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School-Based Interventions With Youth Engaging In Bullying Behaviors: Effective Strategies From The Perspective Of School Social Workers, Elizabeth A. Crowe Jan 2026

School-Based Interventions With Youth Engaging In Bullying Behaviors: Effective Strategies From The Perspective Of School Social Workers, Elizabeth A. Crowe

Electronic Theses & Dissertations (2024 - present)

Bullying is a nationally recognized social problem associated with harmful consequences for all youth involved. Despite their crucial role in bullying interventions and student success, the practices and perspectives of school social workers are notably absent from academic literature. This survey research study sought to identify strategies that school social workers use with youth engaging in bullying behavior; distinguish which strategies are the most and least effective from the perspective of school social workers; and recognize the supports and barriers school social workers face when implementing bullying interventions.

Survey data from a sample of school social workers answered these questions. …


Applications Of Machine Learning For Evaluating Downward-Coupled Stratosphere-Troposphere Interactions And Subseasonal Forecasts Of Opportunity, Elena M. Fernandez Jan 2026

Applications Of Machine Learning For Evaluating Downward-Coupled Stratosphere-Troposphere Interactions And Subseasonal Forecasts Of Opportunity, Elena M. Fernandez

Electronic Theses & Dissertations (2024 - present)

Wintertime stratospheric dynamics provide key information for understanding atmospheric teleconnections and improving subseasonal-to-seasonal (S2S) predictions on timescales of two weeks to two months. Periods of enhanced predictability, often referred to as forecasts of opportunity, arise from large-scale teleconnected variability, within which the stratosphere serves as an important precursor for tropospheric states, such as near-surface temperatures. While traditional diagnostics of downward coupled stratosphere-troposphere interactions typically rely on zonal-mean representations of wind and geopotential height, this dissertation presents an alternative vortex-centric framework through metrics that capture the daily geometric and dynamical evolution of the stratospheric polar vortex. The proposed stratospheric …


The Moderating Effect Of Self-Efficacy On The Relationship Between Social Determinants Of Health And Alcohol Use In A Diverse Adult Sample, Cara L. Fresquez Jan 2026

The Moderating Effect Of Self-Efficacy On The Relationship Between Social Determinants Of Health And Alcohol Use In A Diverse Adult Sample, Cara L. Fresquez

Electronic Theses & Dissertations (2024 - present)

Heavy alcohol consumption is associated with a range of psychosocial problems and chronic conditions, resulting in approximately 140,000 preventable deaths each year. With these potential consequences in mind, it is understandable that 46% of individuals who consume alcohol report attempting to reduce the quantity of alcohol they drink; however, very few enter formal treatment. Despite this, many people will decrease their heavy drinking over time, presumably due to individual and environmental factors, particularly self-efficacy and protective social determinants of health (SDoH). This study aimed to answer the research question “How is SDoH adversity related to the likelihood of reporting reduced …


The Instruments Of Chinese Economic Statecraft, Wilson Han Jan 2026

The Instruments Of Chinese Economic Statecraft, Wilson Han

Electronic Theses & Dissertations (2024 - present)

The global economic order is undergoing a profound transformation as China increasingly leverages its vast commercial resources not merely for market expansion, but as strategic instruments to reshape global governance and secure its national interests. Moving beyond traditional analyses that rely on aggregate macroeconomic indicators, this dissertation investigates the targeted, highly asymmetrical mechanisms of Beijing’s economic statecraft. It systematically examines three specific instruments – institutional, financial, and trade – through which China projects structural power and constructs an alternative economic order.

