Digital Commons Network^™

Proteomic Signatures Of 3-Year Progression From Impaired Fasting Glucose To Diabetes: The Atherosclerosis Risk In Communities (Aric) Study, Mary R Rooney, Justin B Echouffo Tcheugui, Jingsha Chen, Keenan A Walker, Christie M Ballantyne, Eric Boerwinkle, Tanika N Kelly, Chiadi E Ndumele, James S Pankow, Morgan E Grams, Wendy S Post, Peter J Ganz, Alexis C Wood, Jerome I Rotter, Elizabeth Selvin, Josef Coresh

Faculty, Staff and Students Publications

Objective: To identify proteomic signatures underlying 3-year progression from impaired fasting glucose (IFG) to diabetes.

Research design and methods: We examined IFG progression in the Atherosclerosis Risk in Communities (ARIC) study from visit 2 (1990-1992) to visit 3 (1993-1995). We tested associations of 4,955 plasma proteins (SomaScan version 4.0) with ∼3-year progression from IFG (FG 100-125 mg/dL without diabetes) to diabetes (diagnosis, medication, or FG ≥126 mg/dL) using logistic regression models adjusted for demographics, cardiometabolic risk factors, and baseline glucose with Bonferroni correction (P < 10-5). We explored biological pathways enriched among the top proteins and calculated improvements in prediction (ΔAUC and net reclassification using 3-year risk thresholds of 6% and 15% in 80% training and 20% internal validation subsamples). We validated results in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.

Results: There were 3,786 ARIC participants with IFG (mean [SD] age 57 [6] years, 52% female, …

Perceived Negative Acts And Emotional Well-Being In Healthcare Education At A Hispanic-Serving Institution: A Cross-Sectional Study, Deborah Rocha Seixas, Patricia Montemayor Garcia, Tyreen Heybeck, Eduardo Sanches Gonçales, Cláudia Cristina Biguetti

School of Podiatric Medicine Publications

Purpose: Negative acts (NA), including work-related bullying, person-related bullying, and physical intimidation, are inappropriate behaviors that should not occur in workplaces or schools. Healthcare students may be exposed to these experiences during their training, although exposure may vary across demographics. This study aimed to assess self-reported NA and the emotional well-being among healthcare students from different family immigration backgrounds at a Hispanic-serving institution on the U.S.–Mexico border and to explore potential associations between NA exposure and demographic characteristics. Methods: The NA Questionnaire-Revised (NAQ-R) assessed work-related bullying (WB), person-related bullying (PB), physical intimidation (PI), and total NAQ-R score (TNAQ-R). Participants also …

Nutrition Considerations In Youth With Type 2 Diabetes Using Glucagon-Like Peptide-1 Receptor Agonists: A Commentary, Maria E Diaz, Grace Kim, Mili Vakharia

Faculty, Staff and Students Publications

No abstract provided.

Cost-Effectiveness Of Hes V2.0 And Galad For Hepatocellular Carcinoma Surveillance In Patients With Cirrhosis, Mert Sahinkoc, Gizem S Nemutlu, Hashem B El-Serag, Mary Linton B Peters, Ali Hajjar, Anthony E Samir, Leigh Anne Dageforde, Fasiha Kanwal, Jagpreet Chhatwal

Faculty, Staff and Students Publications

Background: Ultrasound-based surveillance for HCC is limited by suboptimal sensitivity and low adherence. Blood-based biomarkers are potential alternatives for routine HCC surveillance. We aimed to define optimal sensitivity, specificity, and cost parameters under which blood-based biomarkers could serve as cost-effective alternatives in patients with cirrhosis.

