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Determining The 3d Structure And Dynamics Of Mouse Notch1 Epidermal Growth Factor-Like Repeat 26 Using Nuclear Magnetic Resonance Spectroscopy, Kendra D. Jenkins

LSU Doctoral Dissertations

NOTCH is a transmembrane protein that transmits signals between cells in direct contact and alters gene expression. The signaling pathway is important because it is involved in cell fate determination. The NOTCH1 extracellular domain has 36 epidermal growth factor-like (EGF) repeats that are responsible for ligand binding. Mutations in the EGF-like repeats cause various neurological and developmental disorders. NOTCH1 signaling initiates when DSL ligands bind to EGF11-12, the minimum Ligand Binding Domain (LBD). The Abruptex region of the NOTCH1 protein (EGF24-29) is a highly glycosylated, flexible region with calcium binding sites that regulates NOTCH1 signaling and binding by interacting with …

Reimagining Rhetorical Ability: (Dis)Embodiments Of Disabled Speakers In The Stuttertalk Podcast And The 2020 Democratic National Convention, Katherine Mulle

Communication ETDs

While communication scholars have dedicated much research towards defining and furthering effective communication, explorations of speech disability, especially from a critical lens, are largely absent in these pursuits. I conducted a critical rhetorical analysis of the (dis)embodiments of disabled speakers through examining segments from the 2020 Democratic National Convention (DNC) program that cover Joe Biden’s story as a person who stutters, and episodes of StutterTalk, a podcast created by and featuring people who stutter. Moreover, I organize this thesis around two claims: (1) As a person who stutters with certain privilege and power, Joe Biden’s DNC story further secured …

Social Media Use And Application During Covid-19 By Special Libraries In Nigeria: Case Study Of Justice Babasola Ogunade Law Library, Nigeria, Daniel Olufemi Oladeji Mr, Dorcas O. Bakare

Library Philosophy and Practice (e-journal)

Abstract

This study examines the use of social media during covid-19 by the Justice Babasola Ogunade Law Library of Ajayi Crowther University, Oyo State, Nigeria.

In achieving the set objectives for this study, Focus Group Discussion (FGD) was conducted among the six staff of the Hon. Justice Babasola Ogunade Law Library, Ajayi Crowther University, Nigeria. For the purpose of ensuring that the discussion revolved round the intended construct. The researchers made use of prepared structured questions and checklists that made the process of data collection easier.

Findings from the study (95% of the respondents) revealed that the law library had …

Lessons From Bright-Spots For Advancing Knowledge Exchange At The Interface Of Marine Science And Policy, Denis B. Karcher, Christopher Cvitanovic, Putten Ie Van, Rebecca M. Colvin, Derek Armitage, Shankar Aswani, Marta Ballesteros, Natalie C. Ban, María José Barragán-Paladines, Angela Bednarek, Johann D. Bell, Cassandra M. Brooks, Tim M. Daw, La Cruz-Modino R De, Tessa B. Francis, Elizabeth A. Fulton, Alistair J. Hobday, Draško Holcer, Charlotte Hudson, Tim C. Jennerjahn, Aimee Kinney, Maaike Knol-Kauffman, Marie F. Löf, Priscila F.M. Lopes, Peter C. Mackelworth, Abigail Mcquatters-Gollop, Ella Kari Muhl, Pita Neihapi, José J. Pascual-Fernández, Stephen M. Posner, Hens Runhaar, Keith Sainsbury, Gunnar Sander, Dirk J. Steenbergen, Paul M. Tuda, Elizabeth Whiteman, Jialin Zhang

School of Biological and Marine Sciences

Evidence-informed decision-making is in increasing demand given growing pressures on marine environments. A way to facilitate this is by knowledge exchange among marine scientists and decision-makers. While many barriers are reported in the literature, there are also examples whereby research has successfully informed marine decision-making (i.e., ‘bright-spots’). Here, we identify and analyze 25 bright-spots from a wide range of marine fields, contexts, and locations to provide insights into how to improve knowledge exchange at the interface of marine science and policy. Through qualitative surveys we investigate what initiated the bright-spots, their goals, and approaches to knowledge exchange. We also seek …

