Digital Commons Network^™

Repurposing Cyclin-Dependent Kinase Inhibitors For The Discovery Of Novel Antiplasmodial Compounds, Ritam Bhowmik

Honors Undergraduate Theses

Malaria remains a major global health burden with over 282 million cases annually and rising resistance to artemisinin-based combination therapies. Plasmodium falciparum, the most lethal malaria parasite species in humans, relies on tightly regulated cell cycle progression during replication within red blood cells. Cyclin-dependent kinases (CDKs) are central regulators of eukaryotic cell division and transcription, and several CDK-like enzymes in P. falciparum, including Pfmrk and PfPK6, are essential for parasite growth and structurally distinct from human kinases. This study evaluated whether commercially available human CDK inhibitors (CDKIs) targeting cancer pathways could be repurposed as novel antimalarial compounds. A library of …

Self-Reported Psychological Effects Of Rock Climbing In Adults On The Autism Spectrum, Brennan Gleason

Honors Undergraduate Theses

Background: Prior research has shown rock climbing to have considerable therapeutic potential through such mechanisms as boosting self-esteem, promoting mindfulness, and creating a supportive social community. (Liu et al., 2022, Osborne et al., 2025). Meanwhile, autistic adults experience mood disorders at a significantly higher rate than the general population; upwards of 54% are diagnosed with a psychiatric condition (Croen et al., 2015). Many of the issues negatively affecting autistic adults align with the benefits of rock climbing, including low self-esteem, inadequate social support, and anxiety.

Objective: This study aimed to find differences in mental health outcomes between autistic adults who …

Manuka Honey Modulates Oxidative Stress In Neuro2-A Cells Through Mitochondrial Regulation, Rachel Abramovici

Honors Undergraduate Theses

Manuka honey is known for its vital usage in wound healing, being an agonist towards fighting infections, and is an acting antioxidant [32]. Its main constituents are flavonoids and phenolic compounds, with methyl syringate (MSYR) being a major active ingredient. The specific compounds responsible for these antioxidant effects, particularly in the CNS, remain unclear. It is hypothesized that pre-treatment of mouse neuroblastoma cells with MSYR followed by hydrogen peroxide exposure will activate the AMPK/SIRT1/PGC-1a pathway, due to MSYR’s phenolic structure, and thus reduce oxidative stress and improve mitochondrial biogenesis. Hydrogen peroxide is a standard reactive oxygen species (ROS) treatment to …

Transforming Florida Chemistry Education: Exploring Information Literacy Strategies From Singapore, Han N. Le

Honors Undergraduate Theses

This study explores the applicability of Singapore’s information literacy (IL) strategies within Central Floridian higher education environments. Singapore’s national IL framework, supported by its Ministry of Education, integrates information and communication technology (ICT), professional development, and lifelong learning initiatives through a standardized, systemwide approach. In contrast, IL instruction in the United States is largely decentralized, often limited to one-time sessions or elective courses. To investigate the feasibility of adapting Singapore’s practices, surveys were distributed to faculty and librarians across Florida’s twelve public universities, yielding responses that highlighted varying levels of IL integration, limited institutional support, and minimal professional training related …

A Systematic Literature Review Of The Possible Negative Impacts Of Overconsumption Of Mass Media And Technology On Elementary-Aged Members Of Generation Z (1997–2012) And Generation Alpha (2013–2024), Ashya Y. Warren

Honors Undergraduate Theses

This thesis explores the possible negative impacts of overconsumption of mass media and technology on the elementary-aged members of Generation Z (1997-2012) and Generation Alpha (2013-2024). This research is aimed at establishing the relationship between excessive and uncontrolled exposure to digital media and cognitive, emotional, social, behavioral, and academic difficulties at a critical period of child growth. The purpose of this systematic literature review can be explained by the author's experience with technology overuse and professional interests as a future teacher, who should be prepared to help promote healthy childhood and development. The systematic literature review was based on peer-reviewed …

Impact Of Lifestyle Factors On Allergic Rhinitis Symptoms And Quality Of Life Among College Students, Lina Saint-Hilaire