The first empirical study explores China’s institutional statecraft by analyzing its bid to join the Comprehensive and Progressive Agreement …


New Game Start: Playing With Power, Community And Change In Video Gaming Culture, Jonathan D. Muller Jan 2026

New Game Start: Playing With Power, Community And Change In Video Gaming Culture, Jonathan D. Muller

Electronic Theses & Dissertations (2024 - present)

Video gaming culture has long been a site associated with norms and values of whiteness, masculinity, and neoliberalism, with games, players, and developers all reinforcing these. Recently though, gaming culture has been directly involved with social movements and forms of resistance that are contrary to these norms and values. The typical gamer is no longer a white man, and gaming culture is now acknowledged to include race and gender dynamics that are close to that of the broader population. These communal shifts have both challenged and reinforced existing power structures. This research addresses these shifts and struggles by analyzing how …


Weighing The Costs: Understanding How Eating Disorder History And Motivation For Use Impacts Experience On A Glucagon-Like Peptide-1 Receptor Agonist And Interest In Future Use, Kimberly M. Gauert Jan 2026

Weighing The Costs: Understanding How Eating Disorder History And Motivation For Use Impacts Experience On A Glucagon-Like Peptide-1 Receptor Agonist And Interest In Future Use, Kimberly M. Gauert

Electronic Theses & Dissertations (2024 - present)

Glucagon-Like Peptide-1 receptor agonist (GLP-1 RA) medications have become popular tools due to their effectiveness regarding weight loss and chronic disease management. The drastic increase in demand for these medications has led to widespread availability and an increase in “off-label” use for cosmetic purposes. Although GLP-1 RA medications have the potential to positively impact overall health and wellbeing, there is also concern regarding potential misuse of these medications by those with a history of eating disorder behaviors. However, few studies to date have examined the relationship between a history of eating disorder pathology, reason for GLP-1 RA use, and current …


K-3 Literacy Teachers’ Sensemaking Of Early Literacy Policies In New York State: A Survey Study, Abigail Ferris Jan 2026

K-3 Literacy Teachers’ Sensemaking Of Early Literacy Policies In New York State: A Survey Study, Abigail Ferris

Electronic Theses & Dissertations (2024 - present)

Teachers must have opportunities to engage deeply in sensemaking during periods of major literacy reform, as unclear expectations can limit their ability to implement policy with fidelity. Using a cross-sectional survey design, this study explored K-3 literacy teachers’ perceptions, awareness, and factors related to their sensemaking of three science of reading literacy policies and initiatives in New York State. Findings suggested varying levels of awareness of the three literacy policies and initiatives, with teachers reporting that policy messages were communicated primarily through top-down structures, such as principals and literacy coaches within their organizations. Participants drew on personal, organizational, and external …


Viral Diversification And Host-Specific Fitness Of Powassan, Heartland, And Bourbon Viruses In New York State, Rachel E. Lange Jan 2026

Viral Diversification And Host-Specific Fitness Of Powassan, Heartland, And Bourbon Viruses In New York State, Rachel E. Lange

Electronic Theses & Dissertations (2024 - present)

This dissertation reports important progress for our understanding of emerging and re-emerging tick-borne viruses circulating in North America including Powassan, Deer Tick, Heartland, and Bourbon viruses. Chapter 2 describes important tools for these viruses including multiplex assays for viral and bacterial pathogens in field-collected ticks and mammals, development of full genome sequencing assays and bioinformatic pipelines for evolutionary analysis, and establishment of tick-specific tools for viral isolation and characterization. Chapter 3 focuses on the disease focality of Deer Tick virus, reporting transovarial transmission in nature in Ixodes scapularis for the first time, further evidence to incriminate shrews as potential Deer …


A Multi-Omic Approach For Understanding The Individual Roles Of Atf4 And Atf3 Upon Induction Of Different Branches Of The Integrated Stress Response, Elianna T. Cruz González Jan 2026

A Multi-Omic Approach For Understanding The Individual Roles Of Atf4 And Atf3 Upon Induction Of Different Branches Of The Integrated Stress Response, Elianna T. Cruz González

Electronic Theses & Dissertations (2024 - present)

The integrated stress response (ISR) is a critical cellular pathway that coordinates adaptation to various stressors, including endoplasmic reticulum (ER) stress, amino acid (AA) starvation, heme deficiency, and viral infection. Central to this pathway are the transcription factors ATF4 and its downstream target ATF3, which regulate gene expression programs that influence cell survival, metabolism, and immune responses. While previous studies have identified ATF3 as an antiviral factor during Zika virus (ZIKV) infection, the broader relationship between ATF3 and ATF4 across multiple branches of the ISR remains incompletely understood.

