Digital Commons Network^™

A 3d Tissue Engineering Model To Study Mitral Valve Annulus Calcification Under Diabetic Conditions, Erin James

All Theses

The most complex heart valve is the mitral valve (MV). Many pathologies can affect the MV, including stenosis, regurgitation, prolapse, and mitral annulus calcification (MAC). MAC is chronic degeneration of the annulus, which is the fibrous, saddle-shaped “ring” that can contract and relax with the myocardium. The prevalence of MAC is around 15% but increases in patients with other cardiovascular diseases and risk factors. It is also thought to increase in patients with type 2 diabetes, but MAC has not been properly characterized within this population because of confounding factors such as cardiac disease and kidney disease. The goal of …

An Evaluation Of Energy Consumption Comparing Conventional Water Treatment Plants To Microfiltration And Ultrafiltration Water Treatment Plants, Danielle Larsen

All Theses

The use of low-pressure, hollow fiber microfiltration (MF) and ultrafiltration (UF) membranes has become increasingly prominent in drinking water treatment plant configurations over the past 30 years. At the same time, the topics of energy efficiency and sustainability in industry are becoming progressively more important. Although MF and UF are highly successful in filtration, they are generally thought of as significant energy consumers; however, the data have not yet been available to compare multiple plants in various contexts to determine the factors that most affect energy use. This research compares the energy use of MF and UF treatment plants to …

Development Of A New Affinity Membrane For Rapidly Purifying Non-Antibody Proteins, Friendship Edioma

All Theses

This thesis project describes the modification and evaluation of a new affinity membrane for rapid chromatographic purification of non-antibody proteins. The affinity membrane utilizes Im7/CL7 coupling technology developed by Dr. Vassylyev's lab at the University of Alabama Birmingham (UAB), licensed by TriAltus Bioscience. The behavior of the membrane was evaluated using purified CL7-tagged Cas9 as my model protein for static and dynamic binding capacity analysis.

Chapter one provides an overview on biopharmaceutical drug production process development. I discuss how protein drugs are produced, isolated, and purified from the cell supernatant after upstream phases are completed. Despite increasing demands for biologics, …

The Digital Reconstruction And Simulation Of Civil War Garments Recovered From The H. L. Hunley, Hanna George

All Theses

Costumes are a crucial element in the representation of historical figures. Beyond reflecting aesthetic trends, clothing is closely intertwined with culture, economics, and the personal history of the individual who wore them. Fabric simulation allows for the digital creation and animation of garments too fragile or incomplete to be used directly in film or education. This thesis demonstrates the digital reconstruction of the clothing worn by H. L. Hunley crew member James Wicks. The H. L. Hunley is a submarine from the Civil War. It was the first in history to successfully sink an enemy ship, but never returned from …

Digital And Gradient Refractive Index Planar Optics By Nanoimprinting Porous Silicon, Anna Hardison

All Theses

Due to the drawbacks of traditional refractive optics, the implementation of planar or nearly planar optical devices has been of research interest for over a century. Subwavelength gratings are a particularly promising option for creating flat optical devices; however, the implementation of subwavelength grating-based optics is limited by fabrication constraints. Recently, we implemented flat optical devices using the nanoimprinting of refractive index (NIRI) process, a process which was pioneered in a previous study but remained largely unproven in terms of device fabrication. The planar, gradient index microlenses we fabricated were found to possess an effective medium similar to a subwavelength …

The Evacuation Simulation Of Wheelchair Users In A Building Fire: An Initial Dynamic Characterization Of Structural Egress Components, Haley Hostetter

All Theses

People with disabilities are one of the most vulnerable groups involved in building fires. According to the U.S. Fire Administration, in the United States alone, an estimated 700 home fires involve people with physical disabilities each year while over 1700 involve those with mental health disorders. Despite this, the current body of literature shows few studies focused on the evacuation of disabled people. This is a direct result of past and present social injustice on people with disabilities and has resulted in high injury and death rates during fires. To combat this, enrich the literature, and improve their experiences in …

The Effects Of Short Chain Fatty Acids On Clostridioides Difficile Growth, Sporulation, And Toxin Production, Michelle Baldassare

