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Steroid Dari Kulit Batang Aglaia Glabrata Dan Aktivitas Sitotoksinya Terhadap Sel Kanker Leukemia P-388, Risyandi Anwar, Desi Harneti, Vidia Afina Nuraini, Faizah Maira, Nurlelasari Nurlelasari, Tri Mayanti, Rani Maharani, Unang Supratman, Khalijah Awang

Chimica et Natura Acta

Steroid saponin baru, b-sitosterol-3-O-beta-D-galaktopiranosil-(1-4)-beta-D-glukopiranosida (1), bersama dengan empat steroid yang diketahui (2-5) diisolasi dari kulit batang dari Aglaia glabrata. Struktur kimia senyawa baru dijelaskan berdasarkan data-data spektroskopi. Semua senyawa diuji aktivitas sitotoksiknya terhadap sel kanker leukemia murine P-388. Diantara senyawa yang diisolasi tersebut, stigmasterol (4) menunjukkan aktivitas sitotoksik terkuat dengan nilai IC50 sebesar 12.2 mg/mL.

Review Article: Effect Of Co-Expression Chaperones On The Expression Of Intracellular Recombinant Proteins In Escherichia Coli, Diandra Firdiani Utami, Mamlikatu Ilmi Azizah, Sriwidodo Sriwidodo, Ryan Adibagus Haryanto, Riyona Desvy Pratiwi, Iman Permana Maksum

Chimica et Natura Acta

Escherichia coli is widely used as a host for expressing recombinant proteins due to its well-studied genetics, fast growth, relatively low production costs, and high rate of protein expression. However, despite the high rate of protein expression, the availability of chaperone proteins was often insufficient, resulting in the formation of inclusion bodies due to errors in protein folding. These inclusion bodies can cause the protein to become inactive, and proper protein folding is crucial for maintaining the structure and function of proteins in living organisms. To overcome this limitation, chaperones have been developed as a strategy to help prevent protein …

Review, Dark Mirror: Edward Snowden And The American Surveillance State, By Barton Gellman, Patrice Mcdermott

Secrecy and Society

No abstract provided.

Daunting Encounters: La Hague’S Infrastructures Of Secrecy, Agnes Villette

Secrecy and Society

The article explores secrecy, more particularly, nuclear secrecy in relation to two nuclear facilities situated at the tip of the Norman peninsula of La Hague, in France. Both sites - the CSM nuclear waste repository and the close-by refueling plant - were developed at the end of the 1960s in connection with France’s extensive civil and military nuclear program. While institutional archives and access to the sites remain tedious, the article contends that the nuclear secrecy shielding the facilities can be approached by unpacking the numerous accidents that took place at the site. Silenced and subjected to amnesia, spills and …

Optimization Of A Constellation Deployment And Renewal With Petri Nets, Anton Roig

Small Satellite Conference

This poster analyzes deployment scenarios of the IoT constellation SIROCO in order to characterize the impacts of the working hypotheses – including the type and number of satellites, the in-orbit stock management, the reliability of the satellites and launchers – on the expected performances and costs of the system.

Simple Scheduling Algorithm For Growing Constellations, Lauren Fitzgibbon, Chris Shaffer

Small Satellite Conference

As the number of satellites in orbit grows, satellite constellation operators must consider better ways to balance the usage of ground assets. In general, ground asset availability does not grow linearly with the number of satellites launched, so alternative approaches to divide usage amongst a limited number of ground assets are required. While advanced techniques exist to manage these factors, they are often not practical for small and growing constellation managers.