Electronic Information Resources Use And Research Productivity Of Lecturers In Private Universities In Oyo State, Oladeji Daniel Olufemi Mr, Adeyeye Sophia V. Phd

Library Philosophy and Practice (e-journal)

Abstract

It is impossible to overstate the importance of librarians in the intellectual development of any institution. The impact of this function can also be seen in librarians' productivity. In other words, when librarians are productive, they contribute significantly to the organization's long-term viability. If this isn't the case, the organization has a good chance of collapsing. In this light, the purpose of this study is to look into Electronic Information Resources (EIRs) Use and Research Productivity (RP) of lecturers in private universities in Oyo state. The study used a Descriptive research design. Population consists of 520 lecturers in private …

Introducer-Free Mis-Assisted Ventriculoperitoneal Shunt Placement: A Technical Document, Eric Chen, Patrick Opperman, Edson Deoliveira, Priscila Rodrigues Armijo, Vishal Kothari, Daniel Surdell

Graduate Medical Education Research Journal

Background

The placement of the distal catheter of a ventriculoperitoneal shunt (VPS) can be challenging in patients with a large body habitus. Given the complications associated with ventriculoperitoneal shunts and known infection risk of obese patients, new techniques for VPS placement that bypass the abdominal fat must be sought. By avoiding the abdominal fat, decreased complications and infection risk may be possible.

Objective

The objective of this technical document is to describe a laparoscopic approach to the abdominal cavity during ventriculoperitoneal shunt surgery that makes use of a direct tunneling technique into the peritoneal space.

Methods

We perform a ventriculoperitoneal …

Scholarly Activity In Residency: A Needs Assessment Of Challenges And Proposed Solutions, Jonathan Hall, Jana L. Wardian Phd, Jasmine R. Marcelin

Graduate Medical Education Research Journal

Introduction

Resident physician participation in scholarly activity is associated with significant benefits ranging from trainees’ personal development to improved quality of patient care. Residency programs have taken varied approaches to improve resident engagement in scholarship, though interventions have demonstrated mixed results regarding objective measures of scholarly productivity. Concerns regarding waining interest in scholarship amongst internal medicine residents prompted a department-wide needs assessment to evaluate opportunities for scholarship and challenges preventing resident participation.

Methods

A web-based survey was developed and distributed to Department of Internal Medicine faculty and residents at the PGY2 level or higher and recent graduates within the last …

Leadership And Human Resource Management During Crisis, Ghenwa Al Hakim, Bettina Lynda Bastian, Madonna Salameh Ayanian, Nada Sarkis

Arab Economic and Business Journal

The present paper investigates the role of leadership and human resource management (HRM) in times of crisis. The analysis is situated within the context of Lebanon which is facing the challenges of the COVID-19 pandemic whilst undergoing a devastating economic crisis and downturn. Based on 23 interviews with managers, the paper recognizes attributes of effective leadership in a crisis management approach, as well as the role that the HRM plays in driving employee and organizational performance despite external challenges. In this context, several leadership and HRM practices in response to crisis are identified and discussed.

The Church And Michael Brown: The Influence Of Christianity On Racialized Political Attitudes In Ferguson, Missouri, Tyler Chance

The Simon Review (Occasional Papers of the Paul Simon Public Policy Institute)

This study examines whether the Christian faith played a pacifying or inspiring role in racialized politics following the death of Michael Brown and subsequent uprisings in Ferguson, Missouri. To evaluate the role of religion in responding to racialized crisis, the author examines both the attitudes of individual citizens and the actions of faith leaders. Using data gathered from two exit polls conducted by the author in Ferguson and the surrounding area during the period between the death of Michael Brown and the decision not to indict the officer who killed him and then again after the grand jury decision, the …

Issue 398: July 14-28, 2022, The Local Voice

The Local Voice

No abstract provided.

Vol.49 N.51 July 14th 2022, Voice Media Ventures

Black Voice News

No abstract provided.

