Digital Commons Network^™

The Urgent Need For Global Nuclear Disarmament: An Occupational Therapy Perspective, Ryan Thomure, Leon Kirschner, Robert Croonquist

The Open Journal of Occupational Therapy

The risk of nuclear war, exacerbated by recent global conflict, poses an existential threat to humanity and undermines the ability of individuals and communities to engage in meaningful occupation. This article argues that occupational therapists and occupational therapy assistants have a role to play in supporting global nuclear disarmament and that such efforts align with both our ethical responsibilities and scope of practice. It explores the profound impact of nuclear weapons on health and well-being, emphasizing the relevance of this issue to occupational therapy. The article outlines practical strategies for occupational therapists to engage in advocacy, including public education campaigns, …

Prevalence Of Incivility And Bullying In Occupational Therapy Fieldwork, Edwin Myers, Kaitlyn Cremer

The Open Journal of Occupational Therapy

The prevalence of incivility and bullying in the domain of occupational therapy warrants attention. The long-term effects of incivility and bullying can be profound and multifaceted. These may include job dissatisfaction, depressive symptoms, heightened hostility, and an increased likelihood of malpractice. Despite the implications of such behavior, there remains a noticeable gap in existing literature. This study investigated the prevalence of incivility and bullying occurring during occupational therapy (OT) fieldwork. The Negative Acts Questionnaire-Revised (NAQ-R) was completed by 702 occupational therapists, occupational therapy assistants, and students regarding their fieldwork experiences. Over 80% of participants reported being exposed to bullying or …

Occupational Therapy Students’ Perceptions Of Using Chatgpt For An Academic Course Assignment, Diane Tom, Robyn Wu, Chi-Kwan Shea

The Open Journal of Occupational Therapy

Chat Generative Pre-Trained Transformer (ChatGPT), a natural language based artificial intelligence (AI), has been either welcomed or maligned by academia. This project aimed to: (a) provide a structured opportunity for students to use ChatGPT and critique its responses and (b) investigate student perceptions before and after using ChatGPT for a class assignment. Forty graduate occupational therapy students used ChatGPT to complete two written assignments. Pre- and post-ChatGPT assignment surveys completed by students were analyzed. After using ChatGPT to complete course assignments, students were significantly more likely to agree that: (a) ChatGPT is helpful for completing assignments, (b) ChatGPT provides accurate …

Becoming A Skater: A Mixed Methods Study Exploring Supports And Barriers To Participation In Adaptive Skateboarding, Megan Sandwith, Susan Macdermott, Amy Griswold

The Open Journal of Occupational Therapy

Background: The occupation of adaptive skateboarding expands concepts of skateboarding through modifications that support performance for individuals with disabilities. There is a gap in the literature representing the experience of individuals with disabilities who desire to participate in adaptive skateboarding. The intent of the research study was to provide a foundational understanding of the occupation of adaptive skateboarding by exploring the question: What are the supports and barriers to participation in adaptive skateboarding?

Methods:This mixed-methods study was comprised of a 14-question virtual survey, a semi-structured interview, and an optional video submission.

Results: A total of 41 participants participated …

Paving A Path From Occupational Therapy Clinician To Researcher: A Grounded Theory, Marissa J. Wuennemann, Barbara Nadeau

The Open Journal of Occupational Therapy

Background: Research is vital for continued development and support of practice for occupational therapy, yet little is known about occupational therapists currently in research roles. Occupational therapists who primarily conduct research see themselves as a unique minority in the profession. This study aimed to understand the process of occupational therapists who shift their professional identity from being a clinician to a researcher.

Method: Purposive and snowballing sampling was used to recruit occupational therapy clinicians who transitioned into roles where they spend the majority of their time conducting research. Data was collected through individual, semi-structured interviews and analyzed following …

Breastfeeding Interventions For Dyads With Medical Complexity: A Mixed Methods Study, Jairrah L. Godsil, Julia R. Farrell, Julia Shin, Cary C. Moore, Yongyue Qi, Vanessa D. Jewell

The Open Journal of Occupational Therapy

Background: Breastfeeding dyads with medical complexity have lower success with direct breastfeeding. Evidence to support occupational therapists working with this population is limited. This study explored occupational therapists' experiences, training, and interventions for breastfeeding dyads with medical complexity.

