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Chapter 1: The Merits Of A Chief Diversity Officer (Cdo): Enterprise Training Program Strategy, Abeni El-Amin Ph.D. Jul 2022

Chapter 1: The Merits Of A Chief Diversity Officer (Cdo): Enterprise Training Program Strategy, Abeni El-Amin Ph.D.

Management Faculty Publications

Developing an enterprise training program requires a commitment to cultivating diversity, equity, inclusion, and belonging (DEIB) organizational initiatives while providing alignment to the organizational mission, vision, and ethos. With this knowledge, enterprise training programs benefit organizations by fostering authentic cultures to resolve persistent issues of bias, implicit bias, and offenses of corporate policies. As a value, organizational leadership must lead and champion diversity initiatives to ensure stakeholders understand the importance of complying with organizational policies. The problem is that effective DEIB initiatives need implementation or an overhaul. Institutional DEIB initiatives fail because they have yet to identify the rationale for …


Antonia Udasco-Kist V. Thomas Jefferson University Ho Jul 2022

Antonia Udasco-Kist V. Thomas Jefferson University Ho

2022 Decisions

USDC for the Eastern District of Pennsylvania


On Job Resiliency Training, Tailored For Hospital Nurses: A Feasibility Study, Zach Gerber, Sigal Shafran-Tikva, David Anaki Jul 2022

On Job Resiliency Training, Tailored For Hospital Nurses: A Feasibility Study, Zach Gerber, Sigal Shafran-Tikva, David Anaki

Journal of Wellness

Introduction: Burnout is a primary threat to professional wellness and performance. It reflects work-related emotional stress and is commonly manifested among professional caregivers. This study explores whether self-compassion training can alleviate hospital nurses' work-related emotional stress and burnout.

Methods: In the present study, we conducted a weekly, 7-session, self-compassion training program among 15 hospital nurses, primarily working in critical care units, between January 22, 2020, and March 4, 2020. A group of nine other nurses, comprising a waiting list for the following training workshop, served as a control group. Beyond feasibility assessment, we also measured outcome effects according to previous …


Factors Influencing The Adoption Of Smart-Home Appliances: Users' Perspectives, Prakash Shahi Jul 2022

Factors Influencing The Adoption Of Smart-Home Appliances: Users' Perspectives, Prakash Shahi

Dissertations

Smart appliances will be a significant part of the annual $300 billion smart-home market by 2025. Their use is expected to grow at a compounded annual growth rate of 31% for the foreseeable future. Currently, 12-16% of households use smart-home products in the U.S., including thermostats, TVs, refrigerators, coffee machines, garage door openers, and vision-equipped doorbells. Smart appliances provide significant benefits to us over traditional appliances. Smart appliances simplify our lives by automating various tasks in our homes and allowing us to monitor and control them remotely from our offices, grocery stores, and wherever we may be.

Despite the usefulness …


Social Role And Role Congruity Influences On Perceived Value Of Women’S Leadership At Southwestern Research Universities, Stephanie J. Jones, Patricia Ryan Pal Jul 2022

Social Role And Role Congruity Influences On Perceived Value Of Women’S Leadership At Southwestern Research Universities, Stephanie J. Jones, Patricia Ryan Pal

Journal of Women in Educational Leadership

This qualitative survey study, framed by social role and role congruity theories, explored the perceptions and experiences of 33 women faculty and academic administrators at doctoral-granting highest research-intensive universities located in the Southwestern region of the U.S. The purpose of the study was to expand on our understanding of how social role and role congruity theories can explain and further our understanding of how women are perceived to be valued as leaders in the higher education space, and how society supports this continued valuation. For purposes of this study, social value is explored through the operational processes of higher education …


Jul. 18, 2022, Am Sec, Draft Accountability Mechanism Operating Procedures, Am Sec Jul 2022

Jul. 18, 2022, Am Sec, Draft Accountability Mechanism Operating Procedures, Am Sec

World Bank Inspection Panel 1994-Present

No abstract provided.


