Digital Commons Network^™

Plants As Vectors For Environmental Prion Transmission, Christina M Carlson, Samuel Thomas, Matthew W Keating, Paulina Soto, Nicole M Gibbs, Haeyoon Chang, Jamie K Wiepz, Annabel G Austin, Jay R Schneider, Rodrigo Morales, Christopher J Johnson, Joel A Pedersen

Faculty, Staff and Student Publications

Prions cause fatal neurodegenerative diseases and exhibit remarkable durability, which engenders a wide array of potential exposure scenarios. In chronic wasting disease of deer, elk, moose, and reindeer and in scrapie of sheep and goats, prions are transmitted via environmental routes and the ability of plants to accumulate and subsequently transmit prions has been hypothesized, but not previously demonstrated. Here, we establish the ability of several crop and other plant species to take up prions via their roots and translocate them to above-ground tissues from various growth media including soils. We demonstrate that plants can accumulate prions in above-ground tissues …

T1 And Flair Signal Intensities Are Related To Tau Pathology In Dominantly Inherited Alzheimer Disease, Farzaneh Rahmani, Matthew R Brier, Brian A Gordon, Nicole Mckay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph-Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A Raji, Jorge J Libre-Guerra, Richard J Perrin, Eric Mcdade, Alisha Daniels, Celeste Karch, John C Morris, Randall J Bateman, Tammie L S Benzinger, Et Al.

2020-Current year OA Pubs

Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the Dominantly Inherited Alzheimer Network Observational Study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of T1-weighted and Fluid attenuated inversion recovery (FLAIR) MR scans. There was an exponential decrease in FLAIR-μ in mutation …

Cut Flower Markets And Marketing In The Intermountain West, Makylie Langford, Kynda R. Curtis, Melanie Stock

All Current Publications

This fact sheet discusses different markets for cut flowers in the Intermountain West, including wholesale and direct-to-consumer markets. Farmers markets, community-supported agriculture and subscription services, u-pick operations, farm venues, and online options are explored, as well as using social media to advertise and build clientele.

A Novel Application Of The Coras Framework For Ensuring Cyber Hygiene On Shipboard Radar, Gizem Kayisoglu, Pelin Bolat, Kimberly Tam

School of Engineering, Computing and Mathematics

No abstract provided.

A Critical Discourse Analysis Of Hate Speech Directed Towards Iraqi Tv Series’ Performers On Social Media, Mahmood Adil Almuslehi

Alustath Journal for Human and Social Sciences

This study investigates online hate speech directed against Iraqi actors and actresses in the online environment of Facebook and Instagram platforms. Fairclough’s (2001) Three-Dimensional Model is employed in this study to unravel the delicate fabric of language used in hate remarks, demonstrating its function in generating discriminatory discourse and falling under the broad purview of Critical Discourse Analysis (CDA). To provide nuanced insights into the mechanisms by which online hate speech operates and the wider socio-cultural implications it engenders, it also seeks to uncover the latent ideologies and belief systems that underlie hate comments and to illuminate their intersections with …

Artificial Intelligence And Teachers' Sustainability :Preschool Teachers' Perceptions Of Conditions And Level Of Support For Professional Development In Early Childhood Special Education, Rana Saleh Alghamdi, Amr Mahmoud, Tahany Sabry Shaaban

Alustath Journal for Human and Social Sciences

The purpose of this research is to explore Saudi early childhood special education (ECSE) teachers' attitudes towards professional development programs in ECSE. For this reason, survey data was obtained from 30 Saudi ECSE teachers who worked in Saudi Arabian early childhood stages, and then an interview was conducted with five of them to find out their training needs and the challenges they face. The researchers used the qualitative technique, which included a pre-survey and interviews. An online questionnaire was provided to the participants in order to examine their impressions of the professional development programs and assess their judgments of the …

The Effect Of Bilingualism On Cognitive Development In Children Review Article, Amal Mahmoud Ali