In this study, I employed multi-omic approaches to characterize the roles of …


Social Class Differences Between Client And Therapist: A Grounded Theory Study Of Working-Class Clients' Perspectives, Micah Herman Jan 2026

Social Class Differences Between Client And Therapist: A Grounded Theory Study Of Working-Class Clients' Perspectives, Micah Herman

Electronic Theses & Dissertations (2024 - present)

Although a substantial body of research highlights the importance of broaching differences related to race, ethnicity, gender, and sexual orientation in psychotherapy, considerably less attention has been paid to social class, a dimension of socio-cultural identity that profoundly shapes individuals’ life circumstances, their sense of self, and their relationships with others. In recognition of our limited understanding of how working-class clients perceive and respond to class-based cultural differences between themselves and their therapists, the present grounded theory study addressed (1) how working-class clients experience and make meaning of social class differences in the therapeutic relationship and (2) what clients see …


Taking Scale Seriously In Technology Law, Mark P. Mckenna, Woodrow Hartzog Jan 2026

Taking Scale Seriously In Technology Law, Mark P. Mckenna, Woodrow Hartzog

Faculty Scholarship

Issues of scale—the relationship between the amount of an activity and its associated costs and benefits—permeate discussions around law and technologies. Indeed, it’s not much of an exaggeration to say that scale is the reason for most technology regulation.

But it’s not always clear how lawmakers and judges conceptualize “scale” when approaching questions around automated technologies. Scale is often used intuitively, just to mean “more.” But scale is not always just about more—scale can introduce new harms and benefits along different dimensions, not simply costs or efficiencies of greater magnitude.

In this Article, we argue for a more sustained interrogation …


The Missing Constitutional Law Of Executive Conditions, Nicole Huberfeld, Matthew B. Lawrence Jan 2026

The Missing Constitutional Law Of Executive Conditions, Nicole Huberfeld, Matthew B. Lawrence

Faculty Scholarship

This Article contributes to development of the constitutional law of executive conditions. Courts are wrestling with the constitutionality of federal efforts to encourage what the federal government cannot mandate—speech on particular subjects, participation in cooperative federalism programs, and so on—but have failed to appreciate an important distinction. Binding statutory conditions articulated by Congress or an executive branch delegee (statutory conditions) and non-binding executive conditions articulated by executive branch actors engaged in regulation by deal (executive conditions) are different in constitutionally salient ways that can and should inform the development of workable doctrine. Yet courts, advocates, and scholars have only begun …


Five Lessons From Ken Kersch’S Conservatives And The Constitution For The Present Moment, James E. Fleming, Linda C. Mcclain Jan 2026

Five Lessons From Ken Kersch’S Conservatives And The Constitution For The Present Moment, James E. Fleming, Linda C. Mcclain

Faculty Scholarship

Timothy Snyder’s On Tyranny, a New York Times bestseller, has the subtitle, “Twenty Lessons from the Twentieth Century.” Ken Kersch’s Conservatives and the Constitution: Imagining Constitutional Restoration in the Heyday of American Liberalism (2019) provides at least twenty lessons from the second half of the Twentieth Century about the development of conservative constitutional thought and activism. Although conservatism has changed in many ways since the 1954-1980 period on which Kersch’s book focuses, these lessons are relevant for understanding the present political moment, filled with concerns that the U.S., during the second Trump Administration, is lurching toward tyranny, authoritarianism, and …