Real-World Third Covid-19 Vaccine Dosing And Antibody Response In Patients With Hematologic Malignancies, Michael A. Thompson, Sigrun Hallmeyer, Veronica E. Fitzpatrick, Yunqi Liao, Michael P. Mullane, Stephen C. Medlin, Kenneth Copeland, James L. Weese Jul 2022

Real-World Third Covid-19 Vaccine Dosing And Antibody Response In Patients With Hematologic Malignancies, Michael A. Thompson, Sigrun Hallmeyer, Veronica E. Fitzpatrick, Yunqi Liao, Michael P. Mullane, Stephen C. Medlin, Kenneth Copeland, James L. Weese

Journal of Patient-Centered Research and Reviews

Purpose: This study sought to describe the changes in immune response to a third dose of either Pfizer’s or Moderna’s COVID-19 mRNA vaccine (3V) among patients with hematologic malignancies, as well as associated characteristics

Methods: This retrospective cohort study analyzed pre-3V and post-3V data on 493 patients diagnosed with hematologic malignancies across a large Midwestern health system between August 28, 2021, and November 1, 2021. For antibody testing, S1 spike antigen of the SARS-CoV-2 virus titer was used to determine serostatus.

Results: Among 493 participants, 274 (55.6%) were seropositive both pre- and post-3V (+/+) while 115 (23.3%) seroconverted to positive …


Hanaway Named To Martha Robinson Tankersley Endowed Professorship In Transplant Clinical Excellence, Staff Jul 2022

Hanaway Named To Martha Robinson Tankersley Endowed Professorship In Transplant Clinical Excellence, Staff

Browse All News

No abstract provided.


[Excerpt From] Ethical Case Studies For Advanced Practice Nurses: Solving Dilemmas In Everyday Practice, Amber L. Vermeesch, Patricia H. Cox, Inga M. Giske, Katherine Roberts Jul 2022

[Excerpt From] Ethical Case Studies For Advanced Practice Nurses: Solving Dilemmas In Everyday Practice, Amber L. Vermeesch, Patricia H. Cox, Inga M. Giske, Katherine Roberts

Sigma Publications: Book Excerpts

This item record pertains to an excerpt from Ethical Case Studies for Advanced Practice Nurses, which is provided free of charge by the publisher.

About this book:

Ethical Case Studies for Advanced Practice Nurses improves APRNs' agility to resolve ethical quandaries encountered in primary care, hospital-based, higher education, and administration beyond community settings. Through case studies examining various types of ethical conflicts, the authors empower APRNs and students with the critical knowledge and skills they need to handle even the most complex dilemmas in their practice. By applying a set of criteria and framework, this book guides APRNs to …


4d Spatio-Temporal Electric Field Characterization Of Ultrashort Light Pulses Undergoing Filamentation, Lana Neoričić, Christoph Jusko, Sara Mikaelsson, Chen Guo, Miguel Miranda, Shiyang Zhong, Felix Garmirian, Balazs Major, Jeffrey M. Brown, Mette B. Gaarde, Arnaud Couairon, Uwe Morgner, Milutin Kovačev, Cord L. Arnold Jul 2022

4d Spatio-Temporal Electric Field Characterization Of Ultrashort Light Pulses Undergoing Filamentation, Lana Neoričić, Christoph Jusko, Sara Mikaelsson, Chen Guo, Miguel Miranda, Shiyang Zhong, Felix Garmirian, Balazs Major, Jeffrey M. Brown, Mette B. Gaarde, Arnaud Couairon, Uwe Morgner, Milutin Kovačev, Cord L. Arnold

Faculty Publications

We present an experimental method capable of capturing the complete spatiotemporal dynamics of filamenting ultrashort laser pulses. By employing spatially resolved Fourier transform spectrometry in combination with the capability to terminate the filament at any length, we can follow the nonlinear dynamics in four dimensions, i.e. the transverse domain, time and filament length. Our method thus not only enables the full characterization of the filamentation process throughout its evolution, but also allows to identify and select laser pulses with desired parameters.


