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Articles 23521 - 23550 of 933495
Full-Text Articles in Entire DC Network
Fabrication Of A Chitosan‒Fe3o4/Activated Carbon/Tio2 Nanocomposite As A Pb(Ii) Heavy Metal Adsorbent, Berliantty Warim Putri, Arif Hidayat, Lya Rizka Herawati, Poppy Puspitasari, Nandang Mufti, Yap Wing Fen, Muhammad Safwan Abdul Aziz, Tahta Amrillah, Ahmad Taufiq
Fabrication Of A Chitosan‒Fe3o4/Activated Carbon/Tio2 Nanocomposite As A Pb(Ii) Heavy Metal Adsorbent, Berliantty Warim Putri, Arif Hidayat, Lya Rizka Herawati, Poppy Puspitasari, Nandang Mufti, Yap Wing Fen, Muhammad Safwan Abdul Aziz, Tahta Amrillah, Ahmad Taufiq
Journal of Metals, Materials and Minerals
Nowadays, water pollution by heavy metal Pb(II) is a significant issue in many countries, including Indonesia. To overcome this problem, a suitable and efficient waste treatment method is necessary. Therefore, in this work, Fe3O4/AC/TiO2 nanocomposite modified with chitosan (CS) for the treatment of Pb (II) waste were investigated. CS was used due to its OH and NH2 functional groups, which enable the formation of a new hybrid nanocomposite that can be used repeatedly. To reduce production costs, environmentally friendly, raw natural materials, such as iron sand, coconut shells, and shrimp shells, were employed. The XRD characterization results indicate that the …
Effects Of Various Heat Treatment Cycles On Mechanical Properties And Wear Resistance Of 65mn Carbon Steel, Amir Abbas Mojahedi, Seyed Abdolkarim Sajjadi, Fatemehsadat Sayyedan
Effects Of Various Heat Treatment Cycles On Mechanical Properties And Wear Resistance Of 65mn Carbon Steel, Amir Abbas Mojahedi, Seyed Abdolkarim Sajjadi, Fatemehsadat Sayyedan
Journal of Metals, Materials and Minerals
The aim of the present study is to investigate the effect of various heat treatment cycles on mechanical properties and wear resistance of 65Mn carbon steel. For this purpose, five different heat treatment cycles including normalizing, austenitizing, quenching, and tempering were performed at different austenitization temperatures and tempering times. Subsequently, effects of the parameters on tensile strength, toughness, hardness, and wear resistance of the heat-treated samples were investigated. X-ray diffraction (XRD) and scanning electron microscopy (SEM) equipped with energy dispersive X-ray spectroscopy (EDS) were employed to analyze microstructure of heat-treated samples. To study the wear resistance of the samples after …
Synthesis And Characterization Of New Graft Copolymers Based On Ozonized Polyethylene: Comparative Approach Between Mass And Solution Grafting, Mostapha Karaoui, Samira Kharchouf, Houda El Yakoubi, Kaouthar Boumane, Mohammed Assouag
Synthesis And Characterization Of New Graft Copolymers Based On Ozonized Polyethylene: Comparative Approach Between Mass And Solution Grafting, Mostapha Karaoui, Samira Kharchouf, Houda El Yakoubi, Kaouthar Boumane, Mohammed Assouag
Journal of Metals, Materials and Minerals
New graft copolymers were developed from low-density polyethylene (LDPE) and high-density polyethylene (HDPE) following an initial ozonation step to introduce reactive functional groups onto the polymer backbone. Among the two polymers, LDPE demonstrated superior susceptibility to ozonation, making it the preferred substrate for subsequent grafting. Grafting was then performed primarily on ozonized LDPE using various functional monomers, including acrylic acid (AA), 4-vinylpyridine (4VP), acrylonitrile (AN), chloromethylstyrene (CMS), as well as copolymers such as AA–vinylphosphonic acid (AA-co-VPA) and AN–vinylphosphonic acid (AN-co-VPA). Grafting was carried out using both solution and melt techniques. The resulting materials were characterized by elemental analysis and Fourier …
Hybrid Interface Effect Of G-C3n4/Zno Nanocomposites On The Photoelectrochemical Cathodic Protection Of 304 Stainless Steel In Chloride Solution, Htet Yadanar Soe, Thanate Na Wichean, Jularpar Sunttiprapar, Parichart Chaum, Gasidit Panomsuwan, Oratai Jongprateep, Ratchatee Techapiesancharoenkij
Hybrid Interface Effect Of G-C3n4/Zno Nanocomposites On The Photoelectrochemical Cathodic Protection Of 304 Stainless Steel In Chloride Solution, Htet Yadanar Soe, Thanate Na Wichean, Jularpar Sunttiprapar, Parichart Chaum, Gasidit Panomsuwan, Oratai Jongprateep, Ratchatee Techapiesancharoenkij
Journal of Metals, Materials and Minerals
