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Articles 41881 - 41910 of 934121
Full-Text Articles in Entire DC Network
Advanced Clinical Pastoral Education, Tapiwa Mucherera
Counseling Practicum, Dr. Kenneth Myers
Pilgrimage: Spiritual Formation And Morality, James Thobaben
Pilgrimage: Spiritual Formation And Morality, James Thobaben
Syllabi
No abstract provided.
Mentored Ministry - Three, Julie Broderson
Counseling Adolescents: Advanced Skills In Professional Practice, Jasmine Knight
Counseling Adolescents: Advanced Skills In Professional Practice, Jasmine Knight
Syllabi
No abstract provided.
The Theology And Practice Of Preaching, Stacy Minger
Theology Of John Wesley, Thomas Mccall
Biblical Narrative, Brian Russell
Theology And Practice Of Christian Leadership, Osias Segura
Theology And Practice Of Christian Leadership, Osias Segura
Syllabi
No abstract provided.
Mentored Ministry - Two, Joy Ireland
Mentored Ministry - Two, Joy Ireland
Investigating Genes Associated With Oncogenic Pka Activity In Fibrolamellar Carcinoma, Ananya Singh
Investigating Genes Associated With Oncogenic Pka Activity In Fibrolamellar Carcinoma, Ananya Singh
Undergraduate Honors Theses
Fibrolamellar Carcinoma (FLC) is a rare liver cancer, predominantly affecting younger individuals with no history of primary liver disease. As FLC comprises only < 1% of all liver tumors, our understanding of its development and treatment are extremely limited. All clinical cases of FLC contain a specific DNAJB1-PRKACA fusion. The mutation produces an oncogenic form of Protein Kinase A (PKA), known as DNAJ-PKAc, with enhanced binding activity compared to wild-type PKA. Specifically, DNAJ-PKAc interacts with different substrates than wild type PKA, affecting downstream signaling pathways to promote cancer development. However, the genetic dependencies that result from oncogenic DNAJ-PKAc signaling are not known. In this paper, I will show the process of performing a genome-wide CRISPRi screen in AML12DNAJ-PKAc cells to identify genes associated with oncogenic DNAJ-PKAc signaling. I will detail the preliminary benchmarking experiments, the screening process, the preparation of genomic DNA for sequencing, and the ongoing validation of screen results. I anticipate that this project will discover genes whose knockdown inhibits oncogenic DNAJ-PKAc signaling and reduces cell growth exclusively in the presence of PKA. The identified genes could represent potential therapeutic targets for cancer drugs that inhibit FLC progression. However, additional research is necessary to characterize their interactions with DNAJ-PKAc and their specific role in FLC development.
Church History - One, Luther Oconer
Church History - Two, J. (Steve) O'Malley
Theology And Practice Of Christian Leadership, Thomas Tumblin
Theology And Practice Of Christian Leadership, Thomas Tumblin
Syllabi
No abstract provided.
Professional Development Meeting 1, Jacqueline Smith
Counseling Internship - One, Tiffany Arrows
Community Counseling, Andrew Graham
Counseling Internship - Two, Jacqueline Smith
Christian Ethics, Maria Kenney
Theological Aesthetics, James Thobaben
Mentored Ministry - Two, Eliseo Mejia
Mentored Ministry - Three, Robert (Jeff) Hiatt
Mentored Ministry Practicum, Eliseo Mejia
Missional Formation: The Church In A Global Era, Kristina Whiteman
Missional Formation: The Church In A Global Era, Kristina Whiteman
Syllabi
No abstract provided.
History Of The Christian Movements, Sue Russell
Elementary Greek - One, Cody Westcott
New Testament Introduction, Russell Morton
Clinical Pastoral Education, Tapiwa Mucherera
Faith, Reason, And Christian Belief, Kevin Kinghorn