Using The Community Of Practice Model To Shape Approaches To Education For Sustainable Development Across Disciplines In A Technological University Context: A Roundtable Podcast, Patrice Behan, Shaun Ferns, Sheona Foley, Olivia Freeman, Odette Gabaudan, Alacoque Mcalpine, Cormac H. Macmahon, Lucia Walsh Jul 2022

Using The Community Of Practice Model To Shape Approaches To Education For Sustainable Development Across Disciplines In A Technological University Context: A Roundtable Podcast, Patrice Behan, Shaun Ferns, Sheona Foley, Olivia Freeman, Odette Gabaudan, Alacoque Mcalpine, Cormac H. Macmahon, Lucia Walsh

Conference Papers

This roundtable discussion podcast comprises eight colleagues engaged in reflective discussion of their shared experiences of being members of SDG Literacy.ie, a Community of Practice (CoP) first established in TU Dublin in 2020. This CoP focuses on and promotes the enhancement of Sustainability Literacy among student cohorts as one measure to be employed in strengthening Education for Sustainable Development (ESD) in line with the broader strategic aims of the university. Harvey et al. (2021) in a case-based paper which includes examination of the CoP discussed here conclude that teaching and learning innovation took place as a consequence of the resource-sharing, …


Accelerating High School Students’ Science Career Trajectories Through Non-Formal Science Volunteer Programs, K. Ren Rende, M. Gail Jones, Emma Refvem, Sarah J. Carrier, Megan Ennes Jul 2022

Accelerating High School Students’ Science Career Trajectories Through Non-Formal Science Volunteer Programs, K. Ren Rende, M. Gail Jones, Emma Refvem, Sarah J. Carrier, Megan Ennes

Teacher Education Faculty Publications

Extensive research shows that non-formal science education programs effectively build and sustain long-term interest and persistence in science careers. Framed by expectancy-value theory, this study examined the academic and career outcomes of students who participated in a multi-year volunteer program at a science museum. Twenty-one participants were interviewed about their motivations for volunteering and the impact of participation on their science career trajectories. Data were coded for factors related to expectancy-value including goals, motivations, previous non-formal science experiences, and family attitudes towards science and STEM. Results showed participants of the volunteer program pursued science careers at higher rates than the …


Atomic Layer Deposition And High Sensitivity-Low Energy Ion Scattering For The Determination Of The Surface Silanol Density On Glass And Unsupervised Exploratory Data Analysis With Summary Statistics And Other Methods, Tahereh Gholian Avval Jul 2022

Atomic Layer Deposition And High Sensitivity-Low Energy Ion Scattering For The Determination Of The Surface Silanol Density On Glass And Unsupervised Exploratory Data Analysis With Summary Statistics And Other Methods, Tahereh Gholian Avval

Theses and Dissertations

With the increasing importance of hand-held devices with touch displays, the need for flat panel displays (FPDs) will likely increase in the future. Glass is the most important substrate for FPD manufacturing, where both its bulk and surface properties are critical for its performance. Many properties of the glass used in FPDs are controlled by its surface chemistry. Surface hydroxyls are the most important functional groups on a glass surface, which control processes that occurs on oxide surfaces, including wetting, adhesion, electrostatic charging and discharge, and the rate of contamination. In this dissertation, I present a new approach for determining …


Standalone, Supplemental, And Embedded Microlearning Development Alternatives For Federal Programs During A Pandemic, Tod M. Hebenton Jul 2022

Standalone, Supplemental, And Embedded Microlearning Development Alternatives For Federal Programs During A Pandemic, Tod M. Hebenton