Method: Occupational therapists providing clinical breastfeeding services for parents and or children with medically complex conditions participated in this study. The study employed an explanatory, sequential mixed-methods design, consisting of an online survey (N = 102) followed by two 75-min semi-structured focus groups (N = 7).

Results: Occupational therapists with more clinical breastfeeding experience (p = .003) and …

Use Of Podcasts As Emerging Technology In Occupational Therapy Education, Abbigail Kubiak, Karen Jacobs, Varsha S. Kulkarni, Maruška Vizek

The Open Journal of Occupational Therapy

Podcasts are an emerging modality with a developing evidence base to reinforce their use in educational settings; in particular, to support knowledge retention and introduce topics. This research demonstrates the potential of podcasting in an educational context. Podcasts were used to educate occupational therapy (OT) students about emerging and innovative OT career opportunities. A series of 13 standardized 20- to 30-min podcasts featuring occupational therapists in emerging and innovative practice areas (E/IPA) globally were developed. In each podcast, the occupational therapist described implicit and explicit aspects of their career experiences. The podcasts were piloted in an entry-level OT doctoral course …

A Qualitative Study Of Disabled Performance Art In Occupational Identity Formation And Empowerment, Lisa Mahaffey, Kristin Chrissos, Kate Wettergren

The Open Journal of Occupational Therapy

Background: Disabled performance artists use their occupation of performance art to challenge the attitudes of their audience toward disability, leading to a greater sense of empowerment and a strong identity as disabled people.

Method: This project used a narrative approach to qualitative inquiry to explore how engagement in performance art influences occupational identity and empowers disabled artists. Personal connections and snowball sampling resulted in six self-identified disabled performance artists participating in 60- to 90-min interviews. A thematic analysis resulted in three overarching themes.

Results: (a) Belonging to a community of disability activists promotes feelings of empowerment for disabled performance …

A Seventh Amendment Remedy For Housing Instability, Gregory M. Zlotnick

Maine Law Review

After the 2023–2024 Supreme Court term, housing advocates despaired over the expected, yet still unwelcome, decision in City of Grants Pass v. Johnson. While focusing on this case is understandable, this Article suggests that scholars, policymakers, and advocates should train their focus on another, perhaps less-expected case from the previous Supreme Court term: SEC v. Jarkesy. In Jarkesy, the Court affirmed a defendant’s constitutional right to a jury trial in an administrative proceeding that sought to enforce a right similar to one found at common law. The Court’s capacious interpretation of the Seventh Amendment in Jarkesy has implications for state-law …

Chi Chung's Voice

V Music Magazine

No abstract provided.

Nanoporous Gold Nanoparticles And Model Membrane Systems Applied To The Study Of Lipopolysaccharide (Lps), Dhanbir Lingden

Dissertations

Lipopolysaccharide (LPS), a key structural component of Gram-negative bacteria, is a major trigger of sepsis and septic shock, the systemic inflammatory conditions responsible for millions of deaths annually. Even at concentrations as low as 1 ng/mL, LPS can activate the immune system and initiate inflammatory cascades. According to the Global Burden of Disease Study 2017, sepsis accounted for 48.9 million cases globally, with 11 million deaths, emphasizing the urgent need for improved diagnostic and therapeutic strategies.

Accurate and rapid detection of LPS is vital for early intervention and improved clinical outcomes. While traditional detection methods are still widely used, modern …

Screen Foundations: How Pediatric Nurse Practitioners Can Implement ‘Family Media Use Plans’ In Primary Care To Reduce Pediatric Behavior Concerns, Katie Anderson

Dissertations

Abstract for:

Screen Foundations: How Pediatric Nurse Practitioners Can Implement ‘Family Media Use Plans’ in Primary Care to Reduce Pediatric Behavior Concerns

Problem: Parents of children 2-5 years-old increasingly reach out to PCPs for escalating behavior concerns, including when the child doesn’t listen well, is inattentive, having tantrums, meltdowns, hitting, yelling, etc. Referrals to psychiatry and/or play therapy result in long waits, or referrals not accepted. Coincidingly, toddler and preschool aged children continue to exceed daily screen time recommendations. This results in a gap of care for families with young children and externalizing behavior.

Methods: This quality improvement project addressed …

Featuring Ir Collections With Monthly Snapshot, Alice W. Sherwood

Library Staff Publications

Join Alice for this lightning round talk on how she has developed snapshots of her collections to highlight special topics and notable cultural events.

