Digital Commons Network^™

Transcriptional Coregulator Zmiz1 Modulates Estrogen Responses That Are Essential For Healthy Endometrial Function, Sylvia C Hewitt, Frank Orellana, Ryan M Marquardt, Myeongjin Yi, Cynthia J Willson, Mark Y Chiang, Yong Song, Goutham Venkata Naga Davuluri, Christopher Day, Ramakrishna Kommagani, Joseph Rodriguez, Asgerally T Fazleabas, John P Lydon, Francesco J Demayo

Faculty, Staff and Students Publications

Estrogen is a critical regulator of endometrial health. Aberrant estrogen stimulation can result in infertility, endometrial cancer, and endometriosis. Here, we identified Zinc Finger MIZ-Type Containing 1 (Zmiz1) as a coregulator of uterine estrogen signaling. ZMIZ1 is colocalized with an estrogen receptor α–binding (ESR1-binding) super enhancer. ZMIZ1 mutations are found in endometrial cancer and its RNA levels trend toward reduction in endometrium of patients with endometriosis. ZMIZ1 is dynamically expressed in human endometrial tissues during the menstrual cycle. Disrupting ZMIZ1 in cultured human endometrial stromal cells resulted in impaired cell proliferation and decidual differentiation. Ablation of Zmiz1 using …

A Model For Developing Subspecialty Clinical Practice Guidelines: The Geriatric Emergency Department Guidelines 20, Satheesh Gunaga, Christopher R Carpenter, Maura Kennedy, Lauren T Southerland, Alexander X Lo, Sangil Lee, Kirby Swan, Fabrice Mowbray, Rachel M Skains, Teresita M Hogan, Martin F Casey, Kei Ouchi, Naomi R George, Kerstin De Wit, Cameron J Gettel, Katherine Selman, Luna C Ragsdale, Anita N Chary, James D Van Oppen, Glenn Arendts, Charles L Maddow, Katherine M Hunold, Katren R Tyler, Danya Khoujah, Ula Hwang, Shan Liu

Faculty, Staff and Students Publications

The original consensus-based Geriatric Emergency Department (GED) Guidelines, published in 2014, established a framework of core principles for delivering high-quality, age-appropriate emergency care for older adults. In response to significant advances in geriatric emergency medicine research and evolving clinical priorities, we developed the GED Guidelines 2.0 to ensure continued relevance, clinical utility, and evidence-based rigor. This concept paper describes the systematic and iterative process undertaken to update the guidelines, including the formation of multidisciplinary working groups and the application of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. Unlike the original GED Guidelines, our approach prioritized methodological transparency, …

Part Ii Common Questions And Misconceptions About Creatine Supplementation: What Does The Scientific Evidence Really Show?, Jose Antonio, Ann F Brown, Darren G Candow, Philip D Chilibeck, Stacey J Ellery, Scott C Forbes, Bruno Gualano, Andrew R Jagim, Chad Kerksick, Richard B Kreider, Sergej M Ostojic, Eric S Rawson, Michael D Roberts, Hamilton Roschel, Abbie E Smith-Ryan, Jeffrey R Stout, Mark A Tarnopolsky, Trisha A Vandusseldorp, Darryn S Willoughby, Tim N Ziegenfuss

Faculty, Staff and Students Publications

Creatine monohydrate supplementation (CrM) is a safe and effective intervention for improving certain aspects of sport, exercise performance, and health across the lifespan. Despite its evidence-based pedigree, several questions and misconceptions about CrM remain. To initially address some of these concerns, our group published a narrative review in 2021 discussing the scientific evidence as to whether CrM leads to water retention and fat accumulation, is a steroid, causes hair loss, dehydration or muscle cramping, adversely affects renal and liver function, and if CrM is safe and/or effective for children, adolescents, biological females, and older adults. As a follow-up, the purpose …

Insights From A Survey Of School Nurses: Assessing The Challenges Of Constipation In Schools, Andrew S Chu, Eric H Chiou

Faculty, Staff and Students Publications

Objectives: School nurses are key responders to students with constipation, yet their experiences are underreported. This study surveyed their observations regarding constipation, identified barriers to student restroom access, and assessed educational needs.

Methods: In this descriptive, cross-sectional survey study, an anonymous online survey was distributed to school nurses participating in a virtual education series. The survey assessed nurse demographics, frequency of encounters with constipation and encopresis, school restroom policies, barriers to restroom use, accommodation requests, and training in constipation management.