The development of efficient and environmentally friendly corrosion protection systems for metals in aggressive environments has become a critical area of research, particularly for stainless steel used in marine and industrial applications. In this study, a series of graphitic carbon nitride (g-C3N4) and zinc oxide (ZnO) composites with varying g-C3N4 weight ratios (10 wt% and 30 wt%), are integrated to form heterojunction structures with enhanced charge separation and interfacial activity. The g-C3N4/ ZnO (ZCN) composite thin films were prepared using a facile thermal mixing method and were characterized using XRD, SEM, BET, FTIR, UV-Vis, and PL to confirm their structural, …
Surface Characteristics Of Montmorillonite Reinforced Cellulose Membranes Derived From Pineapple Waste, Naufal Rizky Amasda, Heru Suryanto, Aminnudin Aminuddin, Uun Yanuhar, Nanda Lidya Cinta Aulia Sari, Agus Suyetno, Komarudin Komarudin, Fajar Nusantara, Gaguk Jatisukamto, Aulia Surya Ramadhan
Surface Characteristics Of Montmorillonite Reinforced Cellulose Membranes Derived From Pineapple Waste, Naufal Rizky Amasda, Heru Suryanto, Aminnudin Aminuddin, Uun Yanuhar, Nanda Lidya Cinta Aulia Sari, Agus Suyetno, Komarudin Komarudin, Fajar Nusantara, Gaguk Jatisukamto, Aulia Surya Ramadhan
Journal of Metals, Materials and Minerals
This study aims to investigate the effect of montmorillonite on the surface characteristics and porosity of bacterial nanocellulose (BNC) membranes derived from pineapple peel waste. The bacterial cellulose was synthesized using Acetobacter xylinum using pineapple peel extract as medium component. Bacterial nanocellulose membrane (BNC) was obtained by crushing and homogenizing bacterial cellulose in a high-pressure homogenizer. BNC membrane was reinforced with montmorillonite content of 2 wt% to 8 wt%. The membrane was characterized for its properties using SEM, FTIR, surface roughness tester, tensile tester, water holding capacity test, and BET analysis. The results showed that montmorillonite was well-dispersed within BNC …
The Times They Are A-Changin’: How Bob Dylan’S Music Helped To Change An Era, Emily Newby
The Times They Are A-Changin’: How Bob Dylan’S Music Helped To Change An Era, Emily Newby
Honors Program Theses
No abstract provided.
Predictors Of Resilience Among East Asian American Adults: The Role Of Ethnic Identity, Parental Cultural Socialization And K-12 Experiences Of Stereotype-Related Stress, Regina Lee
Selected Full Text Dissertations, 2011-
This quantitative retrospective study examined predictors of resilience among East Asian American adults reflecting on their K-12 educational experiences of stereotype-related stress. Guided by Asian Critical Theory (AsianCrit), Ethnic Identity Theory, Resilience Theory, and Quantitative Critical Race Theory (QuantCrit), the study investigated whether ethnic identity and parental maintenance of heritage culture during K-12 schooling predicted adult resilience. Participants (N = 207) completed validated measures of ethnic identity (MEIM; Phinney, 1992; Roberts et al., 1999), parental maintenance of heritage culture subscale (AAPRES; Juang et al., 2016), stereotype-related stress (MMM Scale, Thompson & Kiang, 2010; Perpetual Foreigner subscale, Liang et al., 2004), …
Play-Based Learning In Private International Preschools In Cairo: Teachers' Perspectives, Kesha L. Stovall
Play-Based Learning In Private International Preschools In Cairo: Teachers' Perspectives, Kesha L. Stovall
Theses and Dissertations
This thesis explores how play-based learning is practiced and contextualized in private, international preschools in Cairo, Egypt through the perspective of teachers. It calls upon both historical and contemporary theories of play and play pedagogies ranging from the times of Plato and Al-Farabi to the 21st century with Montessori and Dewey. Using a contemporary theory of play presented by Stuart Lester and Wendy Russell as a guiding framework, it examines how play and play-based learning are implemented, shaped and even challenged in a Cairene context. These contexts include sociocultural factors such as parents’ expectations and aspirations, institutional barriers, teacher development …
Today And Yesterday, Vol. 50, 2026, Illinois State University, Department Of History
Today And Yesterday, Vol. 50, 2026, Illinois State University, Department Of History
Today and Yesterday
Newsletter of the Illinois State University Department of History
Human Rights Education For Children And Youth On Human Rights And Digital Technologies, Diane A. Desierto, Faisal Yamil Meneses, Notre Dame Global Human Rights Clinic
Human Rights Education For Children And Youth On Human Rights And Digital Technologies, Diane A. Desierto, Faisal Yamil Meneses, Notre Dame Global Human Rights Clinic
Journal Articles
AI Generated Summary
This document outlines the importance of human rights education for children and youth, particularly in relation to digital technologies, emphasizing the need for comprehensive, inclusive, and accessible educational frameworks.