Gender, Monastic Life, And The Lay Community During The Pandemic, Stephen Covell, Diane Riggs, Cameron Borg

Modules for Teaching Pandemic Response and Religion in the USA

The following teaching module is designed for high school and college level instructors who seek to teach a lesson on the impact the COVID-19 pandemic had on the monastic life of both Buddhists and Catholics. The teaching module features a lesson plan, case studies, and assignments that can be incorporated as the instructor sees fit. This teaching module was created by Wester Michigan University's Department of Comparative Religion.

Exploring Dating As An Occupation For Young Heterosexual Women In Ireland, Karen Mccarthy, Jeanne Jackson

Occupational Therapy | Faculty Scholarship

Purpose – Dating is a meaningful occupation for many single people. The occupation of dating has transformed considerably in Ireland due to recent changes in Irish culture and the advent of online dating technology. The purpose of this study was to explore the complexities and intricacies of dating in an Irish context.

Design/methodology/approach – A qualitative research approach was used and data were collected using semi-structured interviews with ten heterosexual women (age 24-34) living in urban areas of Ireland. Data were analysed using inductive thematic analysis (Braun and Clarke, 2006).

Findings – Dating did not fully resonate with their experience, …

The Unique Seed Protein Composition Of Quality Protein Popcorn Promotes Growth Of Beneficial Bacteria From The Human Gut Microbiome, Nate Korth, Leandra Parsons, Mallory J. Van Haute, Qinnan Yang, Preston Hurst, James C. Schnable, David R. Holding, Andrew K. Benson

Food for Health: Publications

The effects of fiber, complex carbohydrates, lipids, and small molecules from food matrices on the human gut microbiome have been increasingly studied. Much less is known about how dietary protein can influence the composition and function of the gut microbial community. Here, we used near-isogenic maize lines of conventional popcorn and quality-protein popcorn (QPP) to study the effects of the opaque-2 mutation and associated quality-protein modifiers on the human gut microbiome. Opaque-2 blocks the synthesis of major maize seed proteins (α-zeins), resulting in a compensatory synthesis of new seed proteins that are nutritionally beneficial with substantially higher levels …

Listen Anywhere: One Heart With Courage Available As Audiobook, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

Teri Rizvi's award-winning One Heart with Courage: Essays and Stories (Braughler Books) has been released as an audiobook narrated by Sheri Saginor. Royalties benefit the Erma Bombeck Writers' Workshop Endowment Fund.

Protecting The Sovereign's Money Monopoly, Gary B. Gordon, Jeffery Zhang

Law & Economics Working Papers

Sovereign states have had a monopoly over the production of circulating currencies for well over a century. Governments, not private entities, issue circulating currencies. Indeed, in 1986, Milton Friedman and Anna Schwartz declared that “[t]he question of government monopoly of hand-to-hand currency is likely to remain a largely dead issue.” The advent of stablecoins—privately issued digital money that are pegged to fiat currencies like the U.S. dollar or the Euro—raises the question of the money monopoly from the grave.

Why did sovereign money monopolies come into existence in the 19th and 20th centuries? Should circulating private money coexist once again …

Three Essays On Student Enrollment Responses To General Household And Education-Specific Assistance Programs, Usamah Wasif

Economics ETDs

Greater educational attainment is associated with an increase in expected income, lowering of internal discount rates, and improved financial and health literacy. Income transfers have the potential to positively impact educational attainment by either reducing the direct cost of college attendance or by inducing an income effect that nudges students to decrease labor supply and devote greater time to studies. Whether assistance leads to more education depends on the circumstances, particularly the educational stage and assistance type. High school students may react differently to assistance relative to college students and both may react differently to general household income transfers compared …

Reports Of Adverse Events Associated With Use Of Novel Psychoactive Substances, 2017-2020: A Review, Amanda L A Mohr, Barry K Logan, Melissa F Fogarty, Alex J Krotulski, Donna M Papsun, Sherri L Kacinko, Marilyn A Huestis, Jeri D Ropero-Miller