Findings: Of 125 respondents, 95% encountered students with constipation at least monthly and 55% reported ≥ 6 encounters monthly. Commonly …

The Neonatal Gut Microbiome In Health And Disease, Geoffrey A Preidis

Faculty, Staff and Students Publications

No abstract provided.

A Protectorate Divided: The Otjimbingue Petition And Settler Contestations Of Railway Construction In German Southwest Africa, 1897–1902, Marta Millar

Publications and Research

Supporters of the State Railway in German Southwest Africa heralded its construction as ‘the dawn of a new era for the protectorate’ (Windhoeker Anzeiger, 27 October 1898). While railways did enable the expansion of colonial communities, not all settlers wrote as optimistically about this change as did the Anzeiger’s editor. Between 1897 and 1902, familial correspondence and debates in the protectorate’s first newspaper, the Windhoeker Anzeiger, reveal how various settlers negotiated the railroad’s transformative impact on colonial society and their everyday lives. Opposition voices argued that the railroad would harm the fragile colonial economy, serving only …

Navigating Seismic Anisotropy, With Applications To Alaska, Aakash Gupta

Geosciences

Seismic anisotropy characterizes how elastic waves travel through solid materials with different speeds, depending on the direction of the waves and the direction of particle motion of the waves. Evidence of seismic anisotropy in the Earth is widespread, from seismic waves sampling the crust, mantle and even the core, to active-source, industry-scale seismic experiments, to laboratory mea­ surements of rock samples from boreholes or at the surface. Global models of the Earth provide a highly averaged image of anisotropy. Studies based on shear wave splitting measurements from local and global earthquakes indicate that the anisotropy in the Earth is much …

Where, How, And How Much? A Multicenter Cohort Study Of The Relationship Across Lupus Decision-Aid Modality, Place Of Administration, Interruption And Viewing Completeness, And Patient-Reported Outcomes, Jasvinder A Singh, Mark Beasley, Larry R Hearld

Faculty, Staff and Students Publications

Objective: We assessed whether shared decision-making (SDM) and patient acceptability, feasibility, and overall satisfaction with a computerized patient decision aid (PtDA) for patients with systemic lupus erythematosus (SLE) differs by PtDA setting, modality, and the viewing experience.

Methods: Patients with SLE were invited to view a self-administered computerized SLE PtDA during regular clinic visits at 15 rheumatology clinics in an implementation trial. Patients completed a survey that included SDM measures including the decision conflict scale (DCS), Preparation for Decision Making (PDM) scale, and CollaboRATE scale, and we measured perceived patient acceptability, feasibility, and satisfaction. Patients viewed the SLE PtDA in …

Benchmarking Empirical Severity For The Yale-Brown Obsessive Compulsive Scale-Second Edition, Caitlin M Pinciotti, Juliana Avery, Chencheng Zhang, Josselyn S Muñoz, Dayan Berrones, Vanessa Zavala Cruz, Andrew D Wiese, Jacey L Anderberg, Renee M Frederick, Tomás Miño, Nuria Lanzagorta, Juan Camilo Restrepo, Marcos E Ochoa-Panaifo, Wayne K Goodman, James J Crowley, Eric A Storch, Matti Cervin

Faculty, Staff and Students Publications

The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) is considered the primary instrument for assessing the presence and severity of obsessive-compulsive disorder (OCD). Conceptual and empirical critiques inspired the development of an updated version of the instrument, the Yale-Brown Obsessive Compulsive Scale-Second Edition (Y-BOCS-II), with a higher ceiling of OCD severity to better differentiate between severe and the most debilitating OCD presentations, among other revisions. The Y-BOCS-II has demonstrated sound psychometric properties across diverse samples. Empirically derived severity benchmarks have been proposed for the original Y-BOCS, yielding somewhat different ranges than what has been commonly used in clinical and research settings, yet …

Voting Under Contradictory News, Arnab Mitra, Quazi Shahriar

Economics Faculty Publications and Presentations

How much do opposing news sources distort private information and how do voters use distorted contradictory information regarding candidate quality? In a two candidate voting game, we derive and experimentally test an “average-opinion” hypothesis, where two opposingly biased sources, capable of forming an unbiased estimate of candidate quality as well as a distorted estimate within a bound, symmetrically distort their reported estimates in opposite directions, and voters split the estimate difference to decipher the unbiased estimate. Data support the hypothesis and show that voters benefit from sources’ competition, compared to a control treatment without competition. When sources are allowed to …

The Library Instructor As Learner: A Survey Of Reflective Teaching Practices In Us Academic Libraries, Alicia G. Vaandering, Amanda Crego-Emley

