Digital Commons Network^™

Incomplete Toxicity Reporting And Use Of Toxicity-Minimizing Language In Phase Iii Oncology Trials, Avital M Miller, Adina H Passy, Alexander D Sherry, Ramez Kouzy, Joseph Abi Jaoude, Timothy A Lin, Gabrielle S Kupferman, Esther J Beck, Pavlos Msaouel, Ethan B Ludmir

Faculty, Staff and Student Publications

Purpose: This study aimed to determine complete toxicity reporting (CTR), and the use of subjective toxicity-minimizing language (TML) among phase III oncology trials.

Methods: Two-arm superiority-design phase III oncology trials published from 2002 to 2020 were reviewed for toxicity data. CTR was defined as reporting total adverse events (TAEs), total serious adverse events (SAEs), total deaths, and study therapy discontinuations because of toxicity. Guideline concordance was defined according to guidelines published in the BMJ (defined as reporting total SAEs, total deaths, and study therapy discontinuations because of toxicity). TML was defined as a set of terms that subjectively downplay the …

Βiv Spectrin Abundancy, Cellular Distribution And Sensitivity To Akt/Gsk3 Regulation In Schizophrenia, Jessica Di Re, Michela Marini, Syed Ibrar Hussain, Aditya K Singh, Akshaya Venkatesh, Musaad A Alshammari, Tahani K Alshammari, Abdul-Rizaq Ali Hamoud, Ali Sajid Imami, Zahra Haghighijoo, Nickolas Fularcyzk, Laura Stertz, Derek Hawes, Angela Mosebarger, Jordan Jernigan, Claire Chaljub, Ralda Nehme, Consuelo Walss-Bass, Anton Schulmann, Marquis P Vawter, Robert Mccullumsmith, Robert D Damoiseaux, Agenor Limon, Demetrio Labate, Michael F Wells, Fernanda Laezza

Faculty, Staff and Student Publications

Schizophrenia (SCZ) is a complex psychiatric disorder with unclear biological mechanisms. Spectrins, cytoskeletal proteins linked to neurodevelopmental disorders, are regulated by the AKT/GSK3 pathway, which is implicated in SCZ. However, the impact of SCZ-related dysregulation of this pathway on spectrin expression and distribution remains unexplored. Here, we show that βIV spectrin protein levels were reduced in neurons of the dorsolateral prefrontal cortex in SCZ postmortem samples compared to healthy control (HC) from the Human Brain Collection Core (HBCC). To investigate potential links between βIV spectrin and the AKT/GSK3 pathway, we analyzed the PsychEncode dataset, revealing elevated SPTBN4 and AKT2 mRNA …

Feasibility Of Monte Carlo-Based Patient-Specific Quality Assurance In 15 Tesla Magnetic Resonance-Guided Online Adaptive Radiotherapy: A Multi-Institutional Study, Ruiqi Li, Yao Zhao, Jingying Lin, Tsuicheng Chiu, Weiguo Lu, Jinzhong Yang, Mu-Han Lin

Faculty, Staff and Student Publications

Introduction: To evaluate the feasibility of Monte Carlo (MC)-based patient-specific quality assurance (PSQA) for MR-guided online adaptive radiotherapy and to explore the potential to eliminate the post-delivery measurement-based PSQA.

Material and methods: A total of 113 cases from two institutions, treated on MR-Linac machines, were included in the study. A customized GPU-accelerated, Monte Carlo-based secondary dose verification software (ART2Dose) was developed and integrated into the QA workflow, accounting for a 1.5 Tesla magnetic field. PSQA included ArcCheck (AC) delivery QA and online MC calculation-based QA. Reference plans underwent offline validation with AC and MC, while adapt-to-shape (ATS) plans were processed …

Heat Shock Induces Alternative Polyadenylation Through Dynamic Dna Methylation And Chromatin Looping, Emily E Fink, Yi Zhang, Briana Santo, Anwita Siddavatam, Rosie Ou, Vishal Nanavaty, Byron H Lee, Angela H Ting

