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Articles 13531 - 13560 of 933494
Full-Text Articles in Entire DC Network
Centering Student Voices: Comprehensive Bfa And Mfa In Film Survey, Alex Méndez Giner
Centering Student Voices: Comprehensive Bfa And Mfa In Film Survey, Alex Méndez Giner
One University Assessment Celebration
No abstract provided.
Understanding Post-Nicu Caregiver Mental Health And Occupational Participation: Implications For Healthcare Practice, Emily S. Knight
Understanding Post-Nicu Caregiver Mental Health And Occupational Participation: Implications For Healthcare Practice, Emily S. Knight
Student Capstone Papers
This capstone project explored the mental health challenges experienced by caregivers following their infant’s discharge from the neonatal intensive care unit (NICU) and the resulting impact on occupational participation. Using a mixed-methods design, data was collected through an anonymous survey of 46 post-NICU caregivers, incorporating both quantitative and qualitative responses. Findings revealed that caregivers commonly experienced significant mental health concerns, including stress, anxiety, and depressive symptoms, particularly within the first year following discharge. Although results demonstrated a statistically significant improvement in mental health over time, many caregivers reported limited access to mental health resources and professional support. Importantly, the study …
The Scarlet - Volume Civ, No. 10 (April 10, 2026), Scarlet Staff
The Scarlet - Volume Civ, No. 10 (April 10, 2026), Scarlet Staff
The Scarlet (Student Newspaper) (2011-present)
The April 10, 2026 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University. This issue is a satirical April Fools Day edition of The Scarlet.
Advocating For Children And Youth With Special Healthcare Needs Through Development Of A Sustainable Ambassador Program At The Center For Courageous Kids.Pdf, Alexandria West
OTD Capstone Projects
Children and youth with special healthcare needs (CYSHCN) often benefit from community-based programs that promote participation, social engagement, and psychosocial well-being. The Center for Courageous Kids (CCK) is a nonprofit medical camp dedicated to providing empowering camp experiences for children with disabilities or lifelong illnesses and their families at no cost. During this doctoral capstone experience, a needs assessment identified limited structured university outreach, decreased volunteer awareness, and the need for improved long-term volunteer recruitment and advocacy efforts.
The purpose of this capstone project was to develop a sustainable ambassador program designed to increase community engagement, strengthen advocacy efforts, and …
Parental Awareness And Response To Cyberbullying: A Qualitative Study Of Nigerian Parents, Adaobi Jennifer Iloakasia, Nneka Anthonia Obumse
Parental Awareness And Response To Cyberbullying: A Qualitative Study Of Nigerian Parents, Adaobi Jennifer Iloakasia, Nneka Anthonia Obumse
Jurnal Kajian Bimbingan dan Konseling
The problem of cyberbullying has been gaining momentum in modern society because of the dynamic development of digital technologies and the extensive use of social media by adolescents. This paper thus examined the parental cognition and reaction to cyberbullying of Nigerian parents with a particular emphasis on Anambra State. The research design in the study was a qualitative one, based on a phenomenological approach to reflect the experiences of parents. Purposive selection of parents with children in secondary schools was done (30 parents). The collection of data was done via semi-structured interviews, and thematic analysis was used to analyze the …
A Bibliometric And Analytical Study Of Previous Studies Related To Digital Citizenship, Hafidha Bint Saif Bin Suleiman Al- Karusi, Ruqaiya Bint Khamis Al- Alshibli
A Bibliometric And Analytical Study Of Previous Studies Related To Digital Citizenship, Hafidha Bint Saif Bin Suleiman Al- Karusi, Ruqaiya Bint Khamis Al- Alshibli
Journal of Arts and Social Sciences
The current study aimed to investigate previous studies that addressed the topic of curriculum analysis in light of digital citizenship. To achieve the current study’s objective, the researchers employed the descriptive approach “bibliometric analysis.” They used an analysis card to evaluate 31 peer-reviewed scientific studies prepared during the past seven years, from 2017 to 2023. The current study reached several results, the most important of which are: Through its bibliometric analysis of previous studies, the current study demonstrated the low inclusion of digital citizenship in educational curricula, reaching a low rate of 90%. The researchers from Kingdom of Saudi Arabia …
The Perceptions Of Special Education Teachers In The Sultanate Of Oman Regarding The Challenges They Face In Enhancing The Cultural Identity Of Their Students In The First Cycle Of Basic Education., Ruqayah Bint Hassan Al-Hadbiya, Zakia Bint Rashid Bin Amer Al-Siyabi
