Digital Commons Network^™

Investigating The Kshb V246s Mutation In The Kshab Protein Complex Found In Mycobacterium Tuberculosis, Malika Cruickshank

Undergraduate Review

This research centered on studying the interactions between the KshA and KshB subunits of the 3-ketosteroid-9α hydroxylase (KshAB) protein complex found in Mycobacterium tuberculosis (M. tuberculosis). Interactions between the two protein subunits were computationally explored using the protein docking program ClusPro and a location in the KshB subunit at Val 246 was found to be in proximity with nearby amino acids in the KshA subunit. This was determined to be a possible location for docking the protein complex. Val 246 of KshB was mutated into a serine residue to explore changes in the electron transfer pathway upon disruption of this …

The Effects Of Multilingual Learning On Social-Emotional And Cognitive Development In Children, Jasmine Won

Undergraduate Review

No abstract provided.

Data Drives Nebraska: Technology Advancements Impact Agriculture And Natural Resources, Laura E. Young, Emily Hatterman, Chandra Spangler, Alexis Corman, Klanie David, Jennifer Velasquez-Perfecto, Gracie Stout, Noelle Philippi, Emma Hoffschneider, Taylor Gregory-Jensen, Saskia Lanwermann, Abigayle Warm, Jared Dehaan, Brianna Gable, Sarah Eberspacher, Trisha Dybdal, Jadyn Heckenlively

Strategic Discussions for Nebraska

Strategic Discussions for Nebraska 2023

Data Drives Nebraska: Technology Advancements Impact Agriculture and Natural Resources

Exploration Of Electron Dynamics In A Strong Field By Time Dependent Configuration Interaction With A Complex Absorbing Potential, Paul Hoerner

Wayne State University Dissertations

Strong field electron dynamics are a quickly developing field of study in physical chemistry. In order to better understand experimental observations, there is a need for computational tools to simulate electron dynamics in a strong field. Due to the nature of strong electric fields, this requires the solving of the time dependent Schrödinger equation (TDSE). Various methods have been used to solve the TDSE in a strong field. In order to look at molecular systems while accurately treating the underlying physics, a method that balances computational affordability with theoretical rigor is necessary. The chosen method that matches these criteria is …

Happiness And Government : The Role Of Public Spending And Public Governance, Lok Sang Ho, Minhui Liu, Yew-Kwang Ng, Jia Wu

SERC Working Paper Series

We explain total life satisfaction using Wave 5 of World Value Survey data covering 58 countries /jurisdictions with a regression to estimate optimal government spending for healthcare, education, and total government spending by maximizing wellbeing We find that the average of total public spending for countries of good public governance is almost identical to the average of estimates of optimal total public spending, which stands at 36. 85 % of GDP. We also find significant over spending or under spending for individual countries. Optimal spending on healthcare and education increase s with population aging. Per capita GDP reduces optimal healthcare …

Cultural Values And Maintaining The Status Quo, Andrew Clapper, Adam Smiley, Michael Oliver

Science University Research Symposium (SURS)

Research on status quo bias suggests that all else equal, people prefer to maintain the current state of the world rather than making changes (Samuelson & Zeckhauser, 1988). Relatedly, people tend to value objects more when they possess them than when they do not, in what is known as the “endowment effect” (Kahneman et al., 1991; Morewedge et al., 2015). However, little attention has been paid to reaction times in making decisions in the presence of a status quo or a possessed object. Our study examines the individual differences which affect reaction times in selecting between status quo and novel …

The Effect Of Eye Contact On Auditory Recall, Sara Grace Lill, Isha Kapoor, Oluwatoni Akanda, Khanh Nguyen

Science University Research Symposium (SURS)

