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Articles 1771 - 1800 of 713656
Full-Text Articles in Entire DC Network
High-Level Trajectory Learning For Non-Prehensile Object Manipulation With Hierarchical Reinforcement Learning, Gulsum Tuba Cibuk Girgin
High-Level Trajectory Learning For Non-Prehensile Object Manipulation With Hierarchical Reinforcement Learning, Gulsum Tuba Cibuk Girgin
Discovery Day - Daytona Beach
Site exploration requires in-situ resource utilization when the physical properties of resources are unknown. Therefore, a generalizable object manipulation method is crucial for extraterrestrial environments. Existing studies develop reinforcement learning policies that enable interaction with objects, in which quadruped robots learn to reach commanded goals with one foot while balancing with the remaining legs. However, in these studies, goal-oriented task execution relies on high-level trajectories provided by human experts, which limits autonomous robotic operations. In this study, we propose a hierarchical DRL in which a high-level pedipulation policy outputs commands for a low-level reach policy, enabling autonomous, smooth and affordable …
Ai Race Between The Us And China, Kennedy Lyon-Lindersmith
Ai Race Between The Us And China, Kennedy Lyon-Lindersmith
Discovery Day - Daytona Beach
Technological leadership in AI and semiconductor manufacturing are both directly linked with military power and geopolitical influence. At the same time, the U.S. and China are currently defining the future of conflict in the cyber domain and are in strategic competition as China attempts to displace the U.S. as a global leader in AI. These factors contribute to an important national security threat that the U.S. is facing right now: An AI race between the U.S. and China, specifically regarding military cyber operations. This paper discusses some of the implications of a digital battlefield and analyzes international laws, international institutions, …
Geometry-Conditioned Adversarial Defense For Sar Automatic Target Recognition Via Regime-Specialist Classification Heads, Skyler Fabre
Geometry-Conditioned Adversarial Defense For Sar Automatic Target Recognition Via Regime-Specialist Classification Heads, Skyler Fabre
Discovery Day - Daytona Beach
This project, titled Geometry-Conditioned Adversarial Defense for SAR Automatic Target Recognition via Regime-Specialist Classification Heads, addresses the critical vulnerability of deep neural networks deployed in Synthetic Aperture Radar (SAR) Automatic Target Recognition (ATR) systems to adversarial perturbations. This is where imperceptible pixel-level modifications cause confident misclassification, posing serious risks in defense and aerospace applications. The objective is to develop and evaluate RegimeResNet, a geometry-conditioned classification architecture that exploits sensor metadata unique to SAR collection systems. Rather than treating all images uniformly, RegimeResNet partitions the SAR capture space into nine geometric regimes defined by depression angle and target azimuth angle extracted …
Sequential Causal Architecture For Multimodal Aviation Accident Prediction, Kaitlyn Cavanaugh, Isaac Morrison
Sequential Causal Architecture For Multimodal Aviation Accident Prediction, Kaitlyn Cavanaugh, Isaac Morrison
Discovery Day - Daytona Beach
Aviation accidents are rarely the result of a single failure but rather from a complex causal chain of latent failures. While traditional data mining models often predict incident occurrence, they frequently overlook the sequential mechanics defined by known accident causation theoretical frameworks like the Swiss Cheese Model and the FAA's HFACS. This project addresses the need for interpretable, reliable, multi-stage forecasting by proposing a Sequential Causal Architecture that transforms theoretical causation models into a structured Directed Acyclic Graph (DAG) for multimodal accident causation chain prediction. Data from the NTSB and DOT is used and connected together in a meaningful way …
Energy-Aware Bimodal Contact Detection For Leg Odometry, Emre Girgin
Energy-Aware Bimodal Contact Detection For Leg Odometry, Emre Girgin
Discovery Day - Daytona Beach
Autonomous exploration of extraterrestrial environments using legged robots requires robust GNSS-free 3D state estimation. Standard leg odometry relies on Zero-Velocity Updates (ZUPT), which assume a grounded foot remains completely stationary. This assumption consistently fails on deformable granular terrain due to unobservable slippage, rapidly degrading state estimation. To mitigate this critical failure mode, we propose a dual contact-detection framework designed to robustly gate an Error-State Extended Kalman Filter (ESEKF) tracking pose, velocity, and IMU biases. The architecture isolates physical load and kinematics by modeling contact detection as two independent parallel Hidden Markov Models (HMMs). The Load HMM processes Ground Reaction Forces, …
