Digital Commons Network^™

Discovery Of A Small Molecule Tlr3 Agonist Adjuvant, Branden Lee, Danica Dong, Etsuro Nanishi, John Mark Awad, Kimia Abedi, Yoshine Saito, Francesco Borriello, Soumik Barman, Byron Brook, Aisling Kelly, Manisha Menon, Constance Marques-Mourlet, Maansi Gupta, Ida Lister, Chiwoo Oh, Kevin Lyskawa, Morgan Goetz, Kristina Walker, Wing Ki Cheng, Spencer Brightman, Pankaj Sharma, Timothy O'Meara, Katherine Chew, Daniel Vieira, Kevin Ryff, Cali Sweitzer, Sanya Thomas, Simon Van Haren, Matthew Pettengill, Hyuk-Soo Seo, Sirano Dhe-Paganon, Wei Zhang, Ofer Levy, David Dowling

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Pattern-recognition receptor (PRR) agonists are valuable agents across multiple medical applications, from vaccinology to immune-oncology. However, well-defined and potent small molecule agonists for many PRRs still await discovery and development. Screening of chemical libraries of ~200,000 small molecules for maturation of human monocytic cells by quantifying NF-κB activation and cell adherence was completed. From this screen, we selected a thiazole benzamide derivative, PVP-057, for its robust immunomodulatory properties, low toxicity profile, and concentration-dependent activity. In vitro investigation of pathway and receptor activation reveals that PVP-057 is a Toll-like receptor 3 (TLR3) agonist. As a single-component adjuvant, administered intramuscularly or intradermally …

Addressing Injustices Toward Individuals With Schizophrenia-Spectrum Conditions: A Call To Action For Social Work Practice, Shannon M. Blajeski, Lindsay A. Bornheimer, Jessica A. Wojtalik, Lynette Studer, Shelly Ben-David, Patricia R. Turner, Ana T. Flores, Matthew J. Smith, Nev Jones, Jordan E. Devylder

School of Social Work Faculty Publications and Presentations

The field of social work has a lengthy history of training social workers for community mental health settings, and an ethical commitment to advance human rights and social justice. However, individuals with schizophrenia-spectrum conditions continue to suffer from myriad social injustices, including poverty, social isolation, and lower-life expectancy. This paper outlines these injustices, and reviews historical social work contributions and current training for supporting this population. Finally, the authors outline actions to 1) adopt national practice guidelines that formally acknowledge injustices, including anti-oppressive practice guidelines that are inclusive of lived experience, and 2) revitalize social work’s contributions to models of …

Myths And Memories: The New South & Lost Cause In Georgia, Stephen Bliss Jones

Doctoral Dissertations and Projects

The defeat of the Confederacy led way to the development of two related but distinctly separate ideological movements, the New South and the Lost Cause. However, in the course of Civil War historiography, the two have been conflated with one another, with the Lost Cause winning out as the solely accredited ideological product of the vanquished Confederacy. The modern Neo-Reconstruction school of thought discredits the New South as a distinct sociopolitical movement, and frequently associates its cultural products to the Lost Cause. This dissertation examines the cultural and political evolution of each movement, with a focus upon their primary cultural …

The Lived Experiences Of Black Women Who Pastor Men In The Christian Methodist Episcopal Church, Karen En Bailey Garrison

Doctoral Dissertations and Projects

This qualitative phenomenological research project will explore the lived experiences of Black women pastoring at least three (3) who are not genetically related, weekly attending male congregants in the historically patriarchal culture of the Christian Methodist Episcopal (CME) Church with a minimum of at least one hundred (100) weekly attendees or more, and actively ordained. The CME Church has traditionally believed that the Bible prohibits women from serving as pastors or in any position of control over men. In four previous studies, Harden (2023), Morgan (2024), Tribble (2005), and Williams (2024) found that female pastors encountered obstacles throughout their journey …

The Lived Experience Of Child Sexual Abuse Material Investigators: A Phenomenological Study, Andrea Ruth Sorber

Doctoral Dissertations and Projects

This transcendental phenomenological study describes the resiliency-building skills implemented by investigators during pre-engagement, engagement, and post-engagement with Child Sexual Abuse Material (CSAM) cases. This study will include no non-adults, as participants are those in the law enforcement field assigned to investigating CSAM cases. The theory guiding this study is Husserl’s transcendental phenomenology, which focuses on intentionality while suspending judgment and moving toward awareness. Schlossberg’s Transition Theory (STT) provides the theoretical framework for the study, which aims to answer the following primary research question: How do investigators handling CSAM describe their strategies to sustain resilience during engagement with distressing digital content? …