Memory is at the basis of perception and provides functionality to our daily lives. Auditory stimulation has been shown to bias eye movement and improve memory (Liping, et. al, 2021), but the mechanisms behind the guidance of eye movements remain unclear (Higgins, et. al, 2014). This study investigates the correlation between eye contact and memory, focusing on recall, and exploring eye contact’s potential to enhance recall during both immediate and delayed assessments (Craft 21 Recall). Thirty undergraduate students from Belmont University, completed the Craft 21 Recall assessment after watching a video featuring a virtual speaker reading a short story. The …

Tennessee Brewconomy: Navigating The Wholesale Beer Tax Landscape, Lauren E. Dansbury

Science University Research Symposium (SURS)

In 2013, Tennessee transitioned from a price-based wholesale tax model to a per barrelage assessment. This research delves into the repercussions of this tax reform, assessing its impact on the brewing and wholesale distribution sectors. Despite the shift, Tennessee maintains the nation's highest wholesale beer tax for 16 consecutive years. The study examines the opportunity costs associated with this elevated tax, exploring alternative uses for the funds. Utilizing data on annual revenue collected by wholesalers from 2019 to 2022, segmented by city and county, the research provides actionable insights advocating for a reduction in the wholesale tax. The argument posits …

Does Birth Order Have An Effect On An Individual’S Conscientiousness?, Micah D. Wilson, Ashely Richmond, Emma Sells, Scovs Major, Waldron Collins

Science University Research Symposium (SURS)

Looking at familial relationships, specifically between sibling dynamics, has been focused on in many different angles in the field of psychology. Psychologists seek to understand the relationships between siblings, and how the relationships affect their bond, personality, and social life. Past studies have shown that siblings do tend to bounce off of each other, such as older sibling control having more of an effect in conflicts rather than in intimacy (Tucker & Updegraff). We hypothesized that the oldest siblings would clean up after themselves or not make a mess, middle children would clean up after themselves, the youngest would make …

The Influence Of Parental Behavior On Emerging Adult Egocentrism, Lilly E. Rogers, Nicole Buttrey, Monica Bennett, Olivia Harris

Science University Research Symposium (SURS)

Existing research indicates that adolescent egocentrism, people of adolescent age being overly interested in oneself, is influenced by numerous factors, including identity development and parental behavior (Scarfo, 1993). Though it has been shown that this link between perceived parental behavior and adolescent egocentrism exists (Adams & Jones, 1982), research has not yet examined this relationship in emerging adults. Thus, the purpose of the current study was to explore the relationship between parental behavior/support and egocentrism in emerging adults, while controlling for personality. Emerging adult college students (N = 46), completed a Qualtrics survey that measured imaginary audience (a component of …

Historical And Potential Future Climate Of Extreme Daily Precipitation Over The Contiguous United States Using Convection-Permitting Simulations, Sylvia Stinnett

Graduate Research Theses & Dissertations

The impacts of anthropogenic climate change will be felt most strongly through changes in hazards such as extreme precipitation. The potential for extreme precipitation changes—both increases and decreases—may have significant societal impacts (e.g., agriculture production, loss of life and property). However, limited research has quantified future projected changes in extreme precipitation due to computational limitations and considerable time expenditure for convection-permitting simulations of substantial duration.This project sought to analyze changes in extreme daily precipitation—defined as the 99th percentile daily accumulated value—due to climate change in the contiguous United States (CONUS) using a dynamically downscaled and convection-permitting regional climate modeling framework. …

Modulating Photochemical Properties To Enhance The Stability Of Electronically Dimmable Eye Protection Devices, Sruthy Baburaj, Jayachandran Parthiban, Sarvar Aminovich Rakhimov, Rasheedah Johnson, Ludmila Sukhomlinova, Paul Luchette, Steffen Jockusch, Malcolm D. E. Forbes, Jayaraman Sivaguru

Chemistry Faculty Publications

The study evaluates compatibility of stabilizers with dye doped liquid crystal (LC) scaffolds that are used in electronically dimmable materials. The photodegradation of the materials was investigated and suitable stabilizers were evaluated to slow the degradation process. Various types of benzotriazole-based stabilizers were evaluated for stabilizing the liquid crystals. Based on spin trapping experiments, radicals generated upon UV exposure is likely responsible for the degradation of the system. The radical generation is competitively inhibited by the addition of stabilizers.

