Digital Commons Network^™

Exploring Traditional Breast Cancer Risk Genes Among Aboriginal And Torres Strait Islander Women, Katie Meehan, Leanne Pilkington, Azim Khan, Nicholas Pachter, Lisa Spalding, Ayeisha Milligan Armstrong, Cameron Redfern, Andrew Redfern

Research outputs 2022 to 2026

Background: Germline pathogenic variants in BRCA1/2 increase breast and ovarian cancer risk, but their prevalence in Aboriginal and Torres Strait Islander (herein referred to as Aboriginal) families has never been studied. Consequently, their contribution to breast cancer in this population is unknown.

Methods: This retrospective cohort study included 259 Aboriginal women and 789 age- and remoteness-matched non-Aboriginal women diagnosed with breast cancer (2001–2016). We assessed family history, genetic service referral and testing rates, and pathogenic variant rates in the context of testing access.

Results: Family history data were available for more Aboriginal than non-Aboriginal cases (46% vs. 34%, p < 0.001), with no difference in reported first-degree relatives with breast (22.5% vs. 22.4%, p = 0.98) or ovarian cancer (4.2% vs. 2.2%, p = 0.29). Similar proportions were referred to genetic services for testing eligibility (5.4% vs. 7.2%, p = 0.392). Of those referred, similar proportions were offered testing (86% vs. 81%, p = 0.66). Across the full cohort, BRCA1/2 pathogenic variants were detected in 0.77% of Aboriginal versus 2.4% of non-Aboriginal women (p = 0.127); any pathogenic gene variant was detected in 0.77% versus 3.0% (p = 0.039).

Conclusions: …

Gut Microbiome Changes In Preclinical Alzheimer’S Disease, D. M. Sithara Dissanayaka, Stephanie R. Rainey-Smith, Hamid R. Sohrabi, Thilini N. Jayasinghe, Vincent Ho, Vijay Jayasena, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W. M.A.D.Binosha Fernando

Research outputs 2022 to 2026

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that develops many years before clinical symptoms appear. The biological changes involved in the earliest stages remain poorly understood, particularly during the preclinical stage. Our previous work has identified gradual gut microbial and metabolic changes during this stage, suggesting these may represent early biological shifts that precede disease progression. Recent studies suggest that the gut microbiome may contribute to early AD processes through its effects on immune regulation, metabolism, and gut–brain communication. Changes in gut microbial composition, including reduced levels of short-chain fatty acid (SCFA)-producing bacteria, such as Faecalibacterium, Roseburia, and Eubacterium, …

Comparison Of Lower-Extremity Coordination Patterns During Countermovement Jumps Between Dancers And Nondancers, Danielle Joseph

Honors Theses

Jumping is a skill essential to several different sports, including dance. For athletes in jump-dominant sports, jump strategies can vary with differences in task demands while jump performances are similar. The countermovement jump (CMJ) has been utilized to analyze jumps because of their reliable indications of power and neuromuscular function. Methods of describing jump strategies using CMJ, such as force plate metrics, vector coding analysis, and coordination phases, have been used to describe the jumps of athletes in jump dominant sports such as basketball and volleyball. However, less jump strategy research has been done on dancers, especially to describe the …

Patients’ And Carers’ Experiences Of The Postoperative Care Pathway Following Coronary Artery Bypass Grafting: A Descriptive Qualitative Study, Dima Nasrawi, Sharon Latimer, Debbie Massey, Brigid M. Gillespie

Research outputs 2022 to 2026

Aim: This study aimed to understand patients’ and carers’ experiences of the inpatient postoperative care pathway during Phase 1 cardiac rehabilitation, including patients’ recommendations to improve its delivery, their engagement, and discharge preparation.

Methods: This was a descriptive qualitative study. Recruitment occurred over 1 month (February to March 2023) in a cardiac surgical ward at a large tertiary hospital. Adult patients who had recently undergone coronary artery bypass grafting and their carers were interviewed. Inductive content analysis was used to analyse interviews.