Assured Learning For Intelligent Dynamic Systems: A Metacognitive Framework, Rocio Jado Puente, Michael Budihartono, Eduar Cabrera Gaspar
Assured Learning For Intelligent Dynamic Systems: A Metacognitive Framework, Rocio Jado Puente, Michael Budihartono, Eduar Cabrera Gaspar
Discovery Day - Daytona Beach
Assured Learning for Intelligent Dynamic Systems: A Metacognitive Framework Advanced Air Mobility systems, including electric vertical takeoff and landing (eVTOL) aircraft and autonomous drone platforms, require increasingly high levels of autonomy and safety. Meeting these demands calls for intelligent systems that can adapt in real time to uncertainty and changing environmental conditions. However, traditional certification methods are not well suited to rigorously measure or quantitatively verify the performance of online learning components because of their non-deterministic behavior. This work introduces a novel runtime safety assurance method based on a metacognitive architecture (MCA) that supervises and regulates learning-enabled components. The approach …
Motivational Outsourcing: Ai, Self-Determination, And The Changing Nature Of Adult Learning, Zoe Spanos
Motivational Outsourcing: Ai, Self-Determination, And The Changing Nature Of Adult Learning, Zoe Spanos
Discovery Day - Daytona Beach
Artificial intelligence (AI) is increasingly embedded into adult learning and higher education, serving not only as a support tool for cognitive aid but also as a system that can shape how learners regulate their motivation and engagement. This presentation examines how the use of AI in adult learning contexts may support or undermine self-determined motivation, drawing from Self-Determination Theory (SDT). It is a conceptual paper that draws on existing literature and theoretical analysis, examining AI reliance from minimal use to full automation across SDT's three basic psychological needs: autonomy, competence, and relatedness. Motivation is essential for learning, but the quality …
Learning Motion Primitive Selection And Environment Abstraction, Edison Alberto Martinez Samaniego, Natalie Alexander, Kaelyn Weddle
Learning Motion Primitive Selection And Environment Abstraction, Edison Alberto Martinez Samaniego, Natalie Alexander, Kaelyn Weddle
Discovery Day - Daytona Beach
Learning Motion Primitive Selection and Environment Abstraction Advanced Air Mobility (AAM) is emerging as a transformative solution for short and medium range transportation; however, it introduces an operational model that differs significantly from conventional aviation. AAM vehicles are expected to operate closer to populated areas, with increased autonomy, in dense urban and suburban environments. These settings present constrained maneuvering conditions which highlights the importance of maintaining safe operation under degraded flight conditions. Abnormal conditions may endanger onboard passengers, people on the ground, and surrounding infrastructure, making rapid detection and mitigation essential to prevent loss of control. Recent research has explored …
Modeling Aircraft Collision Risk Using Machine Learning And Traffic Density Data Ac, Jadia Renee Ewing, Alexander Van Baelan, Conrad Prisby, Rafal P. Smietana
Modeling Aircraft Collision Risk Using Machine Learning And Traffic Density Data Ac, Jadia Renee Ewing, Alexander Van Baelan, Conrad Prisby, Rafal P. Smietana
Discovery Day - Daytona Beach
Air traffic congestion is an increasingly important factor in aviation safety as global flight activity continues to grow. This project investigates whether higher traffic density is associated with an increased risk of aviation incidents and identifies key contributing factors. Using publicly available flight (ADS-B) and incident (NTSB) data, we apply several machine learning models to analyze traffic patterns and predict risk. We begin with logistic regression to evaluate the relationship between density and incident probability, followed by decision trees to extract interpretable rules describing high-risk conditions. K-nearest neighbors (KNN) is used to examine similarity in traffic patterns among incident flights, …
Low-Rank Spectral Analysis For The Reddening Of The Seven Sisters Star Cluster, Eric Rodarte, Angelina Scalice, Madison Warner, Kevin Numbe