All Theses

Short chain fatty acids (SCFAs) are products of bacterial fermentation that help maintain important gut functions such as the intestinal barrier, signaling, and immune homeostasis. The main SCFAs acetate, propionate, and butyrate have demonstrated beneficial effects for the host, including importance in combatting infections caused by pathogens such as Clostridioides difficile. C. difficile infection (CDI) is a public health concern and causes 30,000 deaths each year mainly due to the overuse of antibiotics. Despite the potential role of SCFAs in mitigating C. difficile infection, their direct effect on C. difficile remains unclear. Through a set of in-vitro experiments, we …

Exploring Visitor Perceptions Of Popular Culture Tourism In Sleepy Hollow, New York, Danielle Baker Kreh

All Theses

Popular culture tourism can present itself in many forms including travel based on popular literature, film, and television series. Popular culture tourism destinations exist from the assumption that tourists wish to visit destinations based on their popular culture connections. In fact, destinations may choose to emphasize their popular culture connections for the purpose of attracting more visitors. Such is the case with Sleepy Hollow, New York, which has many popular culture connections including the original short story “The Legend of Sleepy Hollow” by Washington Irving. Using the village of Sleepy Hollow as an example, the purpose of this study is …

Opioid-Related Content On Twitter And The Impact Of Covid-19 Government Stimulus Distribution, Alyssa Seeman

All Theses

The United States has continuously faced an opioid epidemic that has resulted in a severe loss of human life. The coronavirus pandemic began in December 2019 and affected many aspects of daily life. One result of this pandemic was government financial aid in the form of stimulus checks that were directly deposited into peoples’ bank accounts. This study aims to understand better the impact stimulus checks had on opioid overdose rates within America by using content collected from Twitter to gauge public opinion. The sample consisted of a stratified random sample of 600 overall tweets that contained at least one …

Generating Sex Trafficking Networks From Text Documents, Maria Diaz

All Theses

Qualitative coding is a long and strenuous process that requires a well-skilled investigator. Natural language processing techniques have made leaps and bounds as far as usability and application domain, although it does not work for every task. In this work, we have created a natural language processing framework to help qualitative coders automatically obtain the nodes and node arcs from federal case files, dockets, and indictments within a sex trafficking network. The produced nodes and arcs allows us to perform network modeling by providing us with the information needed to create network structures that can then be used for interdiction …

Modeling Hierarchical Porous Electrodes With Tailored Anisotropic Structure, Debanjan Sarker

All Theses

Modern electric vehicles and consumer electronics applications demand high specific energy from Li-ion batteries, which can be charged and discharged faster. In the search for high specific energy, researchers have tried to make thicker battery electrodes which contain a greater proportion of active material. While chemical and structural modification of electrodes can help to increase the electronic conductivity of active material, the microstructure of porous electrodes can be engineered to enhance ion transport for fast charge and discharge. Previous research has shown that macropores introduced by directional freeze tape casting can enhance the performance of thick porous electrodes. For instance, …

Teachers’ Views Of Situational Factors Influencing Teaching Efficacy During The Covid-19 Pandemic, Holly Gillespie

All Theses

COVID-19 created many disruptions in the field of education as teachers and administrators navigated the many changing protocols affecting learning environments and pedagogy over the past two years. This thesis examines secondary teachers’ perceptions of managing these protocols through their lived experiences while teaching during the COVID-19 pandemic through the 2020-2021 school years. Previous research has shown a teacher’s sense of self-efficacy is related to both learning situations and teacher performance. However, research exploring the impact COVID-19 has had on teachers and their learning environments is limited. This qualitative exploratory study fills the gap by investigating situational factors in learning …

Climbing The Masculine Hierarchy: Examining Constructions Of Masculinity Through Incel Identities, Alyssa Jewel Davis

All Theses

In a gender-segregated digital space known as the Manosphere, a group of men calling themselves “Incels,” or involuntary celibates, express feelings of hostility and hatred towards women. Incels hold a low position on a masculine hierarchy where the men who hold the most power in society are those who have access to women’s emotional and sexual services. Incels are characterized by feelings of entitlement to women’s services and aggrievement by their inability to access them. As a result, they often appear to fantasize about or engage in acts of violence to compensate for their lack of masculine privilege. However, there …