Methods: We developed a microsimulation model of the natural history of HCC in individuals with compensated cirrhosis. We compared the cost-effectiveness of biannual surveillance using 2 blood-based biomarkers-HES V2.0 and GALAD-versus ultrasound-based surveillance across a range of sensitivity, specificity, test costs, and adherence levels. Outcomes included quality-adjusted life years (QALYs), costs, and incremental cost-effectiveness ratios …

Collegiate Athletes’ And Coaches’ Communicative Constitution Of Resilience: A Case Study, Lillian B. Feder

College of Communication Faculty Research and Publications

Resilience processes are communicative in nature and vital to the wellbeing and success of athletic personnel and organizations. However, the communicative components of resilience-building are largely ignored in sport scholarship and practice. This study seeks to bridge that gap by using the communication theory of resilience as a sensitizing concept to develop a thorough understanding of communicative resilience-building processes in athletics. Semi-structured in-depth interviews with members of a Division I college baseball team were analyzed using thematic co-occurrence analysis. Findings indicate that collegiate athletes and coaches experience resilience-building as a combination of mental toughness (i.e., persistence and discipline) and resourcefulness …

De-Centering And Re-Centering Digital Scholarship, Ten Years On, Matthew Hunter, Aaron Retteen, Micah Vandegrift

Faculty Scholarship

Ten years after the publication of a manifesto attempting to describe what digital scholarship could do for and within libraries, some of the original authors reflect on the progress of the call-to-action. This article describes areas in which the integration of digital scholarship activities as core parts of librarianship has and has not become commonplace and traces larger-scale developments in the academy and global knowledge landscape that have contributed to the accuracy of the predictions made in 2017.

Editorial: Spontaneous Bacterial Peritonitis-Redrawing Empiric Therapy In The Era Of Multidrug Resistance. Authors' Reply, Rohit Mehtani, Nipun Verma

Faculty, Staff and Students Publications

No abstract provided.

Long-Term Outcomes In Seronegative Rheumatoid Arthritis, Bradly A Kimbrough, Roslin Jose George, Cynthia S Crowson, Sara J Achenbach, Elizabeth J Atkinson, Vanessa L Kronzer, John M Davis, Elena Myasoedova

Faculty, Staff and Students Publications

Objective: The purpose of this study was to determine the cumulative incidence of diagnosis switching, drug-free remission, and initiation of a biologic or targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD) in individuals with seronegative rheumatoid arthritis (RA).

Methods: Adult residents of Olmsted County, Minnesota, with incident seronegative (rheumatoid factor negative/anti-cyclic citrullinated peptide antibody negative) RA meeting the 1987 and/or 2010 American College of Rheumatology classification criteria were included. Data were collected from January 1, 2005, to December 31, 2023, through manual chart review. Drug-free remission was defined as a period of at least six months where the individual was no longer …

Vitamin B6 Predicts Poor Outcomes In Geographically Distinct Populations With Primary Sclerosing Cholangitis, Peder R Braadland, Ahmad H Ali, Philip Puchas, Brian D Juran, Elizabeth J Atkinson, Erik M Schlicht, Jackie K Bianchi, Bryan M Mccauley, Sara K V Tjønnfjord, Hólmfríður Helgadottir, Per M Ueland, Arve Ulvik, Peter Sauer, Trine Folseraas, Tom H Karlsen, Mette Vesterhus, Michael T Dill, Konstantinos N Lazaridis, Johannes R Hov

Faculty, Staff and Students Publications

Background & aims: Primary sclerosing cholangitis (PSC) has a variable disease course, complicating patient counseling and the timing of liver transplantation. Vitamin B6 deficiency predicts reduced liver transplantation-free survival in Scandinavian PSC cohorts. Here, we aimed to validate this observation in US and German PSC cohorts and to expand our analyses to include hepatic decompensation as a clinical outcome.

Methods: Serum active vitamin B6 (pyridoxal 5'-phosphate [PLP]) was analyzed using liquid chromatography-tandem mass spectrometry in retrospective cohorts of people with PSC from Norway (n = 315), the USA (n = 756), and Germany (n = 149). Cox proportional hazards and …

Deep Learning-Based Comparison Of Knee Minimum Joint Space Width In Patients With Rheumatoid Arthritis And Osteoarthritis Before Total Knee Arthroplasty, Miguel M Girod, Monty Khela, Sami Saniei, Kellen L Mulford, Cassondra A Hulshizer, Elizabeth J Atkinson, Cody C Wyles, John M Davis, Gavin A Mckenzie, Cynthia S Crowson

Faculty, Staff and Students Publications

Objective: Although both osteoarthritis (OA) and rheumatoid arthritis (RA) can necessitate total knee arthroplasty (TKA), their mechanisms and radiographic patterns of joint space narrowing (JSN) differ. Deep learning (DL) enables compartment-specific measurement of minimum joint space width (mJSW). This study compared JSN patterns between patients with RA and OA undergoing TKA and evaluated the associations between mJSW and RA disease activity.