The Perceptions Of Special Education Teachers In The Sultanate Of Oman Regarding The Challenges They Face In Enhancing The Cultural Identity Of Their Students In The First Cycle Of Basic Education., Ruqayah Bint Hassan Al-Hadbiya, Zakia Bint Rashid Bin Amer Al-Siyabi
Journal of Arts and Social Sciences
The current study aimed to reveal the challenges faced by first-year special education teachers in the Sultanate of Oman towards enhancing cultural identity among deaf students. To achieve the goal of the study, an open interview was used, which in its final form consisted of ten main questions on a sample of 15 teachers, in various specializations. The results of the study indicated that the challenges lie in the lack of appropriateness of the curriculum for the hearing disabled, the lack of linguistic stock among the hearing disabled, the difficulty and scarcity of educational resources and means, the difficulty of …
The Image Of Omani Society And The Factors Shaping It Among Non-Omanis., Rahma Harith Nasser Al-Harrasi
The Image Of Omani Society And The Factors Shaping It Among Non-Omanis., Rahma Harith Nasser Al-Harrasi
Journal of Arts and Social Sciences
The current study sought to identify the image of the Omani society among non-Omani. Random stratified sampling was used to recruit 245 non-Omani academics working at Sultan Qaboos University, where online questionnaires were distributed. The study revealed that the respondents’ evaluation of the image of the Omani society was high which means that the image of Omani society among non-Omanis is positive. Moreover, the highest evaluation was for the phrase “Omani society is a cohesive society that supports each other”. The study identified several factors that shaped the Omani society’s image among non-Omani such as personal communication, social media, academic …
Ot’S Role In Promoting Independence And Employment Readiness Skills For Adults With Intellectual Or Developmental Disabilities (Idd), Grace Tompkins, Cynthia Haynes
Ot’S Role In Promoting Independence And Employment Readiness Skills For Adults With Intellectual Or Developmental Disabilities (Idd), Grace Tompkins, Cynthia Haynes
Spring 2026 OTD Capstone Symposium
This capstone project is a six-week program that addresses OT's role in work readiness skills for adults with intellectual or developmental disabilities (IDD) who are living independently in Jacksonville, Florida. This program consisted of six group sessions with topics including social participation, time management, stress management, financial management, personal hygiene, and executive functioning.
The Role Of Occupational Therapy In Adaptive Sports: Implementation Of A Young Athletes Program In St. Johns County, Gabriellea Elizabeth Zito Fernandez, Cynthia Haynes
The Role Of Occupational Therapy In Adaptive Sports: Implementation Of A Young Athletes Program In St. Johns County, Gabriellea Elizabeth Zito Fernandez, Cynthia Haynes
Spring 2026 OTD Capstone Symposium
This doctoral capstone project examined the feasibility and acceptability of implementing the Special Olympics Young Athletes Program (YAP) within St. Johns County, Florida, an area with limited early childhood adaptive sports opportunities. Grounded in Social Cognitive Theory and the occupation-centered program development model, the project aimed to support participation in inclusive recreation for children ages 2–7 with and without disabilities.
A comprehensive needs assessment, community resource mapping, and collaboration with Brooks Rehabilitation Adaptive Sports & Recreation informed program planning and implementation. A five-week YAP pilot program was conducted, focusing on foundational motor skill development through structured, play-based activities centered on …
Understanding Post-Nicu Caregiver Mental Health And Occupational Participation: Implications For Healthcare Practice, Emily S. Knight, Zeida Gutierrez, Maureen Fischer
Understanding Post-Nicu Caregiver Mental Health And Occupational Participation: Implications For Healthcare Practice, Emily S. Knight, Zeida Gutierrez, Maureen Fischer
Spring 2026 OTD Capstone Symposium
This capstone project explored the mental health challenges experienced by caregivers following their infant’s discharge from the neonatal intensive care unit (NICU) and the resulting impact on occupational participation. Using a mixed-methods design, data was collected through an anonymous survey of 46 post-NICU caregivers, incorporating both quantitative and qualitative responses. Findings revealed that caregivers commonly experienced significant mental health concerns, including stress, anxiety, and depressive symptoms, particularly within the first year following discharge. Although results demonstrated a statistically significant improvement in mental health over time, many caregivers reported limited access to mental health resources and professional support. Importantly, the study …
Merrimack County Advisory Council 2025-2026 Meeting Minutes, Extension
Merrimack County Advisory Council 2025-2026 Meeting Minutes, Extension
UNH Cooperative Extension
No abstract provided.