Optimizing Crispr/Cas9-Mediated Knockdown Of Angptl3 In Liver Cell Lines And Mouse Hepatocytes, Meredith Reeves

All Theses

Familial hypercholesterolemia (FH) is a genetic condition characterized by elevated levels of low-density lipoprotein cholesterol (LDL-C) that leads to an increased risk of developing cardiac disease early in life (Shah et al., 2020). Current treatments such as statins and PCSK9 inhibitors have helped lower LDL-C levels, however they require repeated administration every 4-6 weeks to remain effective (Raal et al., 2018). Angiopoietin-like 3 (ANGPTL3) is an inhibitor of plasma lipid metabolism that has become a promising molecular target for the treatment of FH. Individuals with non-functional copies of ANGPTL3 demonstrate low levels of plasma LDL-C and triglycerides, indicating a protective …

Yoga In Criminal Justice Facilities: A Descriptive Study, Rachel Broome

All Theses

The United States currently incarcerates more individuals than any other country in the world, creating an effect known as mass incarceration. While incarcerated, individuals’ physical and mental health can be affected. Yoga is a feasible, cost-effective modality that may be utilized in criminal justice facilities, to assist in the process of improving the physical and mental health of individuals who are incarcerated or in confinement. The purpose of this study was to explore the structure of yoga programs that are being implemented throughout United States criminal justice facilities and the effects that the COVID-19 pandemic had on programs. Through a …

The Forgotten Faith: The Experiences Of Enslaved Muslims And The Influence Of Islam In The United States From 1730-1864, Amani Altwam

All Theses

Muslims were present in North America before the establishment of the

American/British colonies. The first Muslims in America were not citizens, but

enslaved Africans forced into the slave trade in the eighteenth century. Muslim slaves

in America were much more prevalent than anyone could have imagined and yet, the

religion of these slaves was rarely ever brought to the surface. In this thesis, I argue

that Muslim slaves not only existed in America but most of them were literate in

multiple languages, well-educated, and were capable of holding on to a set of beliefs.

History books and previous literature have …

A Comparative Study Of Physical Cinematography That Influences Layouts In Animated Production, Daniel C. Hudson

All Theses

What makes good cinematography? There are many examples of cinematogra- phy that stand out in the minds of viewers, yet many cant exactly say with certainty why these shots are considered great. Is it because they convey the visual and emo- tional content of their stories successfully, the technical brilliance of the frame, or both? Whether realistic or exaggerated, the range of cinematography tools and tech- niques are proof that creativity and an eye for detail are the most important elements in great cinematography. Cinematography includes composition, movement, lighting, and other visual information within the frame. This is true in …

Depot-Specific Patterns Of Mrna And Mirna Gene Expression In Adipose Tissue From Texel-Cross And Suffolk Lambs, Aliute-Nkoyo Udoka

All Theses

This work hypothesizes that miR-199a-3p influences SCD-1 expression and monounsaturated fat content of lamb fat depots. The objectives of this study were to: 1) measure miR-199a-3p, SCD1, and fatty acid composition in various tissues (longissimus muscle and liver) and fat depots (omental, mesenteric, subcutaneous, intermuscular, perirenal) in Suffolk and Texel-sired lambs, and 2) evaluate the role of miR-199a-3p in adipocyte hypertrophy in ovine stromal vascular (SV) cells in vitro. Suffolk lambs (n=4) and Texel-Suffolk cross lambs (n=5) were finished to day 203 of age. The liver, the longissimus muscle, kidney fat, mesenteric fat, omental fat, subcutaneous fat, and intermuscular fat …

Covid-19 Risk Perceptions And Health Behaviors In Puerto Rico, Charlie Vidal, Page D. Dobbs, Emily Herrman, Daniela Ameijeiras Mena, Ches Jones