The Punishment Paradox, Steven Arrigg Koh Jan 2026

The Punishment Paradox, Steven Arrigg Koh

Faculty Scholarship

What does criminal punishment do? Across centuries of criminal legal thought, a shared answer persists: punishment incapacitates the wrongdoer. And yet punishment sometimes yields its opposite. Paradoxically, punishment sometimes becomes a rallying point-expanding community identification and solidarity around the defendant. This Article shows this punishment paradox using the 2023-24 prosecutions of President Trump and recent and historical case examples-from Luigi Mangione to Karen Read to Rosa Parks. By arguing that criminal law can generate solidarity rather than stigma, the Article both rethinks foundational theories of punishment and reconsiders the role of criminal law in democratic politics. Such an approach transcends …


Drag’S Impact On Drag Lives, José L. Oropeza Iii Jan 2026

Drag’S Impact On Drag Lives, José L. Oropeza Iii

Anthós

Drag’s Impact On Drag Lives

In light of recent political developments where Drag and Trans identities are being punished, why do people still participate in Drag? If there are repercussion to face for being a Drag Queen, then surely it must affect their lives for the better for them to continue the practice.

Through an autoethnographic approach to researching the Portland, OR Drag community, I collected transcripts of conversations with local Queens, took notes of community interactions, and put myself in Drag for the first time as a Queer man to better understand the Drag community and why they Drag. …


Gendered Words And Patent Grant Rates: A Textual Analysis, Deborah R. Gerhardt, Miriam Marcowitz-Bitton, W. Michael Schuster, Avshalom Elmalech, Omri Suissa, Moshe Mash Jan 2026

Gendered Words And Patent Grant Rates: A Textual Analysis, Deborah R. Gerhardt, Miriam Marcowitz-Bitton, W. Michael Schuster, Avshalom Elmalech, Omri Suissa, Moshe Mash

Faculty Publications

Text is a vehicle to convey information that reflects the writer’s linguistic style and communication patterns. By studying these attributes, we can discover latent insights about the author and their underlying message. This article uses such an approach to better understand patent applications and their inventors.

While prior research focuses on patent metadata (i.e., filing year or gendered inventor names), we employ machine learning and natural language processing to extract hidden information from the words in patent applications. Through these methods, we find that inventor gender can often be identified from textual attributes—even without knowing the inventor’s name. This ability …


Who's Afraid Of Copyright And Ai?, Deborah R. Gerhardt Jan 2026

Who's Afraid Of Copyright And Ai?, Deborah R. Gerhardt

Faculty Publications

Copyright and AI need not be a copyright no man’s land. Recent decisions by the Copyright Office have gotten so much media attention that many creators are unsure if they can secure copyright protection if they use AI as a creative tool. The proposed creative control paradigm can help us all tackle the challenge of determining when works created with the assistance of AI are copyrightable. Instead of relying on long-established nuanced precedent for protecting works generated with new technology, the Copyright Office asserts that any content generated with assistance from AI tools is unprotectable. This position is radically inconsistent …


Adolescent Relationships With Digital Actors And Their Influence In A Classroom Setting: An Interpretive Case Study, Kerry A. Hancock Jan 2026

Adolescent Relationships With Digital Actors And Their Influence In A Classroom Setting: An Interpretive Case Study, Kerry A. Hancock

Theses and Dissertations--Curriculum and Instruction

In this post-COVID-19 society students are strongly influenced by their use of digital text and electronic devices. The assumption of the study was that if students spend time with devices and digital text that it might be possible for them to develop relationships with the non-human actors that exist as part of the learning environments in schools. This  interpretive case study rooted, in Posthumanist ideology, used Latour’s Actor Network Theory to approach data collection.