Experiences Of Attachment And Childhood Sexual Abuse In Transgender Adults, Kimberly M. Langford

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to understand the experiences transgender adults have with attachment and childhood sexual abuse (CSA). The theory guiding this study is John Bowlby’s attachment theory, as secure attachment has the potential to act as a buffer against increased risks in cases where histories of CSA have occurred. Patterns of insecure and disorganized attachment are found at higher percentages within the transgender and gender dysphoric population than the cisgender population when a history of CSA is present. Research was needed to further explore and better understand the transgender population’s experiences of attachment and CSA with …

There Is No Finish Line: The Intersection Of Sport And Race In St. Louis During The Civil Rights Era, Brandon Winfred Black

Doctoral Dissertations and Projects

This project focuses on the intersection of sport and race in St. Louis during the 1950s and 1960s, revealing how Black athletes became both symbols of progress and targets of resistance, illustrating the broader Civil Rights Movement’s parallel fight for visibility and systemic change. St. Louis was a city of contrasts. Its location and culture made it a focal point for the racial struggles that defined the Civil Rights Movement, often symbolizing both the persistence of inequality and the potential for change. Black athletes not only challenged racial barriers on the field but also catalyzed social change off it, revealing …

The Shared Experiences Of Betrayed Women In North Carolina Dealing With Long-Term Issues From Trauma Associated With Marital Infidelity: A Phenomenological Study, Anita M. Pittman

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological study was to describe the shared lived experiences of women affected by marital infidelity in North Carolina. Physical, emotional, and spiritual issues arise due to betrayal and brokenness of secure attachments. Findings from this study revealed that some shared emotional issues women faced following infidelity included depression, guilt, self-blame, and low self-esteem. Some issues took longer to recover from than others, such as loss of trust, low self-esteem, and varying physical health-related issues. The guiding theories for this study were Bowlby and Ainsworth’s Attachment Theory, Emotion-Focused Therapy developed by Greenberg and Johnson, and Vygotsky’s …

The Discoveries Of Key Elements Behind A Central Texas Title 1 Public School District’S Academic And Relational Success Amid Learning Loss In State Trends: A Qualitative Single Case Study, Hannah Deborah-Johns Fountain

Doctoral Dissertations and Projects

The purpose of this qualitative single case study is to discover the key elements behind a central Texas Title 1 Public School District’s academic and relational success amid learning loss experienced in other similar Texas public school districts during the COVID pandemic. From the years prior to the pandemic to three years post, Sunflower Independent School District (SISD) has remained steadfast in demonstrating superb state ratings via STAAR and TELPAS assessments. It has also received continuous spotlight district recognition through Capturing Kids’ Hearts (CKH) – a social emotional learning (SEL)/character enriching program. Texas Public Education throughout the years has looked …

Investigating Personality Themes And Constructs Among Professional Horse Trainers, Jenny Norton Schamber

Doctoral Dissertations and Projects

The relationship between horses and humans has evolved and now horses are a part of therapy, leisure activities, competitions, and companionship with humans, and this evolution beckons further research into aspects that contribute to positivity in this relationship. This research examined the themes of personality among professional horse trainers by utilizing the Riso-Hudson Enneagram Type Indicator (RHETI), the Ten-Item Personality Inventory (TIPI), and semi-structured interviews. To be included in the study, participants needed to be at least 18 years of age, live in the United States, and receive at least half of their yearly income from training horses. There were …

The Lived Experiences Of School Administrators Addressing School Violence Prevention Strategies And Safety Policies In Tennessee: A Transcendental Phenomenological Study, Trinka Hicks

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the lived experiences of urban high school administrators addressing school violence prevention policies and strategies in academic settings in an urban school district in Tennessee. The central research question used to lead this study is, what are the experiences of school administrators addressing school violence prevention strategies and safety policies in the academic setting? The theory that guided this study is Bandura’s social cognitive theory. Social cognitive theory emphasizes observation, imitation, and modeling, and the relative connection between behavior and the social environment was applied in this study to evaluate …

