rn, Fcan, Anita Kothari

Publications

Crisis communication strategies must be tailored to the unique nature of social media. In response to the COVID-19 pandemic, public health agencies have widely used social media to address vaccine hesitancy and misinformation. This research utilized the social media pandemic communication model to describe the key themes disseminated through the Ontario government and the Public Health Agency of Canada's vaccine-related crisis communication on X (formerly Twitter). Between 27 January 2020 and 6 April 2021, 1271 posts related to COVID-19 vaccination were collected from three official government X accounts—two from the province of Ontario and one from Canada. Posts were analyzed …

The Seed Pile Project - A Reflection, A. Haven Kiers, Caroline Larsen, Kate Hayes, Sahar Sadegh Malak Abadi, Ashley Hong, Billy Krimmel

Cities and the Environment (CATE)

We conducted a community-science project in Northern California - the Seed Pile Project - with three broad goals: 1) to test which locally-native, seed-dispersed plants would thrive without intervention in human-occupied spaces, 2) to engage the public with the often-ignored biodiversity along our roadsides, sidewalks, and other highly-disturbed spaces, and 3) to create community around rewilding our urban areas. We conducted the project initially as a pilot project in 2020-2021, then as a community-science project in 2021-2022 and 2022-2023. The project design was intentionally simple to make it accessible for participants of all ages: participants received free packets of native, …

Advancing Recovery Of Endangered San Joaquin Kit Foxes Through Urban Rewilding, Brian L. Cypher, Erica C. Kelly, Jaime L. Rudd

Cities and the Environment (CATE)

San Joaquin kit foxes (Vulpes macrotis mutica) are endemic to arid habitats in the San Joaquin Valley region of central California. This species is listed as Endangered due to profound habitat loss throughout its range caused by agricultural, industrial, and urban development. Interestingly, kit foxes currently occur in three cities with the population in the city of Bakersfield being large (several hundred foxes) and self-sustaining. Demographic and ecological attribute values for this population are among the highest observed in San Joaquin kit fox populations. Loss of natural habitat is still occurring and additional urban kit fox populations could …

Ethical Considerations In Lgbtqi+ Clinical Care, Thomas G. Plante

Psychology

Much recent attention has focused on the emerging area of LGBTQI+ health care and evidence-based best practices for professionals providing physical and mental health services to clients from this community. Advocacy and politics have also received a great deal of press attention that might impact the delivery of much needed professional health care services. Issues related to non-binary, transgender, and gender affirming health care have received perhaps the most attention and can be polarizing in some communities with politicians and state legislators weighing in and micromanaging access to available treatment as well. Psychologists and other health care professionals must be …

2025 Revised Draft Final Unreclaimed Sites Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

The Argument For Lobbyists: How Lobbying Brings Policy Experts Back Into The System, Luke Cambra

Washington Semester Program

No abstract provided.

Spectator 2025-05-15, Editors Of The Spectator

The Spectator

No abstract provided.

Quick And Easy Method For The Determination Of Cocaine And Six Metabolites In Postmortem Hair, Samantha C. Mulkeen

Student Theses

Hair testing is increasing in popularity in toxicology because of its long window of detection and ease of collection and sample storage. However, it has its limitations largely due to external contamination of drugs. In particular, cocaine (COC) is a common offender of this as it has several routes of consumption. Analyzing metabolites of COC may be the key to distinguishing between consumption and external contamination. The aim of the present study was to develop a quick, easy, and sensitive method for the detection and quantification of COC, benzoylecgonine (BE), norcocaine (NCOC), cocaethylene (CE), anhydroecgonine methyl ester (AEME), meta-hydroxy-cocaine (m-OH-COC), …

Unveiling The Underbelly Of Artificial Intelligence: The Inadequacies Of The Legal System With Regard To Victims Of Nonconsensual Sexual Deepfakes, Zilana Lee

Journal of Law and Policy

Artificial intelligence-powered deepfake technology has ushered a new era of digital sexual abuse, allowing for the seamless fabrication of explicit images that violate bodily autonomy with alarming realism. With little more than a photograph scraped from social media, individuals can use AI tools to fabricate hyper-realistic nude images and pornographic videos of people without their consent. These nonconsensual sexual deepfakes are rapidly spreading online, often going viral before victims are even aware of their existence. The technology can affect anyone, but women and girls remain disproportionately targeted. Recent incidents involving minors highlight both the reach and severity of this harm. …

The Jack Pine And Four Other Solo Piano Works Composed By Five Canadian Women In The Twenty-First Century, Huanwen Wang

Dissertations, 2020-current

This document aims to shine a light on five distinctive piano works by five twenty-first century Canadian women composers. The pieces are Minute Etudes (Book Two) (2002) by Emily Doolittle, From Wapta Ice (2003) by Diana McIntosh, The Jack Pine (2010) by Jocelyn Morlock, Smoke Darkened Sky (2021) by Kelly-Marie Murphy, and …our inner lives were entwined… embroidered with the same pattern... (2021) by Karen Sunabacka. The main objective of this document is to identify stylistic traits in the selected pieces, discuss the source of inspiration of each piece and illustrate how the musical elements reflect the source of …