Generative Ai For Born-Digital Collections: A Case Study For Metadata Management In An Institutional Repository, Tang (Cindy) Tian
Generative Ai For Born-Digital Collections: A Case Study For Metadata Management In An Institutional Repository, Tang (Cindy) Tian
Journal Articles
This case study examines the application of generative artificial intelligence (AI) tools, specifically ChatGPT-4o, ChatGPT-5, and Google Gemini 2.5 Flash, to streamline metadata extraction and creation for a born-digital collection within a digital repository environment. Testing four descriptive metadata elements—titles, abstracts, keywords, and full-text URLs—the study shows that AI improves efficiency in structured tasks but remains limited in semantic ones such as keyword matching. Results demonstrate that AI can streamline metadata workflows for small or resource-constrained institutions while emphasizing the continuing importance of human oversight and ethical responsibility in AI-assisted metadata workflows.
Democracy In Practice, Stefanos Milkidis
Democracy In Practice, Stefanos Milkidis
Open Educational Resources
In this assignment, students are asked to write a public-facing blog post that connects a theme from American government to a current issue, event, or personal experience. The goal is to practice civic dialogue and critical thinking, while contributing to a broader public conversation about American government, politics, and democracy.
Distinct Glycosyltransferase Expression Governs Organ-Specific Survival In Pancreatic Cancer Metastasis, Venkatesh Varadharaj, Frank Leon, Nivedeta Krishna Kumar, Palanisamy Nallasamy, Pratima Raut, Annant Bir Kaur, Kirtana Arikath, Wyatt Petersen, Sanchita Rauth, Neelanjana Gayen, Zahraa Wajih Alsafwani, Poompozhil Mathivanan, Saravanakumar Marimuthu, Kavita Mallya, Madhu Bommideni, Jesse L. Cox, G. Talmon, Paul M. Grandgenett, Michael A. Hollingsworth, Dominick J. Dimaio, Jean L. Grem, Surinder K. Batra, Moorthy P. Ponnusamy
Distinct Glycosyltransferase Expression Governs Organ-Specific Survival In Pancreatic Cancer Metastasis, Venkatesh Varadharaj, Frank Leon, Nivedeta Krishna Kumar, Palanisamy Nallasamy, Pratima Raut, Annant Bir Kaur, Kirtana Arikath, Wyatt Petersen, Sanchita Rauth, Neelanjana Gayen, Zahraa Wajih Alsafwani, Poompozhil Mathivanan, Saravanakumar Marimuthu, Kavita Mallya, Madhu Bommideni, Jesse L. Cox, G. Talmon, Paul M. Grandgenett, Michael A. Hollingsworth, Dominick J. Dimaio, Jean L. Grem, Surinder K. Batra, Moorthy P. Ponnusamy
Journal Articles: Biochemistry & Molecular Biology
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, with over 83% of patients presenting metastases to vital organs such as the liver, lungs, and peritoneum. Although glycosylation has been established as a critical factor in PDAC development, little is known about the molecular underpinnings of organ-specific metastasis. In this study, we investigated the role of glycosyltransferases (GTs) in mediating PDAC metastatic organotropism. Through an unbiased transcriptomic screen, we identified distinct GT expression patterns in liver- and lung-tropic PDAC cells. Notably, GCNT3 and B3GNT3 were selectively upregulated in liver and lung-tropic cells, respectively. These mutually exclusive expression patterns were …
The Coalition Of Inclusive School Leaders Framework & Guidebook, K. Adams, Meghan Cosier, Audri Sandoval Gomez
The Coalition Of Inclusive School Leaders Framework & Guidebook, K. Adams, Meghan Cosier, Audri Sandoval Gomez
Thompson Policy Institute on Disability Policy Reports
"The purpose of this inclusive leadership framework, also supplemental, is to expand further on those actionable steps in the PSEL 2015 and Promoting Principal Leadership for the Success of Students With Disabilities document for direct use with future and current school and district administrators, framing a more inclusive-focused leader than the initial development of the CPSEL and PSEL. This framework will guide leaders toward improving access, equity, and inclusion for students with disabilities (SWD) and other students from traditionally marginalized backgrounds (e.g., students who are Black, Latinx, and Indigenous; students who are LGBTQIA+; and students who are experiencing poverty across …