Health, Human Performance and Recreation Faculty Publications and Presentations

Preventative health behaviors were encouraged for all at the beginning of the COVID-19 pandemic. However, as the pandemic continued after 2020, some people stopped implementing all measures. It is unknown if people living in Puerto Rico continued to perform preventive health behaviors throughout the pandemic. The purpose of this study was to explore if the risk perceptions of COVID-19 were associated with preventative health behaviors among Puerto Ricans during the COVID-19 pandemic. A sample from Puerto Rico (N = 285) was recruited from January to March 2021 to participate in a cross-sectional, online survey about health behaviors and risk …

Google Trends On Human Papillomavirus Vaccine Searches In The United States From 2010 To 2021: Infodemiology Study, Akshaya Srikanth Bhagavathula, Philip M. Massey

Health, Human Performance and Recreation Faculty Publications and Presentations

Background:

The human papillomavirus (HPV) vaccine is recommended for adolescents and young adults to prevent HPV-related cancers and genital warts. However, HPV vaccine uptake among the target age groups is suboptimal.

Objective:

The aim of this infodemiology study was to examine public online searches in the United States related to the HPV vaccine from January 2010 to December 2021.

Methods:

Google Trends (GT) was used to explore online searches related to the HPV vaccine from January 1, 2010, to December 31, 2021. Online searches and queries on the HPV vaccine were investigated using relative search volumes (RSVs). Analysis of variance …

A Novel Technique For Secure Data Cryptosystem Based On Chaotic Key Image Generation, Mustafa Dhiaa Al-Hassani

Baghdad Science Journal

The advancements in Information and Communication Technology (ICT), within the previous decades, has significantly changed people’s transmit or store their information over the Internet or networks. So, one of the main challenges is to keep these information safe against attacks. Many researchers and institutions realized the importance and benefits of cryptography in achieving the efficiency and effectiveness of various aspects of secure communication.This work adopts a novel technique for secure data cryptosystem based on chaos theory. The proposed algorithm generate 2-Dimensional key matrix having the same dimensions of the original image that includes random numbers obtained from the 1-Dimensional logistic …

Consequences Of Warming And Acidification For The Temperate Articulated Coralline Alga, Calliarthron Tuberculosum (Florideophyceae, Rhodophyta), Emily M. Donham, Scott L. Hamilton, Ivano Aiello, Nichole N. Price, Jennifer E. Smith

Faculty Research, Scholarly, and Creative Activity

Global climate changes, such as warming and ocean acidification (OA), are likely to negatively impact calcifying marine taxa. Abundant and ecologically important coralline algae may be particularly susceptible to OA; however, multi-stressor studies and those on articulated morphotypes are lacking. Here, we use field observations and laboratory experiments to elucidate the impacts of warming and acidification on growth, calcification, mineralogy, and photophysiology of the temperate articulated coralline alga, Calliarthron tuberculosum. We conducted a 4-week fully factorial mesocosm experiment exposing individuals from a southern CA kelp forest to current and future temperature and pH/pCO2 conditions (+2°C, −0.5 pH units). Calcification was …

Fake News Detection On Social Media: A Word Embedding-Based Approach, Muammer Eren Sahin, Chunyang Tang, Mohammad A. Al-Ramahi

Computer Information Systems Faculty Publications (Archived)

The rapid development of social media, together with the large number of user-generated content on them, has not only connected an unprecedented number of people together to do good stuff, but also has provided convenient platforms to spread misleading pieces of information such as fake news. Existing research has attempted to leverage machine learning to automatically classify fake news. In this paper, we extend such literature by proposing an approach that utilize word embedding and Long Short-Term Memory (LSTM) neural network algorithm. Unlike existing studies, we used two publicly available datasets of news articles to evaluate the proposed model. The …

Pathway To Promote Diversity Within Public Transit Workforce, Mehri Mohebbi, Sumita Raghuram, Ahoura Zandiatashbar

Mineta Transportation Institute

There are many aspects of the transportation industry that can be focused on, but the lack of resiliency is one of the most urgent. Enhancing resiliency and creative problem-solving is essential to the industry’s growth and survival. But it cannot happen without building a more diverse workforce. Women still make up a small fraction of transportation workers, and African American and Hispanic employees are even less represented. These disparities are increasingly pronounced in many senior positions, particularly in STEM fields. Meanwhile, the public transportation industry is experiencing a severe and worsening workforce shortage and many agencies have reported substantial difficulty …