Minimize Barriers, Maximize Success: Optimizing The Private Trumpet Lesson Experience For Students With Adhd, Stefanie M. Tetzloff

Dissertations, 2020-current

Attention Deficit Hyperactivity Disorder (ADHD) is a high-prevalence neurodevelopmental disability found in an estimated 6% to 16% of children ages 3-17 in the United States. A recent survey showed that 84% of private piano and string lesson instructors have taught students with disabilities and needed to adapt their teaching, but most cited having little to no education in how to appropriately do so. While public school teachers may receive support from specialists and recommended accommodations in an Individualized Education Program (IEP) or 504 plan, private lesson instructors may not be informed of a student’s disability and often lack resources to …

There’S A Crisis Brewing In Higher Education, Caroline M. Graham

Dissertations, 2020-current

This dissertation addresses the increasing need to enhance crisis preparedness among student affairs practitioners in higher education. With the growing frequency and complexity of campus crises—ranging from mental health emergencies to incidents of violence, the preparedness and self-efficacy of those in student support roles are paramount. This three-manuscript dissertation explores crisis intervention training, crisis self-efficacy, and the lived experiences of student affairs practitioners navigating campus crises. The first manuscript provides a conceptual overview of the gaps in current crisis intervention training within graduate programs, advocating for the integration of core competencies informed by accreditation standards and professional associations. The second …

Exploring Trauma Education And The Intersection Of Self-Efficacy, Ashlea Yearwood

Dissertations, 2020-current

Trauma education in counselor training programs is not only required for those accredited by the Council for Accreditation of Counseling and Related Educational Programs (CACREP), but a critical component in preparing counselors-in-training to work with clients who have been directly or indirectly impacted by a traumatic event. This three-article dissertation includes a conceptual manuscript, qualitative manuscript, and a quantitative manuscript regarding trauma education for counselors. The conceptual manuscript offers an approach to mitigating compassion fatigue through the utilization of attachment-based supervision when working with counselors-in-training. The qualitative manuscript aimed to utilize an interpretative phenomenological analysis to explore and understand what …

Ethics And Clinical Supervision: Understanding The Needs Of Counselors In Training And Self-Efficacy Development In Clinical Supervisors, Brooke Carroll

Dissertations, 2020-current

This dissertation examines foundational principles of ethics, clinical supervision, and clinical supervisor ethical decision-making self-efficacy development. Counselors-in-training, those who have completed their degrees but are not yet licensed, are profoundly impacted by their experience in clinical supervision. Therefore, it is imperative for the clinical supervisors who are leading this new generation of counselors to embody the highest respect and execution of ethical practice and ethical decision making. To do this, clinical supervisor ethical decision-making self-efficacy must be tended to, developed, and understood. When mastered, these clinical supervisors are better equipped to assist their supervisees through ethical dilemmas and critical incidents. …

Burnout And Self-Efficacy: Exploring The Rewards And Challenges Faced By Crisis Counselors Working In Emergency Department Settings, Ellen Dotas

Dissertations, 2020-current

This dissertation explores burnout and self-efficacy in counselors who work with clients in crisis in emergency department settings. Mental health and emergency departments are two areas that tend to report higher levels of burnout than are reported in other occupational fields. While much research has been done on the topics of burnout and self-efficacy, limited information is available about counselors who work in these crisis roles. This dissertation follows a three-manuscript format and includes a conceptual, qualitative, and quantitative manuscript. The conceptual manuscript explores the nature of the crisis assessment itself, focusing on the area of risk assessment. The qualitative …

Exploring Ecowellness And Attachment Dynamics: Understanding Parental Experiences, Youth Perceptions, And Counseling Implications, Katelyn Dolieslager

Dissertations, 2020-current

This dissertation investigated the way in which EcoWellness and Attachment Theory implications interact, specifically emphasizing how integrating these components can enhance clinical practice with caregivers and youth. The first component of the dissertation explored how EcoWellness principles could be applied to strengthen child attachment through family engagement in outdoor activities. The conceptual article discussed how shared outdoor play and recreation offer families the opportunity to bond, improve communication, and develop secure attachments. It provides a framework for clinicians to use EcoWellness to help children recognize their connection to the broader natural world, which fosters emotional growth and attachment. The second …

The Dynamics Of Us-Bangladesh Relations: Before, During And After The 1971 War Of Liberation, 1947-1975., Mdaminul Islam

Masters Theses, 2020-current

This thesis traces the dynamics relations between Bangladesh and the United States before, during and after the Liberation War of Bangladesh in 1971. The thesis argues that during the Cold War era the US wanted to build good relations with Pakistan to curb communism in the Middle East and the South Asia. As a result, during the Liberation War of Bangladesh in 1971, the Nixon administration did not support Bangladesh’s independence, even though US diplomats and other officials reported the ongoing genocide. Despite this fraught history and Bangladesh’s pro-Indian, pro-Soviet leanings, relations formed between independent Bangladesh and the United States …