Faculty, Staff and Student Publications

Alternative cleavage and polyadenylation (APA) is a gene regulatory mechanism used by cells under stress to upregulate proteostasis-promoting transcripts, but how cells achieve this remains poorly understood. Previously, we elucidated a DNA methylation-regulated APA mechanism, in which gene body DNA methylation enhances distal poly(A) isoform expression by blocking CCCTC-binding factor (CTCF) binding and chromatin loop formation at APA control regions. We hypothesized that DNA methylation-regulated APA is one mechanism cells employ to induce proteostasis-promoting poly(A) isoforms. At the DNAJB6 cochaperone locus, acute heat shock resulted in binding of stress response transcription factors heat shock factor 1, ATF6, and YY1 at …

Dynamic Contrast-Enhanced Mri Processing Comparison For Distinguishing True Progression From Pseudoprogression In High-Grade Glioma, Ahmad Amer, Shehbaz Ansari, Apollo Krayyem, Suprateek Kundu, Swapnil Khose, Halyna Pokhylevych, Susana Calle, Chirag B Patel, Zixi Yang, Ho-Ling Anthony Liu, Jason M Johnson

Faculty, Staff and Student Publications

Background: Treatment-related changes may occur due to radiation and temozolomide in glioblastoma and can mimic tumor progression on conventional MRI. DCE-MRI enables quantification of the extent of blood-brain barrier (BBB) disruption, providing information about areas of suspicious postcontrast T1 enhancement. We compared DCE-MRI processing methods for distinguishing true disease progression from pseudoprogression in high-grade gliomas (HGGs).

Methods: We identified 110 patients with HGG treated with surgery and chemoradiation who underwent DCE-MRI to further interrogate areas of new/increasing enhancement. All patients had confirmatory surgery/biopsy with pathology-confirmed progression or pseudoprogression. Scans were performed at 3T and analyzed using nordicICE. The MCA, SSS, …

1d Thermoembolization Model Using Ct Imaging Data For Porcine Liver, Rohan Amare, Danielle Stolley, Steve Parrish, Megan Jacobsen, Rick R Layman, Chimamanda Santos, Beatrice Riviere, Natalie Fowlkes, David Fuentes, Erik Cressman

Faculty, Staff and Student Publications

Innovative therapies such as thermoembolization are expected to play an important role in improving care for patients with diseases such as hepatocellular carcinoma. Thermoembolization is a minimally invasive strategy that combines thermal ablation and embolization in a single procedure. This approach exploits an exothermic chemical reaction that occurs when an acid chloride is delivered via an endovascular route. However, comprehension of the complexities of the biophysics of thermoembolization is challenging. Mathematical models can aid in understanding such complex processes and assisting clinicians in making informed decisions. In this study, we used a Hagen-Poiseuille 1D blood flow model to predict the …

A Follow-Up Study On The Novel Use Of Contrast-Enhanced Susceptibility-Weighted Imaging For Extremity Desmoid Fibromatosis Response Assessment, Raul F Valenzuela, Elvis Duran-Sierra, Mathew Antony, Behrang Amini, Sam Lo, Keila E Torres, Ken-Pin Hwang, Jingfei Ma, R Jasson Stafford, Ravin Ratan, John E Madewell, Dejka Araujo, William A Murphy, Colleen M Costelloe

Faculty, Staff and Student Publications

Desmoid tumors are rare mesenchymal neoplasms characterized by a clonal proliferation of fibroblasts and myofibroblasts. Using the novel contrast-enhanced susceptibility-weighted imaging (CE-SWI) for characterizing desmoid tumors can enhance the separation between fibrous T2-hypointense and cellular T1-enhancing components. We aim to evaluate the effectiveness of the CE-SWI signal, volumetric, and radiomics-derived features in assessing desmoid treatment response. This IRB-approved study included 17 single-lesion extremity desmoid fibromatosis patients who underwent standard-of-care MRI, including CE-SWI, from March 2021 to February 2024. Measurements of maximum diameter, volume, and the modified Choi (m-Choi: tumor/muscle T2 ratio) were computed based on CE-SWI and T2-STIR volumetric tumor …

The Sports-Betting Market: A Road To Sports Betting As Viable Investing, Tyler Gottlieb

Vanderbilt Journal of Entertainment & Technology Law

Since its legalization, sports betting has experienced rapid growth, both in terms of economic output and expansion into more states. The current system of sports betting in the United States requires individuals to place bets using a sportsbook. The sportsbook sets the lines on every bet. If an individual wins their bet, the sportsbook pays them money according to the listed odds. If an individual loses their bet, the sportsbook keeps the amount staked. Sportsbooks set lines in a way to ensure that on average, they make money on every bet. This system has been widely accepted, often based on …