Methods: In this retrospective study, 409 patients with RA undergoing TKA (2000-2021) were age- and sex-matched with OA patients. A validated DL model quantified medial and lateral mJSW from anteroposterior knee radiographs at 2 timepoints: early (> 2 years …

Associations Of Polygenic Risk Scores For Type 2 Diabetes With Metabolic Measures In Pacific Islanders From Guam And Saipan, Maria J. Ramirez-Luzuriaga, Saied Safabakhsh, Rasol Salehi, Sayuko Kobes, Tanisha F. Aflague, Jenny Duenas Sarmiento, Joanne Curran, Robert G. Nelson, Jeffrey M. Curtis, Carol D. Moffett

Human Genetics Publications

Several polygenic risk scores (PRSs) for type 2 diabetes (T2D) have been derived from genome-wide association studies (GWASs), but Pacific populations have generally not been represented in these GWASs. The aim of this study was to examine the association of PRS for T2D with diabetes and clinical measures in Pacific Islander populations from Guam and Saipan. We analyzed seven constructions of PRSs in 1990 participants in a GWAS from a community-based cross-sectional study of diabetes. Associations of T2D PRS with diabetes, maximum body mass index (BMI), fasting glucose, and HbA1c were examined with adjustment for age, sex, and the first …

Engagement Of Understudied Populations As Community Change: The South Texas Adrc Model, Gladys E. Maestre, Neela K. Patel, Rosa V. Pirela, Robin C. Hilsabeck, Kendra Stine, Neyra García, Roberto Reyes, Omar Oropeza, Cristian Maestre, Jesus D. Melgarejo, Sarah Williams-Blangero, Ney Alliey Rodriguez, Sylvia A. Robles

School of Medicine Publications

Many populations experiencing the highest burdens of Alzheimer's disease and related dementias remain understudied, in part because traditional recruitment and retention models are insufficient to support sustained engagement. The Outreach, Recruitment, and Engagement Core (OREC) of the South Texas Alzheimer's Disease Research Center reconceptualized participant recruitment as a long-term system change in a Hispanic-majority, urban–rural region. OREC institutionalizes shared power through community advisory governance, aligns research protocols with local lived realities (through patient navigators, community health workers/promotores, and decentralized access points), and employs a data-driven feedback loop for continuous improvement. In 1 year, 46 outreach events touched 10,134 individuals (71% …

Timing Of Middle Meningeal Artery Embolization And Surgery: Analysis Of The Embolise Trial, Maxim Mokin, Jared Knopman, Jason M. Davies, Ameer E. Hassan, Robert E. Harbaugh, Alexander Khalessi, Jens Fiehler, Elad I. Levy

School of Medicine Publications

Background: The EMBOLISE trial (The Embolization of the Middle Meningeal Artery With Onyx Liquid Embolic System in the Treatment of Subacute and Chronic Subdural Hematoma) demonstrated that middle meningeal artery embolization as an adjunct to surgical drainage reduces recurrence of symptomatic subacute and chronic subdural hematomas. We performed a subgroup analysis of the EMBOLISE surgical cohort to determine how the timing of embolization relative to surgery impacted various outcomes.