Alustath Journal for Human and Social Sciences

Bilingualism has become an increasingly common phenomenon in today’s globalized world, with many children growing up exposed to two or more languages. As a result, there has been growing interest among researchers in understanding the impact of bilingualism on thinking development in young and children. Some studies confirmed that bilingualism can have a positive effect on children’s perception cognitive development, particularly in the zones of attention control, Operational memory, and cognitive flexibility. Dual-language learners may also have better Planning and organization skills, such as task-switching and inhibitory control, compared to monolingual children. These cognitive advantages may be due to the …

Retreat Village Design In Letchworth State Park Region: An Architecture Development In A Highly Valued State Park Meets The Triple Bottom Line Of Sustainability, Jing Hua

Theses

Letchworth State Park, located in Livingston and Wyoming counties, New York, renowned as the “Grand Canyon of the East”, is one of the most scenically magnificent areas in the eastern United States. However, there are no well-developed leisure centers around or in the park. The lack of good accommodations, in contrast to the availability of restaurants with local character, leisure activities, and other supporting facilities in the area, fails to fully achieve the development potential of the natural scenery of the region. This thesis demonstrates that a retreat complex village that brings people closer to the natural landscape of Letchworth …

Lilrb3 Modulates Acute Myeloid Leukemia Progression And Acts As An Effective Target For Car T-Cell Therapy, Sunny Mai, Alan Hodges, Hui-Ming Chen, Jilu Zhang, Yi-Ling Wang, Yongbin Liu, Fumiko Nakatsu, Xiaoxuan Wang, Jing Fang, Yitian Xu, Vitaliy Davidov, Kyeongah Kang, Sai Ravi Pingali, Siddhartha Ganguly, Masataka Suzuki, Marina Konopleva, Brooke Prinzing, Youli Zu, Stephen Gottschalk, Yong Lu, Shu-Hsia Chen, Ping-Ying Pan

Faculty, Staff and Students Publications

Identifying novel cell surface receptors that regulate leukemia cell differentiation and can be targeted to inhibit cellular proliferation is crucial to improve current treatment modalities in acute myeloid leukemia (AML), especially for relapsed or chemotherapy-refractory leukemia. Leukocyte immunoglobulin-like receptor type B (LILRB) is an immunomodulatory receptor originally found to be expressed in myeloid cells. In this study, we found that LILRB receptors can be induced under inflammatory stimuli and chemotherapy treatment conditions. Blockade of LILRB3 inhibited leukemia cell proliferation and leukemia progression. Additionally, treatment with LILRB3 blocking antibodies upregulated myeloid lineage differentiation transcription factors, including PU.1, C/EBP family, and IRF, …

Enniatin A Inhibits The Chaperone Hsp90 And Unleashes The Immune System Against Triple-Negative Breast Cancer, Nada H Eisa, Vincent M Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T F Tsai, Paulo C Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli

Faculty, Staff and Students Publications

Low response rates and immune-related adverse events limit the remarkable impact of cancer immunotherapy. To improve clinical outcomes, preclinical studies have shown that combining immunotherapies with N-terminal Hsp90 inhibitors resulted in improved efficacy, even though induction of an extensive heat shock response (HSR) and less than optimal dosing of these inhibitors limited their clinical efficacy as monotherapies. We discovered that the natural product Enniatin A (EnnA) targets Hsp90 and destabilizes its client oncoproteins without inducing an HSR. EnnA triggers immunogenic cell death in triple-negative breast cancer (TNBC) syngeneic mouse models and exhibits superior antitumor activity compared to Hsp90 N-terminal inhibitors. …

Creativity Of Librarians As Determinant Of Job Performance In Some Selected Polytechnic Libraries In Delta State, Nigeria, Patrick Chukwuma Iheme Mr, Chika Chinonso Ejiakor Mrs, Peter O. Moneke, Oluchi Juliet Nwagu, Ufuoma Eruvwe Dr

Library Philosophy and Practice (e-journal)