The authors have developed a computationally simple method for dividing available antenna time between satellites, considering available access windows. This was designed to adapt to any number of heterogenous …

Enabling Mission Success: A Student's Perspective On Developing A Ground Station, Sean Svihla, Adrian Bryant, Lucia Witikko

Small Satellite Conference

In recent years, The University of Colorado Boulder’s Laboratory for Atmospheric and Space Physics (LASP) has grown its SmallSat Operations (SMOPS) program into a large team of students and professionals managing the operations of multiple SmallSat missions. The team responsible for the on-site ground station (GSOPS) includes a small team of students alongside professionals who help manage the on-site UHF and S-band antennas, making use of open-source, commercial, and in-house software. In this process, the student ground station team has adapted the limited time and resources of a single ground station to accommodate the needs and science objectives of multiple …

Educational And Real-World Satellite Mission Operations Center At The Us Naval Academy, Noah Loftis, Ethan Schneider, Christine Maceo, Jin S. Kang, Michael Sanders

Small Satellite Conference

For successful satellite missions at the United States Naval Academy (USNA), a critical element is the
/="/">establishment of a capable and dynamic Satellite Mission Operations Center (SOC). In addition to powerful hardware, flexibility and adaptability allow the SOC to continue to support operations, even as new protocols arise and communication architectures change with the rapid pace of small satellite advancement. Software-defined radios (SDRs) provide the necessary flexibility for the SOC to easily change configurations and network with other ground stations. However, the resulting high-tech, turn-key operations of an advanced SOC tend to alienate students from hands-on learning experiences. The …

Space Station Operations Capabilities In A Shoebox: Marshall Space Flight Center’S Telescience Resource Kit, Jeff Lippincott, Michelle Schneider, Steve Chubb, Sam Digesu, Darren Wallace

Small Satellite Conference

The International Space Station (ISS) has provided the world an unprecedented capability, establishing a continuous human foothold in outer space for more than 22 years now. But maintaining that capability and supporting the ambitious portfolio of scientific research it hosts has required another unprecedented capability – providing ground-based operations support for the crew and a diverse manifest of research payloads, all simultaneously. To help meet this challenge, NASA’s Marshall Space Flight Center (MSFC) developed TReK, the Telescience Resource Kit, providing a robust solution for data, command, metadata, and file transfer capabilities. In response to an increasingly wide and diverse need …

Supporting Data For Figures In "Wind-Enhanced Separation Of Large-Scale River Plumes From Coastal Corners", Michael M. Whitney

Department of Marine Sciences

This archive contains the supporting data for figures in the manuscript "Wind-enhanced separation of large-scale river plumes from coastal corners" by Michael M. Whitney. This study analyzes idealized models to quantify how large-scale river plumes and wind-driven currents interact at perpendicular coastal corners. Data are from the Regional Ocean Modeling System (ROMS) results for idealized model configurations. The Zip file (Figure_data.zip) contains MATLAB data files, which are named FigureXX_data.mat. Variable names and units correspond to graphed data of each figure in manuscript. Full descriptions of research methods and results are included in manuscript.

A Comparative Study Of A Machine Learning Approach And Response Surface Methodology For Optimizing The Hpt Processing Parameters Of Aa6061/Sicp Composites, Waleed H. El-Garaihy, Abdulrahman I. Alateyah, Mahmoud Shaban, Mohammed F. Alsharekh

Faculty Journal Articles

No abstract provided.

Conquer And Prevail Issue 144 August 10 2023, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

Ranking And Analysis The Strategies Of Crowd Management To Reduce The Risks Of Crushes And Stampedes In Crowded Environments And Ensure The Safety Of Passengers, Waleed Tawfiq Al-Nami

Neutrosophic Systems with Applications

Public gatherings, transit hubs, stadiums, and crowded retail malls are just a few examples of places where crowd management has become an urgent issue in recent years. Effective crowd management strategies have been required due to the increasing population, urbanization, and frequency of large-scale meetings. These strategies are used in dynamic, sometimes chaotic, circumstances to protect people and facilitate their free movement. The purpose of this study is to analyze and rank various strategies for crowd management to reduce the risks of crushes and stampedes, improve security, and facilitate smoother traffic flow. This study used the single-valued neutrosophic set to …

Physics-Guided Modeling Of Acoustic Environments Using Limited Spatio-Spectro-Temporal Data, Mylan Ray Cook