Results: Nine patients and five carers were interviewed. Patients were mainly male (n=8), while carers were mostly female …

Right-Sized Glycolysis In Growing Children: A Muscle Mass-Based Scaling Perspective, Sébastien Ratel, Joffrey Bardin, Anthony J. Blazevich

Research outputs 2022 to 2026

No abstract provided.

Safety And Effectiveness Of Behavioural Activation For Chronic Pain: A Protocol For A Systematic Review And Meta-Analysis Of Randomised Controlled Trials, Fangyuan Zheng, Laura Hynes, Richard J. Gray, Irene Ngune, Jacqueline Sin, Martin Jones

Research outputs 2022 to 2026

Background/Objectives: Chronic pain is a prevalent and complex condition associated with substantial physical, psychological, and social burden. Behavioural activation (BA), a structured psychological intervention originally developed for depression, may be relevant to chronic pain through its focus on reducing behavioural avoidance and increasing engagement in meaningful activities. Although BA has been applied in studies involving people with chronic pain, the safety and effectiveness of BA in this population have not been comprehensively synthesised. This systematic review and meta-analysis will examine the safety and effectiveness of BA for people with chronic pain.

The Massbank Contributions Of The Mfam Collaboration, Anusha Ahlendorf, Asaph Aharoni, Khabat Vahabi, Tillmann G. Fischer, Pierre Marie Allard, Megan Augustin, Ulschan Bathe, David Broadhurst, Corey Broeckling, Joerg Buescher, Adrian Covaci, Katyeny Manuela Da Silva, Ric C.H. De Vos, Micha Gracianna Devi, Stefanie Döll, Maximilian Frey, Andrej Frolov, Emmanuel Gaquerel, Vasuk Gautam, Esteban Charria-Girón, Alain Goossens, Jeremy Grosjean, Maria Halabalaki, Elias Iturrospe, Kim Kultima, Stephanie Herman, Toni M. Kutchan, Romain Larbat, René Meier, Eleni V. Mikropoulou, Gregory Mouille, Luca Nicolotti, Nir Shahaf, François Perreau, Pierre Pétriacq, Michael Reichelt, Stacey N. Reinke, Rani Robeyns, Alena Soboleva, Otmar Spring, Akshai Parakkal Sreenivasan, Alain Tissier, Jean Chrisologue Totozafy, Hiroshi Tsugawa, Josep Valls-Fonayet, Maria Van De Lavoir, Justin J.J. Van Der Hooft, Fredd Vergara, David Wishart, Ludger A. Wessjohann, Jean-Luc Wolfender, Jörg Ziegler, Gerd Ulrich Balcke, Steffen Neumann

Research outputs 2022 to 2026

Introduction: The analysis of metabolic profiles using high resolution mass spectrometry (MS) data provides deep insights into biological processes. In metabolomics, MS analysis generates a large number of features that represent metabolites. However, identifying specific metabolites from these features can be challenging. One of the major bottlenecks in the metabolomics field is the identification of MS features, which is a prerequisite for any biochemical interpretation. By identifying similarities and differences within a metabolite family (mFam), evaluating MS features at the metabolite family level can help assigning functional roles to individual MS features. These data can help interpreting metabolic pathways and …

The Reliability And Validity Of Manual Palpation To Assess Lower Limb Arterial Occlusion Pressure In Older Adults, For Application In Blood Flow Restriction Exercise, Michael Beere, Isaac Selva Raj, Jeremiah J. Peiffer, Keith D. Hill, Peter K. Edwards, Belinda Brown, Brendan R. Scott

Research outputs 2022 to 2026

(A) Investigate test-retest reliability of posterior tibial pulse palpation to determine arterial occlusion pressure (AOP) and examine validity against hand-held Doppler ultrasound. (B) Investigate the suitability of using 130% systolic brachial blood pressure for prescribing cuff inflation pressure for blood flow restriction (BFR) exercise. Repeated measures, crossover design. Lower limb AOP was assessed in 20 adults ≥ 60 years using hand-held Doppler ultrasound and posterior tibial pulse palpation. Brachial systolic blood pressure (bSBP) was measured to predict cuff inflation pressures (bSBP130%). On three occasions > 24 hours apart, three AOP measurements were recorded by the same blinded rater to determine intra-rater …