Health Risk Assessment Of Multiple Mycotoxins In Rice , Maize , Soybean , And Wheat Flour Marketed In Shanghai, Zuoyin Zhu, Jie Wang, Junmei Ma, Hanke Zhao, Haisheng Cheng, Chengbao Huang, Junhua Yang

Journal of Food Science and Biotechnology

[Objective ] This study aims to evaluate the potential health risks to consumers from exposure to multiple mycotoxins in grains.[Method ] Point and probabilistic assessment models were adopted to analyze the dietary exposure risks of adult residents in Shanghai to aflatoxins (AFs),ochratoxin A (OTA ),zearalenone (ZEN ),deoxynivalenols (DONs ),and fumonisins (FBs) through consumption of rice,maize,soybeans,and wheat flour.[Result ] The margin of exposure values (MoE ) for AFs in maize and aflatoxin G 1 (AFG 1) in soybeans exceeded 10 000,indicating no dietary exposure risk.In contrast,AFs in rice and wheat flour,as well as aflatoxin B 1 (AFB 1),aflatoxin B 2 (AFB …

Better Together: Collaborative Approaches To Teaching Primary Source & Information Literacy, Rebecca Fitzsimmons

Faculty and Staff Publications – Milner Library

Special collections librarians and their research & instruction colleagues discuss collaborative approaches to primary source and information literacy instruction in the university classroom. Through presentations and panel discussion they cover the types of classes where they collaborate, including a representative example class; how they work with teaching faculty; their favorite learning objectives; and how their partnerships have made them better teachers.

Panelists represent public universities in Arkansas, Illinois, and Maine, and a private college in Ohio.

Effects Of Political Predispositions, Media Use, And Media Evaluation On Policy Malaise Among Indonesian And German People, Irma Garnesia

JURNAL KOMUNIKASI INDONESIA

This study explores a comparative analysis of Germany and Indonesia in the context of the Covid-19 pandemic, emphasizing the importance of addressing cross-cultural dimensions in global health crises—a field that remains underexplored. By enhancing preparedness for future emergencies, the research critically examines whether theoretical assumptions developed in Global North contexts can be meaningfully extended to Global South settings. Specifically, this study hypothesizes that political predispositions, media use, and media evaluation are associated with policy malaise, and investigates these associations in light of cross-cultural differences. Using data from Germany (n = 1,458) and Indonesia (n = 1,043), the findings reveal significant …

Ole Miss Student-Athlete Wins Sec Startup Contest, Marvis Herring

University of Mississippi News

OXFORD, Miss. – Cole Piotrowski spent years outrunning the competition on the track. Now, the University of Mississippi graduate has outpaced Southeastern Conference's business competitors in a different kind of race, a business pitch competition.

Online Citizen Science In Higher Education Courses, Stacy Cotey, Amy K. Dunbar-Wallis, Yaela N. Golumbic, Pankaj Mehrotra, David A. Beamer, Heather D. Vance-Chalcraft

Michigan Tech Publications

Climate change and biodiversity loss require us to engage the next generation of scientists in addressing global ecological issues. Introducing undergraduate students to citizen science allows them to learn scientific processes and content while contributing to real-world applications. We conducted a systematic review of literature to (1) identify what types of undergraduate courses and institutions use citizen science, (2) list the projects and platforms that have been implemented in online courses in undergraduate education, (3) examine how students participated in the projects through online courses, and (4) summarize learning objectives and reported benefits of student participation. In all, 44 studies …

Experiences Of Supervisees Developing Culturally Responsive Skills Through Clinical Supervision, Jaime Lyn Parker

Walden Dissertations and Doctoral Studies

Culturally responsive supervision has been shown to be beneficial to supervisees (Adams et al., 2023). A research gap exists in culturally responsive clinical supervision through the lens of supervisees’ experiences; as a result, supervisors are ill-equipped to offer culturally responsive clinical supervision. The purpose of this narrative inquiry study was to explore supervisees’ culturally responsive experiences in clinical supervision. Grounded in critical race theory, this study highlights the narratives of marginalized voices as they share their stories of developing culturally responsive skills through clinical supervision. That is, the research question explored the experiences of counseling supervisees as they develop culturally …

Everyday Life In The U.S.: An Intersectional Approach To A North Korean Refugee Woman’S Identities, And Experiences, Lyounghee Kim