A Quest For Food In Bedford-Stuyvesant And Brooklyn Heights: Residential Interactions With Neighborhood Food Resources, Aidan Carroll , ‘26
A Quest For Food In Bedford-Stuyvesant And Brooklyn Heights: Residential Interactions With Neighborhood Food Resources, Aidan Carroll , ‘26
Senior Theses, Projects, and Awards
This thesis examines urban inequalities situated across Brooklyn, New York by speculating residential interactions with food resources in their neighborhood such as gardens, grocery stores, restaurants, and food pantries. With a specific focus on the areas Bedford-Stuyvesant and Brooklyn Heights of Brooklyn, New York, the study utilized qualitative data such as interviews and dietary food logs during ethnographic fieldwork in order to assess the ways in which experiences with accessing food can reveal a deeper message about systemic inequalities along the lines of racism and class if we are to consider food apartheid. That said, I found that food apartheid …
Undermining Discretion: The Selective Attacks On Progressive Prosecutors, Angela J. Davis
Undermining Discretion: The Selective Attacks On Progressive Prosecutors, Angela J. Davis
Cardozo Law Review
Prosecutors are the most powerful officials in the criminal legal system. They decide whether to bring criminal charges and what those criminal charges should be. These decisions are totally within their discretion. The U.S. Supreme Court has consistently protected the power and discretion of prosecutors in making these decisions, and legal challenges to the exercise of prosecutorial discretion have been largely unsuccessful.
In recent years, a growing number of individuals have successfully run for chief prosecutor on platforms of reducing the prison and jail populations, consistent with public safety. They pledged to use their power and discretion to implement policies …
Rivers Of Sovereignty: The Epa’S New Water Quality Standards Rule As A Potential Channel For Revitalizing Tribal Reserved Water Rights, Mostyn Josty
Cardozo Law Review
This Note explores the federal government’s evolving approach to its obligation to protect tribal reserved water rights through a case study of the Environmental Protection Agency’s (EPA) 2024 Water Quality Standards Regulatory Revisions to Protect Tribal Reserved Rights rule (the “WQS Rule”). It argues that while the WQS Rule represents a step forward in safeguarding tribal water rights, the legal challenge it faces underscores broader issues of federalism, administrative authority, and the country’s fluctuating commitment to tribal sovereignty. The Note examines the WQS Rule’s legal foundation, its potential challenges, and the implications for tribal self-determination, emphasizing the need for a …
Data Rights For Workers, Pauline Kim, Rachel Leavitt
Data Rights For Workers, Pauline Kim, Rachel Leavitt
Scholarship@WashULaw
Workers are subject to immense amounts of data collection on the job, and the algorithmic management tools built with that data can produce negative effects, including deskilling jobs, unstable work hours, reduced wages, and dangerous and degrading working conditions. Workers thus have significant interests how their data are collected and used, and yet they have been excluded from nearly all the recently enacted or proposed data protection laws. Their exclusion stems from data protection’s roots in privacy law and theory, which primarily focused on consumers as data subjects. Current data protection laws, even if expanded to cover workers, would provide …
Some Caution About Novel State Constitutional Rights, Nick Brod
Some Caution About Novel State Constitutional Rights, Nick Brod
Campbell Law Review
No abstract provided.