Honors Undergraduate Theses

This study aims to examine the influence of certain lifestyle factors on the presentation of allergic rhinitis symptoms and the quality of life of college students. Factors of interest include residential setting, household cleaning habits, age of symptom onset, and exposure to household pets. Additional analysis includes assessment of the impact of allergic rhinitis symptoms on sleep. Using a cross-sectional survey design, student responses were self-reported through a paper survey distributed during tabling days at the University of Central Florida (UCF) main campus. Eligible participants had to be 18 years or older and current UCF graduate and undergraduate students. Survey …

Slay Her: The Rhetoric Of Violation In Buffy The Vampire Slayer, Lea N. Wright

Honors Undergraduate Theses

This research draws on feminist theory and monster theory to perform a close rhetorical analysis of incidents in the television show Buffy the Vampire Slayer (Buffy) where female characters are violated physically, psychologically, and/or sexually. Buffy is one of the most-analyzed television shows of all time, with a particular emphasis on the show’s engagement with feminism; however, the issue of violation has received little scholarly investigation despite multiple instances of it within the show. Through examining the rhetorical elements (such as dialogue, camerawork, body language, and character response) that surround incidents of violation, this research reveals that Buffy …

Gen Z Perspectives On Mental Health Service Interaction: A Qualitative Content Analysis Of Reddit Discourse, Victor A. Aguiar

Honors Undergraduate Theses

Compared to prior generations, Generation Z engages with mental health and mental health service interaction in distinct ways, frequently using social media platforms to share experiences, concerns, and opinions. Previous research has examined mental health discourse on Reddit; however, much of this work relies on inductive thematic approaches and offers limited focus on mental health service interaction and the factors influencing utilization. Guided by the Theory of Planned Behavior (TPB), this study examines how Generation Z discusses mental health service use through online discourse. Public Reddit posts authored by users identifiable as Generation Z, based on self-reported age, school enrollment, …

Social Determinants Of Health Affecting Cardiovascular Health Among South Asian Americans, Ann Mary Thomas

Honors Undergraduate Theses

Background: South Asian Americans experience disproportionately high rates of cardiovascular disease, yet the social determinants contributing to these disparities remain understudied.

Objective: This systematic review examines the role of social determinants of health (SDOH) in shaping cardiovascular outcomes among South Asian Americans.

Methods: A systematic literature search was conducted across PubMed, MEDLINE, and Web of Science using predefined search terms related to South Asian populations, cardiovascular health, and SDOH. The review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 reporting guidelines, and study screening and management were performed using Covidence. A total …

Impact Of Senescence On Breast Cancer Outcomes, Gracie Sous

Honors Undergraduate Theses

Cellular senescence is a biological process in which damaged cells exit the cell cycle while remaining metabolically active and accumulating within tissues. Senescence plays a complex role in breast cancer progression, largely through the secretion of senescence-associated secretory phenotype (SASP) factors. These factors include a broad range of inflammatory cytokines, chemokines, and signaling molecules that can influence the tumor microenvironment.

Studies suggest that senescence may significantly promote cancer metastasis. Therefore, this study aims to investigate the genes involved in cancer progression and to improve understanding of how SASP is regulated, which is critical for improving breast cancer outcomes. The central …

Investigating The Interaction Of Gram-Positive Lactobacillus Species With Mucin In The Context Of Barrett's Esophagus, Ritisha Suresh

Honors Undergraduate Theses

Gastroesophageal Reflux Disease (GERD) can progress to the precancerous Barrett’s Esophagus (BE) condition, in which the normal esophageal squamous epithelium is replaced with a columnar epithelium containing goblet cells. Mucins, sticky substances, are secreted in response to bile acid exposure during reflux episodes to protect the esophageal epithelium. Goblet cells secrete these mucins, which can also scaffold microbial colonization. Probiotic Lactobacillus bacteria can use glycosidase enzymes to process mucin and metabolize them into their component sugars (glycans). This project aims to identify the role of the Lactobacillus-mucin interaction in BE, as glycan availability could confer an advantage to Lactobacillus …

Advancing Greenhouse Air Filtration: Biodegradable Nanofiber Filters With Sustained Antimicrobial Performance, Amirali Bajgholi, Reza Jafari, Alireza Saidi