Low-Rank Spectral Analysis For The Reddening Of The Seven Sisters Star Cluster, Eric Rodarte, Angelina Scalice, Madison Warner, Kevin Numbe
Discovery Day - Daytona Beach
The Pleiades, also known as the Seven Sisters, is a stunning star cluster located approximately 440 light-years from Earth. This vibrant assemblage of hot blue stars in the Taurus constellation can be admired with the naked eye or through binoculars during early autumn. In this presentation, we utilize spectral theory to measure the reddening in the Pleiades star cluster. To evaluate the impact of interstellar dust on reddening, we employ principal component analysis (PCA) on a matrix representing color indices from various photometric bands linked to the cluster’s photometric data. This dataset was obtained from VIZIER. Our PCA analysis of …
Vibration And Thermal-Vacuum Feasibility For Micro Carbon Fiber Filled Nylon Filament Lunar Applications, Andrew Murphy, Shannon O'Sullivan, Daniel Lopez
Vibration And Thermal-Vacuum Feasibility For Micro Carbon Fiber Filled Nylon Filament Lunar Applications, Andrew Murphy, Shannon O'Sullivan, Daniel Lopez
Discovery Day - Daytona Beach
The proposed work seeks to improve the fundamental understanding of the properties concerning 3-D printing filaments that have potential to be used for lunar applications. The associated properties in focus for the proposed study, vibration and thermal-vacuum-resistance, are fundamental aspects of spaceflight and are critical to mission success for objectives associated with the environmental factors in space. The successful outcome of the proposed work will answer questions relating to the feasibility of micro carbon fiber filled nylon 3-D printing filaments such as Markforged’s Onyx® for application for projects in the Space Technologies Laboratory, including for the development of structures relating …
A Comparative Classical And Data-Driven Facial Analysis Of Wide-Field-Of-View Lens Captures, Andrew Murphy, Giovanni C. Decapua, Anthony M. Cafiso, Max E. Raabe, Kaden E. Van Leuven
A Comparative Classical And Data-Driven Facial Analysis Of Wide-Field-Of-View Lens Captures, Andrew Murphy, Giovanni C. Decapua, Anthony M. Cafiso, Max E. Raabe, Kaden E. Van Leuven
Discovery Day - Daytona Beach
WFOV lenses are becoming popular in facial recognition due to the fact that they enhance subject coverage and improve the chances of detecting target faces. However, wide-angle optics introduce nonlinear distortion around the image periphery, which degrades the performance of recognition pipelines. In this poster presentation, we use WFOV lens captures to analyze facial recognition using classical low-complexity algorithms based on the discrete Fourier transform (DFT), discrete cosine transform (DCT), principal component analysis (PCA), and data-driven learning with convolutional neural networks. Finally, we present computational efficiency, compression, accuracy, and precision of recognizing distorted images with qualitative and quantitative measures.
Advancements In Spacecraft Trajectory Generation Through Matrix Decomposition Techniques, David Stoev, Oshani Jayawardane, Kaitlyn Cavanaugh, Kristiyan Stefanov, Andrew Murphy
Advancements In Spacecraft Trajectory Generation Through Matrix Decomposition Techniques, David Stoev, Oshani Jayawardane, Kaitlyn Cavanaugh, Kristiyan Stefanov, Andrew Murphy
Discovery Day - Daytona Beach
The Circular Restricted Three-Body Problem (CR3BP) is renowned for its intricate and chaotic dynamics, leaving it without a closed-form solution. In this poster, we introduce an innovative approach to determine spacecraft trajectories within the CR3BP framework using matrix factorization techniques. We formulate a matrix equation where the right-hand side vector is constructed from the spacecraft's position and velocity data, while the coefficient matrix is derived from the spacecraft's temporal data. Subsequently, we apply several matrix decomposition techniques, including modified Gram-Schmidt, the Householder technique, and Givens Rotation, to analyze the coefficient matrix and derive the spacecraft trajectories. Finally, we evaluate the …
Earthquake-Resistant Design And Base Isolation Techniques, Christian George, Jacob Sweeten, Gabriela Cotto, Savion Stewart
Earthquake-Resistant Design And Base Isolation Techniques, Christian George, Jacob Sweeten, Gabriela Cotto, Savion Stewart
Discovery Day - Daytona Beach
