Digital Commons Network^™

Albumin-Binding Domains In Therapeutic Protein Engineering: A Structural And Computational Perspective On Rational Design, Matthew Argyle, Dallin M. Chipman, Anna Claire Woolley, Bradley C. Bundy, Dennis Della Corte

Faculty Publications

Therapeutic proteins face a critical pharmacokinetic challenge: rapid clearance from circulation limits their clinical efficacy. Albumin-binding domains (ABDs) offer an elegant solution by enabling therapeutic proteins to “hitchhike” on serum albumin’s favorable 19-day half-life through FcRn-mediated recycling. Clinical validation through approved therapeutics like ozoralizumab demonstrates the success of this approach, with preclinical studies showing fusion to an ABD extended half-life to 18 days. This review provides an analysis of ABD-fusion protein design, integrating structural biology, computational prediction, and rational engineering principles. We catalog the major classes of albumin-binding modalities, including bacterial three-helix bundle domains, engineered peptides, antibody-derived binders, and alternative …

Regression With Microdata And Microsoft Excel®, Humberto Barreto

Economics and Management Faculty publications

A free eversion is available at http://ggl.link/regbook with open-access course materials at dub.sh/regcourse.

The Pain Scale, Eula Biss

Creative Nonfiction Magazine

No abstract provided.

Luke And Leonardo

Creative Nonfiction Magazine

No abstract provided.

Then You’Ll Be Straight, Margaret Price

Creative Nonfiction Magazine

No abstract provided.

Comprehensive Framework For Artificial Intelligence Model Testing: Integrated Validation Methodologies, Global Regulatory Compliance, And Enterprise Implementation Strategies For 25 Years, Ramkumar Bharathan

Defensive Publications Series

The proliferation of artificial intelligence systems across critical infrastructure necessitates a paradigm shift from traditional software quality assurance toward probabilistic validation methodologies. This paper presents a comprehensive framework for AI model testing that synthesizes regulatory requirements across multiple jurisdictions—including the EU AI Act (Regulation 2024/1689), NIST AI Risk Management Framework 2.0, Federal Reserve SR 11-7, Colorado AI Act, NYC Local Law 144, and sector-specific regulations—into an integrated validation architecture applicable across financial services, healthcare, insurance, manufacturing, and retail sectors.

The framework encompasses twelve distinct testing dimensions: functional correctness, performance benchmarking, bias and fairness assessment, robustness and adversarial resilience, explainability validation, …

Prismatic Subspace Projection For Semantic Control Of Vector Embeddings, Thomas Joseph Duerig, Yichang Chen, Jiří Iša

Defensive Publications Series

Vector search effectiveness may be reduced by semantic mismatches where nuisance dimensions, such as formality or complexity, can degrade retrieval relevance. Addressing these dimensions could involve resource-intensive model retraining. Systems and methods are described for dynamically modifying vector embeddings using prisms, which can be vector representations of certain semantic concepts. For example, a prism can be calculated from the vector difference between embeddings of two data items that differ primarily along a given semantic axis. To refine a search, a query or document embedding can be modified through a geometric projection into a subspace orthogonal to a prism vector. This …

Quantitative Importance Attribution For Source Documents In Generative Models, N/A

Defensive Publications Series

Generative models that utilize external information sources may not include mechanisms to quantitatively measure the contribution of each source document to a generated output. Disclosed are systems and methods for quantitatively attributing source importance. A technique can involve calculating numerical importance scores for constituent parts of a model's output, for instance, by analyzing internal model attention scores or semantic similarity to a user prompt. A remapping process then can trace these scored parts back to their original source documents to assign an overall importance score to each source. This quantitative attribution data can provide a basis for feedback mechanisms for …

The Future Of West African Cacao Farming, Kathryn Lesniewski

CAFE Symposium 2026

This poster covers the detrimental impact climate change has had on the West African cacao farming industry. It also covers long and short term solutions to climate change, and how the global chocolate market has been impacted by climate change.