Methods: We performed a post hoc subgroup analysis to examine the association of the timing of embolization relative to surgery with the primary end point (hematoma reoperation within 90 days), secondary …

From Genes To Streams: Mitochondrial Approaches To Population Monitoring Of The Santa Ana Sucker Catostomus Santaanae, Mariana Antonio

Electronic Theses, Projects, and Dissertations

This study was developed to use aquatic environmental DNA (eDNA) as a tool to detect the presence of the Santa Ana sucker (Catostomus santaanae), a federally threatened fish species, across the Santa Ana River in Southern California. Environmental DNA is any genetic material that an organism sheds into the environment. We can get an idea of what aquatic species are present when sampling water at a given site. We sequenced the complete mitochondrial genome (mitogenome) of the Santa Ana sucker and designed custom DNA primers to improve eDNA detection accuracy. These primers were selected based on high genetic …

Advantages Of Dynamic Representation For Related Rates Problems In Calculus, Eri Osuna

Electronic Theses, Projects, and Dissertations

Related-rates problems are a standard yet persistently difficult topic in first-semester calculus. Research increasingly recommends dynamic visualization tools such as GeoGebra, but direct comparisons of static and dynamic representations in related-rates settings remain scarce. This qualitative study examines how representation type shapes the quality of students' reasoning and their perceived experience during related-rates problem solving. Six mathematics students who had completed Calculus —a group of four undergraduates and a pair of graduate students—completed a static sliding-ladder task and a dynamic airplane-and-camera task supported by an interactive GeoGebra applet, followed by an interview. Findings indicate that the two representations supported reasoning …

The Effect Of Telehealth Expansion On The Health Equity Of Underserved Populations, Mansi B. Satani

Electronic Theses, Projects, and Dissertations

The rapid expansion of telehealth, during and after the COVID-19 pandemic, has changed healthcare delivery in the United States. The use of telehealth can potentially decrease disparities related to isolation, shortage of providers and barriers to transportation, however, its impact on health equity in underserved populations is unknown. This paper explores how telehealth expansion impacts rural populations' access to healthcare, health outcomes, and equity. It also examines its impact on populations with low income, racial, ethnic minorities, and Medicaid recipients who frequently encounter obstacles to healthcare and digital access (Nouri et al., 2020; Shah et al., 2024). A mixed-method design …

How Recent Medicaid Defunding Has Impacted San Bernardino County Residents Access To Health Care Services, Samantha I. Rios

Electronic Theses, Projects, and Dissertations

Background: Medicaid is a critical source of health insurance for low-income populations in the United States, providing access to essential preventative, primary, and reproductive health care services (Donohue et al., 2022). The Medicaid defunding of 2025 and policy changes that follow have raised concerns regarding increased barriers to care, particularly among low-income and vulnerable populations who rely on safety-net providers such as Planned Parenthood (Planned Parenthood, 2025). The purpose of this study was to examine how the 2025 Medicaid defunding has impacted access to general and reproductive health care services among residents of San Bernardino County, California.

Conclusion: The research …

Effects Of Photosynthetic Mode On Growth In Closely Related Tillandsia Species, Jeremy L. Read

Electronic Theses, Projects, and Dissertations

To examine the effects of photosynthetic mode (C3 vs CAM) on plant productivity, subjects of the sister taxa Tillandsia confertiflora (a C3 species) and Tillandsia latifolia (a CAM species) were grown under controlled conditions via growth chamber over 30 weeks. These subjects were divided into non-stressed and drought stress groups. Subjects were compared for total biomass gained or lost over the time period as well as physiological stress measures and CAM activity. The primary conclusion is that usage of CAM does not show major differences or tradeoffs for overall productivity. Future work is needed to clarify if this holds true …

Utilizing Implementation Science To Systematically Improve Multi-Tiered Systems Of Support (Mtss) Practices, Jessica Ann Sporbert

Theses and Dissertations

The overarching goal of a Multi-Tiered Systems of Support (MTSS) framework is to ensure equitable and high levels of learning for all students. This study utilized two cycles of action research through implementation science to support practices of a North Dakota school district to improve district level alignment, procedures, and practices to improve academic achievement growth. District leadership paired with building leadership to develop a MTSS handbook based on evidence-based practices that could be shared in subsequent years to continue full implementation and continually providesupport for positive changes for their students.

