Digital Commons Network^™

Expression And Purification Of Prohibitin Proteins And Investigation Of Their Interaction With Mycobacterium Tuberculosis’S Virulence Factors, Zeina Rhaim

Open Access Theses & Dissertations

Prohibitin (PHB) is a highly conserved mitochondrial protein involved in cell cycle regulation, apoptosis, mitochondrial integrity, macrophage activation, cytokine production and many other critical cell functions. The prohibitin complex, formed by Prohibitin-1 (PHB1) and Prohibitin-2 (PHB2), functions as a mitochondrial membrane-associated receptor. Cancer, neurodegenerative disorders, and renal conditions were found to be linked to an irregular PHB expression. Emerging evidence has also highlighted a significant role for PHB in tuberculosis (TB), particularly through its interactions with Mycobacterium tuberculosis (Mtb) virulence determinants. The molecular mechanisms by which PHB influences TB pathogenesis remain poorly understood. Our preliminary studies showed that PHB1 was …

Ode To The Infomercial, Edward Wade

Open Access Theses & Dissertations

'Ode to the Infomercial' is a poetry collection in five sections which explores themes of contemporary American life, parenthood, and the media landscape. While primarily written in a narrative voice, the poetic approach is as diverse as the content. Interwoven throughout the collection is religious imagery and political posturing accompanied by healthy doses of self-criticism and humor.

J Mich Dent Assoc December 2025

The Journal of the Michigan Dental Association

Each month, the Journal of the Michigan Dental Association delivers news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. It remains the main publication reaching Michigan dentists and is available worldwide through ADA Commons. The December 2025 (Volume 107, No. 11) issue of the Journal is published in a digital-only format to provide updates and insights for Michigan's oral health community and MDA members. Print editions will resume in the new year.

This issue includes feature articles on the Michigan Dental Foundation, A Case for Credentialing Dental Assistants, and a feature …

Community Approaches To Digitally Documenting And Sharing Conjunto Music In The South Texas Borderlands, René Antonio Ballesteros

Theses and Dissertations

This thesis explores the rich tradition of conjunto music within the South Texas borderlands, examining how integrating community engagement and digital humanities methodologies can effectively enhance the documentation, conservation, and presentation of this place-based expressive culture. Recognizing existing archival gaps, the research employed community-engaged programming to gather and preserve valuable cultural data. A key methodology outcome involved creating digital maps utilizing place-based data related to conjunto music sites and activities, subsequently integrating these maps into an ArcGIS Online story map for public online access. The findings demonstrate the significant potential of community collaboration and digital humanities tools in amplifying cultural …

Mda Insurance: Offer Group Health Insurance To Entice Recruits, Retain Valuable Staff, Craig Start

The Journal of the Michigan Dental Association

Amidst a competitive labor market, offering group health insurance is critical for attracting and retaining qualified dental staff, as it is the most highly valued employee benefit. Dentists can establish an employment policy stipulating cost-sharing for premiums, rather than paying the entire cost. The MDA strongly encourages investigating the exclusive MDA Health Plan, which offers 11 distinct plan designs powered by Priority Health. For 2026, the MDA Health Plan is increasing rates by only 4%, significantly lower than commercial group plans requesting double-digit increases (10% to 18%). Plans can be started at any time during the year, requiring about 30 …

Future Screens. Special Issue. Editorial, Gianni Corino, Andrew Prior, Tatiana Mazali

School of Art, Design and Architecture

No abstract provided.

The Use Of Alcohol-Free And Low-Alcohol Drinks In Pregnancy In The Uk, Kate Maslin, Heather Hopper, Jill Shawe