Instructional Design Capstones Collection

Microlearning has been studied since the early 2000’s. Comparisons of microlearning and eLearning are found throughout the research. Some research has presented developing microlearning as an alternative to developing eLearning courses. However, this action research paper is written in support of developing microlearning to be implemented alongside or as a component of eLearning. Microlearning benefits learners because it can be developed as standalone, supplemental, or embedded course content. A literature review and close examination of a series of microlearning videos developed for a federal program will highlight how microlearning can be developed as standalone or supplemental course content that can …


Elemental Sulfur And Metal Sulfide Minerals For Autotrophic Denitrification: Applications To Aquaculture, Groundwater Treatment, And Domestic Wastewater Treatment, Erica Amah Dasi Jul 2022

Elemental Sulfur And Metal Sulfide Minerals For Autotrophic Denitrification: Applications To Aquaculture, Groundwater Treatment, And Domestic Wastewater Treatment, Erica Amah Dasi

USF Tampa Graduate Theses and Dissertations

Nutrient pollution of waterways, from excess N and P, is a global concern that results in harmful impacts the environment, human health, and aquatic animals. This dissertation harnesses sulfur autotrophic denitrification to remove nutrients from groundwater, domestic wastewater, and wastewaters produced from marine recirculating aquaculture systems (RAS). Part 1 evaluates the denitrification performance of woodchips and elemental sulfur in cyclic denitrification filters (WS-CDFs) integrated into marine RAS operated under saline conditions. Part 2 investigates the use of metal sulfide minerals, with and without oyster shells, for supporting nutrient removal from groundwater in batch reactors. Part 3 assesses …


Does Finance Make Us Less Social?, Henrik Cronqvist, Mitch Warachka, Frank Yu Jul 2022

Does Finance Make Us Less Social?, Henrik Cronqvist, Mitch Warachka, Frank Yu

Business Faculty Articles and Research

Informal risk sharing within social networks and formal financial contracts both enable households to manage risk. We find that financial contracting reduces participation in social networks. Specifically, increased crop insurance usage decreased local religious adherence and congregation membership in agricultural communities. Our identification utilizes the Federal Crop Insurance Reform Act of 1994 that doubled crop insurance usage nationally within a year, although changes in usage varied across counties. Difference-in-difference and Spatial First Difference tests confirm that households substituted insurance for religiosity. This substitution was associated with reductions in crop diversification and crop yields, indicating an increase in moral hazard.


On The Role Of The Microstructure In The Deformation Of Porous Solids, Sansit Patnaik, Mehdi Jokar, Wei Ding, Fabio Semperlotti Jul 2022

On The Role Of The Microstructure In The Deformation Of Porous Solids, Sansit Patnaik, Mehdi Jokar, Wei Ding, Fabio Semperlotti

Purdue University Libraries Open Access Publishing Fund

This study explores the role that the microstructure plays in determining the macroscopic static response of porous elastic continua and exposes the occurrence of position-dependent nonlocal effects that are strictly correlated to the configuration of the microstructure. Then, a nonlocal continuum theory based on variable-order fractional calculus is developed in order to accurately capture the complex spatially distributed nonlocal response. The remarkable potential of the fractional approach is illustrated by simulating the nonlinear thermoelastic response of porous beams. The performance, evaluated both in terms of accuracy and computational efficiency, is directly contrasted with high-fidelity finite element models that fully resolve …


The Effects Of A One-To-One Technology Implementation On High School Students' Communication, Collaboration, Critical Thinking, And Creativity Skills, Hilary Bertsch Jul 2022

The Effects Of A One-To-One Technology Implementation On High School Students' Communication, Collaboration, Critical Thinking, And Creativity Skills, Hilary Bertsch

Dissertations, Theses, and Projects

The purpose of this causal-comparative study was to employ a quantitative research paradigm to determine the impact of a one-to-one technology initiative on the development of the 4 C skills of high school students. An objectives-based evaluation model was used to review the one-to-one implementation for future planning and continuous improvement. COVID-19 provided an additional factor that forced both teachers and students to use their newly acquired one-to-one technology tools faster and more extensively than anticipated. The immersion into the new learning environments were captured through pre and post COVID-19 experiences.