Communication ETDs

This dissertation examines everyday experiences of a North Korean refugee woman in the U.S., centering her narratives as sites of critique, resistance, and meaning-making. Grounded in Critical Refugee Studies, Asian American Studies, and Critical Intercultural Communication and framed by intersectionality, it explores how interlocking structures of power shape and are shaped by her life. Rather than focusing solely on trauma or assimilation, this study highlights her digital storytelling, faith, and mutual aid practices as acts of survival, dignity, and moral agency. Using a qualitative, narrative inquiry approach grounded in critical reflexivity, it thematically analyzes her stories to reveal how she …

The Influence Of Family Literacy Playgroups On Early Childhood Development And Parent Efficacy In Hispanic Families: A Qualitative Phenomenological Case Study, Karen R. Loper

Graduate Theses, Dissertations, and Capstones

This qualitative phenomenological case study is focused on the engagement of Hispanic children between 18 and 36 months of age and their parents in a family literacy program. Participation in a family literacy program was associated with changes in the cognitive, social, and emotional development of children, as well as the self-efficacy of their parents in parenting skills. Grounded in the social theories of Vygotsky, Bandura, and Bronfenbrenner, this study relates the importance of language acquisition, literacy skills, and self-efficacy to a community setting where conversation is encouraged and reading engagement is modeled. The Hispanic population is underrepresented in the …

Knowledge And Practice Of Undergraduate Medical Students Regarding Self-Medication: A Cross-Sectional Survey In Baghdad, Iraq, Samer Shukur Mohammed, Wael Waleed Mustafa

Iraqi National Journal of Medicine

Background: The global trend of self-medication is rising, making it a priority to investigate associated risks that could lead to life-threatening complications. Aim: To assess self-medication practices among undergraduate medical students and evaluate their knowledge and the factors influencing their use of self-medication Methods: A cross-sectional questionnaire-based study was conducted among 234 medical students from various medical colleges in Baghdad between November 2023 and March 2024. Participants were selected randomly. Data were collected and analyzed using SPSS version 23. The chi-square significance test was performed, and P-values ≤ 0.05 were considered statistically significant. Results: The study found that 72% of …

Mothers’ Plan To Protect Their Children From Covid-19 And Other Viral Illnesses, Miami Kadhum Yossif, Rehab Abdulwehab Jaafer

Iraqi National Journal of Medicine

Background: Mothers play a critical role in safeguarding the health and well-being of their children—a vulnerable population—particularly during outbreaks of infectious diseases. Aim: This study investigated the strategies employed by mothers to protect their children from COVID-19 and other viral illnesses. Methods: A cross-sectional study was conducted at the outpatient pediatric clinics of Basra Maternity and Children Hospital and Almawani Teaching Hospital, 118 mothers were enrolled from diverse backgrounds. Data was collected through structured interviews and a standardized questionnaire designed to assess maternal practices, attitudes, and experiences concerning the protection of their children. The key areas explored included hygiene practices, …

Self-Reported Post-Covid-19 Vaccine Signs, Symptoms Among Vaccinated Medical Staff: Types, Severity, And Associated Factors, Ali Khalid Saeed, Yousif Abdul Raheem

Iraqi National Journal of Medicine

Background: Vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection vary in mechanisms, side effects, and effectiveness. Health care professionals have shown high vaccine coverage rates. Aim: This study aims to assess the prevalence of self-reported clinical signs and symptoms of COVID-19 infection among health care professionals in Iraq and determine the type and severity of COVID-19 vaccine-related symptoms. Methods: A cross-sectional survey was conducted from January 1st to July 1st, 2023, using an online questionnaire disseminated through social media platforms. Results: Among 770 participants, common symptoms included body aches (36.9%), malaise (34%), headache (22%), and fever (20%), with chest …

Research Integrity Risk Index (Ri²) And Iraqi Universities, Dhurgham A. Abdulwahid

Iraqi National Journal of Medicine

No abstract provided.

