Digital Commons Network^™

Voltage-Gated Sodium Channel Nav1.7 Subtype: A Promising Therapeutic Target For Metastatic Medullary Thyroid Cancer, Piyasuda Pukkanasut

All ETDs from UAB

Medullary thyroid carcinoma (MTC), a rare neuroendocrine tumor, presents considerable clinical challenges due to its tendency to metastasize to organs such as the liver, bones, and brain, resulting in poor patient outcomes. Voltage-gated sodium channels (VGSCs) have emerged as potential therapeutic targets in various malignancies due to their crucial role in promoting cancer cell progression, migration, invasion, and metastasis. This dissertation investigates the specific contributions of the VGSC NaV1.7 subtype in MTC, evaluating its potential as a therapeutic target and elucidating its mechanistic involvement in MTC. Initially, we assessed VGSC subtypes expression in MTC cells. The screening revealed an overexpression …

New Frontiers In Synthesis Of High-Entropy Materials Enabled By Microwave-Induced Plasma, Bria Christina Storr

All ETDs from UAB

This dissertation presents the novel approach for synthesizing high entropy borides (HEBs) and high entropy alloys (HEAs) using microwave-induced plasma as a rapid and efficient processing tool. High entropy materials (HEMs) have peaked interested in recent years due to their unique properties and practical applications such as thermal stability, and corrosion and wear resistance. HEMs are designed by combining multiple principal elements in near-equimolar ratios, enhancing stability, and offering a broad spectrum of tailored mechanical properties. The inclusion of multiple transition metals within these structures increases hardness and oxidation resistance, and the flexibility in element selection enables precise tuning for …

Teachers' Perspectives Of Mandated Health Education Curriculum Goals In Grades K-3, Ashley Baker

Walden Dissertations and Doctoral Studies

This study addressed the challenges faced by many Grades K–3 teachers in north central Georgia in consistently implementing mandated health education curriculum goals (Villegas et al., 2021). The purpose of this basic qualitative study was to explore teachers’ perspectives on the barriers to consistent health education delivery in elementary schools. The study was guided by the concerns-based adoption model, which provided a framework for understanding how teachers navigate changes in curriculum and instruction. The key research questions focused on identifying the specific challenges teachers encounter in implementing health education and their perceived needs for support. Semi structured interviews were conducted …

Key Degradation Mechanisms Of Perovskite Solar Cells And Strategies For Enhanced Stability: Issues And Prospects, Md Helal Miah, Md Bulu Rahman, Mohammad Nur-E-Alam, Mohammad Aminul Islam, M. Shahinuzzaman, Md Rezaur Rahman, Md Habib Ullah, Mayeen Uddin Khandaker

Research outputs 2022 to 2026

Perovskite materials have garnered significant attention within a very short period of time by achieving competitive efficiency. In addition, this material demonstrated intriguing optoelectronic properties and versatile applications. Although they have confirmed amazing efficiency in solar cells at the laboratory scale, mass commercial manufacturing of perovskite solar cells (PSCs) is still a problem due to their poor longevity. Researchers have identified several intrinsic and extrinsic factors contributing to the instability of perovskite compounds and PSCs, and various approaches are being used to increase material quality and stability in order to extend the lifespan of PSCs. Despite these challenges, the potential …

A Survey On Food Ingredient Substitutions, Hyunwook Kim, Revathy Venkataramanan, Amit P. Sheth

Publications

Diet plays a crucial role in managing chronic conditions and overall well-being. As people become more selective about their food choices, finding recipes that meet dietary needs is important. Ingredient substitution is key to adapting recipes for dietary restrictions, allergies, and availability constraints. However, identifying suitable substitutions is challenging as it requires analyzing the flavor, functionality, and health suitability of ingredients. With the advancement of AI, researchers have explored computational approaches to address ingredient substitution. This survey paper provides a comprehensive overview of the research in this area, focusing on five key aspects: (i) datasets and data sources used to …