The school district studied was comprised of eleven elementary …

On Design Of Sustainable Additively Manufactured Composite And High Performance Ceramic Structures, Awad E Ahmed Elhassan

Theses and Dissertations

This thesis presents two complementary approaches for developing sustainable engineering materials through additive manufacturing and advanced ceramics. The first study investigates the utilization of recycled wind turbine blade waste as reinforcement in Selective Laser Sintering (SLS) of Nylon 12 composites. Composites containing 5 vol.% resin powder and 4.65 and 18.82 vol.% wind turbine waste were fabricated in both solid and porous configurations, and evaluated for their mechanical, tribological, and surface properties. The results demonstrated that 4.65 vol.% reinforcement provided the optimal balance between mechanical performance and sustainability, while 18.82 vol.% significantly enhanced the wear resistance. The second study focuses on …

Geographic 3d-Digital Preservation Tools And Applications In Heritage Tourism, Ricardo Alejandro Gomez-Nieto

Theses and Dissertations

This thesis is more a micro-case study than usual in historical geography focused on land use change, historic preservation, heritage tourism, and informal education at the Grand Forks County Historical Society Museum Village in Grand Forks, North Dakota. The research questions focused on the interconnections of the relationships among people’slocation value, the reinterpretation of the location through historical lenses, and the sequence occupance of the area. The research methodology was grounded in traditional themes of historical geography and was a mixed methods style of data collection and data analysis. The tools of inquiry emphasized the use of 3D imaging, aerial …

Tribal Reciprocity In Action: Good Medicine For Community & Academia, Keona Marie Manuelito

Theses and Dissertations

The practice of good medicine should be universal and accessible to all; however, for many Indigenous communities, equitable healthcare remains elusive. The historical trauma experienced by Indigenous peoples continues to shape health disparities and institutional mistrust, yet Indigenous communities persist through strength, resilience, sovereignty, and Indigenous knowledge systems. The products that follow embody strengths-based approaches that elevate and support Indigenous science, health, and self-determination. The manuscript identifies key elements necessary to establish the feasibility and institutional support for a peer-reviewed journal centered on Indigenous Health within the United States. A qualitative descriptive study was conducted using semi-structured interviews with journal …

Qualitative Exploration Of Understanding Gluten Intolerance: Knowledge, Experiences, And Perceptions Among American Indian Adults Living On The Mandan, Hidatsa, And Arikara Nation, Roselle M. Martin

Theses and Dissertations

Background: This dissertation examines gluten intolerance, particularly celiac disease (CD), within American Indian communities. Although CD has been traditionally considered more common among people of European descent, emerging evidence suggests increasing rates among American Indian populations as dietary patterns have shifted from traditional, naturally gluten-free foods to diets containing higher levels of gluten. These dietary changes, along with possible genetic factors and historical underdiagnosis, highlight the importance of understanding how gluten-related health concerns are recognized and discussed within American Indian communities. Lower rates of diagnosis may reflect limited awareness of symptoms and challenges in communicating gluten-related health experiences rather than …

Public Good, Politics, And Public Goods: The Social Construction Of Educators In Progressive Era North Dakota, Kevin Joel Read

Theses and Dissertations

This dissertation examines education reforms in North Dakota’s early Nonpartisan League period (circa 1916-1920) by focusing on three policy vignettes located in the local, state, and higher education domains. Together, this dissertation investigates the tensions and nuances of modernizing education in the state including the conditions which created a moment for rapid policy implementation, and the factors which led to that moment ending. The local vignette focuses on housing policy for educators, and the state’s consolidation of education governance into a Board of Administration is explored in the state and higher education chapters. Additionally, the role educators in the state …

Cultural Identification And Preferences In Treatment For American Indian Adults With Substance Use Disorder, Megan Kay Saboo