Theses and Dissertations

When creating data-based models it is important to include the underlying physical characteristics and constraints of the data. If physical characteristics are not properly included in the model, results may be infeasible or physically impossible. Acoustic environments are better characterized by ensuring that models include the fundamental spatial, spectral, and temporal characteristics of noise sources, or how they change based on location, frequency, and time. When model data are limited, in availability or in reliability, additional care must be taken to ensure models predict feasible results. This dissertation focuses on physics-guided modeling of acoustic environments using limited data, taking into …

A Step Into Structural Biology: Structural Determination Of Tnk1-Uba And Computational Design Of A Radical Sam Cyclase, Yi-Jie Tseng

Theses and Dissertations

Structural biology uncovers life's secrets by studying protein structures via techniques like X-ray crystallography. This knowledge drives advancements in protein engineering for the improvement of human lives. Yet, obtaining high-quality crystals in X-ray crystallography is challenging. To overcome this, we used Translocation ETS Leukemia protein Sterile Alpha Motif domain (TELSAM), a promising polymer-forming crystallization chaperone (PFCC), to enhance protein crystallization. Human thirty-eight-negative kinase-1 (TNK1), a key player in cancer progression, possess a ubiquitin association (UBA) domain that binds polyubiquitin and regulates TNK1 activity and stability. Although sequence analysis hints at an unconventional TNK1 UBA domain architecture, its molecular structure lacks …

Tailoring Digital Physical Activity Support Messages For Women In Midlife With Elevated Risk For Cardiovascular Disease: A Multicomponent Study, Kiri Baga

Theses and Dissertations

Women in midlife (ages 40-60) are at heightened risk for cardiovascular disease (CVD). Although physical activity (PA) engagement can reduce CVD risk, few women engage in sufficient PA to receive this benefit. They cite lack of social support as a key barrier, but existing interventions that employ social support show limited effectiveness. Digital PA support messages (i.e., brief, text-based messages delivered via smartphone or other device) may be a powerful method to meet social support needs in daily life. However, women’s preferences for and responses to distinct types of messages are not well understood. The aim of this study was …

Machine Learning Approaches To Understanding And Predicting Cancer Screening Follow Through With Population And Health System Data, Matthew Davis

MUSC Theses and Dissertations

Introduction

Cancer is the second leading cause of death in the United States and cancer screening is a primary tool to reduce mortality. However, not all who are recommended to be screened actually follow through. This study investigates whether electronic medical record and geographic data is suitable to predict which patients are at risk of missing recommended screenings. The goal of this investigation is to design a data informed system that can automate the prediction of those at risk for missing screenings and provide insights into underlying reasons. This will enable resources to be focused to increase cancer screening adherence, …

Vitamin C And Total Soluble Solid Content Of Crystal Guava At Different Storage Duration And Ripeness, Abdul Khafid, Yulita Nurchayati, Endah Dwi Hastuti, Nintya Setiari

Jurnal Kultivasi

Crystal guava (Psidium guajava var. 'Crystal') fruit is in great demand because of its delicious taste and high nutritional content. Storage aims to prevent postharvest damage to the fruit. However, storage that is too long causes morphological damage and decreased nutrients. This study aims to determine the effect of storage duration, fruit ripeness stage and the interaction between both factors on vitamin C and total soluble solids (TSS) content of crystal guava, and determine which treatment can produce the highest vitamin C and TSS. Fruits harvested simultaneously with three levels of ripeness based on the skin color: unripe fruit is …

2023 August 10 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Universal Dna Methylation Age Across Mammalian Tissues, A. T. Lu, Jessica Lynn Petersen, Steve Horvath, Et Al.