One Post Too Few: Doxing As A True Threat And North Carolina's Repeated Action Requirement, Abigail C. Akins
One Post Too Few: Doxing As A True Threat And North Carolina's Repeated Action Requirement, Abigail C. Akins
Campbell Law Review
The purpose of this Comment is to argue for the removal of the repeated action and direct targeting requirements for cyberstalking crimes under N.C. Gen. Stat. § 14-196.3. The recent influx of “doxing”1 behavior on the internet has necessitated statutory change for the protection of North Carolinians. This Comment describes the origins and different types of doxing on the internet, as well as the potential mental and physical impacts that doxing has on individuals who have been doxed. Further, this Comment analyzes the legal doctrines at work with doxing, specifically the First Amendment’s free speech protections and the right to …
A Sample Too Small To Sue Over: A De Minimis Approach To Music Sampling In The Fourth Circuit, Jana S. Flowers
A Sample Too Small To Sue Over: A De Minimis Approach To Music Sampling In The Fourth Circuit, Jana S. Flowers
Campbell Law Review
Have you ever listened to a song and gotten the sense that it sounds familiar without knowing why? In copyright law, that recognition (or lack thereof) can determine whether a musician is liable for copyright infringement. Federal courts are sharply divided over whether the unlicensed sampling of sound recordings should give rise to liability when the borrowed sound is trivial or unrecognizable. The Sixth Circuit’s bright-line rule treats any unauthorized sampling as infringement, while the Ninth Circuit preserves the traditional de minimis doctrine. This Comment argues that the Fourth Circuit should adopt the Ninth Circuit’s de minimis standard when faced …
Beyond Digital Pessimism: How A Focus On Trust Can Enhance Eu Digital Law, Neil M. Richards, Woodrow Hartzog, Claire Boine, Lea Despotis
Beyond Digital Pessimism: How A Focus On Trust Can Enhance Eu Digital Law, Neil M. Richards, Woodrow Hartzog, Claire Boine, Lea Despotis
Scholarship@WashULaw
Lawmakers looking to foster technological innovation on the European market are adopting laws they hope will promote consumer trust in digital products. Their strategy can be broken down into three components. First, they aim to empower consumers to choose how much data they want to share with companies through an express consent framework. Second, they seek to avoid harms from digital products through product safety law such as adapting the Product Safety Regulation to digital products or adopting the AI Act. Third, they endeavor to prevent manipulation of consumers through digital means.
In this essay, we argue that while laudable, …
Space Enterprises As International Lawmakers: Nudges, Pledges, And Other Bottom-Up Modalities, Melissa (M.J.) Durkee
Space Enterprises As International Lawmakers: Nudges, Pledges, And Other Bottom-Up Modalities, Melissa (M.J.) Durkee
Scholarship@WashULaw
Private entities are influencing the development of international space law. Space enterprises need regulatory certainty and consistent standards to attract capital and develop their plans for space. Yet, states have lagged in their capacity to make multilateral international space law in traditional public fora. Private entities have responded to this legal lag by attempting to create, develop, and nudge international space law in commerce-friendly ways. This chapter surveys a variety of modalities by which commercial actors can affect the development of international law, offers several examples of how commercial lawmaking efforts
How International Organizations Regulate Lobbyist Access, Melissa (M.J.) Durkee
How International Organizations Regulate Lobbyist Access, Melissa (M.J.) Durkee
Scholarship@WashULaw
This chapter explores how international organizations (IOs) regulate lobbyist access through participation frameworks rather than traditional lobbying laws. While no unified international lobbying regime exists, IOs use rules on NGO 'consultation' and 'engagement' to structure access. These rules, rooted in historical practices like the UN's Economic and Social Council (ECOSOC) accreditation system, prioritize representativeness and legitimacy over transparency and accountability. As lobbying increasingly targets international forums, concerns about undue influence (the 'lobbying critique') and insufficient stakeholder inclusion (the 'access critique') have driven divergent reforms: some IOs, like the World Health Organization, have adopted stricter controls; others, such as the GAVI …
Privatising International (Organizations) Law, Melissa (M.J.) Durkee
Privatising International (Organizations) Law, Melissa (M.J.) Durkee
Scholarship@WashULaw
This essay explores the increasing role of private commercial actors within international organizations (IOs) and the implications for international law. Once conceived as state-centred institutions, IOs now routinely involve corporations, trade associations, and philanthropic foundations in lawmaking, policy-setting, financing, and implementation. These actors participate through multiple channels: as observers, delegates, stakeholders, funders, and partners. While private involvement has historical precedents, its contemporary scale and formalization mark a significant transformation in global governance. International law, however, offers little guidance on the boundary between public and private authority, leaving legitimacy concerns unresolved. To evaluate privatization, the article identifies two competing logics: a …