Theses and Dissertations

Substance use disorders occur at a disproportionately higher rate for American Indian adults in the United States, yet there is a limited understanding of how those in the recovery process perceive their American Indian culture as a meaningful component of their treatment. This study intended to address this gap in the research and to assist with tribal efforts in treating substance use disorder among a small sample of American Indian adults enrolled in a Northern Plains tribe by assessing cultural identification and the importance, contribution, and incorporation of cultural traditions, practices, and ways of living into the recovery process. Results …

Comparison Of Lower-Extremity Coordination Patterns During Countermovement Jumps Between Dancers And Nondancers, Danielle Joseph

Honors Theses

Jumping is a skill essential to several different sports, including dance. For athletes in jump-dominant sports, jump strategies can vary with differences in task demands while jump performances are similar. The countermovement jump (CMJ) has been utilized to analyze jumps because of their reliable indications of power and neuromuscular function. Methods of describing jump strategies using CMJ, such as force plate metrics, vector coding analysis, and coordination phases, have been used to describe the jumps of athletes in jump dominant sports such as basketball and volleyball. However, less jump strategy research has been done on dancers, especially to describe the …

Cae-If: An Anomaly Detection Approach Based On Temporal Representation Of The Reconstruction Error, Haijun Geng, Zhi Zhang, Yuhua Qian, Bo Yang, Qi Ma, Haotian Chi, Jing Yang, Xia Yin

Faculty Research, Scholarly, and Creative Activity

In the field of network traffic anomaly detection, unsupervised learning plays a critical role yet encounters significant challenges, including accurately determining anomaly thresholds and modeling the intricate temporal dynamics of network traffic. To address these challenges, we present a novel approach, termed Convolutional Autoencoder-Isolation Forest (CAE-IF). By leveraging packet-level reconstruction errors with contextual information, our approach obviates the need for manual threshold setting and effectively captures temporal dynamics. The process commences with the application of the damped incremental statistics algorithm to extract statistical features from network traffic with temporal information. Subsequently, the Convolutional Autoencoder (CAE) is employed to compute the …

A Mixed Methods Study: Exploring The Concept Of Rematriation Through The Work Of Indigenous Doulas In New Mexico, Michelle Gutiérrez

Theses and Dissertations

Both the United States and New Mexico are facing a maternal health crisis. Despite significant resources and medical advances, Indigenous mothers continue to be impacted by health disparities. This research study explored the concept of Rematriation, most simply defined, as a return to a traditional and spiritual way of life with respect to Mother Earth or the Land, through the work of certified Indigenous birth doulas in New Mexico. Using a mixed methods approach that integrated a survey, body mapping, and interviews with 10 self-identified Indigenous doulas, this research sought insights and knowledge on their experiences and practices in birthwork, …

Gender Perceptions Of Occupational Therapy Students And The Impact On Academic Experience, John Brian Leclerc

Theses and Dissertations

Since its inception in 1917, the field of occupational therapy has maintained a pronounced gender imbalance, with females comprising the vast majority of practitioners despite major historical shifts in healthcare delivery. This dissertation examines how occupational therapist (OT) and occupational therapy assistant (OTA) students perceive gender and how these perceptions influence their academic experiences and future professional roles.

Using a multi-study design, this dissertation integrates qualitative and quantitative approaches across three articles. In article 1, focus groups were employed with doctoral OT students (N=30) and revealed five central themes: the value of gender diversity for learning, a nurturing and supportive …

Improving Health Literacy In Diagnostic Imaging For Indigenous Populations: Evaluating Practices, Integrating Policy, And Bridging Gaps, Kimberly Harn

Theses and Dissertations

Indigenous populations in the United States and internationally experience persistent disparities in healthcare access, patient communication, and health outcomes, including disproportionate cancer mortality rates and inequitable engagement with diagnostic imaging services. Communication barriers, limited health literacy, historical trauma, cultural incongruence, and structural inequities reduce meaningful participation in imaging-related care and contribute to delayed diagnosis and poorer outcomes. Despite the critical role of diagnostic imaging in disease detection and clinical management, the intersection of Indigenous health, health literacy, patient communication, and cultural safety within diagnostic imaging contexts remains substantially understudied.

This applied dissertation addresses that gap through three integrated scholarly products …