Digital Commons Network^™

Β-Sheets Mediate The Conformational Change And Allosteric Signal Transmission Between The Aslov2 Termini, Sian Xiao, Mayar Terek Ibrahim, Gennady M. Verkhivker, Brian D. Zoltowski, Peng Tao

Mathematics, Physics, and Computer Science Faculty Articles and Research

Avena sativa phototropin 1 light-oxygen-voltage 2 domain (AsLOV2) is a model protein of Per-Arnt-Sim (PAS) superfamily, characterized by conformational changes in response to external environmental stimuli. This conformational change begins with the unfolding of the N-terminal A'α helix in the dark state followed by the unfolding of the C-terminal Jα helix. The light state is characterized by the unfolded termini and the subsequent modifications in hydrogen bond patterns. In this photoreceptor, β-sheets are identified as crucial components for mediating allosteric signal transmission between the two termini. Through combined experimental and computational investigations, the Hβ …

Density And Magnetic Field Asymmetric Kelvin‐Helmholtz Instability, Xuanye Ma, Peter Delamere, Katariina Nykyri, Antonius Otto, Stefan Eriksson, Lihui Chai, Brandon Burkholder, Andrew Dimmock, Yu-Lun Liou, Shiva Kavosi

Publications

The Kelvin‐Helmholtz (KH) instability can transport mass, momentum, magnetic flux, and energy between the magnetosheath and magnetosphere, which plays an important role in the solar‐wind‐ magnetosphere coupling process for different planets. Meanwhile, strong density and magnetic field asymmetry are often present between the magnetosheath (MSH) and magnetosphere (MSP), which could affect the transport processes driven by the KH instability. Our magnetohydrodynamics simulation shows that the KH growth rate is insensitive to the density ratio between the MSP and the MSH in the compressible regime, which is different than the prediction from linear incompressible theory. When the interplanetary magnetic field (IMF) …

Reconsidering The Reliability Of Chemical Process Simulators I: Implementation Of The Murphree And Vaporization Efficiencies, Zachary Braswell, Brian F. Hanley, Holt Ragsdale

Faculty Publications

Most chemical process simulators in widespread use today allow users to apply some type of efficiency correction to individual equilibrium stages or to equilibrium stage sections in order to align the stage or section separation performance more closely to actual tray performance in the field. Some simulators even allow for the use of component efficiencies on individual stages or in stage sections. It is our contention, however, that two of the more commonly available efficiency models, the vaporization efficiency and Murphree vapor phase efficiency, have generally been implemented incorrectly. The three major conceptual inconsistencies are (1) the assumption that the …

An Exposome Atlas Of Serum Reveals The Risk Of Chronic Diseases In The Chinese Population, Lei You, Jing Kou, Mengdie Wang, Guoqin Ji, Xiang Li, Chang Su, Fujian Zheng, Mingye Zhang, Yuting Wang, Tiantian Chen, Ting Li, Lina Zhou, Xianzhe Shi, Chunxia Zhao, Xinyu Liu, Surong Mei, Guowang Xu

Faculty, Staff and Student Publications

Although adverse environmental exposures are considered a major cause of chronic diseases, current studies provide limited information on real-world chemical exposures and related risks. For this study, we collected serum samples from 5696 healthy people and patients, including those with 12 chronic diseases, in China and completed serum biomonitoring including 267 chemicals via gas and liquid chromatography-tandem mass spectrometry. Seventy-four highly frequently detected exposures were used for exposure characterization and risk analysis. The results show that region is the most critical factor influencing human exposure levels, followed by age. Organochlorine pesticides and perfluoroalkyl substances are associated with multiple chronic diseases, …