This study found that teachers did not perceive any …


The Effect Of Competence And Independence On Fraud Detection (Empirical Study At The West Java Representatives Of The Audit Board Of The Republic Of Indonesia), Nenden Indriani, Poppy Sofia Koeswayo, Cahya Irawady Jul 2022

The Effect Of Competence And Independence On Fraud Detection (Empirical Study At The West Java Representatives Of The Audit Board Of The Republic Of Indonesia), Nenden Indriani, Poppy Sofia Koeswayo, Cahya Irawady

Journal of Accounting Auditing and Business

This research examines whether good auditor competence and independence affect fraud detection by the West Java representatives of the Audit Board of the Republic of Indonesia. The population in this research was the auditors of the West Java representatives of the Audit Board of the Republic of Indonesia. The purposive sampling technique was used to obtain 106 auditors of the Audit Board of the Republic of Indonesia. The data for this research were obtained from primary data through a questionnaire. Multiple. Linear regression analysis. It was used to analyze the data in the study. The regression. The coefficient of the …


Factors Affecting Village Financial Management Accountability, Opik Taufik, Syafrizal Ikram Jul 2022

Factors Affecting Village Financial Management Accountability, Opik Taufik, Syafrizal Ikram

Journal of Accounting Auditing and Business

This study aims to analyze the effect of human resource competence and organizational commitment on the use of information technology and its impact on village financial management accountability. This study uses a quantitative approach. The population in this study are villages in Tasikmalaya Regency. This study used the proportional sampling method with a total sample of 187 respondents. The sample of this study consisted of village heads, village secretaries, heads of administrative and general affairs, heads of government sections, and heads of financial affairs from 187 villages in Tasikmalaya Regency. The data collection method is distributing questionnaires measured by a …


Experimental Studies On Prosocial, Divisive And Discriminatory Behavior, Chen Zhang Jul 2022

Experimental Studies On Prosocial, Divisive And Discriminatory Behavior, Chen Zhang

Lingnan Theses (MPhil & PhD)

My PhD thesis contains three experiments: two of them studying prosocial and divisive behavior, guided by Tirole’s (2021) models, and the third studying discriminatory behavior. The first study investigates how people's prosociality changes as public spheres expand. Utilizing the advancement of information technologies, states have begun to introduce social scores to rate and publicize some behaviors in social interactions. With social scores, social interactions are thus divided into a public sphere, which is publicly observable, and a private sphere, which is not. Guided by Tirole’s (2021) model, we experimentally investigate whether social scores promote cooperation in a population with repeated, …


Career Satisfaction Antecedents Of Professional Accounting Returnees In International Workplaces: An Employee Experience Perspective, Nga Thi Thuy Ho, Hung Trong Hoang, Pi-Shen Seet, Janice Jones, Nhat Tan Pham Jul 2022

Career Satisfaction Antecedents Of Professional Accounting Returnees In International Workplaces: An Employee Experience Perspective, Nga Thi Thuy Ho, Hung Trong Hoang, Pi-Shen Seet, Janice Jones, Nhat Tan Pham

Research outputs 2014 to 2021

Purpose: The purpose of this study is to examine the determinants of career satisfaction of professional accounting returnees who have studied and/or worked abroad and then returned to work in different types of international workplaces in their home country.

Design/methodology/approach: A survey of professional accounting returnees in Vietnam was undertaken and multiple regression analysis was applied to test the proposed relationships.

