Digital Commons Network^™

An Annotated Biobank Of Triple-Negative Breast Cancer Patient-Derived Xenografts Features Treatment-Naïve And Longitudinal Samples During Neoadjuvant Chemotherapy, Amanda L Rinkenbaugh, Yuan Qi, Shirong Cai, Jiansu Shao, Faiza Baameur Hancock, Sabrina L Jeter-Jones, Xiaomei Zhang, Emily Powell, Lei Huo, Rosanna Lau, Chunxiao Fu, Rebekah Gould, Petra Den Hollander, Elizabeth E Ravenberg, Jason B White, Gaiane M Rauch, Banu Arun, Clinton Yam, Alastair M Thompson, Gloria V Echeverria, Stacy L Moulder, W Fraser Symmans, Jeffrey T Chang, Helen Piwnica-Worms

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) that fails to respond to neoadjuvant chemotherapy (NACT) can be lethal. Developing effective strategies to eradicate chemoresistant disease requires experimental models that recapitulate the heterogeneity characteristic of TNBC. To that end, we established a biobank of 92 orthotopic patient-derived xenograft (PDX) models of TNBC from the tumors of 75 patients enrolled in the ARTEMIS clinical trial (NCT02276443), including 12 longitudinal sets generated from serial patient biopsies collected throughout NACT treatment and from metastatic disease. Models were established from both chemosensitive and chemoresistant tumors, and nearly 30% of the PDX models were capable of metastasizing …

Integrative Proteogenomics And Forward Genetics Reveal A Novel Mitotic Vulnerability In Triple-Negative Breast Cancer, Nicholas J Neill, Shankha Satpathy, Karsten Krug, Jitendra K Meena, Nivetha Ramesh Babu, Cheyenne Calderon, Desmon Reed, Marcus J Weber, Lacey E Dobrolecki, Alaina Lewis, Christina Sallas, Meenakshi Anurag, Kimberly R Holloway, Chen Huang, Suhas Vasaikar, Maria F Cardenas, Beom-Jun Kim, Doug W Chan, Shayan C Avanessian, Siddhartha Tyagi, Mayra Orellana, Sufeng Mao, Heyuan Li, Fade Gong, Sarah J Kurley, Kristen L Meerbrey, Calla M Olson, Amritha Nair, Tingting Sun, Hsiang-Ching Chung, Elizabeth A Bowling, Jarey H Wang, Pengju Zhang, Peng Xiao, Duxiao Yang, Fabio Stossi, Mei-Yin C Polley, Alexander B Saltzman, Filip Mundt, D R Mani, Michael A Gillette, Susan G Hilsenbeck, George Miles, Carolina Gutierrez, C Kent Osborne, Charles Y Lin, Nathanael S Gray, Jinpeng Sun, David A Wheeler, Charles M Perou, Anna Malovannaya, Michael T Lewis, Bing Zhang, Matthew J Ellis, Steven A Carr, Thomas F Westbrook

Faculty, Staff and Students Publications

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with few effective targeted therapies. Taxanes and other microtubule-targeting agents (MTAs) are frontline chemotherapies for TNBC; however, the molecular pathways that cause TNBC taxane sensitivity are largely unknown, preventing selection of taxane-responsive patients and development of more selective therapeutic strategies. In this study, we identified tumor-selective vulnerabilities in TNBC harboring inactivation of the tumor suppressor PTPN12 by integrating proteogenomic characterization and synthetic lethality screening. We discovered that PTPN12 inactivation drives mitotic defects through aberrant hyperactivation of the ubiquitin ligase complex APCFZR1, a critical regulator of the cell cycle. Consistent …

Exploring Di College Coaches’ Perceptions Of Holistic Coaching And The Factors Impacting Their Ability To Succeed In The Current College Sports Landscape, Deborah V. Hogan Phd

Journal of Issues in Intercollegiate Athletics

In the highly competitive Division I (DI) college sports system, coaches are expected to produce winning programs while developing their college athletes holistically. Recent changes in NCAA policies complicate the coach-athlete relationship, hindering coaches' ability to serve as effective holistic leaders. This study uses grounded theory to understand how DI coaches in high-profile sports perceive their roles as holistic leaders and manage external challenges to provide holistic college athlete experiences. Semi-structured interviews with 12 football and women’s basketball coaches revealed five main themes: 1) coaches are educators, 2) strategies for holistic coaching, 3) supporting Black college athletes, 4) college sports …

Investigating The Glass Cliff Phenomenon In Ncaa Division I Women’S Basketball, Nicholas Swim, Adam R Cocco, Meg Hancock, Nick Kopka