The Complexities Of Impoliteness In Digital Workspaces: A Politeness Theory Analysis Of Gen Z Workplace Communication, Russell D. Jones

Doctoral Dissertations and Projects

The purpose of this qualitative study was to investigate how Generation Z’s on TikTok influences their communication patterns in professional and social contexts, with specific attention to the role of politeness and impoliteness. Addressing a gap in communication scholarship, digital-native practices reshape established theories of interaction and affect workplace expectations were examined. Using a phenomenological design, data was collected from 30 semi-structured interviews and 300 open-ended survey responses to capture a broad and deep account of Gen Z communication. Thematic analysis and triangulation revealed three dominant patterns: (a) the redefinition of professionalism through informal and brief exchanges, (b) the habitual …

Investigating Technology Readiness In Blended Learning Environments For Secondary Education: A Case Study, Philipiah J. Antony

Doctoral Dissertations and Projects

The purpose of this case study was to discover how technological readiness affects the students’ mindset in blended learning environments for secondary school students at secondary schools in Trincomalee, Sri Lanka. The theories guiding this research are the Community of Inquiry (CoI) framework, as it states that blended learning environments connect the teaching and social communities, making a social fabric in which teaching and learning occur, and Bandura’s social cognitive theory, as it proposed students can construct knowledge by interacting with the learning environment lays the theoretical foundation for blended learning that focuses on building knowledge through a commitment to …

A Predictive Correlational Study Of The Relationship Between Faculty Leadership Styles And Teacher Communication Orientation In Jamaica’S Higher Education System, Zandy Uriel Elliott

Doctoral Dissertations and Projects

This quantitative study examined the extent to which faculty leadership styles, gender, and years of experience predict teacher communication orientation, specifically assertiveness (TCO-A) and responsiveness (TCO-R), among higher educational institutions in Jamaica. Grounded in communication theory and leadership frameworks, the study explored how faculty leadership express themselves and respond to others. Data were collected from 216 faculty members using the Multifactor Leadership Questionnaire (MLQ) and the Sociocommunicative Orientation Scale (SCO). Descriptive analyses indicated that participants’ mean responsiveness scores were slightly higher than assertiveness scores across all years-of-experience categories, with many displaying traits consistent with an “Amiable” to “Expressive” communication profile …

Rural Policing In Northern Wisconsin: Will Small-Town Police Officers Stay At Their Current Agency Until Retirement Based On Age And Community Size, Thomas J. Thompson

Doctoral Dissertations and Projects

This study examined the plans of small-town northern Wisconsin police officers to remain at their current agency until retirement, based on age and community size. The hypothesis was that older officers who had been with an agency for a longer period would stay until retirement, while younger officers would be more likely to leave. Younger officers tend to have less buy-in to the community and possibly fewer ties to a specific community. Officers who are older or have been with an agency for a long time have a greater investment in the agency and the community. The study results showed …

The Call For Wailing Women In Jeremiah 9:17: Biblical Theology Of Mourning Within The Context Of Repentance, Nwabuogo N. B. Okafo

Doctoral Dissertations and Projects

The Hebrew Bible features numerous accounts of mourning that reveal it as a significant aspect of the ancient Near Eastern burial customs. Biblical mourning involves an established process of grieving the loss of a dead person by his or her family and community (Deut 34:8; 2 Sam 1:11–12). The Bible also mentions other forms of mourning besides grieving the loss of the dead. Penitential mourning is the expression of sorrow resulting from awareness of personal or corporate sin (Joel 2:12–14; Ezra 10:6). Penitential mourning could be personal or corporate (2 Sam 12:13, 16; Ezra 9:3–4). Corporate mourning involving donning of …

Predicting Georgia Professional Standards Commission Instructional Technology Certification: A Quantitative Predictive-Correlational Study Of Georgia School Librarians’ Technology Self-Efficacy And Anxiety Levels, Ashley Osby

Doctoral Dissertations and Projects

This quantitative, predictive-correlational study examined the relationship between Georgia school librarians' technology self-efficacy, their anxiety levels, and whether they held a Georgia Professional Standards Commission (GaPSC) instructional technology certification. The expanding role of the school librarian has increased demands for technology integration, which can lead to heightened anxiety and lower self-efficacy. This study was significant as its findings can inform professional development and university coursework designed to better equip school librarians for these evolving responsibilities. A convenience sample of 70 certified school librarians working in public K-12 schools across Georgia were recruited through the Georgia Library Media Association (GLMA) listserv. …