Findings: This study finds that career satisfaction is affected by career fit, career sacrifice, types of international workplaces (domestically headquartered firms versus globally headquartered firms) and cross-cultural work readjustment. Further, cross-cultural work readjustment partially mediates the effect of career …


Neuroticism's Ties To Relationship Satisfaction: What Behaviors Matter?, Alexyss M. Lange Jul 2022

Neuroticism's Ties To Relationship Satisfaction: What Behaviors Matter?, Alexyss M. Lange

Theses and Dissertations

In multiple studies, neuroticism and romantic relationship satisfaction are negatively related to one another. Yet, the exact behaviors that link neuroticism to lower relationship satisfaction are unknown. Our seven-day daily diary study (N = 246) identified specific, everyday behaviors that might mediate this association. After establishing positive and negative factors using exploratory factor analysis, we examined whether positive or negative behaviors (and sub-categories of these dimensions) mediate the relationship between neuroticism and relationship satisfaction. Our results showed that negative behaviors mediated the relationship between neuroticism and relationship satisfaction but positive behaviors did not. A subcategory of conflict tactics mediated the …


Does Internalized Stigma Change The Way That Religiousness Relates To Depression For People With Minoritized Sexualities?, G. Tyler Lefevor, Chana Etengoff, Samuel J. Skidmore Jul 2022

Does Internalized Stigma Change The Way That Religiousness Relates To Depression For People With Minoritized Sexualities?, G. Tyler Lefevor, Chana Etengoff, Samuel J. Skidmore

Psychology Faculty Publications

Drawing on minority stress and intersectionality theories, we examine whether the relationship between religiousness and depression among people with marginalized sexualities changes as a function of their experience of internalized stigma. Analyses of a sample of 260 people with marginalized sexualities suggested that the relationship between religiousness and depression was moderated by internalized homonegativity. Simple slopes analyses revealed that when people with marginalized sexualities reported higher degrees of internalized homonegativity, the relationship between religiousness and depression was positive. Conversely, when people with marginalized sexualities reported lower degrees of internalized homonegativity, religiousness was negatively related to depression. Dismantling analyses using subscales …


Trauma Exposure And Trauma Symptoms As Predictors Of Police Perceptions In Latinx Youths, Amanda Venta, German Cadenas, Alfonso Mercado, Luz M. Garcini, Melanie M. Domenech Rodriguez Jul 2022

Trauma Exposure And Trauma Symptoms As Predictors Of Police Perceptions In Latinx Youths, Amanda Venta, German Cadenas, Alfonso Mercado, Luz M. Garcini, Melanie M. Domenech Rodriguez

Psychological Science Faculty Publications

Objective: The Latinx immigrant youth population composes nearly a quarter of all children in the U.S. and are a high-risk group for police encounters. Based on perceptions of Latinxs as criminals, increased enforcement actions against Latinxs in the U.S., and failures of policing and police brutality in immigrants’ home countries, we expected that immigrants who reported increased trauma exposure and symptoms would have more negative perceptions of police.

Method: This study utilized data from 107 recently immigrated Latinx youth to examine how trauma exposure (Child Trauma Screen) and symptoms (Child PTSD Symptoms Scale) related to perceptions of police (Criminal Sentiments …


Points Of Pride, Georgia Southern University Jul 2022

Points Of Pride, Georgia Southern University

Points of Pride (2013-2023)

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Ddr2 Expression In Cancer-Associated Fibroblasts Promotes Ovarian Cancer Tumor Invasion And Metastasis Through Periostin-Itgb1, Favour A Akinjiyan, Ritu M Dave, Emily Alpert, Gregory D Longmore, Katherine C Fuh Jul 2022

Ddr2 Expression In Cancer-Associated Fibroblasts Promotes Ovarian Cancer Tumor Invasion And Metastasis Through Periostin-Itgb1, Favour A Akinjiyan, Ritu M Dave, Emily Alpert, Gregory D Longmore, Katherine C Fuh

2020-Current year OA Pubs

Ovarian cancer has the highest mortality of all gynecologic malignancies. As such, there is a need to identify molecular mechanisms that underlie tumor metastasis in ovarian cancer. Increased expression of receptor tyrosine kinase, DDR2, has been associated with worse patient survival. Identifying downstream targets of DDR2 may allow specific modulation of ovarian cancer metastatic pathways. Additionally, stromal cells play a critical role in metastasis. The crosstalk between tumor and stromal cells can lead to tumor progression. We first identified that tumor cells co-cultured with DDR2-expressing fibroblasts had lower periostin expression when compared to tumor cells co-cultured with DDR2-depleted fibroblasts. We …