Teaching Constitutional Law: Politics, Democracy And History, Andrea Scoseria Katz
Teaching Constitutional Law: Politics, Democracy And History, Andrea Scoseria Katz
Scholarship@WashULaw
Teaching Constitutional Law in the present era presents unique pedagogical challenges. My students arrive skeptical of the field, doubtful of the Supreme Court’s authority, questioning the relevance of legal methods in determining case outcomes, and perceiving constitutional adjudication as irreducibly political. Rather than dismiss these concerns, I argue that constitutional law professors must acknowledge them directly. Our task is not to restore naïve faith in judicial neutrality (an impossible ideal), but to present students with a vision of constitutional meaning-making—one grounded in politics, history, and democratic politics—in which they can recognize themselves as engaged participants in the future of our …
The Attention Safeguard Models: Governing Digital Harm Without Restricting Lawful Speech, Delante Clark
The Attention Safeguard Models: Governing Digital Harm Without Restricting Lawful Speech, Delante Clark
Graduate Scholarship and Creative Works
Digital platforms increasingly govern contemporary social, civic, and psychological life through systems optimized for attention capture, amplification, and monetization. While lawful expression remains protected under the First Amendment, the infrastructural mechanisms that determine how speech circulates have produced a range of attention‑based harms, including cyberbullying, engagement farming, compulsive doom scrolling, emotional dysregulation, and civic polarization. This research paper introduces the Attentional Safeguards Model (ASM), coined and formalized by Delante Clark, as a novel governance framework that mitigates such harms by regulating systems of amplification rather than restricting expression itself. Building on attention economy theory, technological mediation, constitutional free‑speech doctrine, …
Screen Time Use, Reading Achievement, And Thinking Maps: A Correlational Study Of Fifth-Grade Students, Morgan Brooke Unger
Screen Time Use, Reading Achievement, And Thinking Maps: A Correlational Study Of Fifth-Grade Students, Morgan Brooke Unger
Theses and Dissertations
The problem addressed in this study was the fixation of screen time among fifth-grade students at a kindergarten to Grade 12 private school in South Florida. By the time children reach age 12, 69% of adolescents own a smartphone. The purpose of this study was designed to determine (a) the relationship between screen time use and reading achievement among fifth graders, (b) the relationship between parents’ awareness of their child’s screen time use and their child’s actual screen time use, and (c) how well fifth-grade students’ Thinking Maps illustrate the problems associated with screen time fixation at a kindergarten to …
They're Collecting My Data, So What? The Effects Of Privacy Fatigue On Trust And User Experience, Vanessa Brewster
They're Collecting My Data, So What? The Effects Of Privacy Fatigue On Trust And User Experience, Vanessa Brewster
Dissertations from the Executive Doctorate in Business Administration Program
With the increasingly connected nature of Web 4.0 and the AI-enabled internet, new ways to capture biometric data through smart devices are becoming more commonplace, and users are presented with an overwhelming number of decisions regarding how their data is collected and used. As such, concerns about data privacy remain a key issue among those with varying levels of fears of technology. However, privacy concern scales have not yet been updated to give researchers a full picture of the impact, and with control mechanisms varying widely across countries as regulation struggles to keep pace with innovation, trust in technology can …
Microfluidic Encapsulation Of Sorafenib-Loaded Zif-8 Nanoparticles In Ph-Responsive Alginate Microparticles For Oral Chemotherapy Of Hepatocellular Carcinoma, Mojdeh Mirshafiei, Zahra Mahmoudi, Mehdi Mehrpouya, Mahdi Mahmoudi, Masoud Rezaeian, Mona Navaei-Nigjeh, Zahra Katoli, Lobat Tayebi
Microfluidic Encapsulation Of Sorafenib-Loaded Zif-8 Nanoparticles In Ph-Responsive Alginate Microparticles For Oral Chemotherapy Of Hepatocellular Carcinoma, Mojdeh Mirshafiei, Zahra Mahmoudi, Mehdi Mehrpouya, Mahdi Mahmoudi, Masoud Rezaeian, Mona Navaei-Nigjeh, Zahra Katoli, Lobat Tayebi
Electrical & Computer Engineering Faculty Publications
Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality. Sorafenib is the current first-line oral therapy; however, its therapeutic efficacy is limited by poor aqueous solubility, low bioavailability, and gastrointestinal instability. This study aimed to develop a pH-responsive nano-in-microparticle delivery system using a single-step droplet-based microfluidic process to protect sorafenib in the gastric environment and achieve controlled release for enhanced oral chemotherapy. Sorafenib-loaded ZIF-8 nanoparticles (SZ NPs) were synthesized and characterized by scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, Energy-dispersive X-ray (EDX) spectroscopy, and X-ray diffraction (XRD), exhibiting a mean diameter of about 72 nm and …