Technology Roadmap Of Micro/Nanorobots, Xiaohui Ju, Chuanrui Chen, Cagatay M Oral, Semih Sevim, Ramin Golestanian, Mengmeng Sun, Negin Bouzari, Xiankun Lin, Mario Urso, Jong Seok Nam, Yujang Cho, Xia Peng, Fabian C Landers, Shihao Yang, Azin Adibi, Nahid Taz, Raphael Wittkowski, Daniel Ahmed, Wei Wang, Veronika Magdanz, Mariana Medina-Sánchez, Maria Guix, Naimat Bari, Bahareh Behkam, Raymond Kapral, Yaxin Huang, Jinyao Tang, Ben Wang, Konstantin Morozov, Alexander Leshansky, Sarmad Ahmad Abbasi, Hongsoo Choi, Subhadip Ghosh, Bárbara Borges Fernandes, Giuseppe Battaglia, Peer Fischer, Ambarish Ghosh, Beatriz Jurado Sánchez, Alberto Escarpa, Quentin Martinet, Jérémie Palacci, Eric Lauga, Jeffrey Moran, Miguel A Ramos-Docampo, Brigitte Städler, Ramón Santiago Herrera Restrepo, Gilad Yossifon, James D Nicholas, Jordi Ignés-Mullol, Josep Puigmartí-Luis, Yutong Liu, Lauren D Zarzar, C Wyatt Shields, Longqiu Li, Shanshan Li, Xing Ma, David H Gracias, Orlin Velev, Samuel Sánchez, Maria Jose Esplandiu, Juliane Simmchen, Antonio Lobosco, Sarthak Misra, Zhiguang Wu, Jinxing Li, Alexander Kuhn, Amir Nourhani, Tijana Maric, Ze Xiong, Amirreza Aghakhani, Yongfeng Mei, Yingfeng Tu, Fei Peng, Eric Diller, Mahmut Selman Sakar, Ayusman Sen, Junhui Law, Yu Sun, Abdon Pena-Francesch, Katherine Villa, Huaizhi Li, Donglei Emma Fan, Kang Liang, Tony Jun Huang, Xiang-Zhong Chen, Songsong Tang, Xueji Zhang, Jizhai Cui, Hong Wang, Wei Gao, Vineeth Kumar Bandari, Oliver G Schmidt, Xianghua Wu, Jianguo Guan, Metin Sitti, Bradley J Nelson, Salvador Pané, Li Zhang, Hamed Shahsavan, Qiang He, Il-Doo Kim, Joseph Wang, Martin Pumera

Faculty, Staff and Student Publications

Inspired by Richard Feynman’s 1959 lecture and the 1966 film Fantastic Voyage, the field of micro/nanorobots has evolved from science fiction to reality, with significant advancements in biomedical and environmental applications. Despite the rapid progress, the deployment of functional micro/nanorobots remains limited. This review of the technology roadmap identifies key challenges hindering their widespread use, focusing on propulsion mechanisms, fundamental theoretical aspects, collective behavior, material design, and embodied intelligence. We explore the current state of micro/nanorobot technology, with an emphasis on applications in biomedicine, environmental remediation, analytical sensing, and other industrial technological aspects. Additionally, we analyze issues related to …

The Integrated Stress Response Pathway Coordinates Translational Control Of Multiple Immune Checkpoints In Lung Cancer, Shayna Thomas-Jardin, Shruthy Suresh, Ariana Arce, Nicole Novaresi, Qing Deng, Emily Stein, Lisa Thomas, Cheryl Lewis, Chul Ahn, Bret M Evers, Esra A Akbay, Maria E Salvatierra, Wei Lu, Khaja Khan, Luisa M Solis Soto, Ignacio I Wistuba, John D Minna, Kathryn A O'Donnell

Faculty, Staff and Student Publications

The integrated stress response (ISR) is an adaptive pathway hijacked by cancer cells to survive cellular stresses in the tumor microenvironment. ISR activation potently induces PD-L1, leading to suppression of antitumor immunity. In this study, we sought to uncover additional immune checkpoint proteins regulated by the ISR to elucidate mechanisms of tumor immune escape. The ISR coordinately induced cluster of differentiation 155 (CD155) and PD-L1, enhancing translation of both immune checkpoint proteins through bypass of inhibitory upstream open reading frames in their 5' untranslated regions. Analysis of primary human lung tumors identified a significant correlation between expression of PD-L1 and …

Antitumor Efficacy Of Intermittent Low-Dose Erlotinib Plus Sulindac Via Mhc Upregulation And Remodeling Of The Immune Cell Niche, Chakrapani Tripathi, Jorge E Tovar Perez, Sabeeta Kapoor, Ahmed Muhsin, Wan Mohaiza Dashwood, Yunus Demirhan, Melek Demirhan, Alessandro Shapiro, Altaf Mohammed, Shizuko Sei, Jacklyn Thompson, Mahira Zaheer, Krishna M Sinha, Powel H Brown, Michelle I Savage, Eduardo Vilar, Praveen Rajendran, Roderick H Dashwood