Genomic Evolution Shapes Prostate Cancer Disease Type, Dan J Woodcock, Atef Sahli, Ruxandra Teslo, Vinayak Bhandari, Andreas J Gruber, Aleksandra Ziubroniewicz, Gunes Gundem, Yaobo Xu, Adam Butler, Ezequiel Anokian, Bernard J Pope, Chol-Hee Jung, Maxime Tarabichi, Stefan C Dentro, J Henry R Farmery, Cruk Icgc Prostate Group, Peter Van Loo, Anne Y Warren, Vincent Gnanapragasam, Freddie C Hamdy, G Steven Bova, Christopher S Foster, David E Neal, Yong-Jie Lu, Zsofia Kote-Jarai, Michael Fraser, Robert G Bristow, Paul C Boutros, Anthony J Costello, Niall M Corcoran, Christopher M Hovens, Charlie E Massie, Andy G Lynch, Daniel S Brewer, Rosalind A Eeles, Colin S Cooper, David C Wedge

Faculty, Staff and Student Publications

The development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling tumor cells to rapidly proliferate and eventually invade and metastasize to other tissues. We investigated the genomic evolution of prostate cancer through the application of three separate classification methods, each designed to investigate a different aspect of tumor evolution. Integrating the results revealed the existence of two distinct types of prostate cancer that arise from divergent evolutionary trajectories, designated as the Canonical and Alternative evolutionary disease types. We therefore propose the evotype model for prostate cancer evolution wherein Alternative-evotype …

Resolving The Nanoscale Structure Of Β-Sheet Peptide Self-Assemblies Using Single-Molecule Orientation–Localization Microscopy, Weiyan Zhou, Conor L. O'Neill, Tianben Ding, Oumeng Zhang, Jai S. Rudra, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

Synthetic peptides that self-assemble into cross-β fibrils are versatile building blocks for engineered biomaterials due to their modularity and biocompatibility, but their structural and morphological similarities to amyloid species have been a long-standing concern for their translation. Further, their polymorphs are difficult to characterize using spectroscopic and imaging techniques that rely on ensemble averaging to achieve high resolution. Here, we utilize Nile red (NR), an amyloidophilic fluorogenic probe, and single-molecule orientation-localization microscopy (SMOLM) to characterize fibrils formed by the designed amphipathic enantiomers KFE8^L and KFE8^D and the pathological amyloid-beta peptide Aβ42. Importantly, NR SMOLM reveals the helical (bilayer) …

“Educational Facials”: A Healing Tool For The Beautiful Struggle, Kari Kokka, Michelle Cody

Teaching and Learning Faculty Research

Critical educators of Color often work to support their students to work toward justice. However, because we live and work in a society imbued with white supremacy, cisheteropatriarchy, and additional systems of oppression, students and colleagues may resist efforts toward equity and racial justice, especially in mathematics education with women of Color instructors. In this paper, two mathematics educators, a Japanese American woman and a Black woman, elaborate a theory of educational facials, first coined by the second author in 2015. The theory of educational facials is an analytic tool for healing from and navigating harmful school climates. The authors …

Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2024 Type B Borrow Material Submittal #2 (Dated February 14, 2024), Molly Roby

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Investigating The Causes Of Lake Level Variability On A Modern Carbonate Platform, Natalie M. Salazar

USF Tampa Graduate Theses and Dissertations

Lakes on carbonate islands are known to reduce freshwater lens volumes and alter freshwater lens distribution; however, the magnitude and controlling factors between lake and freshwater lens interactions remain poorly understood. Since freshwater lenses are thin and can be fragmented by lakes in small carbonate islands, it is important to understand the magnitude of exchange between lakes and the freshwater lens to understand potential groundwater depletion. This study utilized high temporal resolution water levels and meteorological data to quantify monthly water budgets for seven lakes on San Salvador Island, The Bahamas. The monthly water budgets accounted for rainfall, potential evaporation, …

Development Of N-H N-Heterocyclic Carbene Pd Catalysts For Cross-Coupling Reactions In Organic Synthesis, Rachel Nicole Owens

Theses and Dissertations

The use of N-H N heterocyclic carbene ligands (NHC's) in organometallic chemistry has become a field of interest due to their unique properties that lead to new and interesting reactivity. The hydrogen on the nitrogen of the NHC can be deprotonated, creating an anionic species, or it can participate in hydrogen-bonding with different substrates. In this work we will explore the unique reactivity of N-H NHC palladium complexes in different cross coupling reactions, including the Suzuki-Miyaura and Heck reactions. Our work demonstrates that N-H NHC complexes of palladium can be accessed from 2-phosphinoimidazole ligands via non-oxidative insertion of the palladium …

Explaining Optimisation Of Offshore Wind Farms Using Metaheuristics, M Walter, P Manikowski, M Craven, D Walker

School of Engineering, Computing and Mathematics

No abstract provided.