Abbreviations: LC, liquid crystal; STB, stabilizers.

Artificial Intelligence In Computed Tomography, Cheyenne Dippre

Medical Imaging Senior Posters

Abstract

This research project explains the fundamentals of artificial intelligence (AI) and the ways that AI can be useful in computed tomography (CT). The current state of AI application in CT is still new yet has been advancing with its significant impact on diagnosis, image analyses and patient care. These impacts deal with the challenges that have traditionally been associated with CT scans through a series of techniques and algorithms. In CT, computed tomography angiography (CTA) is a common procedure which is used to diagnose cardiovascular disease (CVD), the leading cause of death worldwide. AI can assist with such a …

Alternating Current Electrolysis For Amine Functionalization And Hydrogen Isotope Exchange, Disni Gunasekera

Wayne State University Dissertations

Electrochemical organic synthesis is experiencing a renaissance driven by the increasing demand for green chemistry and engineering in the pharmaceutical industry. Synthetic organic electrochemical methods can be divided into three types: anodic, cathodic, and paired electrolysis. Paired electrolysis, in which two desirable half-reactions are performedsimultaneously at the two electrodes, is mostly underdeveloped. However, paired electrolysis can be technologically significant because it not only improves energy efficiency by using both electrodes but also provides a unique reaction environment where two redox-opposite reactions of substrates take place in the same pot. A major challenge for paired electrolysis is that the difficulties associated …

Product Development Resilience Through Innovation Management And Agile Efficiency Design, Anna Nguyen

Wayne State University Dissertations

ABSTRACT

PRODUCT DEVELOPMENT RESILIENCE THROUGH INNOVATION MANAGEMENT AND AGILE EFFICIENCY DESIGN

by

ANNA NGUYEN

December 2023

Advisor: Dr. Kai YangMajor: Industrial Engineering Degree: Doctor of Philosophy In recent years there have been constantly changing innovation technology, economic inflation, and material costs considering the various headwinds that the Automotive Industry faced. To adapt to these rapid changes or under non-standard timing circumstances, Auto Parts Manufacturing focuses on technically advanced design-thinking and engineering competency but has limited the manufacturers’ visibility of new product development and control of operations on a global level. Mass production firms focus on identifying new technology but more …

Applied Statistics Course Offerings: Spring 2023, University Of Mississippi. Graduate School

GMAS Course List

No abstract provided.

How Nonmarket Externalities Affect The U.S. Business Dynamism: An Economic Approach To Drug Epidemic, Chukwudi Ikwueze

Pennsylvania Economic Review

Businesses thrive best in an environment devoid of constraints, including those resulting from third-party activities with longstanding economic underpinnings. While existing research has extensively explored how costs and benefits emanating from businesses affect third parties, in the form of market externality, little attention has been given to understanding how costs and benefits arising from third-party activities influence businesses. To fill this gap, this paper aims to introduce the concept of nonmarket externality, which represents the influence of third-party activities on businesses, and use it to examine whether third-party activities associated with the drug epidemic influence the U.S. business dynamism. The …

Engaging High School Students In The Engineering Design Of Dialysis: Effects On Scientific Reasoning And Science Achievement, Dima Kassab

Wayne State University Dissertations

The purpose of this mixed-method study is to determine the effect of integrating Engineering design on high school students’ scientific reasoning and science achievement. Thirteen eleventh-grade students participated in this eight week long study. The intervention engaged students in the Engineering design of a functional Dialysis model. Students followed eight engineering practices to design and build their models. The researcher-developed Dialysis Reasoning Test assessed students’ reasoning in six areas: inductive, deductive, correlational, causal, hypothetical-deductive, and analogical reasoning. Students’ scores on the reasoning and achievement tests demonstrated significant improvements in comparison to the control group. Students’ Dialysis sketches revealed the progress …