Different Beliefs About Collective Victimisation Predict Support For Distinct Resistance Strategies: Survey Findings Among The Kurdish Diaspora, Helin Ünal, Johanna Vollhardt

Psychology

People make sense of their group's collective victimisation in different ways. These different collective victimisation beliefs may be linked to distinct resistance strategies against the ingroup's victimisation. However, most studies have only examined a few collective victimisation beliefs and resistance strategies, limited to prototypical collective action and failed to consider which constructs are most relevant for the given context. Addressing these gaps, the present study uses a multimethod approach with findings from a Q methodology study informing a survey study to examine the relationship between context-relevant, understudied collective victimisation beliefs and resistance strategies among Kurds from Turkey and Northern Kurdistan …

The Impact Of Consumer Complaints On Corporate Digital Transformation, Yingchao Lu, Hailing Chang, Yadan Zhou

Research Collection Lee Kong Chian School Of Business

This paper examines the impact of consumer complaints on corporate digital transformation and its underlying mechanisms. Using quarterly data from China's Shanghai and Shenzhen A-share listed companies from 2018 to 2023, the empirical results show that an increase in consumer complaints significantly hinders corporate digital transformation. Mechanism analysis reveals that consumer complaints raise legal risks and non-productive costs for firms, leading them to allocate more resources toward short-term crisis management rather than long-term digital development. Heterogeneity analysis indicates that this inhibitory effect is more pronounced in firms with weaker cybersecurity governance, firms whose executives lack a digital background, and firms …

Evaluation Of Waste Plastic Addition Via Dry Method On Asphalt Mixture Performance, Isabella Madeira Bueno

Department of Civil and Environmental Engineering: Dissertations, Theses, and Student Research

Incorporating waste plastic (WP) into hot mix asphalt (HMA) offers a promising approach to enhance recycling rates and improve asphalt concrete (AC) performance, particularly in moisture damage resistance. However, results vary widely due to differences in WP types, sizes, and mixing methods. The lack of standardized procedures, especially for the dry process, has led to inconsistent integration and unclear roles of WP in AC mixtures. Studies suggest that introducing WP to pre-heated aggregates at temperatures exceeding its melting point can enhance mixture resistance to rutting, cracking, and moisture damage. In this context, this study was conducted in two phases to …

Chronic Illness Education 2025: Exercise Initiatives To Improve Child Obesity, Alice Werynski, Ashley Simbafo, Diana Kernen, Koa Williams, Linda Beqaj, Noah Krepostman, Trevor Buck

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Improving Outcomes Of Hiv In Marginalized Populations, Aidan Bailey, Alexis Bowles, Ammar Chauhdri, Biola Makinde-Odusola, Dea Kanani, Keshav Sharma, Vasanth Palanisamy, Waffa Bakheet

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Resources To Improve Kidney Disease In Adults, Alan Berkovitz, Alejandro Damian, Anthony Tundo, Haziq Latif-Jangda, Jared Poliskey, Kristen Bartow, Petra Johnson, Sophie Turner

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Improving Lifestyle Choices In Children Withtype-2 Diabetes Mellitus, David Williams, Hariharan Ramakrishnan, Luv Thakkar, Sanjana Kumar, Srikar Munukutla, Stephan Gonzalez, Taqwa Naas, Ted Hirschfield

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Hypertension Prevention Strategies Catered Towards Pre-Menopausal Women, Jack Summers, Juan Rios, Karli Monahan, Lara Thomas, Leah Abdallah, Noah Ramirez, Noor Ghanam, William Merchun

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Environmental And Psychosocial Interventions In Adolescent Depression, Christian Hausner, Deanna Brown, Erica Kruszewski, Mawadda Abdelhai, Mukund Jayaraju, Sabryn Leidlein, Trentin Ines, Tyrnan Mcgowan

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Emotional And Behavioral Concerns With Limited Support, Ahmed Alzubaidi, Ambrielle Stoltz-Bango, Grace Doakes, Ikenna Oduocha, Isaak Miller, Kelly-Ozze Bollou, Marta Haireek, Wyatt Feldman

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Depressive Symptoms And Treatment Hesitancy In A Middle-Aged Male Living Alone, Abdulrahman Altatan, Abigail Biddix, Joseph Kunnappilly, Katherine Zhang, Kehinde Bolaji, Kyrillos Ayoub, Maya Fajardo, Michael Niculcea

Patient Education Projects

No abstract provided.