School of Nursing and Midwifery

Alcohol-free drinks [beers, ciders, wines, and spirits containing <0.05% alcohol by volume (ABV)], and lowalcohol drinks (between 0.05% and 1.2% ABV) are increasingly available and may be used as a harm reduction measure. However, it is not known what pregnant women think and feel about these drinks and how regularly they are consumed before and during pregnancy. A cross-sectional online survey was developed and piloted. Women ≥18 years in the UK who were pregnant, or recently pregnant, were recruited via targeted social media advertising. Of the 2092 respondents, 47.8% (n ¼ 1001) were currently pregnant; 55.7% (n ¼ 1167) were between 25 and 34 years, 90.0% were White (n ¼ 1881); 6.1% (n ¼ 128) were drinking alcohol at “increasing risk” levels (>14 units/week) before pregnancy. During pregnancy, 13.5% (n ¼ 282) consumed alcohol, which was more common in the increasing risk category (P < .01). Alcohol-free or low-alcohol drinks were consumed by 71.3% (n ¼ 1491) of respondents during pregnancy; 91.4% of the increasing risk category versus 69.9% of the lower risk category (P < .01). The most common reasons for consuming alcohol-free or low-alcohol drinks were “to choose a safer alternative” (71.9%, n ¼ 1073) and “to feel included in social events involving alcohol” (68.8%, n ¼ 1026). More than half of respondents (56.7%) thought there was insufficient information available about consuming alcohol-free and low-alcohol drinks during pregnancy, with internet searching the primary source of information. Although alcohol-free and low-alcohol drinks are commonly consumed during pregnancy, there are some safety concerns. Their role as a harm reduction measure in those who are drinking alcohol at increasing risk levels prepregnancy needs further investigation.

Social Media Participation And Scholarly Success In Law, Julian Nyarko, David E. Pozen

Faculty Scholarship

Using a novel dataset on Twitter activity as well as a novel corpus of law journal publications, this paper examines the impact of social media activity on the scholarly success of U.S. law professors. We find that joining Twitter increases citation counts by an average of 22% per year and improves article placements by up to 10 ranks for law professors, relative to a synthetic control group. These positive returns apply across nearly all classes of scholars and are magnified for those who post frequently about their own work. The identified citation boost would be even larger than 22% if …

Típica Style Vs. Latin Jazz: A Comparison Of Traditional Salsa Piano Accompaniment And Latin Jazz Comping, Victorino C. Perez

Electronic Theses and Dissertations

Salsa is a popular Latin American musical genre that combines dance and vocal music with a unique rhythmic style that draws influences from jazz and African rhythms. Salsa shares characteristics with Latin jazz. Traditional salsa, or típica style, features traditional tonal harmonies with few alterations, whereas Latin jazz typically employs complex harmonies including tritone substitutions, chord extensions, and chords with extensions and alterations. The primary argument of this research is that Latin jazz pianists maintain the functions of the traditional salsa while infusing it with jazz harmonic, rhythmic, and textural elements. This thesis compares accompanying (“comping”) traits, including form, harmony, …

Exploring The Lived Experience Of Nursing Faculty In Preparing For The Next Generation Nclex: A Qualitative Study, Mary Granoff, Missilia Gilbert, Marjorie Lima, Erika Nusbaum, Natalie Bermudez

Nursing & Health Sciences Research Journal

Introduction: According to the Nursing Council of State Boards of Nursing (NCSBN), more than half of all errors among new graduate registered nurses are related to a lack of clinical judgment, a critical component of nursing practice. Considering the Next Generation National Council Licensure Examination (NCLEX) focuses on clinical judgment, a greater understanding of faculty’s Next Generation NCLEX (NGN) teaching preparedness is needed. The purpose of this study was to explore nursing faculty’s lived experience preparing students for the NGN.

Methods: This was a qualitative descriptive study. Data were collected via 15-minute individual interviews. Participants were pre-licensure nursing faculty from …

Synthetic Dataset For Understanding Negation In Text-Guided Image Editing, Nhat-Tan Bui

Graduate Theses and Dissertations

Negation is a fundamental linguistic concept used by humans to convey information that they do not desire. Despite this, minimal research has focused on negation within text-guided image editing. This lack of research means that vision-language models (VLMs) for image editing may struggle to understand negation, implying that they struggle to provide accurate results. One barrier to achieving human-level intelligence is the lack of a standard collection by which research into negation can be evaluated. This thesis presents the first large-scale dataset, Negative Instruction (NeIn), for studying negation within instruction-based image editing. Our dataset comprises 366,957 quintuplets, i.e., source image, …

Rights, Contract, And Consideration In The Civil Law And Common Law Traditions, Stéphane Sérafin

UBC Law Review

No abstract provided.