Synthesis And Characterization Of Bimetallic Plasmonic Nanoparticles Using Linear And Nonlinear Spectroscopy, Daniel Babayode

LSU Doctoral Dissertations

Recent exploration in the field of nanomaterials has led to the investigation of noble metal nanoparticles for various nanomedical applications. The spectroscopy of these nanoparticles is studied using both linear and nonlinear optical processes such as second harmonic generation (SHG), two-photon fluorescence (TPF), and extinction spectroscopy. Details pertaining to the growth dynamics of silver-gold core-shell (Ag@Au CS) nanoparticles (NPs) and gold-silver-gold core-shell-shell (Au@Ag@Au CSS) nanoparticles (NPs) are currently being investigated in order to obtain better control and optimization of the nanoparticle size and surface morphology. Transmission electron microscopy (TEM) images show that the nanoparticles have tunable core and shell sizes …

Johann Georg Hamann And The Liberal Project, Jesse D. Ansley

LSU Doctoral Dissertations

This dissertation examines the political thought of Johann Georg Hamann, his relationship to liberalism, and the importance to modern concerns for consensus formation and intercultural dialogue. This contributes to the line of literature sparked by Isaiah Berlin debating the political legacy of Hamann and its relation to the development of modern politics. Berlin labels Hamann an anti-rationalist whose current developed into the ideology of the Nazi party. My work supports the countervailing arguments that Hamann’s work is importantly different from the Romantics he inspired and even more so from the Nazis. By examining two complete works and a number of …

Riding The Wave: Tech Tsunami'S Rhetoric Enables Plain Anabaptist Adopters, Cory Anderson

Journal of Amish and Plain Anabaptist Studies

Arguably, no book has shaped plain Anabaptist discourse about technology more than Gary Miller’s Tech Tsunami. Since its 2016 publication, the book has achieved near-canonical status within certain Conservative and Old Order Anabaptist circles, particularly among business owners wrestling with technology adoption. The book’s influence extends beyond the original text—an audiobook and a youth edition (Tech Talk, 2021) circulate widely, discussion groups form around its ideas, and its vocabulary infiltrates conversations about church rules. The book’s success builds on Miller’s existing platform; his works Kingdom Focused Finances, Church Matters, and Life in a Global Village helped establish him as a …

Evaluation Of Green Tea Yoghurt Enriched With Lacticaseibacillus Paracasei E1 Microcapsules On Macrophage M1 Profile In High Fat-Fructose Diet Mice, Esha Ardiansyah, Nur Alfi Maghfirotus Sa’Adah, Rahmi Izati, Belinda Nabiila Al Faizah, Dawama Nur Fadlilah, Septhyanti Aprilia Kavitarna, Mochammad Fitri Atho’Illah, Siti Nur Arifah, Yoga Dwi Jatmiko, Muhaimin Rifa’I

Karbala International Journal of Modern Science

Obesity is caused by an energy imbalance that increases chronic low-grade inflammation, including macrophage cell infiltration. Adipose tissue macrophages are polarized into pro-inflammatory macrophage type 1 (M1), secrete large amounts of pro-inflammatory cytokines, and activate transcription factors. Yoghurt with probiotics is popular at all ages for its health benefits and must be protected by microencapsulation. Green tea (Camellia sinensis L.) fortification provides yoghurt nutrients while improving its functional qualities and bioactivity. This study aimed to evaluate the effect of microencapsulation of Lacticaseibacillus paracasei E1 in green tea yoghurt (GTY) on the profile of M1 macrophages in mice fed a …

Enhancing Accuracy In Predicting Continuous Values Through Regression, Ahmed Aljuboori, M. M. A. Abdulrazzq

