Digital Commons Network^™

Anti-Holistic Algorithms, Itay Ravid

Vanderbilt Law Review

This Article presents a critical tension in modern criminal justice between holistic criminal justice aspirations and algorithmic governance: whether the holistic rehabilitation and reintegration project can survive technological determinism. As criminal legal systems embrace algorithmic risk assessment tools as solutions to address recidivism, this Article reveals a profound epistemological concern: the fundamental incompatibility between viewing offenders as whole persons capable of transformation and reducing them to statistical probabilities within computational matrices. By doing so, it demonstrates how algorithmic mediation fundamentally alters and potentially destroys the holistic message itself.

In establishing this argument, the Article advances in two stages. It first …

Beyond Autonomy: Rethinking Deception In Sexual Assault Law, Marie Manikis

Vanderbilt Law Review

This Article focuses on recent developments in Britain in which courts have recognised gender deception as a sexual assault by using an autonomy based argument to define deception/fraud that vitiates consent in sexual offences. This Article argues against the defensibility of a framework that criminalizes deception on the basis of an ill defined autonomist based understanding as opposed to a more restrictive standard. It proposes that any adopted standard should incorporate social context and be reflexive of the ways that the state has contributed to these contexts, namely the social conditions under which the deceit takes place as well as …

Anti-Holistic Algorithms, Itay Ravid

Faculty Publications

This Article presents a critical tension in modern criminal justice between holistic criminal-justice aspirations and algorithmic governance: whether the holistic rehabilitation and reintegration project can survive technological determinism. As criminal legal systems embrace algorithmic risk- assessment tools as solutions to address recidivism, this Article reveals a profound epistemological concern: the fundamental incompatibility between viewing offenders as “whole persons” capable of transformation and reducing them to statistical probabilities within computational matrices. By doing so, it demonstrates how algorithmic mediation fundamentally alters—and potentially destroys—the holistic message itself.

In establishing this argument, the Article advances in two stages. It first identifies the development …

Apol2 Stabilizes Ku80 To Confer Nhej-Mediated Radioresistance In Gastric Cancer, Dan Zu, Qimei Bao, Hanyi He, Yuke Zhong, Mingcong Deng, Yangchan Hu, Chunkai Zhang, Chen Liang, Yixing Huang, Haidong Liu, Xiao Li, Yanhua He, Guoyan Luo, Weixin Wu, Fenghui Guan, Shengfeng Xu, Min Liu, Albino Bacolla, Ji Jing, Yian Du, John A Tainer, Yin Shi, Zu Ye, Xiangdong Cheng

Faculty, Staff and Student Publications

Radiotherapy is one of the most important adjuvant treatment methods for gastric cancer (GC). However, radioresistance remains a major clinical obstacle. In this study, APOL2 is identified as a key player in promoting non-homologous end joining (NHEJ)-mediated double-strand break (DSB) repair and enhancing radioresistance in GC. Bioinformatics and clinical data revealed that high APOL2 expression is correlated with poor prognosis in GC patients. Functional experiments showed that APOL2 overexpression enhances genomic stability by accelerating DSB repair via the NHEJ pathway, while APOL2 knockout impairs repair capacity. Mechanistically, APOL2 binds to and stabilizes Ku80 by enhancing USP7-mediated deubiquitylation, thereby increasing Ku80 …

Multiomic And Electrophysiologic Analyses Reveal That An Inherited Mrc2 Variant Causes Fibroblast Dysfunction And Increased Atrial Fibrillation Susceptibility, Kevin S Ho, Joshua A Keefe, Shuai Zhao, Mohit M Hulsurkar, Sung Yun Jung, Md Abul Hassan Samee, Xander H T Wehrens

Faculty, Staff and Students Publications

A recent study identified a rare variant in the mannose receptor C type 2 (MRC2) gene in individuals with familial reentrant supraventricular tachycardia, a Wolff-Parkinson-White (WPW) electrocardiogram pattern, and structurally normal hearts. WPW syndrome is associated with atrial fibrillation (AF), and MRC2 was recently proposed as a protective gene for AF. We determined whether the E990G-heterozygous (het) loss-of-function variant in Mrc2 increases AF susceptibility and identified aberrant cellular mechanisms resulting from Mrc2 deficiency in atrial cardiofibroblasts (ACFs) and atrial tissue in mice that may promote AF. Programmed electrical stimulation was performed to determine AF susceptibility in Mrc2 E990G-het …