Synthesis Of Putative Microcystin-Lr Degradation Products And Full Macrocyclic Cyanopeptide, Mahesh Kumar Yadab

Wayne State University Dissertations

This thesis primarily focuses on synthesizing fragments of microcystin-LR, which is a natural product, with the aim of establishing them as analytical standards for investigating the biodegradation pathways of MC-LR. Despite of the substantial interest in synthesizing, isolating, and degrading Microcystins over the past few decades, the availability of high-purity microcystin standards at known concentration for quantitative analysis of using LC-MS/MS remains limited. The synthesis of the proposed MC-LR fragments employs the Fmoc/t-Bu protecting group strategy to prevent isomerization. Additionally, novel methods for the total synthesis of N-Boc-Adda are explored, incorporating atom-economic approaches, cross-metathesis, and oxidative boron Heck reactions. The …

A Web-Based Synchronized Architecture For Collaborative Dynamic Diagnosis And Therapy Planning, Qi Zhang

Faculty Publications - Information Technology

Clinical treatment delivery often involves multiple medical professionals, where collaborative teamwork is crucial to ensure the quality of diagnosis and therapeutic decision making. With the development of Internet of Medical Things (IoMT) and its applications in mobile health (mHealth), healthcare services can be delivered to remote users. However, a challenging situation arises when the data are volumetric and dynamic, it will be difficult to achieve real-time performance in information streaming and data dynamic rendering and synchronization over Internet, as is the case with cardiac procedures, where both the anatomy and dynamic function characteristics of the organ must be considered. To …

Framework For Trustworthy Ai In The Health Sector, Mykhailo Danilevskyi

Academic Posters Collection

The European Commission defines that Trustworthy AI should be lawful, ethical and robust. The ethical component and its technical methods are the main focus of the research. According to this, the initial research goal is to create a methodology for evaluating datasets for ML modeling using ethical principles in the healthcare domain. Ethical risk assessment will help to ensure compliance with principles such as privacy, fairness, safety and transparency which are especially important for the Health Care sector. At the same time, risks must be evaluated with respect to AI model performance and possible scenarios of risk mitigation. Ethical risk …

Review Of Daniel Farber, Inequality And Regulation: Designing Rules To Address Race, Poverty, And Environmental Justice, David Weisbach

Articles

No abstract provided.

Lessons From Disease And Economic Surveillance During Covid-19, Anup Malani

Articles

This paper describes disease and economic surveillance during COVID, along with the uses of that surveillance, and lessons learned about the pandemic from that surveillance. It ends with policy suggestions on how to gather intelligence during the next pandemic in India and how surveillance informs suppression policy. The important themes that I stress are the value of population-level surveillance, understanding the incentives and disincentives for surveillance and reporting, and tailoring policy to the results of surveillance.

Understanding Scholarly Articles: Teaching A Strategic Reading Method To Academically At-Risk Students, Kimberly Foster, Amy F. Fyn

Library Faculty Publications

In 2018, the library began partnering with the Academic Coaching Experience Department (ACED) to support students. Academic Coaches had been developing a new course for academically at-risk first and second year students and wanted to collaborate with the library on a unit. Typically, library instruction sessions would be oriented toward providing instruction centered on a research assignment, but the new course had none. A fresh approach was needed to provide useful and engaging content for this student population. To avoid redundancy with the research skills addressed in other courses ACED students may be taking, two librarians decided to complement a …

Utilizing Data Analytics On Single-Phase Ac Arc Flash Testing And Model Development, Po-Chen Chen

Electrical Engineering Dissertations - Archive

Arc flash events could result in injuries, fatalities, and lead to severe medical expenses, equipment replacement cost, and even litigation, fines, and loss of business. Such events could also tremendously traumatize the personnel psychosocially and neurologically. Therefore, it is critical to accurately understand the potential arc flash hazards from all the real applications. Yet, due to the random complex nature of arc flash events and great number of uncertain variables involved, there are challenges to provide mathematical models for equipment designers in determining the arc-flash fault current and the incident energy of various types of events. The early arc flash …