Journal of Issues in Intercollegiate Athletics

In 2022-2023, across all Division I women's college sports teams, women only held 42% of all head coaching positions. Women's college basketball represents one of the outlier sports, as almost 70% of their head coaches for NCAA Division I women's basketball teams were women. While women head coaches are well represented in women's college basketball, Gerretsen et al. (2023) suggest inconsistencies exist in past experience, tenure length, and gender perceptions in women's college basketball hiring practices. This study further aimed to investigate these inconsistencies utilizing role congruity theory and the glass cliff phenomenon. To investigate, the researchers collected data on …

Supporting The College Athlete Amidst The Onset Of Name, Image, And Likeness, Brennan K. Berg, Michael Hutchinson, Janelle E. Wells, David W. Walsh, Andre Simmond

Journal of Issues in Intercollegiate Athletics

Athletic administrators often assume a distinct stakeholder role that has the most immediate and frequent impact on college athletes’ well-being and retention. The implementation of name, image, and likeness (NIL) represents a historic transformation in college athletics. Utilizing a sport development framework, particularly the retention stage, to examine elite athlete development, how athletic administrators socially support college athletes in the new context of NIL and its impact on administrators’ work experiences were empirically assessed. Semi-structured interviews were conducted with 18 athletic administrators at nine universities. The themes of Implementation Challenges, Lack of Uniformity, Holistic Benefits to Athlete Well-Being, and Mostly …

Analysis Of Careers In And Through Intercollegiate Compliance, Michael A. Odio, Grace Wright, Thomas J. Aicher

Journal of Issues in Intercollegiate Athletics

This study examines job movements entering, exiting, and between NCAA compliance-related positions using a sample of 100 LinkedIn profiles. The analysis of the 441 job movements establishes job and organizational tenure figures and patterns in how people matriculate through certain positions. Theory related to career boundaries is used to interpret the job movements and draw conclusions about patterns related to educational backgrounds (e.g., master’s and law degrees), the role of internships and graduate assistantships, and more. The findings provide new insight on career dynamics in NCAA compliance and underscore the need to focus on studying subsectors in college sport to …

House Rules: Athlete, Coach, And Staff Perspectives On The Shifting Ncaa Landscape, Daniel Springer

Journal of Issues in Intercollegiate Athletics

The House settlement is an inflection point in NCAA Division I athletics, ushering in a new model of institutional revenue sharing, roster regulation, and athlete compensation. While legal and financial analyses dominate public discourse, less is known about how these shifts are understood by those working and competing within athletic departments. This study draws on narrative analysis of interviews with 11 athletes, coaches, and staff across five anonymized Power 4 institutions to examine how the House settlement is being interpreted as it takes effect. Three narrative foci emerged: 1) financial prioritization and resource allocation, 2) shifting culture, relationships, and meaning, …

On The Cover, Rebecca Craig

Intersections

No abstract provided.

Full Issue

Intersections

No abstract provided.

Building A Third Space In The Age Of Ai : A Conversation With Dr. Walter Earl Fluker, Elizabeth Kubek

Intersections

No abstract provided.

What Is Required Of You?: Higher Education Leadership In A Moral Key, Paul Pribbenow

Intersections

No abstract provided.

Moderators Of Peer Influence Effects For Adolescents’ Smoking And Vaping Norms And Outcomes In High And Middle-Income Settings, Jennifer M. Murray, Sharon C. Sánchez-Franco, Olga L. Sarmiento, Erik O. Kimbrough, Christopher Tate, Shannon C. Montgomery, Rajnish Kumar, Laura Dunne, Abhijit Ramalingam, Erin L. Krupka, Felipe Montes, Huiyu Zhou, Laurence Moore, Linda Bauld, Blanca Llorente, Frank Kee, Ruth F. Hunter

Economics Faculty Articles and Research

Background: Peer influence is central to adolescent smoking initiation, yet its impact varies depending on individual and contextual factors. Understanding which moderators (personality, contextual, cultural, and environmental traits) shape these processes can inform more effective prevention strategies. We investigated hypothesized moderators of peer influence for adolescent smoking/vaping norms and other smoking-related outcomes in high and low-middle-income countries (LMICs): Northern Ireland and Bogotá.