“Tele-Commuting” During The Covid-19 Pandemic And Beyond: Unveiling State-Wide Patterns And Trends Of Telecommuting In Relation To Transportation, Employment, Land Use, And Emissions In Calif, Tianjun Lu, Jian-Yu Ke, Fynnwin Prager, Jose N. Martinez

Mineta Transportation Institute

Telecommuting, the practice of working remotely at home, increased significantly (25% to 35%) early in the COVID-19 pandemic. This shift represented a major societal change that reshaped the family, work, and social lives of many Californians. These changes also raise important questions about what factors influenced telecommuting before, during, and after COVID-19, and to what extent changes in telecommuting have influenced transportation patterns across commute modes, employment, land use, and environment. The research team conducted state-level telecommuting surveys using a crowd-sourced platform (i.e., Amazon Mechanical Turk) to obtain valid samples across California (n=1,985) and conducted state-level interviews among stakeholders (n=28) …

Special Report: The Global South & Ukraine, Paul Rodell, Cathy Skidmore-Hess

Association of Global South Studies (Archived)

Contributions published in this Special Report:

• The Russian Invasion of Ukraine: Economic Impacts on the Developing World - Philip Szmedra
• The War on Ukraine and Global Food Supply: Humanitarian & Structural Considerations - William Biebuyck
• A View of African Interests in the War on Ukraine: The Past and Future of the African Struggle for Non-alignment - Aran MacKinnon and Elaine MacKinnon
• The War in Ukraine and the Middle East - Jacek Lubecki
• Dorothea A.L. Hoffman-Martin, China's Balancing Act in Response to the War in Ukraine
• Kalyan Chatterjee, Russian Invasion of Ukraine – Indian Foreign Policy Turns Full Circle
• Paul A. …

Students Speak: Animating Stories About The Value Of Information, Vanessa Arce, Rena D. Grossman

Publications and Research

No abstract provided.

Emotion Detection Using An Ensemble Model Trained With Physiological Signals And Inferred Arousal-Valence States, Matthew Nathanael Gray

Electrical & Computer Engineering Theses & Dissertations

Affective computing is an exciting and transformative field that is gaining in popularity among psychologists, statisticians, and computer scientists. The ability of a machine to infer human emotion and mood, i.e. affective states, has the potential to greatly improve human-machine interaction in our increasingly digital world. In this work, an ensemble model methodology for detecting human emotions across multiple subjects is outlined. The Continuously Annotated Signals of Emotion (CASE) dataset, which is a dataset of physiological signals labeled with discrete emotions from video stimuli as well as subject-reported continuous emotions, arousal and valence, from the circumplex model, is used for …

Predictors Of Email Response: Determinants Of The Intention Of Not Following Security Recommendations, Miguel Angel Toro-Jarrin

Engineering Management & Systems Engineering Theses & Dissertations

Organizations and government leaders are concerned about cyber incidents. For some time, researchers have studied what motivates people to act in ways that put the confidentiality, integrity, and availability of information in organizations at risk. Still, several areas remained unexplored, including the role of employees’ evaluation of the organizational systems and the role of value orientation at work as precursors of secure and insecure actions in relation to information technologies (information security [IS] action). The objective of this research project was to examine how the evaluations of formal and informal security norms are associated with the intention to follow them …

Medicaid Expansion: Changes In Individual Health Outcomes, Julie Norman

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

The Affordable Care Act is one of the biggest changes in the American healthcare system in the 21st century. One element of the ACA is medicaid expansion, which opened up federal funding for states to cover any individual earning below 138% of the federal poverty line. 21 states expanded medicaid in 2014 while 12 haven’t expanded. This paper utilizes the disparity for a natural experiment to determine the efficacy of the program. Outcome variables of interest include measurements of individual health, health access and utilization, and premature death rates. The results indicate positive, but small improvements due to the policy, …