Pharmacokinetics Of Propofol In Severely Obese Surgical Patients, Martin Rygh Braathen, Ann E. Rigby-Jones, Johan Ræder, Olav Spigset, Tom Heier

Peninsula Medical School

Background: Existing PK models of propofol include sparse data from very obese patients. The aim of this study was to develop a PK model based on standardised surgical conditions and spanning from normal-weight up to, and including, a high number of very obese patients. Methods: Adult patients scheduled for laparoscopic cholecystectomy or bariatric surgery were studied. Anaesthesia was induced with propofol 2 mg/kg adjusted body weight over 2 min followed by 6 mg/kg/h adjusted body weight over 30 min. For the remainder of the operation anaesthesia was maintained with sevoflurane. Remifentanil was dosed according to clinical need. Eight arterial samples …

Medical Monitoring Working Group Meeting Minutes, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Synthesis And Functional Properties Of Metal Chalcogenide Semiconductors, Jiang Luo

Arts & Sciences Graduate Student Theses and Dissertations

Metal chalcogenides exhibit perovskite, chiral, and layered structures, and accommodate many atoms from periodic table, providing abundant properties such as ferroelectricity, circular dichroism, and anisotropic carrier transport. Those various physical properties make metal chalcogenides promising for the applications from electronics to optoelectronics, such as thermoelectrics, photovoltaics, and photodetectors. The upper limit of carrier mobility, termed as intrinsic carrier mobility, is the key factor that determine the performance of the semiconductor-based applications. However, either experiments or first-principle calculations are challenging to obtain the intrinsic carrier mobility over a wide class of materials. I found a descriptor that have a good correlation …

Final 2024 Butte Priority Soils Operable Unit Type B Borrow Material Submittal #2, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Interrelationships Among Local Values Of Wet Bulb Globe Temperature, Heat Index, And Adjusted Temperature, Andrea Giraldo

USF Tampa Graduate Theses and Dissertations

Occupational heat stress significantly affects outdoor workers who face challenges due to increased heat exposure. Because of the prevalence of heat illness, it is important to measure heat stress for outdoor workers. Monitoring occupational heat stress most often relies on the Wet Bulb Globe Temperature (WBGT) measure. Heat Index (HI) is a widely used measure to account for air temperature and humidity. Adjusted Temperature (Tadj) considers air temperature, humidity and estimates radiant heat. There is interest in predicting WBGT from HI and HI from WBGT. This study builds on previous USF research by Bernard and Iheanacho and Irvin to evaluate …

Frontier Analysis Of The Container Ports In Taiwan During The Covid Pandemic, Sen-Kuei Kuo, Guo-Ya Gan, Hsuan-Shih Lee

Journal of Marine Science and Technology–Taiwan

The COVID-19 outbreak has severely impacted global trade and cultural exchanges. Among its impacts are those on the international container shipping market, which is directly related to the national economy and trade and has naturally been affected. This market was in the doldrums during the pandemic. In general, COVID-19 has severely constrained shipping industry development in various countries. To this end, this study analyzes the frontier changes in the efficiency development of Taiwan's international container ports by collecting realistic operational data of the major container ports during the pandemic and combining them with measurements of the Malmquist Productivity Index and …

Lost Chance Of A Better Medical Outcome: New Tort, New Type Of Compensable Injury, Or New Causation Rule?, Kenneth W. Simons

DePaul Law Review

No abstract provided.

Ai Malpractice, Bryan H. Choi

DePaul Law Review

No abstract provided.