Beyond The Chessboard: How Chess Participation Can Improve Cognitive Performance, Siddiquee Siyam

CAFE Symposium 2026

When I arrived at Gettysburg College, it was quite disappointing to me as a chess enthusiast that there was no platform to unite all players on campus. I took the initiative to address this issue by establishing the Gettysburg College Chess Federation (GCCF), only to realize that the GCCF’s activities could also be expanded to address a broader issue. With my first-year seminar (FYS) focusing on changemaking, I decided to turn my passion into my class project, implementing concrete work beyond the theoretical arena to not only promote chess on campus but also to start a teaching program with K-6 …

Dynamic Soliton Solutions And Stability Analysis Of The (2+1)-Dimensional Wazwaz Kaur Boussinesq Equation Using An Efficient Method, Nivan Mohamed Elsonbaty, Hamdy Mohamed Ahmed, Niveen Mohamed Badra, Wafaa B. Rabie

Basic Science Engineering

This paper presents the first application of the Modified Extended Direct Algebraic (MEDA) method to the (2+1)-dimensional Wazwaz-Kaur-Boussinesq equation, a model governing wave dynamics in shallow waters. The approach successfully uncovers previously unreported classes of exact solutions, including combo dark–singular solitons and Jacobi elliptic function solutions. The spectrum of obtained solutions–which also encompasses bright, dark, and singular solitons, as well as hyperbolic, periodic, exponential, and rational functions–reveals rich and complex soliton dynamics. A comprehensive stability analysis confirms the robustness of these solutions under perturbation. These results significantly advance the understanding of wave propagation in nonlinear systems, providing valuable insights for …

Authentication Of Art, Herbert I. Lazerow

Cleveland State Law Review

The authentication of items permeates our law and our markets. While it is important for many consumer goods, authentication is crucial for artworks and artifacts where the value difference between the authentic and the inauthentic is huge. The question is raised most frequently in conflicts between buyer and seller of art where it is claimed that a warranty was breached, or between the owner of artwork and an authenticator where the claim sounds in tort. It also arises in any situation where the value of the art is important, such as tax or antitrust. Authentication of artwork can be difficult …

Uav-Deployable Open-Source Sensor Nodes For Spatial And Temporal In Situ Water Quality Monitoring And Mapping, Matthew Burnett, Mohamed Abdelwahab, Joud N. Satme, Austin Downey, Gabriel Barahona Smith, Antonio Fonce, Jasim Imran

Faculty Publications

Cost efficient, spatially resolved water quality monitoring is essential for managing pollution and protecting aquatic ecosystems. This study presents a low-cost (approximately USD 200), open-source, unmanned aerial vehicle (UAV)-deployable in situ sensor node for real-time assessment of surface-water conditions. The system integrates sensors for pH, turbidity, temperature, and total dissolved solids (TDSs), with onboard data logging and real-time clock (RTC) synchronization. Bench validation of the sensor package yielded mean absolute percentage errors of 1.34% for pH, 5.23% for TDS, and 0.81% for temperature, and the device operated continuously for 42 h. Field deployment demonstrated its ability to resolve spatial gradients, …

Nanoencapsulation Of Tomentosin-Rich Pulicaria Crispa Fraction In Mil-53(Fe) Improves The Release Profile And In Vitro Anti-Colorectal Cancer Activity, Hamies Baher

Dentistry

No abstract provided.