Gis Automated Delineation And Analysis Of Cancer Service Areas In The United States, Changzhen Wang Jul 2022

Gis Automated Delineation And Analysis Of Cancer Service Areas In The United States, Changzhen Wang

LSU Doctoral Dissertations

Delineating a meaningful and reliable geographic unit pertaining to cancer care is essential in examining geographic variations in cancer care for better analysis, management, and planning. Public health researchers have devoted great efforts to defining various service areas, which; however, lack scientific rigor or are unrepresentative of the highly specialized cancer care markets, and their methods have become obsolete in the era of big data and high geo-computation. This study develops the “Spatially Constrained Leiden (ScLeiden)” method, a network community detection algorithm in Geographic Information Systems (GIS), and applies it to delineate a series of coherent cancer service …


Possible Causes Of Leaks In The Transfer Pipeline: Student Views At The 19 Colleges Of The City University Of New York, A. W. Logue, Yoshiko Oka, David Wutchiett, Kerstin Gentsch, Stephanie Abbeyquaye Jul 2022

Possible Causes Of Leaks In The Transfer Pipeline: Student Views At The 19 Colleges Of The City University Of New York, A. W. Logue, Yoshiko Oka, David Wutchiett, Kerstin Gentsch, Stephanie Abbeyquaye

Publications and Research

Only 11% of community college (associate’s-degree) students transfer vertically and obtain a bachelor’s degree within six years, despite over 80% originally intending to do so. These leaks in the transfer pipeline disproportionately affect students from underrepresented groups, who are more likely to attend community colleges and to leak out of the pipeline. To obtain insights about how to decrease these leaks, a survey was distributed to all City University of New York undergraduates; 31,511 responded. The survey concerned students’ life and academic circumstances, as well as their information about and views on transfer. Analyses particularly compared responses of never-transferred associate’s …


Therapeutic Targeting Of Macrophage Plasticity Remodels The Tumor-Immune Microenvironment, Hee-Jin Jang, Hyun-Sung Lee, Wendong Yu, Maheshwari Ramineni, Cynthia Y Truong, Daniela Ramos, Taylor Splawn, Jong Min Choi, Sung Yun Jung, Ju-Seog Lee, Daniel Y Wang, Joel M Sederstrom, Massimo Pietropaolo, Farrah Kheradmand, Christopher I Amos, Thomas M Wheeler, R Taylor Ripley, Bryan M Burt Jul 2022

Therapeutic Targeting Of Macrophage Plasticity Remodels The Tumor-Immune Microenvironment, Hee-Jin Jang, Hyun-Sung Lee, Wendong Yu, Maheshwari Ramineni, Cynthia Y Truong, Daniela Ramos, Taylor Splawn, Jong Min Choi, Sung Yun Jung, Ju-Seog Lee, Daniel Y Wang, Joel M Sederstrom, Massimo Pietropaolo, Farrah Kheradmand, Christopher I Amos, Thomas M Wheeler, R Taylor Ripley, Bryan M Burt

Center for Medical Ethics and Health Policy Staff Publications

Although the majority of patients with advanced lung adenocarcinoma (LUAD) are eligible to receive immune checkpoint blockade, approximately 80% of these tumors are resistant to this therapeutic approach. Insights at the single-cell level into mechanisms that drive LUAD tumorigenesis and the relationship of LUAD histologic heterogeneity to response to immune checkpoint blockade could help identify biomarkers and potential combinational approaches to improve immunotherapy efficacy. Here we used a genetically engineered mouse model that replicates the development of human LUAD through a spectrum of pre-invasive to invasive adenocarcinoma histologic subtypes. A systems onco-immunology approach of integrating the analytical power and unique, …