Georgia Academy Of Science 2024 Annual Meeting Program, Teresa Raczek, Terry Powis, Kisa Ranasinghe, Yian Xu, Ordene Edwards

Georgia Journal of Science

Program

The Postsecondary Success Of Historically Marginalized Black And Latino Male Students: Examining Factors That Impact College Readiness Preparation And Persistence, Molly Croghan, Ebonie Davis, Janci Finkley, Zehra Khan, Yvette Levy, Evans Mudanya, Lizbeth Roman

Dissertations

This qualitative research study investigates the multifaceted factors influencing the postsecondary success of historically marginalized Black and Latino male students, with a particular emphasis on understanding the impact of college readiness preparation and persistence. Employing a comprehensive research design, the study integrates semi-structured interviews with high school teachers and counselors, and Black and Latino male freshmen and sophomores to provide a holistic exploration of the challenges and opportunities within the educational journey. Situated within an interpretive phenomenological paradigm, this study elucidates the experiential realities and viewpoints of the subjects, thereby illuminating the socio-cultural, institutional, and individual factors shaping their trajectories …

Novel Inhibitors To Mmpl3 Transporter Of Mycobacterium Tuberculosis By Structure-Based High-Throughput Virtual Screening And Molecular Dynamics Simulations, Hetanshi Choksi, Justin Carbone, Nicholas J. Paradis, Lucas Bennett, Candice Bui-Linh, Chun Wu

College of Science & Mathematics Departmental Research

Tuberculosis (TB)-causing bacterium Mycobacterium tuberculosis (Mtb) utilizes mycolic acids for building the mycobacterial cell wall, which is critical in providing defense against external factors and resisting antibiotic action. MmpL3 is a secondary resistance nodulation division transporter that facilitates the coupled transport of mycolic acid precursor into the periplasm using the proton motive force, thus making it an attractive drug target for TB infection. In 2019, X-ray crystal structures of MmpL3 from M. smegmatis were solved with a promising inhibitor SQ109, which showed promise against drug-resistant TB in Phase II clinical trials. Still, there is a pressing need to discover more …

Curriculum Subcommittee Minutes March 7, 2024, Utah State University

Educational Policies Committee

• Approval of Minutes – February 1, 2024
• Program Proposals

• Semester Course Approval Reviews: https://usu.curriculog.com/

• Other Business

• Course Requests (Deadline) – Toni Gibbons

• Adjourn: 2:50 pm

Educational Policies Committee Minutes March 7, 2024, Utah State University

Educational Policies Committee

• Approval of Minutes – February 1, 2024
• Subcommittee Reports
• Curriculum Subcommittee (Chad Simon)
• Program Proposals
• Academic Standards Subcommittee (Renee Galliher)
• General Education Subcommittee (Matt Sanders)
• Other Business
• Course Requests (Deadline) – Toni Gibbons
• Adjourn: 4:00 pm

Field-Based Measurement Tools To Distinguish Clonal Typha Taxa And Estimate Biomass: A Resource For Conservation And Restoration, Brian M. Ohsowski, Cassidy Redding, Pamela Geddes, Shane Lishawa

School of Environmental Sustainability: Faculty Publications and Other Works

Two species of clonal Typha [T. latifolia (native) and T. angustifolia (exotic)] hybridize to form the highly invasive, heterotic (high vigor) T. × glauca in North American wetlands leading to increased primary production, litter accumulation, and biodiversity loss. Conservation of T. latifolia has become critical as invasive Typha has overwhelmed wetlands. In the field, Typha taxa identification is difficult due to subtle differences in morphology, and molecular identification is often unfeasible for managers. Furthermore, improved methods to non-destructively estimate Typha biomass is imperative to enhance ecological impact assessments. To address field-based Typha ID limitations, our study developed a predictive …

Spatiotemporal Reaction Dynamics Control In Two-Photon Polymerization For Enhancing Writing Characteristics, Aofei Mao, Sarah Fess, Nada Kraiem, P. Li, Zhipeng P. Wu, Qiuchi Zhu, Xi Huang, Peixun Fan, Bai Cui, Jean-Francois Silvain, Suxing Hu, Mitchell Anthamatten, Sean P. Regan, David Harding, Yongfeng Lu