Single-Nucleus Mrna-Sequencing Reveals Dynamics Of Lipogenic And Thermogenic Adipocyte Populations In Murine Brown Adipose Tissue In Response To Cold Exposure, Janina Behrens, Tongtong Wang, Christoph Kilian, Anna Worthmann, Mark A Herman, Joerg Heeren, Lorenz Adlung, Ludger Scheja

Faculty, Staff and Students Publications

Objective and methods: Brown adipose tissue (BAT) comprises a heterogeneous population of adipocytes and non-adipocyte cell types. To characterize these cellular subpopulations and their adaptation to cold, we performed single-nucleus mRNA-sequencing (snRNA-seq) on interscapular BAT from mice maintained at room temperature or exposed to acute (24h) or chronic (10 days) cold (6 °C). To investigate the role of the de novo lipogenesis (DNL)-regulating transcription factor carbohydrate response element-binding protein (ChREBP), we analyzed control and brown adipocyte-specific ChREBP knockout mice.

Results: We identified different cell populations, including seven brown adipocyte subtypes with distinct metabolic profiles. One of them highly expressed ChREBP …

Restricting Metabolic Plasticity Enhances Stress Adaptation Through The Modulation Of Pdh And Hif1a In Trap1-Depleted Colon Cancer, Hong-Yuan Tsai, Miao-Hsueh Chen, Jihye Yun, Lisa A Lai, John F Valentine, Mary P Bronner, Teresa A Brentnall, Sheng Pan, Ru Chen

Faculty, Staff and Student Publications

Metabolic plasticity allows cancer cells to survive under adverse conditions. To investigate the role of mitochondrial chaperone tumor necrosis factor receptor-associated protein 1 (TRAP1) in this process, we used CRISPR/Cas9 mediated genetic deletion to knock out (KO) TRAP1 in colon cancer cells. Depletion of TRAP1 triggered a series of events: induced metabolic reprogramming, increased glycolytic flux, downregulation of mitochondrial complex I, and elevated ROS generation. TRAP1-deficient cells showed tolerance to Oxidative Phosphorylation (OXPHOS) inhibitors and exhibited a higher extracellular acidification rate (ECAR). Additionally, TRAP1 depletion activated hypoxia response elements (HREs) and upregulated HIF1A target genes such as GLUT1 and MCT1. …

Using Video Ethnography And Stimulated Recall Interviews To Describe The Diagnostic Process In The Emergency Department, Milisa Manojlovich, Caitlin Cassady, Sarah J Parker, Ellie Davis, Charlotte Ahr, David Ryamukuru, Anna Wang, Kalyan Pasupathy, Hardeep Singh, Prashant Mahajan

Faculty, Staff and Students Publications

Objectives: Understanding how physicians make diagnoses is challenging because cognitive processes are unobservable and partly unconscious, making it difficult for physicians to describe how they arrived at a diagnosis. Physicians who work in emergency departments (EDs) are especially vulnerable to making diagnostic errors because the ED is a fast-paced, dynamic setting where complex decision-making occurs under severe time, information, and resource constraints. The purpose of our study was to describe how the diagnostic process evolves for ED clinicians in both pediatric and adult ED settings.

Methods: We used a qualitative, video ethnography study design to capture in situ, real-time ED …

Bicontinuous Interconnected Porous Biomaterials For Tissue Engineering And Regeneration, Aihik Banerjee, Anjana Khanal, Prince D Okoro, Shankar P Kharal, Kevin Dalsania, Baishali Kanjilal, Shiril B Iragavarapu, Yiqing Chen, Janitha M Unagolla, Huinan H Liu, Joshua T Morgan, Robert P Hesketh, Arash Pezhouman, Reza Ardehali, Bahman Anvari, Martin F Haase, Iman Noshadi

Faculty, Staff and Students Publications

Biomaterials mimicking natural extracellular matrix are necessary to create an optimal microenvironment for cell adhesion, migration, proliferation, and differentiation. These scaffolds must possess bicontinuous interconnected porosity to ensure the effective exchange of oxygen, nutrients, and metabolic waste, which are crucial for developing functional tissues. Here, a novel bicontinuous interfacially jammed emulsion (BIJEL)-Integrated PORous Engineered System (BIPORES) is developed to confer bioinert synthetic polyethylene glycol diacrylate (PEGDA) with unique bicontinuous interconnected porosity and surface topography. This platform is fabricated through controlled phase separation and interfacial stabilization of two continuous phases by nanoparticles. Functional validation using human mesenchymal stem cells, and human …