Career Readiness Competencies Among First-Generation Undecided Students And Their Parents In The United States, Nicole M. Kotlan, Evan W. Faidley

Journal of Global Education and Research

The purpose of this study was to investigate the relationship between first-generation status and the value of career readiness competencies of first-generation undecided students (n = 106) and their parents (n = 178), explored through social cognitive career theory and Bourdieu’s theory of habitus and social and cultural capital. A non-experimental design using a non-random sample revealed, through an independent t-test, statistically significant differences in global/intercultural competency among students based on their first-generation status. The results of a multiple linear regression analysis suggest that parents’ values are associated with students’ values and professionalism/work ethic; however, no relationship was …

A Secret Society Of Readers: College-Age Mentors’ Literacy Experiences With Young Adolescent Mentees, Lindsay Persohn, Dulcey B. Hunter, Chelsea Rivera, Karyn Z. Mendez, Cheryl R. Ellerbrock, Lucy Monette

Journal of Global Education and Research

This study occurred within Year One and Year Two of an ongoing literacy initiative designed to build reader identities among underserved middle school students. Using a near-peer mentoring model, mentees were paired with college-student mentors to interact weekly around books and reading. Reader interests and identities are influenced by affective and relational approaches through mentored reading experiences and a variety of texts. This qualitative case study (n = 11 of 24 Year One and n = 13 of 37 Year Two mentors) aimed to identify the ways mentor/mentee relationships affect reader interests, attitudes, and skills, and to evaluate the …

Investigation Of Changes In Exotic Bird Serum Vitamin D Levels Between Indoor And Outdoor Housing, Alexander J. Marley

Department of Animal Science: Dissertations, Theses, and Student Research

Vitamin D is a fat-soluble vitamin that is directly related to sunlight and is involved in multiple physiological processes including calcium metabolism, feather quality, and chick development. Most vertebrate species are capable of both absorption of exogenous vitamin D and internal synthesis of vitamin D, with vitamin D3 (cholecalciferol), being more accessible and bioactive in bird species. In exotic bird species, dietary requirements for vitamin D3 are largely unknown, and the ability to maintain adequate serum concentrations of vitamin D3 metabolites without direct sunlight exposure also requires evaluation. Concerns arise in situations where individuals may be housed indoors for extended …

Advancing Environmental Sustainability In The Uae: The Interplay Of Women’S Empowerment, Financial Development, And Natural Resource Management, Suzanna Elmassah, Eslam A. Hassanein

All Works

This study addresses a critical gap in the literature by exploring the intricate relationships between women’s empowerment, financial development, and natural resource management within the context of environmental sustainability in the United Arab Emirates (UAE). Utilizing the Women, Business, and Law Index to quantify women’s socioeconomic empowerment alongside the ecological footprint as a metric for environmental sustainability, this study employs an autoregressive distributed lag (ARDL) model to analyze data from 1990 to 2021. The findings reveal that women’s empowerment exerts a significant positive effect on environmental sustainability in both the short and long term. While financial development and natural resource …

Genomic And Functional Characterisation Of Endophytic Bacterium Bacillus Cereus Strain E1 Alleviating Salt Stress And Enhancing Tomato Physiology And Spectral Indices, Balamurugan Sadaiappan, Tanveer Alam Khan, Qurban Ali, Sulamita Santos Correa, Mahideen Afridi, Soumaya Tounsi Hammami, Munawwar Ali Khan, Sunil Mundra

All Works

Mangroves in arid environments represent unique ecological niches that support a diverse range of microorganisms. Endophytic bacteria residing within host plants play a crucial role in promoting plant growth by enhancing pathogen resistance and alleviating environmental stress. Identifying novel stress-tolerant strains, specific to arid environments, is essential for expanding the repertoire of plant growth-promoting bacteria (PGPB). In this study, we investigated the saline tolerance of the endophytic bacterium strain E1, previously isolated from the root of Avicenna marina (grey mangrove). Whole-genome sequence (WGS), phylogenetics and average nucleotide identity (ANI) analysis were performed. The strain exhibited high salinity tolerance, growing in …

Applying Ni-Wc As A Composite Coating Combines Both Protective And Repair Functions By Thermal Spray For Hptb Applications, Alaa Dahesh, Ahmed Hassan, Hussain Yousif