Department of Electrical and Computer Engineering: Faculty Publications

Since 2001, 3D microfabrication based on two-photon polymerization (TPP) has drawn extensive attention and interest in biology, optics, photonics, material science, and high-energy physics. The in-volume fabrication capability due to the threshold behavior of two-photon absorption enables TPP higher flexibility compared with other nanofabrication techniques. However, as determined by the in-volume fabrication feature as well as various reaction dynamics, the writing characteristics of TPP, such as throughput, accuracy, surface quality, and fabrication capability, are still limited. Herein, a comprehensive study is performed on the spatiotemporal behavior of reaction dynamics during TPP fabrication, mainly focusing on spatiotemporal characteristics of radical diffusion, …

Does Smart Money Believe In The Hot Hand? Evidence From Daily Fantasy Baseball, Jeremy M. Losak, Andrew P. Weinbach, Rodney J. Paul

Sport Management - All Scholarship

The behavior of informed traders, or 'smart money,' in sports betting markets has long been f interest to researchers. In this paper, we focus specifically on the behavior of smart money in Major league Baseball (MLB) daily fantasy sports (DFS) contests to determine if they avoid cognitive behavioral biases to increase their expected earnings. Specifically, we investigate whether smart money avoids the hot hand bias, where individuals tend to overestimate the likelihood of success for players on a hot streak. Using a dataset of MLB DFS contests, we find that winning lineups have lower usage rates for players exhibiting the …

Novel Lipid Mediator 7s,14r-Docosahexaenoic Acid: Biogenesis And Harnessing Mesenchymal Stem Cells To Ameliorate Diabetic Mellitus And Retinal Pericyte Loss, Yan Lu, Haibin Tian, Hongying Peng, Quansheng Wang, Bruce A. Bunnell, Nicolas G. Bazan, Song Hong

School of Medicine Faculty Publications

Introduction: Stem cells can be used to treat diabetic mellitus and complications. ω3-docosahexaenoic acid (DHA) derived lipid mediators are inflammation-resolving and protective. This study found novel DHA-derived 7S,14R-dihydroxy-4Z,8E,10Z,12E,16Z,19Z-docosahexaenoic acid (7S,14R-diHDHA), a maresin-1 stereoisomer biosynthesized by leukocytes and related enzymes. Moreover, 7S,14R-diHDHA can enhance mesenchymal stem cell (MSC) functions in the amelioration of diabetic mellitus and retinal pericyte loss in diabetic db/db mice. Methods: MSCs treated with 7S,14R-diHDHA were delivered into db/db mice i.v. every 5 days for 35 days. Results: Blood glucose levels in diabetic mice were lowered by 7S,14R-diHDHA-treated MSCs compared to control and untreated MSC groups, accompanied by …

On Generalized Additive Models For Representation Of Solar Euv Irradiance, Daniel A. Brandt, Erick F. Vega, Aaron J. Ridley

Michigan Tech Publications

In the context of space weather forecasting, solar EUV irradiance specification is needed on multiple time scales, with associated uncertainty quantification for determining the accuracy of downstream parameters. Empirical models of irradiance often rely on parametric fits between irradiance in several bands and various solar indices. We build upon these empirical models by using Generalized Additive Models (GAMs) to represent solar irradiance. We apply the GAM approach in two steps: (a) A GAM is fitted between FISM2 irradiance and solar indices F10.7, Revised Sunspot Number, and the Lyman-α solar index. (b) A second GAM is fit to model the residuals …

Professor Acknowledged For ‘Positive Advancement’ Of Diversity, Erin Garrett

University of Mississippi News

OXFORD, Miss. – Rebecca Symula, instructional associate professor of biology, has been recognized by the Mississippi Institutions for Higher Learning for her contributions to the positive advancement of diversity at the University of Mississippi.