Communications in Information Literacy

Reflective practice provides library workers with a critical opportunity to examine professional experiences, question assumptions and approaches, explore new perspectives, and develop innovative solutions to existing problems. When applied to instruction as reflective teaching, this practice better situates library instructors to meet the evolving needs of twenty-first-century library users. This research study explores how library workers engage with reflective teaching in academic libraries across the United States. A survey was distributed to academic library communities, and a total of 153 responses were collected. While 92% of respondents reported participating in reflective teaching practice in a variety of instructional contexts, results …

Teaching Research As An Interdependent Practice: Bringing Alternate Models Into The Scholarly Conversation, Natalia Kapacinskas, Veronica Arellano Douglas

Communications in Information Literacy

The customs and practices of research in academia are often mischaracterized as individualistic pursuits, ignoring the reality that research requires a great deal of collaboration. As teaching librarians, our research instruction often reinforces individualism as a scholarly virtue, even as we simultaneously engage with themes of connection between researchers and their ideas. We propose an approach to teaching research and information literacy grounded in the concept, intention, and practice of interdependence rather than individualism. In doing so, we will call in models of interdependence from critical disability studies, relational-cultural theory, Indigenous Ways of Knowing, and the Cite Black Women movement. …

Searching For Change: Exploring Historical Silences And Counterstorytelling Through Youth-Led Social Justice Movements, Ariana Varela

Communications in Information Literacy

During a first-year engagement program, a librarian and a cohort of students worked towards a shared understanding of dominant narratives, historical silences, and creating counterstories through research to center marginalized stories and complicate existing narratives. As information literacy professionals, we should design interactive lessons that demonstrate critical search and evaluation skills through topics that are relevant to students and encourage them to work with issues that impact their communities. Incorporating critical information literacy, feminist pedagogy, and critical race theory, this two-day micro-seminar introduced first-year students to the legacy of youth community activism in the neighborhoods around their university. They practiced …

Bypassing Cisplatin Resistance In Nrf2 Hyperactivated Head And Neck Cancer Through Effective Pi3kinase Targeting, Pedram Yadollahi, Kelli A Mccord, Yang Li, Hussam Dayoub, Kalil Saab, Fonma Essien, Sean Hyslop, Emerald Kan, Kazi M Ahmed, Parker R Kirby, Vasanta Putluri, Chandra Shekar R Ambati, Karthik Reddy Kami Reddy, Patricia Castro, Heath D Skinner, Cristian Coarfa, William K Decker, Abdullah A Osman, Rutulkumar Patel, Jeffrey N Myers, Stephen Y Lai, Nagireddy Putluri, Faye M Johnson, Mitchell J Frederick, William H Hudson, Vlad C Sandulache

Faculty, Staff and Students Publications

Background: For patients with head and neck squamous cell carcinoma (HNSCC), failure of definitive radiation combined with cisplatin nearly universally results in death. Although hyperactivation of the Nrf2 pathway can drive radiation and cisplatin resistance along with suppressed anti-tumor immunity, treatment-refractory HNSCC tumors may retain sensitivity to targeted agents secondary to synergistic lethality with other oncogenic drivers (e.g., NOTCH1 mutations).

Methods: Using state of the science mechanistic, metabolomic and spatial transcriptomic approaches combined with preclinical models of HNSCC, we tested whether a novel PI3K inhibitor, gedatolisib, can bypass hyperactivation of the Nrf2 pathway.

Results: The PI3K pathway is activated in …

Changing Lives, Transforming Communities: How Young Feminist Organizations Create Change In Mexico And Kenya—Slide Deck, Population Council Kenya

Adolescents and Young People

No abstract provided.

Privacy And Disinformation, Tiffany C. Li

UC Law Journal

All three branches of the federal government have wrestled with how the law could or should regulate social media applications to mitigate the harms of disinformation. However, most proposed solutions make the same critical mistake: Lawmakers may focus on speech regulation or even economic regulation to solve for disinformation but these solutions do not actually address contemporary, technological vectors of disinformation. In today’s increasingly technologically driven global speech environment, the lynchpin for disinformation is not speech but data.