The study investigated the creativity of librarians as determinant of job performance in some selected polytechnic libraries in Delta State. The study adopted a descriptive survey using questionnaire to collect data. The population of the study consists of 45 librarians. A total of 45 questionnaires were distributed only 33 were retrieved using descriptive statistics, the mean and percentage of the data were calculated. A mean score of 2.5 or above and a percentage score of 50% were taken into consideration. The study revealed five (5) creativity factors possess by librarians in some selected polytechnic libraries in Delta state as experience, …

About Books: Poysers And Auntie Eiders, Mark Lynch

Bird Observer

No abstract provided.

The Life And Death Of The Heath Hen, Matthew Kamm

Bird Observer

No abstract provided.

About Books: A List For The Listers, Mark Lynch

Bird Observer

No abstract provided.

Bird Sightings: November/December 2013, Seth Kellogg, Marjorie W. Rines, Robert H. Stymeist

Bird Observer

No abstract provided.

An Accidental Big Year, Neil Hayward

Bird Observer

No abstract provided.

Status And Conservation Of Purple Martins In Massachusetts, Richard Lombard

Bird Observer

No abstract provided.

The Brookline Bird Club: 1988-2013, Jane Lothian

Bird Observer

No abstract provided.

End Of Life In The Ed – Brain Death And Organ Transplantation, Madison Cohen, Donald Penney

The Journal of Integrated Primary Care

Every year thousands of Americans die awaiting an organ transplant. While our knowledge and experience with organ transplantation has only improved, organ availability continues to be a major issue due to a lack of suitable donor organs. A large population of organ donors are those who have been clinically diagnosed as brain dead. Brain death is defined as the irreversible loss of all brain and brainstem functions. Despite brainstem functions being lost, mechanical ventilation and perfusion techniques allow for proper organ maintenance. This gives brain-dead individuals a unique opportunity to serve as multiple organ donors. However, due to mistrust of …

Marsh Birding The West Meadows Wildlife Management Area In West Bridgewater, Steve Arena

Bird Observer

No abstract provided.

About Books: The Serial Fabulist Of Ornithology, Mark Lynch

Bird Observer

No abstract provided.

Not Just Another Birding Contest — This Is The Superbowl!, David Larson

Bird Observer

No abstract provided.

At A Glance, Wayne R. Petersen

Bird Observer

No abstract provided.

Northern Saw-Whet Owls In Massachusetts, Strickland Wheelock, Elizabeth Milke

Bird Observer

No abstract provided.

First Massachusetts Nesting Record For Merlin (Falco Columbarius), Matt Pelikan, Allan R. Keith

Bird Observer

No abstract provided.

About Books: Bower Birds And Art Students: A Conversation With Mike Hansell, Mark Lynch

Bird Observer

No abstract provided.

About Books: What To Make Of A Diminished Thing?, Mark Lynch

Bird Observer

No abstract provided.

Field Notes: Gray Squirrel Preys On Black-Capped Chickadee, Simon Hennin

Bird Observer

No abstract provided.

About Books: The Apotheosis And Damnation Of The Flightless Flocks: March Of The Penguins And The Cultural Divide, Mark Lynch

Bird Observer

No abstract provided.

Nuclear Power: Extremely Dangerous, Perfectly Safe, Or Somewhere In Between?, Jackson Still

Quest

Multiple Genre Argument

Research in progress for ENGL 1301: Composition I

Faculty Mentor: W. Scott Cheney, Ph.D.

Standard research papers and five-paragraph essays can train students to blend quotations and organize paragraphs, but advanced writing in the disciplines and the workplace requires much more robust and nuanced thinking. To this end, the Multiple Genre Argument (MGA) pushes students into new writing situations where they create fictional genres to supplement traditional research—a challenging and often confusing task. Learning new skills requires becoming more comfortable with encountering this kind of difficulty and uncertainty. In their book Writing Analytically, David Rosenwasser and Jill …