Journal of Applied Sciences and Nanotechnology

This work presents a solution to repair the deteriorating High-Pressure Turbine Blades (HPTB) instead of costly replacement by implementing a two-coating layer system for protection and repair. The first layer is a Bonding Coating (BC) that is made from a nickel-based alloy (NiCrBSi); the second layer is a Top Coating (TC), which is composed of a nickel-based composite material that contains tungsten carbide (WC) particles. Both layers were applied to a nickel-based substrate using a flame thermal spraying (FTHS) technique, with the spray parameters chosen based on the Taguchi method. The results were analyzed using optical microscopy, scanning electron microscopy …

Does Reducing Videofluoroscopy Frame Rate Affect Dige/St Grades In Modified Barium Swallow Studies?, Shitong Mao, Carla L Warneke, Sheila N Buoy, Ariana J Sahli, Brinda Rao Korivi, Carly E A Barbon, Kristy K Brock, Katherine A Hutcheson

Faculty, Staff and Student Publications

Understanding the effects of reduced frame rates on the reliability of Modified Barium Swallow (MBS) ratings for swallowing safety and efficiency is essential for clinical practice. While previous research has examined frame rate (simulated pulse rates) implications concerning penetration, aspiration, and residue ratings, the impact on summary grading systems like the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) remains unclear. This study analyzed a total of 315 full MBS videos collected from 278 patients, and 76.25% of patients were diagnosed with head and neck cancer (mean age 62.51 years, SD 8.53; 12.23% female). We performed pairwise comparisons of DIGEST grades …

Periostin Promotes Sarcoma Growth By Promoting Tumor-Associated Macrophage Migration And Differentiation, Jin-Fen Xiao, Kristin Ishaya, Emily Y Ko, Annaliese Fowler, Marina T Broz, Jlenia Guarnerio

Faculty, Staff and Student Publications

Soft-tissue sarcomas (STS) are characterized by abundant extracellular matrix (ECM) deposition, yet the functional contribution of specific ECM components remains poorly understood. In this study, we identify periostin (POSTN), a matricellular protein, as a regulator of sarcoma progression and the tumor immune microenvironment. Analysis of human sarcoma datasets revealed that high POSTN expression correlates with poor prognosis and elevated expression of ECM-related and myeloid cell–associated genes. In murine genetic models of sarcoma, tumors expressing high levels of Postn displayed enhanced expression of ECM genes and monocyte-recruiting cytokines. Functional silencing of Postnin vivo reduced tumor growth without altering tumor cell …

Bayesian Integrated Learning Of Longitudinal Dose-Response Relationships Via Decentralized Clinical Trials, Jingyi Zhang, Tuo Wang, Yongming Qu, Fangrong Yan, Suyu Liu, Ruitao Lin

Faculty, Staff and Student Publications

Decentralized clinical trials (DCTs) extend trial activities beyond traditional sites, enhancing access, convenience, efficiency, and result generalizability. They are particularly promising for chronic conditions like diabetes and obesity, which require longer study durations to evaluate drug effects. However, decentralized data collection raises concerns about increased variability and potential biases. This paper presents a novel Bayesian integrated learning procedure to analyze dose-response relationships using longitudinal data from a phase II DCT that combines centralized and decentralized data collection. We generalize a parametric exponential decay model to handle mixed data sources and apply Bayesian spike-and-slab priors to address biases and uncertainties from …

Artificial Intelligence Biomarker Detects High-Risk Childhood Asthma Subgroup For Respiratory Infections And Exacerbations, Young J Juhn, Chung-Il Wi, Euijung Ryu, Katherine S King, Sunghwan Sohn, Elham Sagheb, Greg Jenkins, David Watson, Miguel A Park, Sergio E Chiarella, Hirohito Kita, Mir Ali, W Charles Huskins, Elizabeth H Ristagno, Imad Absah, Charles Grose, Kathy Ihrke, Elizabeth A Krusemark, Thanai Pongdee, Björn Nordlund, Carla M Davis, Robert J Pignolo, Hongfang Liu

Faculty, Staff and Student Publications

Background: Asthma is associated with an increased risk of acute respiratory infections (ARI). Little is known about whether natural language processing (NLP)-powered digital biomarkers can identify a high-risk asthma subgroup for ARI during early childhood.

Objective: We assessed whether a digital biomarker could identify a high-risk subgroup of childhood asthma for ARI.