Études primaires

Air quality management in greenhouses is critical to safeguarding plant health and occupational safety, yet conventional filtration methods often fall short in performance and sustainability. These enclosed environments are prone to the accumulation of bioaerosols, including fungi, bacteria, pollen, and dust particles, which can compromise crop productivity and pose health risks to workers. This review explores recent advancements in air filtration technologies for controlled environments such as greenhouses, where airborne particulate matter, bioaerosols, and volatile organic compounds (VOCs) present ongoing challenges. Special focus is given to the development of filtration media based on electrospun nanofibers, which offer high surface area, …

Risky Business, Atinuke O. Adediran

Faculty Scholarship

Corporate law scholarship and doctrine have largely operated on the assumption that corporate shareholders are interested in financial goals, while corporate stakeholders—such as employees, consumers, and local communities—are interested in social and environmental goals, like diversity and inclusion and climate change. Because of this assumption, the law largely requires a corporation to disclose information it considers to be “financially material” to shareholders—that is significant enough to impact the company’s financial position—including factors it considers to be financially risky.

Financial materiality is so embedded in corporate law doctrine that even if an issue is about social and environmental concerns, financial materiality …

Rac1 Gtpase Regulates The Scfβtrcp-Mediated Degradation Of Claspin And The Cellular Response Of Pancreatic Cancer Cells To Gamma Rays, Neha Chaudhary, Tabbatha N. Somers, Surinder K. Batra, Ying Yan, Michel M. Ouellette

Journal Articles: Biochemistry & Molecular Biology

BACKGROUND/OBJECTIVES: Pancreatic ductal adenocarcinomas (PDACs) are lethal tumors exhibiting resistance to most cancer therapeutics, particularly DNA-damaging agents. The

METHODS: Western blot analyses were used to assess the impacts of Rac1 inhibition on the components of the ATR/Chk1 cascade.

RESULTS: Here, we show that Rac1 inhibition disrupts ATR/Chk1 signaling by promoting degradation of Claspin, a key component of the fork protection complex needed for the Ser345-phosphorylation of Chk1 by ATR. In PDACs and normal pancreatic ductal cells, Rac1 inhibition (via inhibitors or siRNA) decreased Claspin protein levels without affecting its mRNA, reflecting a >3-fold reduction in Claspin's half-life. Claspin contains a …

Acceptability, Usability, And Clinical Integration Of A Clinic-Based Digital Game For Hpv Education: Qualitative Perspectives From Adolescents, Parents, And Healthcare Providers, Elizabeth Reifsnider, Satya Subedi, Nouran Ghonaim, Megan Whaley, Angela Chia-Chen Chen

Ellmer School of Nursing Faculty Publications

Background/Objectives: HPV vaccination is safe, effective, and recommended at ages 11–12, yet uptake remains suboptimal. Serious video games may offer an innovative strategy to deliver brief, engaging education during clinic visits. This qualitative paper, embedded within a mixed-methods study, examined adolescents’, parents’, and healthcare providers’ (HCPs’) perceptions of the acceptability, usability, and perceived clinical applicability of HPV Detective, a tablet-based digital game designed to provide HPV-related education to parent–child dyads during pediatric clinic wait times. Methods: Eight adolescent–parent dyads (N = 16) and three HCPs from university-affiliated pediatric clinics participated in 30–60-min semi-structured Zoom interviews. Interviews were audio-recorded, transcribed, and …

Increasing Hpv Vaccination Among Early Adolescents Using A Game-Based Digital Intervention: A Randomized Controlled Trial, Angela Chia-Chen Chen, Lihong Ou, Elizabeth Reifsnider, Kimberly Arcoleo, Ashish Amresh, Michael Todd

Ellmer School of Nursing Faculty Publications

Background/Objectives: Human papillomavirus (HPV) vaccination coverage among adolescents remains below public health targets despite strong evidence of vaccine effectiveness in preventing HPV-related cancers. Digital interventions (e.g., serious games) may improve HPV vaccine uptake, but evidence for effects on vaccination behavior remains limited. Methods: This secondary analysis of a randomized controlled trial evaluated a co-designed, game-based digital intervention to increase HPV vaccine initiation among unvaccinated youth aged 11-14 years and their parents. The sample included 64 parent-adolescent dyads (33 intervention and 31 usual care dyads). The primary outcome was HPV vaccine initiation at 2-month follow-up. Results: A significantly greater proportion of …

The International Order, International Law, And The Definition Of Security, Harlan G. Cohen

Faculty Scholarship

As economic security has seemingly moved to the center of American and European foreign policy, both the United States and the European Union have broadened their interpretation of international law rules governing security, coercion, and intervention. But these interpretations are not exactly new, echoing developing state interpretations of international law that developed states had long ago seemingly rejected. How are these once moribund interpretations of security, force, and coercion being brought back to life?