Call To Action-Pediatric Masld Requires Immediate Attention To Curb Health Crisis, Phillipp Hartmann, Marialena Mouzaki, Sara Hassan, Mohit Kehar, Krupa R Mysore, Erin Mauney, Dieudonne Nonga, Sara Karjoo, Shilpa Sood, Andrea Tou, Christine Brichta, Rachel E Herdes, Nikhil Pai, Donna K Garner, Mary E Rinella, Mazen Noureddin, Zobair Younossi, Alina M Allen, Arun Sanyal, Taisa Kohut, Rohit Kohli, Charina M Ramirez, Stavra Xanthakos, Miriam B Vos, Jeffrey B Schwimmer, Samar H Ibrahim, Jennifer Panganiban

Faculty, Staff and Students Publications

Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) has become more prevalent on a global scale over the last decades and is associated with significant comorbidities in childhood and a 40-fold higher risk of early mortality in young adulthood. MASLD has now become the leading indication for liver transplantation in young adults in the United States. However, pediatric MASLD is still perceived as an indolent condition by many patients, families, and clinicians. In this Call to Action, we aim to raise awareness of pediatric MASLD as a public health crisis. Herein, we describe insufficient screening and disease staging practices, and a …

Inhibition Of Bmper Mitigates Pulmonary Hypertension By Modulating Lrp1-Yap Interaction In Smooth Muscle Cells, Hua Mao, Claire M Li, Bing Sun, Christopher S Ward, Alan R Waich-Cohen, Ivan O Rosas, Howard J Huang, Harry Karmouty-Quintana, Liang Xie, Lavannya M Pandit, Xinchun Pi

Faculty, Staff and Students Publications

Background: BMPER (bone morphogenetic protein-binding endothelial regulator) is a secreted protein that is highly expressed in endothelial cells. It regulates the BMP (bone morphogenetic protein) pathway during vascular development and adulthood. Mutations in the BMP pathway are recognized as risk factors for pulmonary arterial hypertension group 1 pulmonary hypertension (PH). However, the roles of BMPER in pulmonary arterial hypertension remain unknown.

Methods: We assessed BMPER expression in Group 1 pulmonary arterial hypertension patient samples and examined its role in vascular remodeling using in vivo and in vitro approaches.

Results: BMPER level was elevated in pulmonary arterial hypertension lungs and significantly …

Maternal Separation Disrupts Noradrenergic Control Of Adult Coping Behaviors, Chayla R Vazquez, Léa J Becker, Chao-Cheng Kuo, Solana A Cariello, Ayah N Hamdan, Ream Al-Hasani, Susan E Maloney, Jordan G Mccall

2020-Current year OA Pubs

Early life stress (ELS) profoundly impacts the brain and correlates with negative affective behaviors in adulthood. The locus coeruleus (LC), a stress-responsive brainstem nucleus that supplies most of the brain with norepinephrine (NE), is known to modulate negative affect. Using repeated maternal separation stress (MSS), we investigated the impact of ELS on the LC and stress-related behaviors in adulthood. We performed ex vivo cell-attached electrophysiology across the lifespan to reveal that MSS significantly increased LC firing during early development and adulthood but not in pre-adolescence and adolescence. We next examined potential changes in the expression of genes linked to LC …

Nirfasterff: An Accessible, Cross-Platform Python Package For Fast Photon Modeling, Jiaming Cao, Samuel Montero-Hernandez, Rickson C Mesquita, Adam T Eggebrecht, Hamid Dehghani

2020-Current year OA Pubs

SIGNIFICANCE: Accurate and efficient photon modeling plays an essential role in the rapidly developing field of diffuse optical imaging, whereby the use of model-based analysis and image reconstruction can provide both educational and research benefits.

AIM: NIRFASTerFF is a cross-platform (Linux, macOS, and Windows) Python package for finite element method (FEM)-based light propagation modeling, supporting continuous-wave, frequency-domain, and time-resolved data for both exogenous and endogenous optical imaging applications. It also enables modeling of the autocorrelation function (

APPROACH: NIRFASTerFF incorporates highly parallelized FEM solvers for efficient computation on both CPU and GPU, leveraging OpenMP and CUDA acceleration. To support image …

Six Drivers Of Aging Identified Among Genes Differentially Expressed With Age, Ariella Coler-Reilly, Zachary Pincus, Erica L Scheller, Roberto Civitelli