Misinformation Regulations: Early Evidence On Corporate Social Media Strategy, Richard M. Crowley, Yun Lou, Samuel T. Tan, Liandong Zhang

Research Collection School Of Accountancy

Against the backdrop of an increasing threat of misinformation on social media, several countries have enacted regulations to curb the spread of misinformation. This study examines how corporate social media strategy responds to misinformation regulations. Using a large cross-country dataset of corporate tweets and a stacked regression analysis, we show that misinformation regulations lead to less corporate social media disclosure. This result suggests that by deterring misinformation, these regulations reduce firms’ need to use social media to counteract its adverse effects. Additional analyses show that the effect is more pronounced among countries with higher social media usage and countries with …

Can Lower(Ed) Expert Opinions Lead To Better Consumer Ratings?: The Case Of Michelin Stars, Xingyi Li, Yiting Deng, Puneet Manchanda, Bert De Reyck

Research Collection Lee Kong Chian School Of Business

Expert opinion exerts tremendous influence on the purchase journey, but its effect on overall consumer experience is ambiguous because it can give rise to both “expectation” and “reputation” effects. This paper explores the effect of expert opinions on consumer experience via the lens of consumer reviews in the restaurant industry, where the expert opinions are conveyed by Michelin stars. The paper uses a unique data set based on the Michelin Guide for Great Britain & Ireland from 2010 to 2020. The data include consumer reviews on TripAdvisor for all restaurants that were awarded Michelin stars during this period and a …

Hernia Recurrence Risk Matters More Than Mesh Type To Patients Undergoing Ventral Hernia Repair, Stephanie Martinez Ugarte, Mokunfayo O Fajemisin, Chelsea J Guy-Frank, Dalya M Ferguson, Jonah J Stulberg, Lillian S Kao, Julie L Holihan

Faculty, Staff and Student Publications

Introduction: Patients' perceptions about synthetic mesh for ventral hernia repair (VHR) may stem from a lack of knowledge of risks. We assessed patients' threshold for accepting the risk of hernia recurrence to avoid synthetic mesh.

Methods: Patients ≥18 y old with prior or upcoming VHR viewed a one-time video decision aid describing recurrence risk with biologic versus synthetic mesh. Patients chose between these options using a probability trade-off (PTO) technique, varying hernia recurrence rate with biologic mesh. Based on randomized trials, the recurrence rate using synthetic mesh was 9%. The PTO score was the recurrence rate (0%-100%) at which patients …

Mixed Quantum/Classical Theory Approach To Rotationally Inelastic Molecular Collisions Implemented On A Quantum Computer, Jonathan Andrade-Plascencia, Tamila Kuanysheva, Dulat Bostan, Brian K. Kendrick, Dmitri Babikov

Chemistry Faculty Research and Publications

All elements of a quantum algorithm for calculations of rotationally inelastic molecule + atom scattering within the framework of a mixed quantum/classical theory are outlined. In this approach, the rotational motion of the molecule is described quantum mechanically using the time-dependent Schrödinger equation, while the scattering process of two collision partners is treated classically. The matrix of potential coupling is precomputed on a classical processor, whereas the quantum hardware is used to propagate the system of coupled equations for the rotational state-to-state transitions. All quantum circuits needed for practical implementation of the algorithm are presented. First, the quantum codes written …

Expanding Equity And Innovation In Pharmaceutical Law And Drug Development: Paying Clinical Trial Participants For Their Data, Steve Calandrillo, Bernadette Tosti, Jefferson Smith, Jamison Koeman

Articles

Bringing a drug to market is exceedingly expensive and exposes pharmaceutical manufacturers to significant legal risk. But when companies are successful, their profits make the PowerBall jackpot look like petty cash. Staggering rewards measure in the billions or millions for the firms, CEOs, pharmacies, drug benefit managers, data brokers, and many more actors in the pharmaceutical-to-patient pipeline. The only individuals who don’t get paid handsomely are the clinical trial participants, whose voluntary participation and data helped make those successes possible. It is long past time that we reform the legal and regulatory roadblocks to paying clinical trial participants in the …

Engage & Empower: Foundations Of Social Work Practice, Elhanan Marvit

Open Touro Created

2025

Engage & Empower: Foundations of Social Work Practice is an open educational resource for social work students in “foundations of social work practice” courses. It begins by explaining Open Educational Resources and their benefits. Students then explore social work fundamentals, including the diverse roles of social workers.