This article argues that these interpretative shifts highlight the role of the international order as an interpretative mechanism within international law. Borrowing from the work of …

Transparency As A Regulatory Duty, Olivier Sylvain

Faculty Scholarship

This symposium piece offers a simple survey of transparency measures addressed to deepfakes and other related consumer harms, as well as the constitutional problems they present.

Book Review Of Political And Social Control In China: The Consolidation Of Single-Party Rule, Carl F. Minzner

Faculty Scholarship

No abstract provided.

Mucin 5ac Modulates Cancer-Associated Fibroblast Heterogeneity Through Epigenetic Reprogramming Of Precursor Cells, Rachel J. Kehrberg, Namita Bhyravbhatla, Zahraa Wajih Alsafwani, Xiaoqi Li, Gopalakrishnan Natarajan, Imran Khan, Randall E. Brand, Maneesh Jain, Surinder K. Batra, Sushil Kumar

Journal Articles: Biochemistry & Molecular Biology

Pancreatic cancer (PC) is characterized by extensive desmoplasia, with heterogeneous cancer-associated fibroblasts (CAFs) as a major component. However, the contribution of distinct precursor cells to CAF heterogeneity remains poorly defined. This study investigated the role of Muc5ac in modulating CAF heterogeneity by maturing precursor cells, including adipose-derived mesenchymal stem cells (AD-MSCs), bone marrow-derived MSCs (BM-MSCs), and pancreatic stellate cells (PSCs), into different CAF subsets. RNA sequencing of precursor cells treated with conditioned media from Muc5ac-proficient or -deficient cancer cells revealed distinct transcriptional profiles. Muc5ac significantly modulated the expression of Dnmts and Tets in AD-MSCs, promoting the acquisition of extracellular matrix …

Iv Contrast For Mri And Ct In Patients With Kidney Disease, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Decreasing Incidence Of Falls During Change Of Shift, Najma Ali Adn, Rn, Kwabena Barnie Adn, Rn, Laura Bishop Bsn, Rn, Shalay Dale Bsn, Rn, Alli Fields Bsn, Rn, Tia Guo Adn, Rn, Ayan Haji Adn, Rn, Halley Spears Adn, Rn, Allison Stewart Adn, Rn, Courtney Uriostegui Bsn, Rn

Nurse Residency Posters

Facilitator: Dustin Eckert, BSN, RN

OhioHealth Riverside Methodist Hospital

From Flexibility To Friction: Intended And Unintended Consequences Of Hot-Desking In Workplaces, Cheuk Hang Au, Lin Yue, Siqi Gao, Guanglei Cheng

Research outputs 2022 to 2026

Purpose: This study aims to theorize the tensions of hot-desking. Moving beyond its surface-level effects, we explain its complex impact on employee well-being and organizational conflict.

Design/methodology/approach: Using a multi-platform netnographic approach, we analyzed unsolicited discussions from online communities to capture diverse, authentic experiences across Eastern and Western contexts.

Findings: Grounded in technology affordance and constraints theory (TACT), our central finding is that hot-desking's affordances and constraints are dynamically co-produced. The organizational affordance of space efficiency is directly experienced by employees as a constraint of spatial insecurity and resource deprivation. This core tension fuels emergent social conflicts, such as senior …

Intersections Of Art And Medicine, Lina Adwer

EMET Projects

No abstract provided.

Unmasking Impression Management: Large Language Models For Detecting Socially Desirable Responding In Open-Ended Situational Judgment Tests, Barret Vermilion

Graduate Studies Theses and Dissertations 2026

Socially desirable responding (SDR) — the tendency to present oneself in an overly favorable light — remains a persistent validity concern in industrial-organizational psychology. Contemporary theory frames SDR as multidimensional, distinguishing agentic impression management (AM; inflating competence, dominance, and achievement) from communal impression management (CM; inflating warmth, cooperation, and prosocial qualities). Existing measures of AM and CM rely on self-report, which captures these constructs only at the level of generalized trait-like tendencies rather than as they naturally unfold in applicants' own language. This dissertation proposes a text-based alternative: detecting AM and CM in open-ended situational judgment tests (SJTs) of Big …