Evaluation And Optimization Of Thermal Solutions In Air And Liquid Cooling Systems For Datacenters, Vibin Shalom Simon

Mechanical and Aerospace Engineering Dissertations - Archive

A data center is a specifically constructed establishment designed to accommodate computing, storage, and transmission equipment, thereby facilitating essential business operations spanning diverse sectors of the economy. This facility serves as the designated physical infrastructure for housing servers, networking components, and data storage systems. In the context of traditional data centers, a substantial portion of energy, specifically around 45% to 55%, is directed towards supporting information technology (IT) operations. Additionally, a considerable allocation, varying from 30% to 40%, is attributed to the facilitation of cooling processes. The scope of this dissertation study comprises nine distinct chapters, each contributing to addressing …

Non-Intrusive Reduced Order Model Formulation For Inverse Shape Design Including Deforming Meshes And Multiphysics Problems., Kapil Aryal

Mechanical and Aerospace Engineering Dissertations - Archive

Despite significant advancements in computer capabilities for numerical simulations, engineers continue to face limitations when dealing with large-scale full-order model(FOM) simulations. These simulations often necessitate repeated solves, such as those encountered in inverse design, real-time solution prediction, error quantification, and solver convergence, among others. To address these challenges, reduced order modeling (ROM) has emerged as a valuable approach. This thesis focuses on the development of an ROM framework that combines Proper Orthogonal Decomposition (POD) with machine learning techniques. This integrated approach is applied to a diverse range of heat transfer and fluid flow inverse design problems. POD constructs optimal sets …

Cooperative Manipulation And Formation Control Using Multiple Aerial Vehicles, Uluhan Cem Kaya

Mechanical and Aerospace Engineering Dissertations - Archive

Recent advancements in autonomous systems have significantly impacted both academia and industry, opening new research avenues. One of them is the collaboration of multiple systems to achieve a common goal, which is known as a cooperative system. In the lack of human intelligence, decision making and perception capabilities, uncrewed autonomous systems could mutually benefit from each other’s capabilities when they are deployed and utilized together. This research tackles the collaboration of group of uncrewed aerial systems (UASs) where the constraint on individual vehicles requires a varying level of coordination and cooperation. Such cooperation can be in the form of a …

Turbulent Shockwave/Boundary-Layer Interactions Generated By Sharp Swept Fins, Dustin Levi Otten

Mechanical and Aerospace Engineering Dissertations - Archive

The shock/turbulent boundary layer interaction (STBLI) generated by a sharp fin with a 60 deg leading edge sweep mounted above a flat plate at Mach 2.5 was studied numerically. Incipient separation due to this highly swept fin was determined by varying the fin angle to the incoming freestream. The effect of a small fin/plate gap on STBLI incipient separation was established. Sweeping the fin increases the deflection required for incipient separation as the sweep reduces the interaction strength. A gap causes flow leakage under the fin, further reducing the interaction strength on the windward side. The incipient angle of attack …

Experimental Study On Thermal Performance Of Metal Foam Heat Sinks In Single Phase Liquid Immersion Cooling, Manish Kumawat

Mechanical and Aerospace Engineering Theses - Archive

In 1965, Intel co-founder Gordon Moore made the observation that the transistor counts on a chip double with a frequency of approximately every two years. This development resulted in more compact and potent ICs. However, the amount of heat produced on a chip increased proportionally with the number of transistors. Later, in the early 2000s, Dennard Scaling broke down. Transistors became so small that leakage currents (unwanted currents that flow within the transistor) emerged as a significant issue, and they contributed substantially to power consumption and heat generation. These tightly packed transistors produced heat, which decreased their performance and shortened …