With this foundation, students engage with the NASW Code of Ethics’ key terms, and principles. This ethical grounding prepares them for the “growth work” needed to develop cultural competence and cross-cultural awareness. They then learn to apply various Generalist Practice skills across different-sized systems to empower client populations.

Next, the book explores …

Institute For Global Health And Development : Issue 11 - July 2025, Institute For Global Health And Development

IGHD Newsletters

• Climate Change, Water, And the Way Forward
• Dr. Zulfiqar Bhutta Joins Global Panel on CGTN America For World Health Day 2025
• IGHD Welcomes New Associate Faculty Members
• Dr. Zulfiqar A. Bhutta Named American Society For Nutrition (ASN) Distinguished Fellow 2025
• IGHD’s Dr. Ammad Qazi Delivers Keynote Address at AKU Climate Change Event
• New IGHD Research Project to Develop Sustainable Health Infrastructure in LMICS

CLIMATE CHANGE, WATER, AND THE WAY FORWARD

I Belong Here And Am Thriving: Understanding Full-Time Graduate Student Well-Being And Belonging In An Msw Program, Lana Hart Elkins

Theses and Dissertations

Graduate-level social work students face high levels of stress that can impact their academic success and well-being. According to a national college health assessment, fulltime Master of Social Work (MSW) students at a southeastern university report significantly more academic, career-related, and financial stress than peers in other graduate programs. This study addressed the need to better understand full-time MSW student experiences and identify ways the program can mitigate stress, promote wellbeing, and foster a sense of belonging. Using a two-phase qualitative action research design, the study first analyzed responses to 12 open-ended questions from four student feedback surveys. These findings …

An Economic Evaluation Of Cook At All Costs, Abigail Green

Theses and Dissertations

Cooking shows have been popular for decades with many variations, prizes, and a collection of talented chefs. The Netflix series Cook at All Costs provides a newer playing field incorporating auctions into the challenging landscape. Home chefs are challenged with creating unique dishes from mystery ingredients boxes acquired through various auction types in hopes of winning a monetary prize. The chefs must balance the trade-off between spending money on higher-quality ingredients to improve their chances of winning and saving money across rounds. This thesis will explore the economic concepts presented in the show by providing an understanding of how the …

Awareness And Practice Methods For Musicians With Invisible Disabilities: Insights Gained From Playing The Flute With Ehlers-Danlos Syndrome, Jessica Pelltier

Theses and Dissertations

Ehlers-Danlos Syndrome (EDS) is a connective tissue disorder that presents significant physical and mental challenges for musicians, particularly in instrumental performance. These challenges may include chronic pain, joint instability, fatigue, anxiety, and depression. While such symptoms are associated with EDS, they are not exclusive to it and are also common among individuals with other invisible disabilities, such as fibromyalgia, postural orthostatic tachycardia syndrome (POTS), celiac disease, attention-deficit/hyperactivity disorder (ADHD), generalized anxiety disorder (GAD), and chronic fatigue syndrome (ME/CFS). This study explores the experiences of flutists with EDS and other invisible disabilities, focusing on the coping strategies and adaptations they use …

Examining Coping, Individual Resilience, And Family Resilience As Strengths-Based Factors For Lgbtq+ Individuals, Elizabeth Moriarty Combs

Theses and Dissertations

Lesbian, Gay, Bisexual, Transgender, Queer/Questioning, and More (LGBTQ+) individuals are part of a diverse and complex community that has unique considerations regarding physical and mental health. While there is ongoing health equity research regarding LGBTQ+ individuals, the focus is often on health disparities. A strengths-based approach to helping LGBTQ+ individuals through research and other avenues may be beneficial. This multi-manuscript dissertation includes two studies that explored the current literature on strengths-based factors such as coping, individual resilience, and family resilience within LGBTQ+ individuals, as well as determined the feasibility of utilizing these factors to assist LGBTQ+ individuals with health and …