The Diamond, April 10, 2026, Dordt University
The Diamond, April 10, 2026, Dordt University
Dordt Diamond
- Front Page: Changing Economies, Rising Prices - The Discussion on Professor Compensation at Dordt; Dordt Women's Basketball Falls Just Short of National Title; Update on Dordt's Plans for Campus Growth and Expansion
- Feature: Creating Community - KHP Room Gets a Facelift; Watch and Think - Thought Provoking Movies; Building Bridges Through Multicultural Leadership; The Terrible Twisting Tornado Season of 2026; Kuyper Honors Program to Turn 21 in the Fall
- Sports: MLB Opening Day Disasters and Surprises
- Politics: Kristi Noem Loses Top Cabinet Position; United States at War with Iran; Social Media Sentences in the U.S. Court …
Wesleyan Hall Work Preserves Part Of University's History, The Timesdaily
Wesleyan Hall Work Preserves Part Of University's History, The Timesdaily
Documents
Preserving Wesleyan Hall at UNA
Cebuano For Missionaries - Missionary Training Center Grammar Book, Jaden Sigua
Cebuano For Missionaries - Missionary Training Center Grammar Book, Jaden Sigua
Instructional Psychology and Technology Graduate Student Projects
This project presents the design and development of Cebuano for Missionaries, a grammar resource created to support language instruction at the Missionary Training Center (MTC). The purpose of the project was to align grammar instruction with communicative missionary tasks and support learners in achieving Intermediate-Low proficiency on the ACTFL scale. The resource was developed using an iterative design process informed by stakeholder interviews, task analysis, and pilot testing. Key design features include simplified grammar explanations, visual reference charts, and task-based study activities to support classroom instruction, tutoring, and independent study. The project also outlines implementation plans, evaluation strategies, and …
Differentials As Models: Constructing A Differentials-Within-Limits Framework For First-Year Calculus And Examining Students' Understanding Of Limits, Differentials, And Derivatives Within It, Alexander A. Swindler
Differentials As Models: Constructing A Differentials-Within-Limits Framework For First-Year Calculus And Examining Students' Understanding Of Limits, Differentials, And Derivatives Within It, Alexander A. Swindler
Theses and Dissertations
Work in first-year calculus has clearly shown the power that treating differentials (such as dx) as tiny quantities affords for first-year calculus learning, yet a traditional limits-based approach leaves no room for them. While some researchers have loosely described informal differentials and limits within the same paradigm, their actual conceptual definitions and relationships have not been explicitly constructed. Continued progress in this area could benefit from theoretical consideration of (a) providing clearer intuitive definitions for differentials inside a limits-based approach to calculus, and (b) defining more exactly the relationships between differentials and limits. In this study, I propose a theoretical …
Advice For Incorporating Ai Tools Into Your Legal Practice, Celia Bigoness, Robert A. Mackenzie, David J. Reiss
Advice For Incorporating Ai Tools Into Your Legal Practice, Celia Bigoness, Robert A. Mackenzie, David J. Reiss
Cornell Law Faculty Publications
We have been speaking with many lawyers and law students about using generative artificial intelligence (AI) tools in their legal practice. We are struck by the fact that many of them have not been experimenting much, if at all, with the tools that are available to them - although many acknowledge that their clients are increasingly integrating generative AI into their businesses. We have been integrating a lot of these tools into our own professional lives, and here are some tips to help lawyers and law students get comfortable with AI tools that can help them, in big ways and …
Sub-Nanometer Nanoclusters Of Copper Atop Single-Atom Copper Moieties Toward Electrochemical Co2 Hydrogenation To Methane, Ahmed Badreldin, Mohammad Bilal Minhas, Shengyao Wang, Gabriella Smith, Shaoqin Chen, Shiwen Wu, Carter Racine, Jin Feng, Yun Hang Hu, Tao Li, Ying Li
Sub-Nanometer Nanoclusters Of Copper Atop Single-Atom Copper Moieties Toward Electrochemical Co2 Hydrogenation To Methane, Ahmed Badreldin, Mohammad Bilal Minhas, Shengyao Wang, Gabriella Smith, Shaoqin Chen, Shiwen Wu, Carter Racine, Jin Feng, Yun Hang Hu, Tao Li, Ying Li
Michigan Tech Publications
The electrochemical CO2 reduction (eCO2R) offers a compelling route for converting CO2 into value-added fuels and chemicals. Among CO2-derived products, methane (CH4) occupies a distinct position, serving both as a key intermediate for emerging cascade electro-oxidation to oxygenates and as a strategically important extraterrestrial fuel that can be generated in situ from off-planet CO2 resources. Although Cu-based catalysts capable of selectively producing CH4 have been reported, they seldom sustain high selectivity at practically relevant current densities. Here, we created a single-step co-pyrolysis strategy toward generating and anchoring Cu sub-nanometer clusters (CuSNC) atop Cu-Nx single-atom (SA) motifs embedded within N-doped carbon …