Optimization Of Lightning Impulse Grounding Performance Of Claw-Shaped Tower Grounding Device, Zhanglei Chen, Tingfang Yang, Chao Zhuo, Gaojia Li, Minghao Feng, Xiong Li

Journal of Electric Power Science and Technology

Transmission line towers are prone to lightning strikes. When the grounding resistance of a tower is too high, the fault rate of the line is increased. To effectively reduce the lightning impulse grounding resistance of typical grounding devices and guide the grounding design of transmission line towers, a composite grounding device consisting of a typical tower foundation combined with a claw-shaped grounding body is proposed. A model of the claw-shaped grounding device is established using CDEGS software, and its time-domain impulse response characteristics are analyzed while considering the soil spark effect. Quantitative comparisons of the impulse grounding resistance of the …

Improving Ground Cover Crop Fractional Vegetation Mapping Via Causality-Based Deep Representation Learning, Atif Latif, Masoumeh Hashemi, Matt Yost, Somayeh Esmaeili, Xiaojun Qi

Computer Science Student Research

Semantic segmentation and deep learning methods have rarely been applied to fractional vegetation cover (FVC) segmentation tasks due to the lack of publicly available datasets for training deep learning models. FVC is a key indicator for assessing vegetation distribution, crop density, and crop responses to water availability and fertilizer application, yet conventional field-based measurement methods are time consuming, costly, labor intensive, and may lack the accuracy required for critical applications such as drought stress evaluation and water productivity. In this paper, we introduced causality-based deep learning techniques for FVC segmentation on a publicly available RGB dataset that consists of four …

Faculty Perceptions About The Challenges Of Declining Enrollment In A Caribbean University, Courtney Palmer

Walden Dissertations and Doctoral Studies

The precipitous decline in enrollment is a concerning aspect of higher education. The problem addressed in this study was that faculty members at a local university on a Caribbean island have faced an approximate 44% reduction in student enrollment over the past six years. Guided by the new learning compact framework (NLC), the purpose of this basic qualitative study was to explore industrial technology lecturers' perceptions from one Caribbean Island university about the challenges they experience from declining enrollment and examine their suggestions to improve enrollment. Twelve lecturers with tertiary-level teaching experience at the institution were interviewed using semi-structured interviews. …

An Autonomous Robotic System For Object Retrieval And Delivery: Enhancing Independence For Users Living With Disability And Older Adults, Jincheng Li, Chenghao Lin, Amna Mazen, Youssef A. Bazzi

Michigan Tech Publications

As the global population ages, there is a growing need for assistive technologies to help older adults maintain their independence. This work presents a cost-effective autonomous socially assistive robot designed for object retrieval and delivery, enhancing accessibility in home environments. The system is built on the Robot Operating System (ROS) framework and integrates three key components: the Pioneer P3-DX mobile robot for autonomous navigation, the ReactorX-200 robotic arm for pick-and-place operations, and the Kinect v2 RGB-D camera for object detection and localization. Users interact with the robot through natural language processing by issuing voice commands to retrieve various objects. Microsoft …

Final Repository Siting Study (Rss) Detailed Evaluation And Recommendations Report, Atlantic Richfield Company, Butte Silver Bow

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Final 2022 Unreclaimed Sites Sampling: Ur-28 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Sullivan County 4-H Presents! 2026, Lynn Brewer

UNH Cooperative Extension

No abstract provided.

Balancing Acts: Gender Parity Law And Cultural Boundaries In Senegal, Seulgie Lim

All Faculty Scholarship

This article investigates the intersection of global gender equality norms with local contexts, focusing on Senegal’s implementation of the 2010 gender parity law. Despite the global trend towards electoral gender quotas, the effectiveness and societal acceptance of these measures vary significantly. Through a critical examination of existing literature on gender quotas and an analysis of the parity law’s reception in Senegal, this article explores the nuanced dynamics between legislative measures and societal norms. It argues that, while gender quotas can enhance women’s visibility in politics, deeply ingrained cultural and religious norms may undermine the more substantive impact of such legislated …

Resilient Grid Architectures For High Renewable Penetration: Electrical Engineering Strategies For 2030 And Beyond, Ehab Bayoumi