A comparative approach was adopted for this interpretive case study research and data were collected in three stages: initial classroom observation and analysis to determine the …


Industry To Classroom: The Role Of Academic Program Consultants In Building Self-Efficacy Among Occupation-Based Career And Technical Education Teachers, Erica L. Settelen Jan 2026

Industry To Classroom: The Role Of Academic Program Consultants In Building Self-Efficacy Among Occupation-Based Career And Technical Education Teachers, Erica L. Settelen

Theses and Dissertations--Educational Leadership Studies

Occupation-based career and technical education (CTE) teachers bring industry expertise to secondary classrooms but often begin teaching without traditional pedagogical preparation or familiarity with public school systems. In Kentucky’s New Teacher Institute (NTI), academic program consultants (APCs) provide program-area support to strengthen induction. Using the framework of self-efficacy and guided by Ivankova’s mixed methods action research (MMAR) framework, this study examined how occupation-based CTE teachers perceived APC engagement during induction and how APC-created asynchronous supports were experienced.

In the Reconnaissance Phase, a sequential Quantitative → Qualitative design included an initial survey followed by interviews. Survey results indicated midrange familiarity with …


Recruitment Messaging, Authenticity, And Representation: A Mixed Methods Action Research Study In A Public School System, Chavis A. Sims Jan 2026

Recruitment Messaging, Authenticity, And Representation: A Mixed Methods Action Research Study In A Public School System, Chavis A. Sims

Theses and Dissertations--Educational Leadership Studies

This study employed a Mixed Methods Action Research (MMAR) design to examine recruitment communication within a public school system facing persistent underrepresentation of minority educators.  Recruitment prototypes were developed in collaboration with district leadership and evaluated in a formative pilot involving 15 educators who provided Likert-scale ratings and written feedback on clarity, cultural relevance, persuasiveness, and engagement.  Quantitative findings indicated that messaging emphasizing professional purpose and pathways into teaching was perceived as clear and engaging.  In contrast, cultural relevance consistently received the lowest ratings across prototypes.  Qualitative responses revealed that reliance on non-local and AI-generated imagery weakened perceived authenticity and …


Perceptions Of Sport Psychology Efforts And Access In Women's Wheelchair Basketball, Lindsay C. Cohen Jan 2026

Perceptions Of Sport Psychology Efforts And Access In Women's Wheelchair Basketball, Lindsay C. Cohen

Theses and Dissertations--Kinesiology and Health Promotion

As the field of sport psychology grows, services and training programs must evolve to properly serve the evolution of athletes seeking care. This could mean discovering new measures, testing different types of interventions, or developing programs that can better accommodate specific populations that are looking for sport psychology services. One such population is para athletes, and although they have expressed interest in learning more about the field of sport psychology and how to implement mental skills efficiently, athletes have reported a lack of access to sport psychology services and sport psychology consultants (SPCs) (Dieffenbach et al., 2009). The purpose of …


Unveiling The Shadows: An Exploratory Study On Ghostwriting, Gray Markets, And The Ethics Of Contract Cheating, Micah Crawford Jan 2026

Unveiling The Shadows: An Exploratory Study On Ghostwriting, Gray Markets, And The Ethics Of Contract Cheating, Micah Crawford

Theses and Dissertations--Educational Policy Studies and Evaluation

Contract cheating has become an increasingly complex challenge for higher education, particularly as digital platforms, global academic labor markets, and generative artificial intelligence reshape the production and detection of academic work. While much of the existing literature examines contract cheating from the perspectives of students, faculty, and institutions, less attention has been given to the individuals who produce ghostwritten academic work. This dissertation addresses that gap by exploring how shadow scholars understand their roles, ethical boundaries, and participation within the academic integrity ecosystem.

Using an exploratory qualitative design, this study draws on twelve semi-structured narrative interviews with six freelance academic …


Leadership Perceptions In Mid-Major Ncaa Athletics: Exploring Women's Teams Head Coaches' Experiences With Athletic Department Senior Staff, Sydnie A. Steele Jan 2026

Leadership Perceptions In Mid-Major Ncaa Athletics: Exploring Women's Teams Head Coaches' Experiences With Athletic Department Senior Staff, Sydnie A. Steele

Theses and Dissertations--Education Sciences

Leadership practices within NCAA Division I athletic departments can shape the professional climate, well-being, and stability of the coaching staff. Yet, limited research has explored how senior administrators influence the experiences of coaches who lead women’s teams at mid-major institutions. This phenomenological inquiry study explored how head coaches interpret their interactions with senior athletic department staff and how these relational dynamics inform perceptions of support.