Iraqi Journal for Computer Science and Mathematics

Enhancing the accuracy in predicting continuous values remains a significant challenge, especially when dealing with imbalanced data and choosing appropriate models. Regression techniques are widely used in data mining, and machine learning fields for this purpose. However, the traditional algorithms struggle to achieve high accuracy because of the limitations in dealing with complex data and imbalanced distribution. This study addresses these gaps by proposing a new framework that evaluates multiple regression models using the Boston House Pricing Dataset (BHD). The examined models involve simple linear, multiple linear, Polynomial, Lasso, Ridge, Random Forest, Keras and Gradient Boosting regression. The models are …

Faculty Senate Monthly Packet January 2025, Portland State University Faculty Senate

Faculty Senate Monthly Packets

The January 6, 2025 monthly packet includes the agenda, appendices, and the Faculty Senate minutes and attachments from the meeting held January 6, 2025.

Lanthorn, Vol. 59, No. 09, January 6, 2025, Grand Valley State University

Volume 59, August 5, 2024 – April 14, 2025

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Met 103-106: Engineering Graphics And Intro. To Cad, Daniel Orlos

School of Applied Engineering and Technology Syllabi

No abstract provided.

The Wright Brothers And Their Genetic Susceptibility To Typhoid Fever, John D. Bullock, H Bradford Hawley

Population and Public Health Sciences Faculty Publications

Importance: Typhoid fever gravely sickened Orville Wright in 1896 and the disease killed his older brother, Wilbur, in 1912. The occurrence of typhoid fever among other Wright family members has never been explored.

Objective: To investigate the number of cases of typhoid fever in the Wright brothers’ family and determine if they had a predisposition to typhoid fever that might have had a genetic basis.

Methods: Biographical information concerning the Wright brothers was examined and a family tree was constructed. Using an estimated untreated case fatality rate of 20%, typhoid fever mortality data from decennial U.S. censuses (1850-1920) was converted …

The Nanograv 15 Yr Data Set: Running Of The Spectral Index, Gabriella Agazie, Akash Anumarlapudi, Anne M. Archibald, Zaven Arzoumanian, Jeremy G. Baier, Paul T. Baker, Bence Bécsy, Laura Blecha, Adam Brazier, Paul R. Brook, Sarah Burke-Spolaor, J. Andrew Casey-Clyde, Maria Charisi, Shami Chatterjee, Tyler Cohen, James M. Cordes, Neil J. Cornish, Fronefield Crawford, H. Thankful Cromartie, Kathryn Crowter, Megan E. Decesar

Pacific Faculty Work

The NANOGrav 15 yr data provide compelling evidence for a stochastic gravitational-wave (GW) background at nanohertz frequencies. The simplest model-independent approach to characterizing the frequency spectrum of this signal consists of a simple power-law fit involving two parameters: an amplitude A and a spectral index γ. In this Letter, we consider the next logical step beyond this minimal spectral model, allowing for a running (i.e., logarithmic frequency dependence) of the spectral index, grun (f ) = g + b ln (f /fref ). We fit this running-power-law (RPL) model to the NANOGrav 15 yr data and perform a Bayesian model …

A Randomized Trial Of Heart Rate Variability Biofeedback Following Traumatic Brain Injury, Leah D. Talbert

Theses and Dissertations

Traumatic brain injury (TBI) affects over 1.7 million people annually in the U.S., often leading to autonomic nervous system (ANS) dysregulation and reduced heart rate variability (HRV), which may impact cognitive performance. This study investigated whether HRV biofeedback (HRV-B) improves HRV at rest and recovery after stress in individuals with TBI. Secondary aims examined links between HRV improvements and reductions in physical symptoms, enhanced emotional functioning, and better cognitive performance, as well as the role of practice adherence in moderating HRV-B effects. This randomized controlled trial compared HRV-B treatment to a sham control using a pre- and post-assessment design. Of …

Restoring The AhupuaʻA: Community-Based Resource Management And Resilience In KauaʻI, Jeffrey W. Walbridge Jr.

