Digital Commons Network^™

Enzymatic Depletion Of Adenosine To Potentiate Cancer Immunotherapy., Omar Sadi Sarkar

Electronic Theses and Dissertations

Immune checkpoint blockade (ICB) therapies have revolutionized cancer treatment, but many patients still do not respond well. To improve therapeutic outcomes, chemotherapy is often combined with immunotherapy, as chemotherapy is known to promote immunogenicity. However, many patients develop resistance to this combination therapy, and the reasons behind it are not fully understood. In this study, we explored how platinum-based chemotherapy, specifically cisplatin, affects tumor signaling to create an immunosuppressive tumor microenvironment (TME). We found cisplatin triggers ataxia telangiectasia mutated (ATM)-mediated DNA damage signaling and induces higher expression of prostaglandin E₂ (PGE₂) via a cyclooxygenase-2 (COX-2) mediated pathway. We speculate DNA …

Experiences Of Title Ix Hearing Panel Members., Amanda Gage Stonecipher

Electronic Theses and Dissertations

The number of allegations of sexual misconduct on college campuses has been increasing over the past decade and higher education institutions are charged with addressing the misconduct. Addressing student behavior on college campuses through a conduct process is woven into the fabric of higher education, and many institutions use a hearing panel model to determine if institutional policies were violated. My research aims to explore how student conduct hearing panel members process the tension between the emotional management required when hearing intimate and traumatic details of a sexual misconduct case. The data for this research were collected via semi structured …

Characterizing The Ethanol Sensitivity Of The Planar Cell Polarity Pathway In Endoderm Morphogenesis And Jaw Development., Raéden Omneil C. C. Rolle Gray

Electronic Theses and Dissertations

Fetal Alcohol Spectrum Disorders (FASD) describes a large range of developmental defects due to prenatal alcohol exposure. It is characterized by neural and facial defects, including jaw hypoplasia. Many factors contribute to the susceptibility of ethanol-induced facial defects, including genetics, yet the genes involved, and the cell events they regulate, are poorly understood. Zebrafish have a large number of tools for genetic manipulation available, share 70% of genes with humans, are fertilized externally and are translucent during embryogenesis, making them great models to study FASD. Previous studies show that two members of the Planar Cell Polarity (PCP) pathway, zebrafish vangl2 …

Teaching Copyright Beyond Campus: Academic Librarians At Pop Culture Conventions, Craig Finlay, Isabel Soto-Luna Ed.

Criss Library Faculty Publications

Academic librarianship has long emphasized campus-based instruction, but transformative learning opportunities often emerge beyond the classroom. This article explores how two librarians extended copyright education into the unconventional setting of multigenre pop culture conventions. Originally developed for faculty, their workshops were redesigned to meet the needs of artists, cosplayers, small business owners, and independent creators seeking practical, legally grounded information about copyright, fair use, and intellectual property. Drawing from real-world interactions, iterative feedback, and instructional theory—including a revised “Informative Avocado” model—the authors describe how their outreach not only empowered new learner communities, but also revitalized their own teaching practices. The …

Attention - Volume 10

be Still

No abstract provided.

I Want You To Want Me, Marianne Koleng

be Still

This piece calls to the theme of "attention" through a mixed media piece incorporating collage, ink, and colored pencil. It embraces the nuances of both anatomy and popular music, rock-and-roll, to be specific. The title is taken from the popular song by Cheap Trick, of the same name in an effort to elude to the desire for human attention in a human form.

The Cost Of Having Everything, Aaron E. Lamont

be Still

This essay explores how our attention is shaped and often scattered by the digital world, especially within the environment of medical school. I hope it can help to encourage others to think more carefully about what really deserves their focus.

Sik2 Inhibitor Grn-300 Enhances Sensitivity To Paclitaxel Treatment In Triple-Negative Breast Cancer, Marc A. Pina

Dissertations and Theses (Open Access)

Breast cancer is one of the most frequently diagnosed cancers worldwide, with approximately 15% classified as Triple-Negative Breast Cancer (TNBC). TNBC lacks expression of estrogen (ER) and progesterone (PR), and does not overexpress HER-2, leaving patients without effective targeted therapies. As a result, treatment primarily relies on chemotherapy, most commonly paclitaxel, a taxane that stabilize microtubules, disrupts chromosome separation and induces apoptosis. However, TNBCs are an aggressive cancer subtype, and patients often will develop resistance after a few rounds of chemotherapy. This study addresses a critical unmet need for more effective TNBC therapies by targeting Salt-Inducible Kinase 2 (SIK2), which …