Twelve Division I head coaches participated in semi-structured Zoom interviews about their experiences at former institutions. The interview protocol integrated the LMX-7 framework with open-ended questions to capture the significance of the head coaches’ lived …


Exploring High School Students’ Learning Interests And Information Sources On Viruses And Covid-19, Sahar Alameh, James W. Keck, Elizabeth Loh, Lin Xiang, Scott M. Berry, Anna G. Hoover, Abigail Knapp, Savannah Tucker Jan 2026

Exploring High School Students’ Learning Interests And Information Sources On Viruses And Covid-19, Sahar Alameh, James W. Keck, Elizabeth Loh, Lin Xiang, Scott M. Berry, Anna G. Hoover, Abigail Knapp, Savannah Tucker

Science, Technology, Engineering, and Mathematics (STEM) Education Faculty Publications

This study investigates high school students’ health-information seeking behaviors related to COVID-19 and viruses in a rural area of the south-central United States, and how these behaviors relate to students’ knowledge, perceptions, and learning interests. Survey data were collected from 83 students in Spring 2023, during the post-pandemic period, as part of a STEM and public health unit. Drawing on frameworks from Health Information-Seeking Behavior and student interest, the study examines students’ COVID-19 information sources, how these sources relate to their knowledge about viruses and their perceptions of COVID-19, and the specific topics about which they were most interested in …


Exploring The Relationships Between Social Influence, Vaping Behaviors, And Susceptibility Across Grade Levels In Kentucky, Raphael Adesiyan, Odunayo O. Omotilewa, Saber Feizy, Melinda J. Ickes Jan 2026

Exploring The Relationships Between Social Influence, Vaping Behaviors, And Susceptibility Across Grade Levels In Kentucky, Raphael Adesiyan, Odunayo O. Omotilewa, Saber Feizy, Melinda J. Ickes

Kinesiology and Health Promotion Faculty Publications

Purpose: This study explored the relationships between social influence, vaping behavior, and susceptibility across different grade levels.   Design: The study design was cross-sectional. Data were collected from middle and high school students who voluntarily participated between September 2022 and April 2023.   Sample: A convenience sample of students in 6th to 12th grades in Kentucky (N = 4677).   Measures: Demographic information, including age, grade level, school location, and race/ethnicity, was collected. The outcome variables included social influence, susceptibility, and vaping behavior.   Analysis: Logistic regression analysis was used to explore the relationships between social influence, vaping behavior, and susceptibility.   Results: …


Critical Discourse Analysis Of Nil Policies: Examining Institutional Control And Economic Opportunities For Division I Football Athletes In Power Four Universities, Allen T. Alvarez Jan 2026

Critical Discourse Analysis Of Nil Policies: Examining Institutional Control And Economic Opportunities For Division I Football Athletes In Power Four Universities, Allen T. Alvarez

Theses and Dissertations--Educational Policy Studies and Evaluation

The adoption of Name, Image, and Likeness (NIL) policies has redefined the economic landscape of collegiate athletics, expanding opportunities for student-athletes and reshaping institutional authority. This dissertation nvestigates how NIL policy language at Division I universities frames economic possibilities for football student-athletes and sustains systems of governance. Through a Critical Discourse Analysis of policy documents from Power Four and mid-major institutions, this study reveals that NIL participation is persistently conditioned by institutional approval, compliance monitoring, and ambiguous definitions, especially regarding boosters and collectives.