Beyond Assumptions: What Students Really Think About School Wellbeing Programs, Amanda Madden

Research outputs 2022 to 2026

The study examined students’ perceptions of effective components in school-based wellbeing programs, addressing a critical gap where adolescent voices are absent. Data was gathered through a questionnaire, individual interviews, and focus groups conducted with 36 Year 12 students across three independent co-educational schools in Western Australia. Thematic analysis identified seven key components essential for effective wellbeing programming: targeted content providing respite from academic pressures, engaging and relatable presenters, strategic timing, developmental appropriateness, meaningful measurement, genuine teacher engagement, and authentic incorporation of student voice. Students valued practical, non-academic content and expressed scepticisms about teacher-delivered programs. Timing emerged as a previously underexplored …

Strengthening Ocean Literacy: Marine Science Education And Training To Ensure Australia's Blue Future, Prue Francis, Rachel Kelly, Louise Swanson, Tanveer M. Adyel, Benjamin Arthur, Kirsten Benkendorff, Melanie J. Bishop, Helen Bostock, Marnie L. Campbell, Emma Church, Corrine Condie, Vaibhavi Dwivedi, Michelle Dyer, Matthew England, Liam Fullbrook, Charlie Huveneers, Malcolm Johnson, Brianna Le Busque, Rebecca R. Mcintosh, Amelie Meyer, Benjamin Mos, Jana Mrazova, Allyson O'Brien, Gretta T. Pecl, Amandine Schaeffer, Rebecca J. Shellock, Grant A. Smith, Scott Smithers, Ana Vila-Concejo, Graham Wood

Research outputs 2022 to 2026

This white paper sets out a national vision for advancing ocean literacy in Australia and outlines the role of marine science in fostering an informed, engaged society capable of addressing the challenges and opportunities of our changing oceans. As environmental pressures intensify, and marine resource demands increase, Australians’ capacity to engage with ocean issues, understand risks and opportunities, and participate in marine decision-making has never been more urgent. Marine science will play a central role in building ocean literacy by delivering credible, actionable science, and strengthening education and training systems that enhance understanding of, and connection to, the ocean. Our …

Reclaiming Constitutional Authority Of Algorithmic Power, Yiyang Mei, Michael J. Broyde

Faculty Articles

Whether and how to govern AI is no longer a question of technical regulation. It is a question of constitutional authority. Across jurisdictions, algorithmic systems now perform functions once reserved to public institutions: allocating welfare, determining legal status, mediating access to housing, employment, and healthcare. These are not merely administrative operations. They are acts of rule. Yet the dominant models of AI governance fail to confront this reality. The European approach centers on rights-based oversight, presenting its regulatory framework as a principled defense of human dignity. The American model relies on decentralized experimentation, treating fragmentation as a proxy for democratic …

Do Emerging Social Media Platforms Shape The Gender Gap In Surveillance Political Knowledge?, Saskia Papsova

Graduate Studies Theses and Dissertations 2026

Abstract

Research shows that men consistently score higher than women on standard political knowledge measures, but as Americans increasingly obtain political information through social media, it is unclear whether different platforms affect this gender gap. This study investigates whether social media platforms shape the gender gap in surveillance political knowledge—knowledge of current political facts and contested claims circulating in the contemporary information environment, and which platforms have the biggest impact. Using data from the ANES 2020 Social Media Study, I estimate weighted OLS regression models testing whether platform-specific usage is associated with surveillance political knowledge and whether these associations differ …

The Effects Of Episodic Facilitation And Immersion On Memory Formation During Learning Of An Exterior Preflight Inspection Procedure, Nathan A. Sonnenfeld

Graduate Studies Theses and Dissertations 2026

This research examined the use of episodic facilitation—instructional elements aligned with episodic memory (EM) processes—to affect learners’ memory of simulation training for an aviation procedure. Despite its assumed benefits in industry and theory, virtual reality (VR) has shown limited advantages over conventional media for training procedures, in part because prevailing frameworks emphasize semantic and procedural outcomes, leaving memory of training experiences as events underexamined. To address this gap, this work advances human factors research by examining EM as a design consideration, an outcome, and an explanatory mechanism for how simulation training experiences are remembered. Grounded in theories of EM and …