Methods: We applied validated NLP algorithms for Predetermined Asthma Criteria (NLP-PAC) and Asthma Predictive Index (NLP-API) to electronic health records of the 1997-2016 Mayo Clinic Birth Cohort. We categorized the cohort into 4 subgroups: both criteria positive (NLP-PAC+/NLP-API+), PAC positive only (NLP-PAC+), API positive only (NLP-API+), and both …

The Longitudinal Impact Of Radiotherapy On Osseointegrated Hearing Aid Outcomes And Complications, Benjamin D Lovin, Mike Hernandez, Paul W Gidley, Karine Al Feghali, Jack Phan, Catherine Wang, Congjun Wang, Dianna Roberts, Marc-Elie Nader

Faculty, Staff and Student Publications

Objective: To evaluate the impact of radiotherapy on osseointegrated hearing aids (OIHA) complications.

Methods: Retrospective review of percutaneous OIHA performed from 2006 to 2021 at an academic institution. Implant and abutment-related complications were evaluated and stratified by radiation parameters. Main outcome measures were abutment, implant, and major complications assessed using the modified Holgers and IPS grading scales.

Results: Total of 190 OIHA were included; 124 (65%) were placed in bones that previously or subsequently received radiation. Total of 84 (44%) OIHA experienced at least one complication at mean 43.3 months. Radiation cohort had greater rates of having any complication (p …

Inhibiting Monocyte Migration Reduces Arterial Thrombosis And Facilitates Thrombolysis, Hee Jeong Jang, Jiwon Kim, Ha Kim, Taesu Kim, Jinyong Chung, Sebastian Cremer, Marvin Krohn-Grimberghe, Eo Jin Kim, Dawid Schellingerhout, Matthias Nahrendorf, Dong-Eog Kim

Faculty, Staff and Student Publications

Background: Monocytes contribute to the initiation and propagation of venous thrombosis. Little is known about the roles monocytes play in arterial thrombosis, the cause of stroke and myocardial infarction.

Methods: We investigated how CCR2 (CC chemokine receptor 2) knockout (-/-)-mediated monocyte deficiency affects platelet function, blood coagulation, thrombus volume, and thrombolytic susceptibility in 666 male mice with FeCl3-mediated carotid arterial thrombosis, including 365 C57BL/6 wild type (WT) mice, 295 CCR2-/- mice, and 6 CX3CR1-GFP (CX3C chemokine receptor 1-green fluorescent protein) mice.

Results: Intravital microscopy and flow cytometry showed that both neutrophils and monocytes were recruited to the acute arterial thrombus, …

Adherence To Breast Cancer Screening Guidelines Among Age-Eligible Us Women: Findings From Nhis 2021, Monalisa Chandra, Joël Fokom Domgue, Robert Yu, Sanjay Shete

Faculty, Staff and Student Publications

Background: Despite the proven benefits of early breast cancer detection in reducing mortality, adherence to breast cancer screening guidelines in the United States is suboptimal. In this study, we assessed the prevalence and factors associated with adherence to breast cancer screening guidelines.

Methods: Using nationally representative data from the National Health Interview Survey 2021, we included breast cancer screening-eligible women (aged 50-74). Descriptive statistics and population-weighted multivariable logistic regression were employed to examine breast cancer screening adherence per the United States Preventive Services Task Force guidelines, and its determinants in this population.

Results: Of the 6814 screening-eligible women included in …

Lymphodepletion, Tumor-Infiltrating Lymphocytes, And High Versus Low Dose Il-2 Followed By Pembrolizumab In Patients With Metastatic Melanoma, Merve Hasanov, Simin Kiany, Marie-Andrée Forget, Roland Bassett, Michael A Davies, Adi Diab, Jeffrey E Gershenwald, Isabella C Glitza, Jeffrey E Lee, Anthony Lucci, Jennifer L Mcquade, Sapna P Patel, Merrick I Ross, Hussein A Tawbi, Jennifer A Wargo, Michael K Wong, Chantale Bernatchez, Patrick Hwu, Cara Haymaker, Rodabe N Amaria