Career Adaptability Of Prospective Teachers With Disabilities In Indonesia: A Phenomenological Study, Rr Dwi Umi Badriyah, Erfan Ramadhani, Ramtia Darma Putri, Syska Purnama Sari, Amândio De Araújo Sarmento, Kadek Suhardita
Career Adaptability Of Prospective Teachers With Disabilities In Indonesia: A Phenomenological Study, Rr Dwi Umi Badriyah, Erfan Ramadhani, Ramtia Darma Putri, Syska Purnama Sari, Amândio De Araújo Sarmento, Kadek Suhardita
Jurnal Kajian Bimbingan dan Konseling
Pre-service teachers with disabilities face career transitions shaped by personal aspirations, accessibility barriers, stigma, and limited role models. In Indonesia, little is known about how they build career readiness for teaching within inclusive unequal educational contexts. This study explores the career adaptability of pre-service teachers with disabilities in Indonesia. Grounded in Career Construction Theory, it examines concern, control, curiosity, and confidence, while extending the framework by considering resilience and flexibility as relevant dimensions. A qualitative phenomenological design was used. Twenty-five students with disabilities enrolled in Primary School Teacher Education and Special Education programs at an Indonesian university participated in semi-structured …
The George-Anne Inkwell Edition, Georgia Southern University
The George-Anne Inkwell Edition, Georgia Southern University
The Inkwell
No abstract provided.
A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink
A Multidomain Peptide Hydrogel-Liposome Composite For Controlled Release Of A Cyclic Dinucleotide In Oral Cancer, Joseph W R Swain, Andrea H Molina, Gemalene M Sunga, Danielle Chew-Martinez, Neeraja Dharmaraj, Alejandra Cobos Perez, Arghadip Dey, Ephraim J Vázquez-Rosado, Simon Young, Jeffrey D Hartgerink
Faculty, Staff and Student Publications
While immunotherapy is a promising treatment strategy for cancer, the majority of head and neck squamous cell carcinoma (HNSCC) patients treated with single-agent immunotherapy do not respond. Therefore, researchers are investigating combination treatments with immunostimulatory molecules that can maximize anti-tumor responses. Cyclic dinucleotides (CDNs) are STING agonists that hold promise in combination approaches, but they require frequent intratumoral administration when used in both preclinical models of HNSCC and clinical trials. To reduce administration frequency, we have created a peptide hydrogel–liposome composite system, K2-Lip(CDN), for local and prolonged availability of CDN. We investigated the loading limits of cationic liposomes in both …
“That Would Be Confusing For Fifth Graders”: Boundary Infrastructure Moves In A Research-Practice Partnerships, Jody E. Clarke-Midura, Alireza Zandi, Saríah López-Fierro, Mimi M. Recker
“That Would Be Confusing For Fifth Graders”: Boundary Infrastructure Moves In A Research-Practice Partnerships, Jody E. Clarke-Midura, Alireza Zandi, Saríah López-Fierro, Mimi M. Recker
Publications
Research Practice Partnerships (RPPs) are a key strategy for educational improvement, yet little is known about the interactional mechanisms that drive their success. This study analyzes a three-year RPP co-designing integrated math and computer science lessons. We identify "boundary infrastructure moves”, actions partners use to navigate differences. Our findings reveal that productive tension, often sparked by a "potential overstep," was highly generative. A case study shows how a teacher challenging a lesson's terminology initiated a negotiation that transformed the artifact and created a new, shared vocabulary tool. We argue that productive tension is an essential mechanism for growth in RPPs …
"Deep In The Trenches": A Multi-Perspective Interpretive Phenomenological Analysis Of Student Mothers Navigating The Hidden Realities Of Postpartum Anxiety, Rhonda Harris
Theses and Dissertations
Despite availability of effective treatments women with postpartum anxiety (PPA) commonly go untreated because of barriers to care. Student mothers are a particularly vulnerable subgroup of women as they tend to be younger, are less likely to be married, and have lower incomes than non-student mothers. As anxiety rates in college women are higher than the general population and higher than college men, student mothers are at high risk of the adverse effects of untreated PPA. There is a paucity of existing literature about student mothers and mental health. The aim of the current study is to understand the help-seeking …
The Mosaic, Georgia Southern University
The Mosaic, Georgia Southern University
George-Anne Media Group: Newsletters & Magazines
No abstract provided.