Policy language presents NIL as an opportunity but embeds institutional control through oversight structures. The analysis further …


Contractual Democracy From Statehouse To School Board: Shifts In Legislation And School Board Authority In Kentucky, Hannah M. Edelen Jan 2026

Contractual Democracy From Statehouse To School Board: Shifts In Legislation And School Board Authority In Kentucky, Hannah M. Edelen

University of Kentucky Doctoral Dissertations

School boards have long been regarded as a cornerstone of American democracy, providing local governance over public education. While considerable scholarship highlights the increasing involvement of state and federal governments in education, relatively few studies examine with specificity how legislatures shape the local authority of these governance structures. This study investigates how the Kentucky State Legislature has influenced the authority of local school boards over three legislative sessions (2020–2022) and how board members perceive their evolving role. Using a multi-method approach and conceptualized in principal-agent theory, this research contributes to understanding how legislatures shape the governing responsibilities of school boards …


Bringing Pandemic Science To The Classroom: Building Public Health Capacity At A Rural Kentucky High School, Sahar Alameh, Anna G. Hoover, James W. Keck, Scott M. Berry, Sagan Goodpaster, Savannah Tucker, Ashley Goodin Jan 2026

Bringing Pandemic Science To The Classroom: Building Public Health Capacity At A Rural Kentucky High School, Sahar Alameh, Anna G. Hoover, James W. Keck, Scott M. Berry, Sagan Goodpaster, Savannah Tucker, Ashley Goodin

Science, Technology, Engineering, and Mathematics (STEM) Education Faculty Publications

In response to the COVID-19 pandemic, a multidisciplinary team at the University of Kentucky developed an interdisciplinary science, technology, engineering, and mathematics and environmental health unit—the Wastewater Assessment for Coronavirus in Kentucky: Implementing Enhanced Surveillance Technology (WACKIEST) Unit—for high school students in summer 2022. This case study outlines the WACKIEST Unit, which focused on wastewater surveillance and COVID-19, the obstacles faced during development and recruitment, and implementation of the WACKIEST Unit in conjunction with a rural wastewater surveillance initiative. The unit was implemented in spring 2023 at a rural high school in Kentucky, spanning 12 days and engaging 190 students. …


Caring For Your Heart During Survivorship After Pediatric Cancer: A Visual Education Guide On Chemotherapy-Induced Cardiotoxicity, Bryona Rose Hamilton Jan 2026

Caring For Your Heart During Survivorship After Pediatric Cancer: A Visual Education Guide On Chemotherapy-Induced Cardiotoxicity, Bryona Rose Hamilton

Theses

Chemotherapy is an effective weapon in the fight against pediatric cancer. However efficient, treatment can lead to side effects that last long after a patient finishes their last round of chemotherapy. This thesis examines current research on chemotherapy-induced cardiotoxicity, a side effect of chemotherapy treatment caused by a class of chemotherapy drugs called Anthracyclines (such as doxorubicin and daunorubicin). While effective chemotherapy agents, these drugs have been known to cause late long-term heart damage when used to treat pediatric cancers such as Acute Lymphoblastic Leukemia (ALL), Acute Myeloid Leukemia (AML) and Pediatric Sarcoma. A written portion of this thesis project …


A Novel Nephron: 3d Visualization Of Glomerular Filtration In The Kidney, Cassie Young Jan 2026

A Novel Nephron: 3d Visualization Of Glomerular Filtration In The Kidney, Cassie Young

Theses

Renal physiology, particularly the process of glomerular filtration, remains one of the most conceptually challenging topics in medical education due to its microscopic scale, dynamic pressure relationships, and structural complexity. Understanding how plasma passes through the glomerular filtration barrier requires spatial reasoning across multiple levels—from the gross anatomy of the kidney to the ultrastructure of capillaries, podocytes, and the glomerular basement membrane. This thesis addresses these challenges through the development of a scientifically accurate three-dimensional (3D) animation that illustrates glomerular filtration within its anatomical and physiological context. Designed as a visual teaching aid, the animation aims to improve comprehension of …