Faculty, Staff and Student Publications

This study evaluated the efficacy and safety of unengineered tumor-infiltrating lymphocytes (TILs) combined with pembrolizumab and either high (HD, Arm-1) or low (LD, Arm-2) doses of IL-2 in patients with metastatic melanoma (MM). Patients were lymphodepleted with cyclophosphamide and fludarabine, followed by TIL infusion and IL-2 (Arm-1: 720,000 IU/kg IV q 8 hrs up to 15 doses; Arm-2: 2 million IU SC for 14 days). Patients received pembrolizumab 200 mg IV starting 21 days post-TIL infusion, and every 3 weeks for up to 2 years. The primary endpoint was overall response rate (ORR) per RECIST 1.1. Blood samples were collected …

Sars-Cov-2 Rna-Binding Protein Suppresses Extracellular Mirna Release, Hyejin Mun, Chang Hoon Shin, Qingxuan Fei, Andrea Estefania Lopez Giraldo, Kyoung-Min Choi, Ji Won Lee, Kyungmin Kim, Kyung-Won Min, Leilei Shi, Mark T Bedford, Dong-Chan Kim, Yoo Lim Chun, Seonghyun Ryu, Dongin Kim, Jeong Ho Chang, Ryan T Westrope, Michelle Shay, Edward Nguyen, Junho K Hur, Abigail Agyenda, Nam Chul Kim, Sung-Ung Kang, Woonghee Lee, Je-Hyun Yoon

Faculty, Staff and Student Publications

SARS-CoV-2 is the betacoronavirus causing the COVID-19 pandemic. Although the SARS-CoV-2 genome and transcriptome were reported previously, the function of individual viral proteins is largely unknown. Utilizing biochemical and molecular biology methods, we identified that four SARS-CoV-2 RNA-binding proteins (RBPs) regulate the host RNA metabolism by direct interaction with mature miRNA let-7b revealed by Nuclear Magnetic Resonance spectroscopy (NMR). SARS-CoV-2 RBP Nsp9 primarily binds mature miRNA let-7b, a direct ligand of the Toll-like Receptor 7 (TLR7), one of the potential SARS-CoV-2 therapeutics. Nsp9 suppresses host gene expression possibly by promoting let-7b-mediated silencing of a cellular RNA polymerase, POLR2D. In addition, …

Communication And Privacy Management Between Female Veterans, Their Military Voluntary Kin, And Biolegal Family Members, Carol Lee Tschampl-Diesing

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Military voluntary kin (MVK) refer to relationships between Service members and/or Veterans that they consider to be “like family,” despite lacking blood or legal ties. The purpose of this qualitative/interpretive communication study was to explore how female Veterans, who are the largest growing population of U.S. Veterans, discursively construct MVK relationships, navigate communication, privacy management, and boundary turbulence with their MVK and biolegal families (BLF). The researcher undertook in-depth interviews with nine female U.S. Veterans who reported having at least one MVK. The researcher posed four research questions, engaging in an interpretive analysis.

Participants described three ways they navigated interactions …

Eyewitness Consent To Be Video Recorded: Implications For Identification Accuracy And Confidence, Sarah Argüelles

Student Theses

Recently, a recommendation has emerged for law enforcement to record the full eyewitness identification procedure, recognizing the critical role eyewitness testimony plays in the justice system (Wells et al., 2020). However, in some states, such as New York, law enforcement is required to seek consent from witnesses before recording (Municipal Police Training Council & Division of Criminal Justice Services, 2017). Since this practice is relatively new, there has been limited research on how obtaining consent may affect eyewitness accuracy. It was hypothesized that obtaining consent to video record could be linked to a witness’s confidence in their identification, with higher …

Imagine The Peace: Exploring The Intimacy Of Imagined Intergroup Contact In Kosovo, Eric Manley

Dissertations

Peacebuilders have utilized positive intergroup contact in various settings to help groups encounter each other. I implemented three different intimate imagined contact scenarios in Peja, Kosovo with Albanian and Serb participants. I conducted this research to understand how multiple intimate social settings could impact individuals’ encounters with the outgroup during each imagined scenario, thus gathering better operationalization efforts regarding intimacy and imagined contact. Using written responses, interviews, and one-year follow-up interviews, the café and workplace scenarios created a positive experience for most participants, and while half of participants had a positive experience with the fiancé scenario, many more had negative …