Earthquake-resistant design has become a critical feature in construction near active fault lines, where seismic activity is most frequent and potentially destructive. In recent years, technological advancements have significantly improved methods for protecting buildings from earthquake damage. Among these innovations, base isolation systems have appeared as one of the most effective solutions. By decoupling a building from ground motion, base isolators reduce the transmission of seismic forces, helping to prevent structural damage and support building stability during earthquakes. In addition to improving safety, base isolation systems can also reduce long-term costs associated with earthquake-related repairs and maintenance. Base-isolated structures are …
Results And Implications For Space Weather Forecasting Of Periodic Mesoscale Solar Wind Structures Responsible For Radiation Belt Particle Loss, Grace Gratton
Discovery Day - Daytona Beach
Highly dynamic and structured mesoscale solar wind continually buffets Earth's magnetosphere, the moon, and Mars. These mesoscale structures cause several significant risks to spacecraft and astronauts, including driving radiation belt depletion and amplifying the hazards of CMEs and SIRs through upstream solar wind preconditioning. Characterizing the solar origins and solar wind properties of geoeffective mesoscale structures is essential for eventually forecasting their arrival and space weather impact at various satellites. In this interdisciplinary work, we leverage modeling and data analysis to characterize a series of events observed by the Balloon Array for Radiation-belt Relativistic Electron Losses (BARREL) instrument – in …
Analyzing Fungal Growth Dynamics Under Different Environmental Conditions Using A Lotka–Volterra Competition System, Maria Ordonez, Fabrio Araujo
Analyzing Fungal Growth Dynamics Under Different Environmental Conditions Using A Lotka–Volterra Competition System, Maria Ordonez, Fabrio Araujo
Discovery Day - Daytona Beach
Fungi play a critical role in ecosystems as decomposers that recycle nutrients and maintain environmental balance. Their populations are influenced by multiple environmental factors such as temperature, humidity, nutrient availability, and interactions with other organisms. In this project, the Lotka–Volterra model is used to analyze how competing fungal species interact and how these interactions influence population dynamics over time. By modeling two fungal populations competing for the same limited resources, the equations illustrate how environmental conditions and competition coefficients determine whether one species dominates; both species coexist, or one species becomes extinct. The model provides insight into how changes in …
Characterization Of An Ambe Tagged Neutron Source For A 30-Ton Wbls Detector, Rylee Grover
Characterization Of An Ambe Tagged Neutron Source For A 30-Ton Wbls Detector, Rylee Grover
Discovery Day - Daytona Beach
Understanding the detection capabilities of water-based liquid scintillator (WbLS) is critical for its deployment in next-generation neutrino detectors such as THEIA and Phase II of the Deep Underground Neutrino Experiment (DUNE). This study focuses on the characterization and alignment testing of an Americium-Beryllium (AmBe) radioactive neutron source. We plan to dope the 30-ton WbLS detector at Brookhaven National Laboratory (BNL) with Gadolinium (Gd) to improve neutron detection capabilities. This will be tested by the implementation of an AmBe source as a calibration metric. The AmBe source emits neutrons coincident with a 4.4 MeV gamma ray, making it possible to perform …
Lightweight Uav-To-Uav Detection And Tracking For Advanced Air Mobility Applications, Taylor Hostetter
Lightweight Uav-To-Uav Detection And Tracking For Advanced Air Mobility Applications, Taylor Hostetter
Discovery Day - Daytona Beach
Lightweight UAV-to-UAV Detection and Tracking for Advanced Air Mobility Applications addresses the significant challenge of reliable UAV-to-UAV detection on resource-constrained platforms, particularly within Advanced Air Mobility (AAM) environments where dense, low-altitude airspace requires robust detect-and-avoid capabilities. This work presents the development and experimental evaluation of a lightweight detection and tracking framework for autonomous detect-and-avoid applications. The approach is designed to support real-time onboard operation in multi-vehicle environments characteristic of emerging AAM systems. The proposed framework integrates optical and LiDAR sensing with a low-complexity machine learning decision-support layer that reduces false detections without replacing the underlying control-oriented detection pipeline. This design …
Project Minerva, Lena Wang, Gannon English, Ethan Yemm, Gabrielle Guirguis, Jose Murphy
Project Minerva, Lena Wang, Gannon English, Ethan Yemm, Gabrielle Guirguis, Jose Murphy
Discovery Day - Daytona Beach