The Performance Of Gender In Sound And Screen: Unpacking And Countering The Double Standards Of Women In Taylor Swift’S “The Man,” Brienne Of Tarth, And The Substance, Alexandra C. Ali

Masters Theses, 2020-current

This rhetorical analysis examines how femininity is constructed, policed, and resisted in popular culture through three case studies: Taylor Swift’s “The Man,” Brienne of Tarth from Game of Thrones, and The Substance, using the lens of Judith Butler’s theory of gender performativity. “The Man,” both the song and the music video, reveals the double standards working against women, incorporating an additional layer of analysis through Kenneth Burke’s perspective on incongruity. Brienne of Tarth from Game of Thrones defies gender expectations, blurring the line between the performance of masculinity and femininity. Additionally, this analysis embodies archetypes of women, such …

Confronting The Postcolonial Condition: A Study On The Blesser-Blessee Phenomenon In South Africa, Thandwa Maphalala

Masters Theses, 2020-current

Age-disparate relationships are causing a public health threat in South Africa and the region at large. However, these relationships and their effects are not unique to South Africa. There has been substantial research conducted to explore the social, cultural or economic meaning of this relationship type, its causes and effects in sub-Saharan Africa or in the interest of individual countries in the region. However, South Africa presents a special case for further study because the older men that adolescent girls and young women (AGYW) date and have sex with are commonly referred to as blessers.

The purpose of this …

College Golf Recruiting: A Qualitative Research Proposal Of Strategies, Challenges, Future Avenues And Best Practices, Nicolas Christian Schlickenrieder

Masters Theses, 2020-current

College golf recruiting is a complex process influenced by evolving factors such as Name, Image, and Likeness (NIL) policies and new alternative professional golf pathways. This qualitative study aims to fill this gap by examining the key strategies, challenges, and best practices National Collegiate Athletic Association (NCAA) Division I college golf coaches use in their recruitment processes. Utilizing interviews with twelve NCAA Division I golf coaches, this study explores how coaches identify potential recruits, evaluate talent, and navigate limitations such as scholarship availability and regulation compliance. Findings highlight the importance of tangible factors, such as tournament performance and statistical analysis, …

Formula 1’S Drive To Environmental Sustainability, Xenia Chiles

Seattle Journal of Technology, Environmental, & Innovation Law

This article explores Formula 1’s (F1) evolving commitment to environmental sustainability, examining the regulatory, technological, and institutional shifts that support its goal of achieving carbon neutrality by 2030. Despite its reputation as a resource-intensive sport, F1 has adopted meaningful reforms, ranging from hybrid power units and alternative fuels to eco-friendly manufacturing practices, without compromising performance. Through an analysis of the Fédération Internationale de l’Automobile’s (FIA) regulatory authority, stakeholder influence, and corporate social responsibility framework, the article argues that F1 is not merely greenwashing but genuinely redefining motorsport’s role in a climate-conscious era. It concludes that profitability and sustainability can—and increasingly …

Complexities Of Ai Trends: Threats To Data Privacy Legal Compliance, Esther Arokun

Seattle Journal of Technology, Environmental, & Innovation Law

This paper examines the intersection of artificial intelligence and data privacy, analyzing how innovations such as generative AI, large language models, and deepfakes are challenging current privacy laws and compliance frameworks. Through a comparative study of the GDPR and CCPA, this paper assesses regulatory gaps, identifies risks such as data misuse and security breaches, and proposes practical solutions, including privacy-by-design and stronger governance protocols. It offers a forward-looking approach to fostering legal and ethical accountability in AI deployment.

The Lived Experiences Of Covid-19 Grief, Loss, And Coping Strategies For Black Family Caregivers Of Covid Orphans, Allison Dalrymple-Mason

Walden Dissertations and Doctoral Studies

Black family caregivers in the United States experienced disproportionately high mortality rates due to COVID-19, resulting in many Black children becoming orphans. The unexpected loss placed a burden on these family caregivers, who navigated their grief while taking on new caregiving responsibilities. Limited studies explored how Black family caregivers experienced the meaning of COVID grief, loss, and coping strategies. The purpose of this qualitative phenomenological study was to gain an understanding of the meaning of grief, loss, and coping strategies for Black family caregivers of COVID orphans, guided by Worden’s task-based approach to supporting people bereaved by COVID-19 and Folkman’s …

Feasibility And Acceptability Of Tap Dance As A Therapeutic Intervention For Adults With Lower Limb Amputation: A Pilot Study, Julianne Roser, Allison Strande, Bailey Taggart

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objectives: This study aimed to evaluate the feasibility, acceptability, and potential efficacy of an 8-week adapted tap dance program as a therapeutic intervention for individuals with lower limb amputation (LLA).

Methods

Three participants with LLA (two with unilateral transfemoral amputation and one with bilateral transtibial amputations) attended weekly 1-hour tap dance classes, with movements adapted for their needs and mobility aids and dance barres available as needed. The Physical Activity Enjoyment Scale (PACES) and participant feedback assessed acceptability. Functional mobility, balance and quality of life were measured using the Activities-Specific Balance Confidence (ABC) scale, Timed Up-and-Go (TUG), Berg Balance Scale …