Structure And Function Studies On Trna Splicing Endonuclease, Justin G. Underwood

Dissertations and Theses (Open Access)

A subset of eukaryotic pre-tRNAs have introns that must be spliced out to become mature molecules capable of functioning in translation. This essential processing step is performed by tRNA splicing endonuclease (TSEN), a highly conserved heterotetramer with two catalytic and two structural subunits. In addition to this conserved function, archaeal TSEN also processes pre-rRNA and yeast TSEN cleaves some mRNAs that encode mitochondrial proteins to initiate mRNA degradation. Interestingly, single amino acid mutations in TSEN cause the human Mendelian disease pontocerebellar hypoplasia (PCH) by an unknown mechanism. Recently, several groups have determined the structure of human TSEN, revealing similarities and …

Host-Intrinsic Factors Determine Anti-Tumor Efficacy Of Exercise In Pancreatic Ductal Adenocarcinoma, Sumedha Pareek

Dissertations and Theses (Open Access)

Pancreatic Ductal Adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths with a low 5-year relative survival rate of approximately 13.3% for all stages combined. We have previously shown that exercise can improve quality of life and enhance functional capacity among patients with PDAC. Exercise induces a variety of changes in the tumor microenvironment with beneficial effects in several tumor types. However, our understanding of the clinical effects of exercise and the mechanisms that mediate anti-tumor effects are limited in pancreatic cancer.

In this project, using C57BL/6 mice from Taconic Biosciences (Tac) and Jackson Laboratories (Jax), we established a …

Shareholder Standoff: The Erosion Of Minority Protections In The Wake Of Sb21, Kiara R. Sims

UC Law Business Journal

No abstract provided.

The (Re)New(Ed) Corporation: Foundation For A Stakeholder Regulatory Agenda, Gregory E. Louis

UC Law Business Journal

Amidst an emerging bipartisan consensus on greater corporate social accountability, America First has joined longstanding solicitude about the racial wealth gap. This Article offers yet another take on corporate purpose. As a project of recovering legal memory like Adrian Vermeule’s common good constitutionalism, it examines scholarship on the history of corporate purpose toward answering whether stakeholder capitalism should inform corporate regulation and, if so, how. It concludes from this history that the Anglo-American legal tradition clearly justifies regulators to hold business corporations accountable to the common good. But it also finds in this history a requirement that stakeholder capitalism be …

Punitive Damages In Products Liability Revisited (1991-2024), Michael L. Rustad

The University of New Hampshire Law Review

No abstract provided.

Cultural Roots Of Eating: A Comparative Analysis Of Organic Discourse And Marketing Practices In China And The United States, Zubing (Jane) Guo

Honors Theses

This thesis examines how cultural frameworks influence the development of the organic food market and shape individual attitudes towards the label “organic” in the U.S. and China. While the popularity of organic food has increased in recent years, cognitive and behavioral reactions toward the label “organic” have differed across societies. In the U.S., healthy eating discourse aligns closely with the individualistic culture and atomistic cognitive style, highlighting the importance of salient elements such as specific nutrients or chemical use. In contrast, Chinese healthy eating discourse is based on balance and harmony, which is directly related to traditional Chinese culture of …

A Systems Approach To Shedding Sunlight On A.I. Black Boxes, Ran Xi

Hofstra Law Review

A substantial body of literature has emerged around concerns that machine learning and artificial intelligence systems are opaque, or "black boxes. " The black box nature ofA.I.-powered services and applications has resulted in alarming risks in social life, including insecurity, mistrust, lack of accountability, and exacerbated bias and discrimination. Despite the call to open the black boxes, corresponding legal and regulatory measures tend to run aground due to their infeasibility, inefficacy, and ambiguity. This Article offers a unique perspective on the A.I black box problem. Using systems theory as a heuristic tool, this Article views A.I. as a law-related system …

The Truth Will Set You Free: The Importance Of A Psychologically Rooted Framework That Encourages The Admission Of Expert Testimony On Eyewitness Memory, Emma C. Kiernan

Hofstra Law Review

No abstract provided.