Project Minerva is a multidisciplinary engineering initiative at Embry-Riddle Aeronautical University (ERAU) dedicated to the design, integration, and deployment of high-altitude balloon (HAB) systems for stratospheric research and aerospace hardware validation. The project challenges student researchers to engineer flight-ready payloads capable of maintaining structural and electronic integrity in extreme temperatures and low-pressure environments in the stratosphere. Typically utilizing 600g latex balloons filled with helium, Project Minerva missions aim to achieve altitudes exceeding 22,000 meters to facilitate vertical atmospheric profiling of variables such as CO₂ concentration, humidity, temperature, and pressure. Beyond its technical objectives, the project serves as a professional training …
System And Method For Detecting Subsurface Voids Using Controlled Heat Addition, Chase Nilsson
System And Method For Detecting Subsurface Voids Using Controlled Heat Addition, Chase Nilsson
Discovery Day - Daytona Beach
This study evaluates controlled heat addition in a confined space to estimate enclosed volumes for irregularly shaped spaces. The intent is to detect hidden voids in cave environments. Conventional methods for identifying such voids are often costly, logistically difficult, and limited in accuracy. Preliminary experiments were conducted with a controlled heat source, a temporary thermal barrier to isolate the test chamber, and simple temperature sensors. Temperatures were recorded for the pre-test baseline, the heating interval, followed by a cooling period. The thermal response showed clear engineering trends that warrant further exploration and modeling. Preliminary results indicate that transient temperature changes …
A Cyber-Physical Flight Simulation Platform For Real-Time Visualization Of Aircraft Dynamics And Sensor-Based Control, Gabriel Martinez, Michael Poinsett
A Cyber-Physical Flight Simulation Platform For Real-Time Visualization Of Aircraft Dynamics And Sensor-Based Control, Gabriel Martinez, Michael Poinsett
Discovery Day - Daytona Beach
Understanding aircraft dynamics through traditional simulations can be limiting, as results are often confined to screen-based visualization. This project aims to enhance learning and experimentation by creating a system where aircraft motion can be both simulated and physically observed in real time. The primary objective is to develop a cyber-physical flight simulation platform that links mathematical models with physical hardware. The system is designed to (1) represent aircraft dynamic behavior through real-time motion and (2) provide a foundation for integrating sensors and control strategies for responsive flight behavior. The platform combines aircraft dynamic models with a hardware interface capable of …
The Impact Of Environmental Contributing Factors In Spatial Disorientation And Non-Spatial Disorientation Related General Aviation Accidents, Victoria Cornaro, Molly Mersinger
The Impact Of Environmental Contributing Factors In Spatial Disorientation And Non-Spatial Disorientation Related General Aviation Accidents, Victoria Cornaro, Molly Mersinger
Discovery Day - Daytona Beach
The Impact of Environmental Contributing Factors in Spatial Disorientation and Non-Spatial Disorientation Related General Aviation Accidents Spatial disorientation (SD) is an inherent risk of flying and with a high risk of resulting in a fatal accident (Gibbs et al, 2011). SD related accidents occur when a pilot’s perception of the aircraft altitude, position, or relative motion conflict with reality (Benson, 1999). SD accidents are significantly more likely to result in a fatality than non-SD cases. The purpose of this study was to investigate the role of different contributing factors on SD and non-SD general aviation accidents. We used the NTSB …
Ai-Driven Predictive Analysis Of Airline Profitability Under Macroeconomic And Sustainable Aviation Fuels, Shivika Singh
Ai-Driven Predictive Analysis Of Airline Profitability Under Macroeconomic And Sustainable Aviation Fuels, Shivika Singh
Discovery Day - Daytona Beach
This study presents an AI-enhanced predictive model to assess airline profitability under the combined influence of macroeconomic trends and the adoption of sustainable aviation fuel (SAF). By including economic indicators such as GDP growth, inflation rates, and fuel price volatility with airline operational data, including ticket prices and fuel costs, the model simulates profitability across multiple carriers. Scenario-based analyses, encompassing optimistic, moderate, and pessimistic projections, illustrate different financial sensitivities between low-cost and legacy airlines.