Environmental Studies Senior Theses

This thesis analyzes Kauaʻi’s evolving resource management practices, examining the intersections of historical governance frameworks, modern legal systems, and indigenous knowledge. Utilizing the traditional ahupuaʻa system, Kauaʻi’s approach once promoted holistic stewardship across water, land, and energy resources. However, colonial policies, corporate influence, and economic pressures have gradually shifted this framework toward a market-driven model, often prioritizing tourism and development over ecological resilience. Key policy shifts as they fight to return to an ahupua'a based model – from the Great Mahele’s introduction of private land ownership to water diversions for plantation agriculture – help examine how these changes continue to …

Stability Of Lif Mirror Coatings On Space Telescopes At L2 Orbit, Devin M. Lewis

Theses and Dissertations

A team at Goddard Space Flight center has developed a coating of aluminum mirrors they term XeLiF. This coating has high ultraviolet reflection and improved environmental stability over similar LiF coatings. For these reasons, it is a potential candidate for the future Habitable Worlds Observatory (HWO) flagship space telescope mission. However, the stability of XeLiF at the planned L2 orbit of HWO has not been investigated. This study highlights the potential damage to XeLiF when irradiated by electrons that will be present at L2. This radiation will begin removing LiF after 6 years of exposure as well as start roughening …

Scproatlas: An Atlas Of Multiplexed Single-Cell Spatial Proteomics Imaging In Human Tissues, Tiangang Wang, Xuanmin Chen, Yujuan Han, Jiahao Yi, Xi Liu, Pora Kim, Liyu Huang, Kexin Huang, Xiaobo Zhou

Faculty, Staff and Student Publications

Spatial proteomics can visualize and quantify protein expression profiles within tissues at single-cell resolution. Although spatial proteomics can only detect a limited number of proteins compared to spatial transcriptomics, it provides comprehensive spatial information with single-cell resolution. By studying the spatial distribution of cells, we can clearly obtain the spatial context within tissues at multiple scales. Spatial context includes the spatial composition of cell types, the distribution of functional structures, and the spatial communication between functional regions, all of which are crucial for the patterns of cellular distribution. Here, we constructed a comprehensive spatial proteomics functional annotation knowledgebase, scProAtlas (https://relab.xidian.edu.cn/scProAtlas/#/), …

Aspdb: An Integrative Knowledgebase Of Human Protein Isoforms From Experimental And Ai-Predicted Structures, Yuntao Yang, Himansu Kumar, Yuhan Xie, Zhao Li, Rongbin Li, Wenbo Chen, Chiamaka S Diala, Meer A Ali, Yi Xu, Albon Wu, Sayed-Rzgar Hosseini, Erfei Bi, Hongyu Zhao, Pora Kim, W Jim Zheng

Faculty, Staff and Student Publications

Alternative splicing is a crucial cellular process in eukaryotes, enabling the generation of multiple protein isoforms with diverse functions from a single gene. To better understand the impact of alternative splicing on protein structures, protein-protein interaction and human diseases, we developed ASpdb (https://biodataai.uth.edu/ASpdb/), a comprehensive database integrating experimentally determined structures and AlphaFold 2-predicted models for human protein isoforms. ASpdb includes over 3400 canonical isoforms, each represented by both experimentally resolved and predicted structures, and >7200 alternative isoforms with AlphaFold 2 predictions. In addition to detailed splicing events, 3D structures, sequence variations and functional annotations, ASpdb uniquely offers comparative analyses and …

Metsdb: A Knowledgebase Of Cancer Metastasis At Bulk, Single-Cell And Spatial Levels, Sijia Wu, Jiajin Zhang, Yanfei Wang, Xinyu Qin, Zhaocan Zhang, Zhennan Lu, Pora Kim, Xiaobo Zhou, Liyu Huang