Nutrient Utilization Efficiency And Antioxidant Profile Of Bc2 Abaca (Musa Textilis Née) Hybrids, Roberto Barba Jr, Antonio Lalusin

The Philippine Agricultural Scientist

Abaca (Musa textilis Née) is an important fiber crop widely recognized for its superior tensile strength, yet its productivity remains constrained by nutrient inefficiency, poor cropping management, and climatic stresses under manual production systems. Efficient nutrient utilization and an understanding of antioxidant compositions are practically relevant to the productivity of the abaca fiber crop. However, despite the crop’s economic importance, limited studies have examined nutrient uptake dynamics and internal utilization efficiency related to fiber synthesis. This study aimed to demonstrate the nutrient utilization efficiency and antioxidant profiles of BC₂ abaca hybrids in relation to fiber yield and quality. Fiber …

Sustainability Policy Proposals For The Township Of Montclair, Nj, Fanny Lauby, Josemy Barrera Cabal, Aaron Chauhan, Chase Geer, Carlos Jimenez, Catherine Khitiri, Jonathan Lockette, Andrew Mapes, Coral Mejía, Jack Nacht, Gabriella O’Keefe, Refia Oral, Sanjeev Rao, Jacob Roby, Julnide Saint Juste, Fiona Slatina

Department of Political Science and Law Faculty Scholarship and Creative Works

This white paper was written as a course requirement for POLS 324 Advanced Public Policy Analysis at Montclair State University in fall 2025. In the course, students analyze public policy and examine current issues. Public policy analysis can be defined as the development and evaluation of policy solutions to public problems. The course's learning objectives include “critically evaluate the goals and assumptions of different policy proposals,” “create a policy proposal for a public problem,” and “evaluate the proposals developed by their peers.” For the fall 2025 iteration of the course, I invited two offices in the township of Montclair to …

Aged 539 Graduate Internship Report- Liberty High School, Brittany N. Johnson

Agricultural Education: Graduate Internship Reports

This document documents the AGED 539 Internship in Agricultural Education and examines the Liberty High School–Brentwood FFA and Agriculture Department’s alignment with the three-component model of agricultural education: classroom instruction, FFA leadership development, and Supervised Agricultural Experience (SAE). Grounded in experiential learning theory, the report reflects on program strengths, challenges, and growth across all twelve California Career Technical Education (CTE) Quality Criteria, supported by narrative reflection and evidence. The internship project focused on developing a formal FFA Program of Activities (POA) to improve chapter organization, goal-setting, and long-term sustainability. Overall, the project highlights intentional program planning and leadership development as …

The Lived Experiences Of School Counselors, Job Burnout, And The Blurred Lines Of The Profession, Cecilia Angelica Gomez

Theses and Dissertations

This phenomenological qualitative study explores the lived experiences of school counselors during and after the COVID-19 pandemic, focusing on job burnout, role ambiguity, and the blurred lines of the profession. Through semi-structured interviews with practicing school counselors, the study identifies common themes including role overload, manifestations of burnout, coping and resilience strategies, and the impact of administrative support. Findings highlight the systemic factors contributing to counselor stress and the importance of self-care, peer collaboration, and role clarity for counselor well-being and student outcomes.

Rethinking The Key Role Of Private Antitrust Enforcement, Filippo Lancieri

Georgetown Law Faculty Publications and Other Works

This Article focuses on the institutional design of American competition policy. It argues that any long-term effective revival of U.S. antitrust policy requires a better acknowledgement of the key and irreplaceable role played by private litigation and proposes a rethink of private anti-trust enforcement policy.

To unpack the nuanced interconnection between public and private competition enforcement, the Article begins by tracing the rise and fall of private antitrust. It builds on a novel, hand-coded, and comprehensive analysis of the entire Supreme Court antitrust track record—all 474 decisions over 130 years—to outline how an ideologically …

Helen Marie Besch… Sure Is A Student At Risd, Helen Besch, Special Collections, Fleet Library

12th Baker & Whitehill Student Artists' Book Contest 2026

Entry for the 12th Baker & Whitehill Student Artists' Book Contest. Opening reception and award ceremony Wednesday, February 25, 2026 at 6:30pm, Fleet Library, 1st Floor Main Reading Room. Juror: Gabrielle Reed.

Utopia, Mohan Qian, Special Collections, Fleet Library

12th Baker & Whitehill Student Artists' Book Contest 2026

Entry for the 12th Baker & Whitehill Student Artists' Book Contest. Opening reception and award ceremony Wednesday, February 25, 2026 at 6:30pm, Fleet Library, 1st Floor Main Reading Room. Juror: Gabrielle Reed.