Supply Chain Analysis: The Oregonator Autocatalytic Case Study, Abigail Butcher
Supply Chain Analysis: The Oregonator Autocatalytic Case Study, Abigail Butcher
Discovery Day - Daytona Beach
Understanding stability in complex supply chains remains a critical challenge due to nonlinear feedback, delayed responses, and sensitivity to parameter changes. This project presents a novel framework that applies bifurcation analysis to evaluate system stability, using the Oregonator autocatalytic chemical reaction model as an analog for supply chain dynamics. A parameter sweep of key model variables, particularly the stoichiometric factor f and the reaction rate constants k, is used to identify transitions between stable and oscillatory regimes. These transitions provide insight into how variations in feedback strength can drive instability in real-world systems. The framework will then be extended to …
Synchrotron X-Ray Diffraction Method For Continuous Strain Analysis Across Heterogenous Material Interface Layers, Sierra Damon
Synchrotron X-Ray Diffraction Method For Continuous Strain Analysis Across Heterogenous Material Interface Layers, Sierra Damon
Discovery Day - Daytona Beach
Synchrotron X-ray diffraction method for continuous strain analysis across heterogenous material interface layers The transfer of strain across a material interface is a relevant concept to quantify for numerous aerospace applications that involve coatings applied to substrates of different materials, particularly in the field of high temperature materials. X-ray diffraction (XRD) is a metrology technique capable of resolving strain within an arbitrary material by quantifying the shifts of Bragg peaks with respect to an unstrained sample and has seen increased use due to the capability of XRD to perform in-situ measurements on materials in extreme environments. Since different materials have …
Asymptotic Enumeration Of K-Bounded Functions Using Toeplitz Matrices, Tiago Cavalcante Trindade, Pedro Martineli
Asymptotic Enumeration Of K-Bounded Functions Using Toeplitz Matrices, Tiago Cavalcante Trindade, Pedro Martineli
Rose-Hulman Undergraduate Mathematics Journal
We introduce the concept of $(\alpha, \lambda)$-bounded functions, characterized by limited local variation, which is especially useful in discrete sets. Initially, we formally define these functions and investigate their fundamental properties, highlighting significant differences from continuous functions. The main result obtained is the asymptotic estimate of $a(n, k)$, representing the number of functions from $[n]$ to $[n]$ that are $k$-bounded with respect to the Manhattan distance. The proof of this result combines Toeplitz matrices with a well-known inequality from graph theory.
Techniques, Skills, And Synthesis For “Cooking” In The Organic Laboratory, Emily C. Sylvester, Tim Evans
Techniques, Skills, And Synthesis For “Cooking” In The Organic Laboratory, Emily C. Sylvester, Tim Evans
Open Education Materials
Lab manual for CHEM 211L, Organic Chemistry I Laboratory. Provides background and procedures for laboratory experiments, including fundamental techniques and several organic syntheses.
Creative Commons attribution.
The Use Of Chitosan-G-Poly (Acrylic Acid-Co-Acrylamide) In The Delivery Of Imatinib In The Small Intestine, Dawson Ohrt, Clint Everard
The Use Of Chitosan-G-Poly (Acrylic Acid-Co-Acrylamide) In The Delivery Of Imatinib In The Small Intestine, Dawson Ohrt, Clint Everard
Nebraska Academy of Sciences: Programs and Proceedings
The use of hydrogels as drug delivery systems is the future of biotechnology, hydrogels can offer a new way of controlled delivery to specific areas of the body. Hydrogel also create new possibilities for treatments of gastrointestinal stromal tumors (GISTs). There are many different types of hydrogels that can be used in drug delivery. Hydrogels offer customizability in regard to the release of drugs in specific environments. The chemical properties of hydrogels allow for them to be manipulated for specific functions such as release at a specific pH . The hydrogel being used in the study is Chitosan-G-Poly (Acrylic Acid …
Developing An Object Level Understanding Of Sine And Cosine As Ratios And A Coherent Trigonometry, Jeffrey Peter Nair
Developing An Object Level Understanding Of Sine And Cosine As Ratios And A Coherent Trigonometry, Jeffrey Peter Nair
Theses and Dissertations
Solving right-triangle problems as well as integrating right-triangle and circular trigonometry into a coherent understanding are documented challenges for students. Prior research has deeply investigated students constructing ratio meanings for sine and cosine using a circle-first approach, which then can be extended to right triangles. Also, past work has separately documented distinct meanings that are useful for sine and cosine, in addition to the ratio meaning, including as lengths in a unit circle and coordinate points. This study took these existing ideas and put them together into one possible developmental progression, based on APOS theory, where students can learn length, …
Synthetic Strategies For Bioactive Peptides: From Aggregation Inhibitors To The Total Synthesis Of Tunicyclin C, Stephanie Graciela Garcia Morin
Synthetic Strategies For Bioactive Peptides: From Aggregation Inhibitors To The Total Synthesis Of Tunicyclin C, Stephanie Graciela Garcia Morin
Theses and Dissertations
In Alzheimer's disease (AD), a brain protein called "tau" abnormally clumps and forms neurofibrillary tangles (NFTs), causing damage to brain cells. Ac-PHF6-NH2 is a hexapeptide segment of tau protein that plays a dominant role in tau aggregation and is used as a model to design tau protein aggregation inhibitors. In this research we synthesized four dehydroamino acid (□AA) containing PHF6 analogues with △Abu (derived from L-threonine) and △Val (derived from □-OH-Valine) at position 2 or 3 via dehydrations or azlactone ring-openings as key reactions. We evaluated their proteolytic resistance, ability to inhibit aggregation of PHF6, and impact on the morphology …