In particular, algorithmic personalization is a new, technological factor that makes disinformation especially harmful. Luckily, data protection and privacy regulation can greatly …

The First Amendment, Global Corporate Responsibility Standards, & The Quest For Online “Speech Nirvana”, Evelyn M. Aswad

UC Law Journal

With large and powerful social media companies operating as worldwide speech regulators, it is unsurprising that governments have attempted to not only regulate how these companies address platform speech but also pressure them to deliver preferred speech outcomes. In 2024, the Supreme Court decided two cases addressing both themes in the U.S. context. In Moody v. NetChoice, the Court explained how legislation regulating private platform curation of usergenerated content runs afoul of First Amendment protections. And, in Murthy v. Missouri, the Court appeared to erect significant hurdles to challenging alleged governmental coercion of such platforms. These cases have left many …

Rap Snitches: A New Framework To Evaluate Rap Lyrics And Creative Expressions As Evidence, Chris Kenefick

UC Law Journal

Rap music has earned its prominent place in American music culture.1 It provides a unique creative outlet for artists to share their experiences and criticize the systems in which they live. Rap lyrics, often metaphorical or exaggerated, have been weaponized by prosecutors to attack the character of artist-defendants at a level not seen with other modes of creative expression. The lyrics of an artist are turned against them in a manner that invites unfair prejudice and improper character evidence into legal proceedings. In the 2020s, major progress has been made to curb this practice, with several jurisdictions introducing legislation that …

Wide Nets, Heavy Burdens: Unpacking Executive Order 14105’S Final Rule, Breanna Li

UC Law Journal

Executive Order 14105 “Addressing United States Investments in Certain National Security Technologies and Products in Countries of Concern” was enacted to protect U.S. national security interests in light of China’s military technological growth. This Executive Order creates an outbound investment review program that restricts investments by a U.S. person into companies in specified countries operating in certain technology sectors. This Note will discuss the background of geopolitical tensions between the United States and China, review E.O. 14105, and argue that the program it creates results in burdensome unintended consequences to the U.S. economy. These unintended circumstances include: (1) high regulatory …

Insurance Under Fire: Assessing How California’S Insurance Industry Is Tackling The Wildfire Crisis And What’S Next, Mackenzie Paskerian

UC Law Journal

California is currently facing an insurance crisis. The increased impact of climate change, including extreme droughts and wildfires, poses new risks to the insurance industry, especially when it comes to homeowner’s insurance. Insurance providers have limited their homeowner coverage, with many companies leaving the state entirely due to the undervaluation of climate risk in the policies they provide. A so-called “climate insurance bubble” is already beginning to burst. The state’s last-resort public insurance program, the FAIR Plan, has expanded rapidly to fill in for the lack of insurance providers in the state. But because FAIR Plan policies are expensive and …

Religious Freedom & The Fertilized Egg, Rabea Benhalim

UC Law Journal

Anti-abortion activism and litigation have challenged established caselaw on the legality of in vitro fertilization (IVF) and the legal treatment of IVF fertilized eggs. These challenges rely on conservative Christian ideologies that full personhood occurs at fertilization. Litigation has primarily arisen out of wrongful death suits and divorce proceedings, wherein a party either has destroyed or seeks to dispose of frozen blastocysts. Some legislatures now seek to regulate the treatment of IVF fertilized eggs vis-á-vis legislation, as politicians increasingly seek to ban any destruction of human fertilized eggs by legally defining human life as beginning at fertilization. However, the question …

Brewing Solidarity: Rights Consciousness And Class Consciousness In Coffeeshop Organizing, Brishen Rogers

UC Law Journal

Almost ten thousand baristas have unionized since 2022 in cafes across the country. Their effort breaks with recent history in several respects. For example, baristas have used a novel “worker-to-worker organizing” model in which workers themselves—rather than union staff and leadership—design and manage campaigns. Also, while scholars and unionists have argued for decades that the National Labor Relations Board’s secret ballot elections process is a dead end, baristas have used that process quite effectively, winning over 85% of their elections against the major company involved. Through their organizing efforts, baristas have centered the issues and voices of LGBTQ+ workers and …

Dei: Definitely Earned It–A Review Of Contemporary Dei Initiatives Against Emerging Legal Frameworks, Joseph Cremona

UC Law Journal

Since 2024, Diversity, Equity, and Inclusion (DEI) programs have ignited a volatile political debate. Fierce opposition continues to attack their very existence. On one hand, proponents of DEI programs argue that such initiatives are a pivotal mechanism for ensuring that historically marginalized communities receive professional opportunities in America. On the other hand, opponents of DEI insist that these programs are detrimental because they prioritize the advancement of minority groups at the expense of their majority counterparts. With the recent enactment of multiple executive orders by President Trump, DEI programs have become the target of a plethora of lawsuits. These legal …