2020-Current year OA Pubs

Many studies have compared gene expression in young and old samples to gain insights on aging, the primary risk factor for most chronic diseases. However, these studies only identify associations without distinguishing drivers of aging from compensatory geroprotective responses or incidental downstream effects. Here, we introduce a workflow to characterize causal effects of differentially expressed genes on lifespan. First, we performed a meta-analysis of 25 gene expression datasets comprising samples of various tissues from healthy, untreated adult mammals (humans, dogs, and rodents) at two distinct ages. Genes were ranked by the number of datasets in which they exhibited consistent differential …

Severe Neurological Presentation In Siblings With Coq5-Related Primary Coenzyme Q10 Deficiency: Expanding Clinical And Molecular Spectrum, Parith Wongkittichote, Rachel M Guerra, Daniel J Wegner, Samantha Toy, Jacqueline A Hauer, David J Pagliarini, Jorge L Granadillo

2020-Current year OA Pubs

Coenzyme Q

Comparison Of Metal Nanoparticles As Antifungal Agents: Efficacy, Mechanisms, And Toxicity Against Candida, Aspergillus, And Cryptococcus, Ahmed Falah Imran, Hayder Hameed Saeed, Khaldoon Jasim Mohammed

AUIQ Complementary Biological System

Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans are the invasive fungi whose diseases are becoming a growing health issue in the global community, particularly in immunocompromised people. The increasing resistance of the conventional antifungals and the shortage of the existing treatment methods require alternative methods. The present review is an evaluation of the antifungal activity of metal-based nanoparticles, including silver (Ag), copper (Cu), zinc oxide (ZnO), titanium dioxide (TiO₂), and selenium (Se) in relation to the three predominant pathogenic fungi. It also talks about their mode of action, relative efficacy, toxicity and their possible future clinical …

Composing A Kaleidoscope: A Scholarly Personal Narrative Of Academia In A Time Of Digital Overload, Suzanne Porath

Mid-Western Educational Researcher

s Scholarly Personal Narrative (SPN) explores the experience of fractured academic identity amid illness, remote teaching, and digital saturation. Anchored in the methodology of SPN as described by Nash (2004) this narrative integrates personal storytelling with critical reflection and theoretical engagement. Drawing on Rushkoff’s concept of digiphrenia, Makowka’s fractal identity, and Gergen’s absent presence, the paper examines how academic life in the digital age increasingly demands simultaneous performances of self across disjointed timelines and virtual spaces. Through vignettes of presenting at concurrent conferences, teaching from chemotherapy bays, and supporting a dissertation defense in unlikely places, this piece reflects on the …

Tax Trends, Harry Z. Garian, John F. Kalben

Tax Adviser

No abstract provided.

Whys And Hows Of Tax Writing, Jerome K. Pescow

Tax Adviser

No abstract provided.

A Love Letter To My Sisters, Angel Jones

Gatherings

This epistolary submission is written in response to experiences at the State of Women of Color in NY Higher Education symposium in March 2025.

Guerrillera Blesson Interlude Vii, María L. Arroyo Cruzado, Julie G. Fogden

Gatherings

Interlude VII is the last of seven reflective pieces interwoven throughout the journal. Each interlude represents a collaborative fusion of María Luisa Arroyo Cruzado’s narrative and Julie Fogden’s visual art, capturing the transformative experience of attending The State of Women of Color in New Higher Education symposium. These interludes draw inspiration from the symposium’s presentations, including thematic content, visual motifs, and the symbolic patterns found in the attire of the presenters. They honor the dedication and labor that women of color invest in both professional and personal spheres, acknowledging the emotional and physical toll of these responsibilities while celebrating the …

Guerrillera Blesson Interlude Vi, María L. Arroyo Cruzado, Julie G. Fogden

Gatherings

Interlude VI is the sixth of seven reflective pieces interwoven throughout the journal. Each interlude represents a collaborative fusion of María Luisa Arroyo Cruzado’s narrative and Julie Fogden’s visual art, capturing the transformative experience of attending The State of Women of Color in New Higher Education symposium. These interludes draw inspiration from the symposium’s presentations, including thematic content, visual motifs, and the symbolic patterns found in the attire of the presenters. They honor the dedication and labor that women of color invest in both professional and personal spheres, acknowledging the emotional and physical toll of these responsibilities while celebrating the …