Growth Potential Of Materials For Decarbonization: Insights From The Cement Industry Value Chain, Noha Mostafa
Growth Potential Of Materials For Decarbonization: Insights From The Cement Industry Value Chain, Noha Mostafa
Mechanical Engineering
To meet the Paris Agreement objectives and limit global warming to 1.5˚C compared to preindustrial levels, it is estimated that the built sector must cut its total emissions by 50% before the year 2030 and fully decarbonize it by 2050. The built environment is estimated to be responsible for 40% of global energy and emissions. These global carbon emissions include both operational carbon—the day-to-day carbon emissions generated through the operation and maintenance of buildings—and embodied carbon. With its recorded high emissions, cement manufacturing is a key area of interest for the decarbonization efforts. To meet the increasing demand for sustainably …
Association Between Dietary Self-Perception And Sugar-Sweetened Beverage Consumption Among Young Adults Latinas, Mi Zhou, A. Susana Ramirez, Angela Xu, Jacqueline Bergman
Association Between Dietary Self-Perception And Sugar-Sweetened Beverage Consumption Among Young Adults Latinas, Mi Zhou, A. Susana Ramirez, Angela Xu, Jacqueline Bergman
Faculty Research, Scholarly, and Creative Activity
Objective: To investigate the relationship between self-perceived overall dietary healthfulness and self-reported sugar-sweetened beverage (SSB) consumption among young adult Latinas, accounting for socioeconomic and acculturation-related factors. Design: Cross-sectional analysis using survey data. SSB intake was assessed using the BEVQ-15, and dietary self-perception was measured via a two-item scale. Multiple linear regression models examined associations between self-perception and total daily SSB intake, adjusting for income, education, and two validated acculturation indicators. Setting: Participants were recruited from a national online panel across the United States. Participants: A total of 881 Latina women aged 18–29 years participated. After removing cases with invalid outcome …
Lisa Cristiani: A Survey And Analysis Of Her Musical Travels Through The Russian Empire (1848-1853), Emilia González Dorantes
Lisa Cristiani: A Survey And Analysis Of Her Musical Travels Through The Russian Empire (1848-1853), Emilia González Dorantes
LSU Master's Theses
Information about French cellist Lisa Cristiani (1825–1853) and her travels through Imperial Russia has mainly reached us thanks to two articles in French periodicals published around the first decade since her death. These sources prioritized the journey itself, centering the narrative on her travels rather than on her musical activities. Recent scholarship on Cristiani has expanded our previously limited knowledge about her life. Scholars such as Hoffmann (2011) and Deserno (2018) have focused on biographical and feminist analysis, and DeVries (2014) has unveiled new documents from Russian sources. Nonetheless, a detailed examination of her musical performances within Imperial Russia has …
H3 Dopaminylation And Camkii Modulate Diffuse Midline Glioma Response To Cdk9 Inhibition, Rebecca L Murdaugh, Brittany R Eberl, Rosemary U Richard, Ena I Campos-Hensley, Adanze N Nnyagu, W Austin Elam, Ai-Ni Tsao, Jack R Tremblay, Ruiying Ma, Alfred K Dei-Ampeh, Kieu Pham, Daniel C Kraushaar, Kwanha Yu, Calla M Olson, Akdes Serin-Harmanci, Benjamin Deneen, Jamie N Anastas
H3 Dopaminylation And Camkii Modulate Diffuse Midline Glioma Response To Cdk9 Inhibition, Rebecca L Murdaugh, Brittany R Eberl, Rosemary U Richard, Ena I Campos-Hensley, Adanze N Nnyagu, W Austin Elam, Ai-Ni Tsao, Jack R Tremblay, Ruiying Ma, Alfred K Dei-Ampeh, Kieu Pham, Daniel C Kraushaar, Kwanha Yu, Calla M Olson, Akdes Serin-Harmanci, Benjamin Deneen, Jamie N Anastas