Faculty, Staff and Student Publications

Cancer metastasis, the process by which tumour cells migrate and colonize distant organs from a primary site, is responsible for the majority of cancer-related deaths. Understanding the cellular and molecular mechanisms underlying this complex process is essential for developing effective metastasis prevention and therapy strategies. To this end, we systematically analysed 1786 bulk tissue samples from 13 cancer types, 988 463 single cells from 17 cancer types, and 40 252 spots from 45 spatial slides across 10 cancer types. The results of these analyses are compiled in the metsDB database, accessible at https://relab.xidian.edu.cn/metsDB/. This database provides insights into alterations in …

Crisprofft: Comprehensive Database Of Crispr/Cas Off-Targets, Grant Wang, Xiaona Liu, Aoqi Wang, Jianguo Wen, Pora Kim, Qianqian Song, Xiaona Liu, Xiaobo Zhou

Faculty, Staff and Student Publications

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated protein) programmable nuclease system continues to evolve, with in vivo therapeutic gene editing increasingly applied in clinical settings. However, off-target effects remain a significant challenge, hindering its broader clinical application. To enhance the development of gene-editing therapies and the accuracy of prediction algorithms, we developed CRISPRoffT (https://ccsm.uth.edu/CRISPRoffT/). Users can access a comprehensive repository of off-target regions predicted and validated by a diverse range of technologies across various cell lines, Cas enzyme variants, engineered sgRNAs (single guide RNAs) and CRISPR editing systems. CRISPRoffT integrates results of off-target analysis from 74 studies, encompassing …

The Manipulation Of Odor Availability Of Training Aids Used In Detection Canine Training, Katylynn B. Sloan, Michele N. Maughan, Caitlin E. Sharpes, Robin R. Greubel, Shawna F. Gallegos, Aleksandr E. Miklos, Lindsay D. Waldrop

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Detection canines can identify numerous substances for which they have been trained. Historically, and a point of ongoing contention, detection canine threshold (i.e., sensitivity or limit of detection) training has primarily focused on changing the weight of the training aid substance used. There has been minimal focus on other principles, such as surface area, confinement, and temperature, which can be manipulated to affect odor availability. That said, trainers have been manipulating odor availability for years without necessarily understanding the governing scientific principles. The aim of this review is to highlight the principles that control odor availability of a substance and …

Alternative Splicing In The Brain: Across Disease States, Sexes, Regions, And Cell Types, Emma Finn Jones

All ETDs from UAB

Molecular phenotype heterogeneity is prevalent across multiple contexts and is mediated by mRNA expression differences and the gene and isoform level. Isoform-level mRNA complexity in the brain is essential for healthy neurodevelopment, and perturbations in AS are associated with many neurological and psychiatric disorders. While previous research has examined how AS changes in the brain, there is still a gap in using newer techniques to study these changes with greater specificity. Therefore, we address this gap by using long-read and scRNA-seq technologies to study isoform-level diversity in AS across four contexts (i.e., disease, sex, region, and cell type) in the …

Autoethnographic Action Research As A Contemplative Practice: Awareness And Transformation Of Inner And Outer Selves, Jiju Varghese, Bal Chandra Luitel, Niroj Dahal

The Qualitative Report

Contemplation as a spiritual practice has taken various forms across different religious traditions and regions worldwide. Over the years, various contemplative practices have evolved and become popular even outside religious traditions to promote the well-being of all for inner and outer selves’ transformation. In education, many scholars worldwide have expounded on the benefits of contemplative practices in the classroom for students and teachers. Contemplative practices have penetrated research practices in the form of contemplative inquiry considering performative, philosophical, and artistic transformations, where researchers enter into a deep, thoughtful, and reflective introspective journey to see the connection between what is seen …

Production And Radiochemistry Of Theranostic Radioscandium Nuclides, Shelbie Jaylene Cingoranelli

