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Apoe As A Potential Link In Glioblastoma Therapeutic Resistance, Xiwen She, Ifelayo Adefuye

SACAD: Scholarly Activities

Glioblastoma (GBM) is a highly aggressive brain tumor characterized by recurrence and resistance to therapy, which are driven by interactions between glioblastoma stem cells (GSCs), tumor-associated macrophages (TAMs), and the tumor microenvironment. In this study, single-cell RNA sequencing data were analyzed using QIAGEN CLC Genomics Workbench to identify genes associated with tumor–immune interactions. Following clustering, differential expression, and a multi-step prioritization strategy, we identified APOE as a top candidate gene connecting tumor and immune processes, contributing to therapeutic resistance in glioblastoma.

Groundwater Nitrate Contamination In Western Kansas, Sihui Wei

SACAD: Scholarly Activities

Groundwater nitrate contamination is a significant environmental concern in agricultural regions of the United States. In Kansas, nitrate concentrations in some groundwater systems approach or exceed the Environmental Protection Agency (EPA) maximum contaminant level of 10 mg/L. This study analyzes nitrate concentration data from groundwater samples in western Kansas, with a focus on the High Plains aquifer, where agricultural activity is intensive. Using data analysis and regression methods, spatial patterns in nitrate distribution were identified. Results indicate that nitrate concentrations vary across sampling locations, with higher levels generally associated with regions of intensive agricultural activity. Several sites approach or exceed …

Desialylation And Sialidase Secretion From Monocytes And Macrophages Upon Lps Activation, Yu Zhao, Majdi Aljohani, Morgan Pychowycz, Xue-Long Sun

Chemistry Faculty Publications

Introduction The cell surface expresses a dense layer of glycans often terminated with sialic acids (Sias), known as sialylation, which represents different cellular statuses. Meanwhile, the removal of Sias from the glycans catalyzed by sialidase (desialylation) is also involved in many biological processes, such as inflammatory responses. Previous studies demonstrated that desialylation is involved in LPS/TLR4 signaling pathway and pro-inflammatory cytokine production. In this report, we systematically profiled desialylation and sialidase activity, expression and secretion from monocytes and macrophages upon LPS activation.Methods THP-1 monocytes and THP-1 macrophages were activated by LPS (100 ng/mL) for 24 hours. The cellular Sia changes …

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Mathematical Modeling, Analysis And Numerical Simulation Of Air Quality Using The Advection-Diffusion-Reaction Equation, Md Timorul Islam

Math Theses

In this thesis, we study an air quality model by using a nonlinear one-dimensional advection-diffusion-reaction system of partial differential equations for NO-NO2-O3 chemical cycle. The model incorporates advection, diffusion, chemical reactions, and source terms, and is formulated based on standard atmospheric chemistry.

We first develop numerical methods to approximate the solutions of the governing equations. Both explicit and implicit finite difference schemes are considered, and the implicit scheme provides approximations without any restrictions on the stability.

The model is then nondimensionalized to identify key parameter combinations governing the system. This leads us to a regime in which the transport and …

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