Faculty, Staff and Student Publications

A previously reported clinical trial in familial adenomatous polyposis (FAP) patients treated with erlotinib plus sulindac (ERL + SUL) highlighted immune response/interferon-γ signaling as a key pathway. In this study, we combine intermittent low-dose ERL ± SUL treatment in the polyposis in rat colon (Pirc) model with mechanistic studies on tumor-associated immune modulation. At clinically relevant doses, short-term (16 weeks) and long-term (46 weeks) ERL ± SUL administration results in near-complete tumor suppression in Pirc colon and duodenum (p < 0.0001). We identify a low-dose threshold for significant antitumor activity in Pirc rats given SUL at 125 ppm in the diet plus ERL at 5 mg/kg body weight via twice-weekly oral gavage (SUL125 + ERL5 × 2). Longitudinal analyses show diminished expression of MHC class I and II genes in polyps larger than Grade 5, a novel finding in the Pirc model. Treatment with ERL ± SUL upregulates the corresponding MHC and immune-associated factors in a subset of Pirc colon polyps, Pirc tumor cell lines, murine colon carcinoma cells, and FAP patient-derived organoids, with Nlrc5 playing a critical role in this effect. Imaging mass cytometry reveals that SUL125 + ERL5 × 2 increases tumor-associated Cd4+ T cells by ~2.6-fold (p < 0.05), with no apparent effect on Cd8+ T cells. The treatment also increases tumor-associated Cd68+ cells (p < 0.05) and decreases Foxp3+ (p < 0.01) and Arg1+ (p < 0.05) cells. Thus, intermittent low-dose ERL + SUL treatment enhances tumor-associated MHC expression and remodels the immune cell niche toward a more permissive "helper" immune microenvironment. We conclude that early immune-interception strategies targeting interferon-γ signaling may benefit FAP patients at drug doses below the clinical standard of care.

What Can We Learn From The High School Math Reform Efforts In California, Georgia, And Oregon? A Policy Analysis, Yanira Vazquez

Teacher Education, Educational Leadership & Policy ETDs

Using publicly available data sources, this policy analysis examined how three states—California, Georgia, and Oregon—approached high school mathematics reforms to address questions regarding what prompted these states to revise their high school math standards and course pathways; how their approaches to reform were similar or different; and what other states could learn from their methods.

Individual state cases were developed, focusing on content standards, course pathways, and graduation requirements. A cross-case study was created to compare reforms from the three states.

While all states aimed to reform high school mathematics to address equity issues and offer options aligned with students’ …

Fgfr3-Induced Y158 Parp1 Phosphorylation Promotes Parp Inhibitor Resistance Via Brg1/Mre11-Mediated Dna Repair In Breast Cancer Models, Mei-Kuang Chen, Hirohito Yamaguchi, Yuan Gao, Weiya Xia, Jeffrey T Chang, Yu-Chun Hsiao, Tewodros W Shegute, Zong-Shin Lin, Chen-Shiou Wu, Yu-Han Wang, Jennifer K Litton, Qingqing Ding, Yongkun Wei, Yu-Yi Chu, Funda Meric-Bernstam, Helen Piwnica-Worms, Banu Arun, Jordi Rodon Ahnert, Jinsong Liu, Jun Yao, Wei-Chao Chang, Hung-Ling Wang, Coya Tapia, Constance T Albarracin, Khandan Keyomarsi, Shao-Chun Wang, Ying-Nai Wang, Gabriel N Hortobagyi, Chunru Lin, Liuqing Yang, Dihua Yu, Mien-Chie Hung

Faculty, Staff and Student Publications

Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) are used to treat BRCA-mutated (BRCAm) cancer patients; however, resistance has been observed. Therefore, biomarkers to indicate PARPi resistance and combination therapy to overcome that are urgently needed. We identified a high prevalence of activated FGF receptor 3 (FGFR3) in BRCAm triple-negative breast cancer (TNBC) cells with intrinsic and acquired PARPi resistance. FGFR3 phosphorylated PARP1 at tyrosine 158 (Y158) to recruit BRG1 and prolong chromatin-loaded MRE11, thus promoting homologous recombination (HR) to enhance PARPi resistance. FGFR inhibition prolonged PARP trapping and synergized with PARPi in vitro and in vivo. High-level PARP1 Y158 phosphorylation (p-Y158) positively …