Methods: Across 12 schools (n = 1,344, age 12–13 years), participants completed novel behavioral economics experiments measuring social norms, and self-report surveys, before and after school-based prevention interventions (ASSIST and Dead Cool). We examined how peer influence …

Subverting The System: Reducing Sex Offender Recidivism And Aiding Reentry Through The Use Of Specialty Courts, Jaymes Fairfax-Columbo, Emma Hamilton, Chelsea Jackson, Lia Knox-Hershey, David Dematteo

Texas A&M Law Review

Sex offender policy in the United States is predicated on accomplishing risk reduction and increasing public safety via punishment and incapacitation. Theoretically, accomplishing these goals should lessen the risk that sex offenders pose to society. However, an accumulated research base suggests that sex offender policies are ineffective in that they do not reduce recidivism rates, do not diminish children’s risk of sexual predation, and produce numerous detrimental collateral consequences. Further, current sex offender policies may actively undermine risk reduction by placing factors known to reduce risk level, such as stable housing, employment, and social support, out of the reach of …

Causation’S Due Process Dimensions, Cassandra Burke Robertson, Charles W. “Rocky” Rhodes

Texas A&M Law Review

For decades, courts have grappled with the tension between compensating victims of mass harms and maintaining fairness to defendants when causation is difficult to prove. This Article argues that the Supreme Court’s due process jurisprudence provides a relevant framework for navigating this tension. We contend that the Court over the last three decades has established a consistent Fourteenth Amendment due process approach in punitive damages and personal jurisdiction cases, which is rooted in antecedents tracing to the nineteenth century and relies on a nexus of interests that balances individual rights, state interests, and federalism concerns. This framework, we argue, has …

That Old College Try: Judge-Made Monopolies In The Market For Affinity Goods, John A. Rothchild

Texas A&M Law Review

There is a large market for goods such as t-shirts, coffee mugs, posters, and baseball caps that are emblazoned with the names and symbols of culturally prominent institutions—universities, athletic teams, musical bands, automobile brands. We buy, wear, and display those goods to express our affinity with the referenced institution. The owners of the trade symbols that adorn these items, which this Article refers to as “affinity goods,” jealously guard what they claim is their sole right, under the trademark laws, to authorize the use of their symbols as decoration. They have brought numerous lawsuits aimed at establishing and enforcing this …

Thermtron: The Unsexy Case The Current Court Should Overturn (Statutory Stare Decisis Be Damned), Christine Tamer

Texas A&M Law Review

Since 1887, Congress has created an impenetrable dike wall to stop appellate review of remand orders in 28 U.S.C. § 1447(d), which provides: “An order remanding a case to the State court from which it was removed is not reviewable on appeal or otherwise . . . .” Then, in 1976, the Supreme Court held “that § 1447(d) does not mean what it says” and, thereby, punctured not a tiny hole, but a big one in Congress’s dike wall that had been impenetrable for nearly 90 years. While you won’t find Thermtron—an unsexy jurisdictional case—on any list of the …

Discerning Interstate Groundwater Law: An Evaluation Of Federal Common Law And Its Impacts On Groundwater Management, Brooke Collishaw

Texas A&M Law Review

The Supreme Court has demonstrated a superficial understanding of ground water over the last century in interstate water disputes. In cases that indirectly affect groundwater, it has ignored the complexities of the resource and its connection with surface water. All but one Supreme Court case that mentions groundwater centers around surface water, leading to the inadequate consideration of groundwater. This has led to the development of a unique federal common law for how federal courts are to resolve interstate water disputes that affect groundwater. While the Court has applied the law consistently, gaps exist. Given the growing reliance on cross-border …

The American Friends Of Irish Neutrality And The American Irish Defense Association: The Last Irish American Committees, Patrick J. Horan

USF Tampa Graduate Theses and Dissertations

This dissertation examines the complex narratives surrounding Irish neutrality during World War II within the Irish American community. It focuses on two key organizations, the American Friends of Irish Neutrality (AFIN) and the American Irish Defense Association (AIDA), arguing that the conflict over neutrality was a pivotal moment in the assimilation of Irish American identity. The study explores how Irish Americans balanced their connection to their ancestral homeland with their desire for full acceptance in the United States.

The research reveals a fervent propaganda war between the AFIN, a grassroots organization defending Ireland’s right to remain neutral, and the AIDA, …

Losing Focus In The Age Of Tik Tok: Clinical Evidence For Policy Action On Social Media Use, Megan Conefrey, Robert Griffin

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

Supporting Single Parents: How Loneliness And Self-Stigma Can Impact Single Parents And Their Quality Of Life, Alana Powell, David Mothersill

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

Ireland Blossoms Through Multiculturalism - Designing For Community Connection, Julia Kuczera, Shirley Casey, Hilary Kenna

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

Unheard And Underserved: Exploring Support For Male Victims Of Partner Abuse, Michael Keenan, Colletta Dalikeni

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

Ireland's Infrastructure: From Delays To Deliveries!, Conor Barnett, Keren Goodman

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

Editorial, Anne M. Friel, Brigid Hooban, Therese Montgomery, Anne Marie O'Brien, Cormac Quigley, Edel Mcneela, Eva Campion, James Walshe, Sinead Loughran