2017 Rocky Mountain National Park Research Conference, United States Department Of Interior

Rocky Mountain National Park

The work highlighted by this conference addresses key issues, including climate change, the spread of exotic plants, large scale restoration needs, environmental contaminants and disease, a need for greater relevancy to youth, and inadequate capacity to keep pace with growing visitation. The NPS Director's Order "Resource Stewardship for the 21st Century" directs park managers to steward resources for continuous change that is not yet fully understood. This challenge makes research, learning, and engagement at local to global scales more important than ever. The magnitude of issues and opportunities currently facing park managers is reflected in the breadth and depth of …

People And Nature And The Mountaintop, Ruth M. Alexander, Catherine Moore

Rocky Mountain National Park

A Resource and Impact Study of Longs Peak in Rocky Mountain National Park

Adamson, Stan; Alexander, James; Aspinall, Wayne; Bird, Isabella; Blaurock, Carl; Bossier, Floyd; Browser, David; Butler, William; Canfield, David; Carr, Ethan; Chapin, Frederick; Charles, Eliot; Clark, Gerald; Collier, Betty; Collier, Robert; Crouch, Dee; Daske, Larry; Davis, Earl; Disney, James; Diver, Van; Eubanks, Bill; Goss, Wayne; Grove, Jim; Hartzog, George; Herkinham, Norman; Holubar, Roy; Hurley, George; Jardine, Ray; Johnson, Dale; Johnson, Lydon Baynes; Kamps, Bob; Kezlan, Richard; Kiener, Walter; Kor, Layton; Lamb, Elkanah; Mclaughlin, John; Mills, Enos; Moomaw, Jack; Muir, John; Nesbit, Norman; Nugent, Jim;

New Member Campaign Highlights Safe Prescribing Procedures

Virginia Dental Journal

No abstract provided.

Be A Media Star Interview Best Practices For Dental Health Experts, Cameron Mcpherson

Virginia Dental Journal

No abstract provided.

Is Your Practice Growing As Much As You Think It Should Be, Theresa Stenger

Virginia Dental Journal

No abstract provided.

A Year In Review, Frank Iuorno Jr., Dds

Virginia Dental Journal

No abstract provided.

Va Dent J October, November And December 2021

Virginia Dental Journal

No abstract provided.

Virginia Dental Family, Scott Berman Dds

Virginia Dental Journal

No abstract provided.

A Proposed Study Of Tone Indicators In Sentimental Analysis And Emotion Detection, Andrea Llanas

Infinite Loop

Sentimental analysis and emotion detection have been an ever-growing field in academic literature in recent years [1,2,3]. There are many methods and techniques to distinguish positive and negative tokens as well as classification of emotions respectively. However, the use of tone indicators has been relatively underexplored within the field.

Tone indicators are a relatively recent trend in social media. Users denote a positive or negative connotation as well as an emotion in a sentence at the moment of conception with syntax such as “/s,” “/pos,” and “/neg.” These annotations often are context-free, or do not depend on previously declared information, …

“River Of Death”: Industrial Pollution And The North Texas Trinity River Inthe Progressive Era, Meghan Scott-Chaber

Journal of Texas History

No abstract provided.

Full Issue, Editorial Team

Journal of Texas History

No abstract provided.

Theorising The Everyday Sporting Lives Of Africans, Manase K. Chiweshe

Journal of Global South Sport Studies

Sport in Africa is often studied through the lenses of elite competitions, colonial legacies, or development agendas, yet the everyday sporting practices of ordinary Africans remain under-theorised. This paper focuses on African agency in producing sporting cultures. Drawing on ethnographic research conducted across Zimbabwe, I argue that informal football matches, schoolyard games, and community fitness rituals are not merely recreational but rather sites of meaning-making, resistance, and social negotiation. Theoretical frameworks from African sociology (e.g., Nyamnjoh’s incompleteness and Mbembe's banality of power) illuminate how sport operates as a terrain of ordinary ingenuity, where tactics such as repurposed equipment, self-organised leagues, …

Martin’S Dream And Malcolm’S Nightmare, Luke V. Horton

Soaring: A Journal of Undergraduate Research

No abstract provided.