An Age Of Statutes Or An Age Of Executive Orders? Conflicting Judicial And Presidential Visions Of Policymaking, Daniel A. Farber

UC Law Journal

Two decades ago, then-Professor Elena Kagan hailed the era of presidential administration in which Presidents would launch major policy initiatives within the executive branch and end run congressional gridlocks. Since then, the President’s role in the regulatory state has snowballed. In his second term, President Donald Trump has used this authority to the utmost in a quantum leap in presidential administration. Paradoxically, the same Justices who have championed the unitary executive have created roadblocks to presidential policymaking. Overruling the Chevron doctrine, the Court has sought to cabin the role of agencies, and thus the newly supreme President, in statutory administration. …

Modeling Reemergence Of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination In The United States, Mathew V Kiang, Kate M Bubar, Yvonne Maldonado, Peter J Hotez, Nathan C Lo

Faculty, Staff and Students Publications

(Abstracted from JAMA 2025;333(24):2176-2187) The development of childhood vaccine protocols has led to the elimination of many infectious diseases from the United States, including measles, rubella, diphtheria, and polio, by maintaining herd immunity. In recent years, especially since the COVID-19 pandemic, vaccination rates have declined due to policy changes, misinformation, distrust, and broader societal shifts.

Why Teens Are Particularly Vulnerable To The Harms Of Vaping Addiction: A Literature Review, Chloe Manning-Floch

University Honors Theses

This literature review examines the factors that have been found to place teens aged 12-18 at particular risk of the harms of vaping addiction. Sixteen relevant research studies are cited, along with four other sources containing information from the FDA, CDC, and NPR, to determine which themes are the most significant and widely identified as risk factors adding to teens' vulnerability. While the body of research on teen vaping addiction is relatively new, strong consensus exists: the most significant factors placing teens at risk of vaping addiction's harms are sweet flavoring appealing to young people, marketing of vapes that has …

Security Vulnerabilities And Defense Tactics For Generative Ai Application Development, Kyle Klein

University Honors Theses

Generative AI (GenAI) applications such as OpenAI's ChatGPT leverage large language models (LLMs) trained on enormous amounts of data to accomplish tasks such as document editing, summarization, and query response. Chatbots and LLM programs that are equipped with retrieval-augmented generation (RAG) have the ability to draw upon data provided by developers and users to improve the quality of the program's responses. LLM technology has even expanded to generate images, audio, and video from user instructions. Designed around unpredictable user input and typically composed of many opaque components, LLM software products face a paradigm shift of new, constantly evolving security challenges. …

A Capstone Review: Strategic Solutions For A Small Macrame Business, Jenna Sarieddine

University Honors Theses

This essay presents an overview of the Business Capstone project, focusing on a macramé business currently facing a $10,000 debt due to limited marketing and financial management skills. The purpose of the project is to support the business in developing an effective elevator pitch, improving its social media presence, strengthening its financial statements, and enhancing both personal and business financial practices. The essay explores the company's strengths, weaknesses, opportunities, and threats, as well as the team's collaborative approach to addressing these challenges. It outlines the goals established for the company, the strategies selected based on our academic backgrounds and business …

Interventions For Online Gambling Addiction With Vulnerable Populations, Ethan Sarin

University Honors Theses

This paper looks at the modern rise of online gambling, what has been done to address it, and how we can improve upon them in the future. Online gambling is gambling done through a digital medium with two distinct forms: gambling adjacent activities (GAAs), and general online gambling. GAAs are activities that highly resemble gambling, but are legally distinct from gambling due to different kinds of obfuscation like using in-game currency to gamble instead of directly real world money. General online gambling is much clearer about it being gambling with many kinds of gambling activities to partake in from digital …

Method For Generation And Ex Vivo Expansion Of Genetically Edited Mouse Tregs, Yosef Gilad, Adam M Dean, Yan Xia, Sang Jun Han, David M Lonard, Bert W O'Malley

Faculty, Staff and Students Publications

Regulatory T cells (Tregs) play a crucial role in the immune system, and their dysfunction can lead to the development of autoimmune conditions. In cancer, tumors frequently hijack the immunosuppressive function of Tregs to evade immune responses. Due to their central role in key pathological processes, Tregs have gained increasing attention as promising targets for various clinical applications. However, their relative scarcity (∼5% to 10% of CD4+ T cells) and instability presents a technical challenge for research and therapeutic development. In congenic animal models used to investigate autologous cell transfer-based therapies, this challenge is even greater, as Treg donor animals …