Experimental And Computational Insights Into Reservoir Rock Mechanics And Petrophysical Properties, Prasad Pothana

Theses and Dissertations

This dissertation investigates the influence of stress, mineralogy, and microstructure on the elastic and transport properties of reservoir rocks. A multi-scale framework integrating laboratory measurements, petrophysical inversion, and discrete-element simulations is developed to quantify the stress-dependent behavior of heterogeneous sedimentary formations relevant to hydrocarbon production and CO2 sequestration.

Core-scale experiments quantify velocity–effective stress and permeability–effective stress relationships in tight siliciclastic and mixed lithologies. Results demonstrate that pore-throat collapse and microcrack closure under confining stress cause systematic reductions in permeability and acoustic velocities. The derived empirical functions provide predictive capability for estimating in-situ stress effects on reservoir performance and time-lapse seismic …

Identity Formation Through The Lived Experiences Of Immigrant Muslim High School Students, Badera Muhanna

Theses and Dissertations

The growing number of Muslim students enrolled in U.S. public schools necessitates a more comprehensive understanding of their unique experiences within their educational environments. This phenomenological qualitative study investigated Muslim students' perceptions of their lived experiences in a high school in the Northern Great Plains of the United States. Six Muslim students in their junior and senior years were selected to participate in semi-structured interviews. Through the lens of Bronfenbrenner’s ecological systems theory, this study aimed to deepen understanding of how Muslim students develop their sense of identity and the factors that contribute to this development. The findings revealed that …

Methane Infusion Improved Oil Recovery In The Bakken Formation, Demetrius Maxey

Theses and Dissertations

This research establishes methane infusion improved oil recovery (MI IOR) as a technically viable and economically attractive early-stage intervention for unconventional reservoirs. Integrated multi-scale investigations included quantum molecular theory, nanoscale characterization, NMR experimentation, and field scale reservoir simulation. FEG-SEM analysis of core samples enabled development of a peer-reviewed pore size classification system informing MI operational design parameters. Integrated well logging quantified petrophysical properties across the Bakken stratigraphy. NMR relaxometry identified the lab-scale pore-level sweep efficiency of MI at 3,750 psi in Bakken core samples. Mobilization of hydrocarbons from Np1, Np2, and Np3 pores yielded recovery factors of 45-60%. Field-scale reservoir …

False Memory Susceptibility In Association With Attachment Theory: Effects On Memory Conformity, Rachel Catherine Miller

Theses and Dissertations

False memory research has been an evident topic in various fields of psychological study. Research in this area has important implications in forensic contexts and clinical settings as false memories can result in an array of harmful consequences. To explain individual differences in susceptibility to endorsing false memories of the rare medical procedure known as the voiding cystourethrogram (VCUG), the current study extended the findings of Herndon and colleagues (2014). It also examined predictor variables from attachment theory (such as attachment anxiety and avoidance), depressive symptomatology, compliance levels (e.g., use of confederates), and the impact of guided imagery (i.e., a …

The Role Of Attitude Ambivalence In Extending The Theory Of Planned Behavior: A Mixed-Methods Study Of Factors Predicting Influenza Vaccine Uptake Intentions Among Active-Duty Military Parents For Themselves And Their Children, Walter Eugene Carroll

Theses and Dissertations

This dissertation is a mixed-methods study examining how U.S. military parents form intentions to vaccinate themselves and their children against influenza. The study applies the Theory of Planned Behavior (TPB) and the construct of ambivalence tounderstand how attitudes, social norms, and perceived behavioral control influence vaccination decisions within the unique institutional and cultural environment of military life. Quantitative data were collected from 341 military parents through an online survey distributed across more than 50 military-affiliated Facebook groups. Regression models tested TPB constructs, flu knowledge, and social media use as predictors of vaccination intention and ambivalence. Results showed that flu shot …

Longingly, Jennifer Vermeer

Pro Rege

No abstract provided.

Rapid Prototyping Of Low-Cost Sensor Systems Towards A Platform For Upper Limb Posture Estimation, Russell Rathbun

Electrical Engineering and Computer Science Undergraduate Honors Theses

Physical therapy requires patients to perform repeated actions to achieve meaningful results in rehabilitation. This thesis explores production methods and various sensor systems by utilizing rapid prototyping, inertial measurement units (IMUs), and capacitive sensor arrays (CSAs). CSAs can be made from a wide ar- ray of materials and techniques including 3d printing and laser ablation–to rapidly create CSAs that can be custom fit to enable proximity, force, and touch detection. IMU and CSA systems individually are able to track upper limb movements, ges- tures, and positions. This combination of sensors enables accurate upper limb pos- ture estimation of patients. This …