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

Encapsulation Of Corrosion Inhibitors: Methods, Preparation, And Emerging Applications, Mahdi M. Hanoon, Baha. S. Mahdi

AUIQ Technical Engineering Science

Corrosion remains a critical global challenge, imposing substantial economic, safety, and environmental burdens across infrastructure, transportation, marine, and energy sectors. Traditional corrosion inhibitors, while effective, suffer from rapid depletion, uncontrolled release, environmental risks, and limited long-term stability. Encapsulation of corrosion inhibitors has emerged as a transformative strategy, enabling controlled and stimuli-responsive release, improved stability, and self-healing capabilities. This mini review provides a comprehensive overview of encapsulation technologies, including polymeric microcapsules, inorganic carriers, hybrid systems, and advanced nanoengineering approaches. Preparation methods, ranging from physical and chemical routes to emerging microfluidic and electrospinning techniques, are critically examined. Furthermore, the article highlights state-of-the-art …

Norms Violation And Dark Personality: Benign Violation Theory For Humor And Dark Humor, Ahmad Naufalul Umam, Regina Okti Rusliyanti, Firdania Reski Oktaviani

Papers from the International Association for Cross-Cultural Psychology Conferences

Benign violation theory of humor has stood for years as a reliable explanation of what makes things funny. Nonetheless, some researchers emphasized the importance of context in various cultures. This research employs the benign violation framework to dissect the antecedents of amusement in violations that occurred in Indonesia's memetic internet content. Study 1 (N = 40) compared the effect of comedic video (vs. neutral video) on participants' perception of the degree of amusement and violation of the videos presented. The result showed that comedic video was perceived as having a higher level of violations, and the degree of amusement was …

The Relationship Between Psychological Acculturation And Bicultural Identity Integration In A Sample Of Migrants Living In Germany, Konrad Dalberg, Viktoria Kohl, Mona Leonhardt, Stephan Bongard

Papers from the International Association for Cross-Cultural Psychology Conferences

Psychological acculturation strategies and bicultural identity integration have mostly been examined separately in the context of migration. This study explores to what extent these constructs and their subdimensions are related and whether there are overlaps or redundancies between them. Using data from an online survey of migrants (N = 147) in Germany, correlation and regression analyses, an exploratory factor analysis, and mean comparisons were conducted. Significant relationships were found particularly between orientation towards the host culture and cultural harmony, while no association between cultural blendedness and psychological acculturation was found. The factor analysis identified four factors, with primary loadings largely …

Comparison Of Human Versus Genai Generated Measurements Of Personal Beauty Values, Fumiko Kano Glückstad, Kohei Kanno, Hiromi Kobayashi, Rie Nakamura

Papers from the International Association for Cross-Cultural Psychology Conferences

It is a challenging task to develop a scale to measure psychological constructs in a non-native language. In this study, we compared reliability and validity of a scale to measure five dimensions of Personal Beauty Values (PBV) generated by ChatGPT4 with a human-generated PBV scale. The original human-generated PBV scale in English consists of 14 items divided into five dimensions. The limitation of this scale developed by non-native English speakers is a restricted number of items, which will potentially limit the applicability of the scale to other cultural contexts. To complement this weakness, we generated additional items of the five …

The Relationship Between Sex Guilt And Sex Anxiety On Sexual Function In Sexually Active Adult Women, Mia Audina Olivia, Ahmad Naufalul Umam

Papers from the International Association for Cross-Cultural Psychology Conferences

Sexuality is a deeply ingrained aspect of human identity and experience, and its importance can vary greatly from person to person and across different cultures and contexts. There is a widely accepted perspective in sexual behavior research that western women have more flexible sexual norms and thus function better than women from eastern cultural background. Meanwhile, research in eastern countries often only focused on health matters and bounded to abstinence-centred moral value. This study addresses this gap by investigating the intricate relationship between sex guilt, sex anxiety, and sexual function among sexually active adult women in Indonesia. A sample of …

#Willsmith: Text Analyses Of X Posts About The Oscar Slap, Merrisa Lin, Nairán Ramírez-Esparza

Papers from the International Association for Cross-Cultural Psychology Conferences

Social media users share their thoughts on social events, offering insights into the sociocultural climate. Since language reflects related culture, analyzing social media discussions in different languages provides a window into the sociocultural context. In this exploratory study, we examined English and Spanish posts related to the Oscar Slap, which sparked race and gender discussions. We analyzed X posts with #willsmith hashtag in English (N = 28,717) and in Spanish (N = 4,251). The Meaning Extraction Method automated text analyses revealed three similar themes across language cultures, a theme specific to English posts, and two themes unique to Spanish posts. …