Mechanical Engineering

The global shift toward decarbonized power systems is driving unprecedented penetration of variable renewable energy sources, especially wind and solar PV. Legacy grid architectures, built around centralized, dispatchable synchronous generation, are ill-suited to manage the bidirectional power flows, reduced inertia, and new stability constraints introduced by inverter-based resources. Existing research offers deep but fragmented insights into individual elements of this transition, such as advanced power electronics, microgrids, or market design, but rarely integrates them into a coherent architectural vision for resilient, high-renewable grids. This review closes that gap by synthesizing technical, architectural, and institutional perspectives into a unified framework for …

Prevalence Of Premenstrual Syndrome, Premenstrual Dysphoric Disorder, And Dysmenorrhea In Nursing Students: A Systematic Review, Meta-Analysis, And Evidence-Based Recommendations, Sabyasachi Maity, Bharathi Gadad, Hansapani Rodrigo, Seham Noorani, Ayesha Usman, Chloe Lark, Mona Attarpour, Ivy Mageto, Lucas Schwartz, Nikhilesh Anand

School of Medicine Publications

Introduction: Menstrual disorders—including premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and dysmenorrhea—are highly prevalent among women of reproductive age and are associated with impaired academic performance, psychological distress, and reduced social functioning. Nursing students are particularly vulnerable due to the combined demands of intensive academic schedules and clinical training, yet prevalence estimates and institutional responses remain inconsistent.

Methods: A systematic review and meta-analysis were conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD420251109363). PubMed, Scopus, Web of Science, CINAHL Ultimate, and APA PsycINFO were searched for studies published between 2016 and 2025. Eligible studies reported prevalence or …

Nonenzymatic Glucose Biosensor Based On Selective Reduction Of Silver Ions, Maryam Sarlak, Shankar B. Rananavare

Chemistry Faculty Publications and Presentations

A nonenzymatic conductivity-based glucose biosensor, reported here, designed for potential noninvasive measurement in accessible biofluids such as saliva, sweat, and tears. The sensor exploits a classic Tollens’ silvering process that deposits metallic silver on a sensitized surface via a quantitative, selective reduction of silver ions by glucose. Of the two surface sensitization methods used, the self-assembled bifunctional thiol/silane surfactant yields a more stable and sensitive sensor than tin(II) chloride. The conductometric sensor consists of two spiral interdigitated silver electrodes fabricated by lithography and wet etching. The sensor impedance changes after selective metallic silver deposition between the electrodes. The sensor exhibits …

Her Numbers, Brian Doyle

Creative Nonfiction Magazine

No abstract provided.

New Century, Natalie Goldberg

Creative Nonfiction Magazine

No abstract provided.

Exploring The Efficacy Of Storytelling In Education About Climate Change, Nina Adjanin, Srijana Katuwal, Heidi Sevestre, Gordon Brooks

Mid-Western Educational Researcher

From bedtime tales to digital narratives, stories wield unparalleled influence, shaping perceptions, and fostering empathy. Through mediums like social media and digital platforms, storytelling becomes a tool for advocacy, amplifying voices, and catalyzing social change. In this qualitative study, 107 higher education students from diverse backgrounds participated. The purpose of this study was to uncover salient beliefs about climate change stories on popular social media platforms among full-time college students. The results are based on three key components of the theory of planned behavior (TPB): affective beliefs, normative beliefs, and control beliefs. The respondents expressed both positive and negative attitudes …

Curriculum Materials Cataloged For Browsing, Michelle Emanuel

Mississippi Libraries

When the University of Mississippi Libraries acquired a collection of state-adopted school textbooks for K-12 from its School of Education, a decision was made to catalog the collection for browsing to anticipate the needs of its primary users, both “in service” and “pre-service” teachers. The textbooks would be grouped according to their grade level, and cuttered by subject area, instead of being classed according to its subject area. As the collection would be integrated into the regular circulating collection, and not into a curriculum materials center, issues arose for both technical services and access services throughout the process, from cataloging …

News Briefs, Marvin H. Jeter Iii, Joyce Shaw

Mississippi Libraries

News updates from Gunter Library at the Gulf Coast Research Laboratory and from the Mississippi Library Commission.