Faculty, Staff and Students Publications
Aberrant neurotransmitter signaling and transcriptional dysregulation are hallmarks of gliomagenesis and represent potential therapeutic targets. Monoamine neurotransmitters such as dopamine and serotonin primarily activate GPCRs but can also function epigenetically as histone H3 modifications. Here, we uncover mechanisms of crosstalk between monoamine neurotransmitter signaling, H3 dopaminylation, and RNA polymerase II (Pol2) transcription in diffuse midline glioma (DMG). We find that co-treatment with Pol2-targeting CDK9 inhibitors (CDK9i) and FDA-approved neuropsychiatric drugs, including selective serotonin reuptake inhibitors (SSRIs), synergistically reduces DMG growth. Mechanistically, CDK9i+SSRI treatment alters H3 dopaminylation patterns and represses synaptic and neurodevelopmental gene transcription associated with CDK9i resistance. Further phospho-proteomic …
Single-Cell Tcr Mapping Reveals Spatially Coordinated T Cell States In Head And Neck Cancer, Kelli A Mccord, Emerald Kan, Sean Hyslop, Amanda Y Xia, Colby J Hofferek, James S Lewis, Andreas Wieland, David J Hernandez, Vlad C Sandulache, William H Hudson
Single-Cell Tcr Mapping Reveals Spatially Coordinated T Cell States In Head And Neck Cancer, Kelli A Mccord, Emerald Kan, Sean Hyslop, Amanda Y Xia, Colby J Hofferek, James S Lewis, Andreas Wieland, David J Hernandez, Vlad C Sandulache, William H Hudson
Faculty, Staff and Students Publications
Current spatial T cell receptor (TCR) profiling approaches lack the resolution needed to link clonal identity, transcriptional state, and spatial positioning of individual T cells in the tumor microenvironment. Here, we introduce a spatial TCR profiling strategy that resolves individual T cell clones together with their transcriptional states at single-cell resolution and applied the method to human head and neck squamous cell carcinoma. Presumed tumor-specific T cells were broadly dispersed throughout the tumor microenvironment, and cells of the same clone occupied distinct transcriptional states in different locations: Immune-rich regions contained more plastic or progenitor cells, whereas tumor-dense regions were enriched …
Loss Of Znrf3/Rnf43 Unleashes Egrfr In Cancer, Fei Yue, Amy T Ku, Payton D Stevens, Megan N Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin-Hua Feng, Galen Hostetter, Xiangwei Wu, Shixia Huang, Noah F Shroyer, Bing Zhang, Bart O Williams, Qingyun Liu, Xia Lin, Yi Li
Loss Of Znrf3/Rnf43 Unleashes Egrfr In Cancer, Fei Yue, Amy T Ku, Payton D Stevens, Megan N Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin-Hua Feng, Galen Hostetter, Xiangwei Wu, Shixia Huang, Noah F Shroyer, Bing Zhang, Bart O Williams, Qingyun Liu, Xia Lin, Yi Li
Faculty, Staff and Students Publications
ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. Conventionally, their biological functions have been associated with regulating WNT signaling receptor ubiquitination and degradation. However, our proteogenomic studies have revealed EGFR as the protein most negatively correlated with ZNRF3/RNF43 mRNA levels in multiple human cancers. Through biochemical investigations, we demonstrate that ZNRF3/RNF43 interact with EGFR via their extracellular domains, leading to EGFR ubiquitination and subsequent degradation facilitated by the E3 ligase RING domain. Overexpression of ZNRF3 reduces EGFR levels and suppresses cancer cell growth in vitro and in vivo, whereas knockout of …