Institute of Emerging Health Professions Faculty Papers

An important role of modern forensic and clinical toxicologists is to monitor the adverse events of novel psychoactive substances (NPS). Following a prior review from 2013 to 2016, this critical literature review analyzes and evaluates published case reports for NPS from January 2017 through December 2020. The primary objective of this study is to assist in the assessment and interpretation of these cases as well as provide references for confirmation methods. Chemistry, pharmacology, adverse events and user profiles (e.g., polypharmacy) for NPS are provided including case history, clinical symptoms, autopsy findings and analytical results. Literature reviews were performed in PubMed …

Glyoxal Fixation Is Optimal For Immunostaining Of Brain Vessels, Pericytes And Blood-Brain Barrier Proteins, Sithara Thomas, Jayanarayanan Sadanandan, Spiros L Blackburn, Devin W Mcbride, Ari Dienel, Sungha Hong, Hussein A Zeineddine, Peeyush Kumar Thankamani

Faculty, Staff and Student Publications

Brain vascular staining is very important for understanding cerebrovascular pathologies. 4% paraformaldehyde is considered the gold standard fixation technique for immunohistochemistry and it revolutionized the examination of proteins in fixed tissues. However, this fixation technique produces inconsistent immunohistochemical staining results due to antigen masking. Here, we test a new fixation protocol using 3% glyoxal and demonstrate that this method improves the staining of the brain vasculature, pericytes, and tight junction proteins compared to 4% paraformaldehyde. Use of this new fixation technique will provide more detailed information about vascular protein expressions, their distributions, and colocalizations with other proteins at the molecular …

Acquisitions Unit Annual Report 2021-2022, Andrée J. Rathemacher

Technical Services Reports and Statistics

Annual Report of the Acquisitions Unit, University Libraries, University of Rhode Island for FY2022. Covers personnel, work flow, special projects, and serial, monograph, and e-resource acquisitions. Supplemental files include data on library materials expenditures by a number of variables as well as important working documents from the year.

Quantifying Protein Quality To Understand Protein Homeostasis, Hsien-Jung Lavender Lin

Theses and Dissertations

Proteins are the center of all biochemical reactions in living organisms. Proteins need to be present at the right time, in the right place, with the correct concentration and have the right shape to carry their designated function. Protein homeostasis is when all proteins in the proteome are in functional balance, and such balance is maintained by synthesis, folding, and degradation machinery. When protein homeostasis is lost, organisms start to age and develop diseases. To truly unveil disease mechanisms and provide more efficient means for treatment and prevention, we need a holistic understanding of the mechanism of protein homeostasis. Currently, …

Measured Spectral, Directional Radiative Behavior Of Corrugated Surfaces, Kyle S. Meaker

Theses and Dissertations

Spacecraft thermal control is entirely reliant upon radiative heat transfer for temperature regulation. Current methods are often static in nature and do not provide dynamic control of radiative heat transfer. As a result, modern spacecraft thermal control systems are typically 'cold-biased' with radiators that are larger than necessary for many operating conditions. Deploying a variable radiator as a thermal control technique in which the projected surface area can be adjusted to provide the appropriate heat loss for a given condition can reduce unnecessary heat rejection and reduce power requirements. However, the radiative behavior of the apparent surface representing the expanding/collapsing …

Towards A Carbon-Neutral City By 2035: Innovative Transformation Of Domestic Solid Waste Collection And Recovery Services In Sharjah, Basem Abu Sneineh

Theses

This study quantifies the impact of an identified major step in the process of significant contribution to the transformation of Sharjah into a carbon-neutral city by the year 2035. This identified step applies to the concept of waste segregation at the residential sector source which means that the waste generators, i.e. Sharjah residents, are required to segregate the waste that they generate in their houses while disposing it. The march towards a carbon neutral city means driving the carbon dioxide emissions of the city to reach net-zero. This requires the UAE adopt this concept to ensure that the emitted amount …

Revisiting ‘Our’ Place On Campus: A Queer(Ed) And In-Depth Interview Study Of Qt Resource Professionals In Higher Education, Kristopher Andrew Oliveira