Guerrillera Blesson Interlude V, María L. Arroyo Cruzado, Julie G. Fogden

Gatherings

Interlude V is the fifth of seven reflective pieces interwoven throughout the journal. Each interlude represents a collaborative fusion of María Luisa Arroyo Cruzado’s narrative and Julie Fogden’s visual art, capturing the transformative experience of attending The State of Women of Color in New Higher Education symposium. These interludes draw inspiration from the symposium’s presentations, including thematic content, visual motifs, and the symbolic patterns found in the attire of the presenters. They honor the dedication and labor that women of color invest in both professional and personal spheres, acknowledging the emotional and physical toll of these responsibilities while celebrating the …

Women, Race, Recovery: How Some Of History’S Most Impactful Thinkers Reflect On Their Own Healing, Karol Cooper

Gatherings

With examples from influential women of color feminists, the essay points to some obstacles in the way to developing a true practice of recovery for women of color academics whose research brings them in continual contact with histories and enactments of harm against women and people of color. As women of color in higher education, articulating our health and healing needs in our own terms would help us clear a path to promoting ourselves as whole and healthy persons, in addition to promoting us along a career path. The essay collects reflections on health struggles from famous women of color …

Guerrillera Blesson Interlude Iv, María L. Arroyo Cruzado, Julie G. Fogden

Gatherings

Interlude IV is the fourth of seven reflective pieces interwoven throughout the journal. Each interlude represents a collaborative fusion of María Luisa Arroyo Cruzado’s narrative and Julie Fogden’s visual art, capturing the transformative experience of attending The State of Women of Color in New Higher Education symposium. These interludes draw inspiration from the symposium’s presentations, including thematic content, visual motifs, and the symbolic patterns found in the attire of the presenters. They honor the dedication and labor that women of color invest in both professional and personal spheres, acknowledging the emotional and physical toll of these responsibilities while celebrating the …

Guerrillera Blesson Interlude Iii, María L. Arroyo Cruzado, Julie G. Fogden

Gatherings

Interlude II is the third of seven reflective pieces interwoven throughout the journal. Each interlude represents a collaborative fusion of María Luisa Arroyo Cruzado’s narrative and Julie Fogden’s visual art, capturing the transformative experience of attending The State of Women of Color in New Higher Education symposium. These interludes draw inspiration from the symposium’s presentations, including thematic content, visual motifs, and the symbolic patterns found in the attire of the presenters. They honor the dedication and labor that women of color invest in both professional and personal spheres, acknowledging the emotional and physical toll of these responsibilities while celebrating the …

Guerrillera Blesson Interlude Ii, María L. Arroyo Cruzado, Julie G. Fogden

Gatherings

Interlude II is the second of seven reflective pieces interwoven throughout the journal. Each interlude represents a collaborative fusion of María Luisa Arroyo Cruzado’s narrative and Julie Fogden’s visual art, capturing the transformative experience of attending The State of Women of Color in New Higher Education symposium. These interludes draw inspiration from the symposium’s presentations, including thematic content, visual motifs, and the symbolic patterns found in the attire of the presenters. They honor the dedication and labor that women of color invest in both professional and personal spheres, acknowledging the emotional and physical toll of these responsibilities while celebrating the …

Gatherings 2.1 Acknowledgement, Table Of Contents And Editors, Roberta Hurtado

Gatherings

Roberta Hurtado, "Acknowledgement" -- Table of Contents -- Editorial Board.

Our Experiences, Julie G. Fogden

Gatherings

This art piece was inspired by presentation topics and visuals, themes, and patterns on clothing worn by the presenters. Our Experiences reflects the time and effort women of color put into our careers and personal lives. It represents the hardship and heartbreak that can come from our responsibilities, and the beauty of strength, resilience and community.

Mixed media: cut paper, acrylic marker, gold ink.

Gatherings 2.1 (Complete Volume), Roberta Hurtado

Gatherings

Proceedings from The State of Women of Color in New York Higher Education.

Roberta Hurtado, "Acknowledgement" -- Table of Contents -- p. vi: Editorial Board.

Journal contents follow: p. 1: Roberta Hurtado (Ed.), "Introduction" -- p. 7: Liz Gil, "Community, Reflection, Wisdom" -- p. 9: Luisa Arroyo Cruzado (narrative) and Julie Fogden (image), "Guerrillera Blesson Interlude I" -- p. 11: Heather Hathaway Miranda, "Round Tables" -- p. 13: Estela López, "Guerrilleras: Speaking Truths and Strategizing Futures" -- p. 17: María Luisa Arroyo Cruzado (narrative) and Julie Fogden (image), "Guerrillera Blesson Interlude II" -- p. 19: Jeanine Irons, "No More Hester …