Department of Animal Science: Faculty Publications

Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, …

Using The Multi-Theory Model (Mtm) Of Health Behavior Change To Explain The Seeking Of Stool-Based Tests For Colorectal Cancer Screening, Manoj Sharma, Christopher Johansen, Kavita Batra, Chia-Liang Dai, Ravi Batra, Traci Hayes, Aditi Singh

Social and Behavioral Health Faculty Research

Colorectal cancer is the third most common cancer worldwide and is the second leading cause of cancer-associated deaths. While colorectal cancer is on the decline in the United States (US), disparities still exist, despite the non-invasive screening modalities, such as stool-based tests have shown themselves to be effective in the detection of colorectal cancer. Many of the existing stool-based test interventions lack the use of a contemporary theory-based approach. Given the paucity of theory-based interventions intended to promote stool-based tests, this cross-sectional study utilizes the multi-theory model (MTM) of health behavior change to explain the seeking of stool-based tests for …

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 17 – Paymaster (Dated July 25, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 31 – Waste Dump #5 (Dated July 25, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 66 – West Ruby Dump (Dated July 25, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 174 – Buffalo Ditch (Dated July 25, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 66 – West Ruby Dump (Dated July 25, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 134 – Star West Dump (Dated July 25, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final Insufficiently Reclaimed Sites – Field Sampling Plan (Fsp) Bres No. 174 – Buffalo Ditch (Dated July 25, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Atrial Fibrillation Management In Hispanic Adults, Tania Borja

Dissertations

Background: Research has found atrial fibrillation (AF) to be the primary or a contributing cause of death on 183,321 death certificates, and an underlying cause of death for 26,535 Americans in 2019. Findings indicate an increased AF diagnosis in White people compared to racial and ethnic minorities, contrasting widespread findings of increased prevalence of cardiovascular disease and ischemic strokes in minorities. Significant disparities—by race and socioeconomic status in disease distribution and access to testing and lifesaving treatments—have been documented, specifically associated with social determinants of health (SDOH); i.e., the conditions in which people are born, grow, live, work, and age. …

Topological Hall Effect In Particulate Magnetic Nanostructure, Ahsan Ullah

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

Conduction electrons change their spin direction due to the exchange interaction with the lattice spins. Ideally, the spins of the conduction electrons follow the atomic spin adiabatically, so that spins like S1, S2, and S3 can be interpreted as time-ordered sequences t1 < t2 < t3. Such spin sequences yield a quantum-mechanical phase factor in the wave function,  →ei, where  is known as the Berry phase. The corresponding spin rotation translates into a Berry curvature and an emergent magnetic field and subsequently, Hall-effect contribution known as the topological Hall-effect. This dissertation explores topological Hall-effect in particulate magnets, where noncollinear spins are stabilized by competition between different magnetic interactions. The topologically non-trivial spin textures in these nanostructures are flower states, curling states, vortex, and magnetic bubbles, which give rise to topological Hall-effect and have finite spin chirality and Skyrmion number Q. Topological Hall-effect is investigated in noninteracting nanoparticles, exchanges coupled centrosymmetric nanoparticles, exchanges coupled non-centrosymmetric nanoparticles which possess Dzyaloshinskii-Moriya interaction (DMI), and exchanged coupled Hard and soft magnetic films. Micromagnetic modeling, simulations, analytical calculations, and experimental methods are used to determine topological Hall-effect. In very small noninteracting nanoparticles, the reverse magnetic fields enhance Q due to the flower state until the reversal occurs, whereas, for particles with a radius greater than coherence radius, the Q jumps to a larger value at the nucleation field representing the curling state. The comparisons of magnetization patterns between experimental and computed magnetic force microscopy (MFM) measurements show the presence of spin chirality. Magnetic and Hall-effect measurements identify topological Hall-effect in the exchange-coupled Co and CoSi-nanoparticle films. The origin of the topological Hall-effect namely, the chiral domains with domain-wall chirality quantified by an integer skyrmion number in Co and chiral spins with partial skyrmion number in CoSi. These spin structures are different from the Skyrmions due to DMI in B-20 crystals and multilayered thin films with Cnv symmetry. In these films THE caused by cooperative magnetization reversal in the exchange-coupled Co-nanoparticles and peripheral chiral spin textures in CoSi-nanoparticles.

Advisor: Xiaoshan Xu