All ETDs from UAB

In nuclear medicine, theranostics utilizes radionuclide pairs for diagnosis and therapy. Radioscandium isotopes (43Sc, 44Sc, and 47Sc) offer a promising alternative to the 68Ga/177Lu theranostic pair due to their identical radiolabeling conditions, complexes and in vivo pharmacokinetics. 43Sc (t1/2=3.89h, β+=88%) and 44Sc (t1/2 =3.97h. β+=94.3%) are suitable for Positron Emission Tomography (PET) imaging whereas 47Sc (t1/2=3.3d. Eβ-ave=162keV) is suitable for targeted radiotherapy and Single Photon Emission Computed Tomography (SPECT). These isotopes require production routes that lead to high radionuclidic purity and radiochemistry development for incorporation into radiopharmaceuticals. This study explores the production, purification, and application of these isotopes. The proton …

Elucidating The Role Of The Secondary Coordination Sphere In Tuning Reactivity Of Synthetic Heme Superoxide Complexes And Other Biologically Relevant Intermediates, Garrett B. Tolbert

All ETDs from UAB

Tryptophan catabolizing human heme-dioxyganase enzymes have been linked to a multitude of disease conditions; therefore, understanding the mechanistic details of their function is of great interest to facilitate the design of effective inhibitors for therapeutic applications. Synthetic model systems have demonstrated dioxygenation of indole moieties, elucidating key mechanistic details of the overall reaction. However, the contrastingly low reactivity of the synthetic heme-superoxide intermediates compared to those of dioxygenase enzymes necessitates the revaluation of these models with direct relevance to their biological mode of action. Herein, we report detailed mechanistic studies on the reactivity of model porphyrin systems with installed non-covalent …

Infografía: El Nexo De Unión Entre Ciencia Y Diseño Gráfico, Ángel Serrano Valverde, Almudena Torres Pardo

GDI. Revista de investigación de Género, Diseño e Innovación

En la divulgación científica, tanto en la que se realiza en congresos de alto impacto y nivel académico, como en la que encontramos en los museos, en los libros de texto o en las redes sociales, se están utilizando infografías. Principalmente, para explicar procesos complejos y sucesos no observables sin el uso de instrumentación específica, o no reproducibles con sencillez.

Este artículo investiga esa relación entre ciencia y diseño a través de la infografía, recorriendo la historia de la infografía científica y su uso en los diferentes ámbitos divulgativos actuales.

Desde un punto de vista científico y de diseño, analizaremos …

Origami Without Paper: Surrogate Folds For Origami-Inspired Mechanisms, Ivyann Oveson Running

Theses and Dissertations

Origami is a useful tool for generating novel spatial mechanisms that can address needs in a variety of fields. However, replicating paper folding in other materials requires surrogate folds---some way to approximate folding in otherwise rigid materials. This work presents a collection of potential surrogate fold designs suitable for use in origami-inspired applications. The designs are sorted into families and rated against several design characteristics of interest to engineers and designers to create the Surrogate Fold Catalog. The catalog is formatted to be searchable and filterable based on manufacturability, kinematic motion, and additional utility. Using this collection of surrogate folds …

Can Trichoderma Spp. Contribute To The Bioremediation And Biostimulation Of Plants In Soil Contaminated With Herbicides?, Elaine Damiani Conte, Elton José Da Rosa, Gabriel Rieth Silvestrini, Daiane Da Silva Motta, Christiane Fernandes De Oliveira, Carine Cocco, Gabriel Fernandes Pauletti, Taísa Dal Magro, Joséli Schwambach

School of Earth, Environmental, & Marine Sciences Faculty Publications

This work aimed to evaluate the potential of Trichoderma spp. in the bioremediation of herbicides and biostimulation of plants in herbicide-contaminated soils. In the first phase, the experiment followed a completely randomized design in a 4 × 3 × 4 factorial scheme with five replications, four strains of Trichoderma spp., three herbicides, and four herbicide doses. The mycelial growth speed index (MGSI) of Trichoderma spp. was obtained by growing it in a Petri dish with PDA associated with different doses of herbicides and evaluated every 24 h for 10 days. Results indicated the selection ofTrichoderma harzianumT1A to continue …