USF Tampa Graduate Theses and Dissertations

This dissertation offers an interactional, structural, and theoretical analysis of the experiences of Queer and Trans (QT) resource professionals in higher education. Data from the empirical chapters draws on 41 in-depth semi-structured interviews that conducted with QT resource professionals from 19 different states across the United States. The interactional and structural chapters reveal tensions between institutional commitments to doing equity work on college campuses and the neoliberal and institutional barriers that QT resource professionals experience in promoting and fostering institutional equity on campus. The third substantive chapter offers a queer of color critique – through Muñoz’s (2019) notion of queer …

Inflammatory Bowel Disease & Social (In)Visibility: An Interpretive Study Of Food Choice, Self-Blame And Coping In Women Living With Ibd, Jessica N. Lolli

USF Tampa Graduate Theses and Dissertations

This dissertation is an interpretive project that uses autoethnography and qualitative interview methods to understand the role Inflammatory Bowel Disease (IBD) plays in women’s quality of life and interpersonal relationships. It focuses on the impacts on patients of dietary changes and how food choice serves to make this ordinarily “invisible” illness visible to others, leading to unwanted exposure. Using Erving Goffman’s stigma theory and its extensions in studies of chronic illness, I demonstrate that IBD is characterized by layers of stigma because it creates situations in which patients are forced to disclose their illness even if they are not ready …

Development Of A Programmable, Open-Source, And Cost-Effective Fluidic System For Cell Culture Applications, Charles Montoya

Biomedical Engineering ETDs

Open-source laboratory equipment has become an increasingly popular alternative to commercially available options due to its simple implementation, capability of user-customized modifications, and cost-effectiveness. Presented here is the development of a programmable and open-source fluidic system comprised of three custom-built syringe pumps for cell culture applications. The fluidic system was directly integrated with a multiwell plate on an environmentally controlled microscope platform for live-cell imaging and time-lapse analyses of cellular responses as culture conditions are adjusted using the programmable fluidic system. Proof-of-concept of this system is obtained by controlling autophagic activity in A549 cells by adjustment of nutrient supply. The …

"Sometimes You Just Want To Be Another Parent And Another Kid At The Party": Exploring Parental Narratives Surrounding Disclosure Of Child's Epilepsy, Lisa German

Communication ETDs

Epilepsy is currently the fourth most common neurological disorder in the world (Epilepsy Foundation, 2022). However, it is largely misunderstood by both the public and those with epilepsy. In addition, epilepsy is still a stigmatized condition in most areas of the world.

In part due to the stigma, as well as the impact on quality of life factors, disclosure of an epilepsy diagnosis can be a struggle for those with epilepsy as well as their parents or caregivers. Therefore, this study explored disclosure challenges faced by parents of children with epilepsy, utilizing Communication Privacy Management theory and Stigma Management Communication …

Implications For Cross-Training Between Applied Behavior Analysis And Speech-Language Pathology, Katherine Lynn Isaacson

Speech and Hearing Sciences Publications

This paper is to provide clarity about the overlaps between the fields of Applied Behavior Analysis (ABA) and speech-language pathology, including evaluation, assessment, intervention planning, and treatment of language development, nine articles were selected for a review of terms and definitions, philosophical and theoretical underpinnings, and licensure/certification requirements pertaining to both scopes of practice. Behavior analysts and speech-language pathologists (SLPs) are likely to provide intervention alongside one another due to their frequent provision of intervention with individuals diagnosed with autism spectrum disorder (ASD). Despite broad, initial overlaps between the professions, the required educational coursework, supervised fieldwork and clinical practicums, and …

Critical Impact Of Fin Thermal Conductivity In The Modeling Of Evaporator Under Frost Conditions, Antoine M. Parthoens, Samuel Gendebien, Vincent Lemort

International Refrigeration and Air Conditioning Conference

No abstract provided.

Effect Of Metal Foam Integration On The Thermal Regulation Performance Of Salt Hydrate-Based Heat Sink, Amr Mohamed Kotb, Sophie Wang

International Refrigeration and Air Conditioning Conference

No abstract provided.