What Is Left After Memory: Love, The Body, And The Unconscious In Little Fish, Paul Longley Arthur, Isabel Smith

Research outputs 2022 to 2026

Chad Hartigan’s science fiction romantic drama Little Fish was released in 2020, soon after the start of the COVID-19 pandemic. However, the disease plaguing communities in Little Fish is not affecting people’s bodies but their minds—those who have contracted Neuroinflammatory Affliction (NIA) are losing their memories. The story centres upon the experiences of one young couple as they anxiously witness the disease take hold of their community, loved ones, and eventually one another. The film explores relationships between memory and identity, and poses questions about the ways these processes interact with those of love and loss. Who are we once …

Assessing And Correcting Bias In Gridded Reference Evapotranspiration Over Agricultural Lands Across The Contiguous United States, John M. Volk, Christian Dunkerly, Justin L. Huntington, Blake A. Minor, Yeonuk Kim, Charles G. Morton, Peter Revelle, Ayse Kilic, Forrest Melton, Richard G. Allen, Christopher Pearson, Adam J. Purdy, Todd G. Caldwell

AES Faculty Publications and Presentations

Gridded reference evapotranspiration (ET_o) data are widely used for agricultural water management and remote sensing evapotranspiration (RSET) models, but biases can arise where coarse meteorological inputs fail to capture agricultural microclimates. We investigated biases in the gridMET ET_o product across irrigated agricultural areas of the contiguous United States using ET_o calculated from 793 agricultural weather stations, then used those stations to develop monthly correction surfaces. Results show that gridMET systematically overestimates ET_o by 10–20% at most cropland sites, while pockets of underestimation appear in some arid western regions, primarily due to wind speed bias. Wind …

Entangled Practice: Living Regenerative Creative Practice, Angie Richard

Postgraduate

This exegesis asks how regenerative creative practice can be explored and illustrated through lived experience. The inquiry is situated inside the hand construction of a twelve-metre Polynesian-inspired catamaran in a boatyard in Brittany, France, built by the author, her husband and a growing volunteer community through the non-profit, the Floating Stories Lab. Conducted through Creative Practice Research and an autoethnographic method, the exegesis treats the build itself as a site of inquiry. It follows writers who frame research as a living relationship to be grown with, sustained past the point any single project would call ‘finished’.

The Living Framework, the …

Multi-Dimensional Framework For Industry 5.0: Integrating Human-Centric, Sustainability, And Operational Resilience, Tamer Adel Mohamed, Mohamed Boumalkha, Ahmed S.I. Amar

Mechanical Engineering

Industry 5.0 reframes digital transformation as a socio-technical endeavor in which automation serves human capabilities, environmental limits, and operational continuity. Yet, much of the current discourse remains either conceptual—lacking implementable metrics—or technologycentric— treating humans and sustainability as constraints instead of design objectives. This paper develops a multi-dimensional implementation framework that operationalizes the three pillars of Industry 5.0: human-centricity, sustainability, and operational resilience. We synthesize recent advances in collaborative robotics and safety-aware human–robot collaboration, digital twins (including human and supply-chain twins), and AI-driven decision support—augmented by emerging 6G ultra-reliable low-latency networking capabilities such as reconfigurable intelligent surfaces, terahertz communications, multi-access edge …

The Startup: Critical Perspectives On Technology Entrepreneurship And Digital Labor, Kochav Koren

All Duquesne Faculty Scholarship

Communication and media studies are rapidly reshaped by socio-technological forces within the framework of informational capitalism, where startups emerge as key drivers of the global creative economy. This study critically examines the global startup movement through political economy, classical sociology, and Southern perspectives to assess whether digital entrepreneurship fosters genuine, decentralized innovation or perpetuates speculative financialization and labor precarity. Employing a multi-layered theoretical framework—including Schumpeterian creative destruction, Marxist commodity fetishism, and Weberian charismatic authority—and qualitative fieldwork across North and Latin American tech hubs, the analysis reveals startups as network enterprises that both disrupt markets and reproduce structural inequalities. The findings …

Using Photovoice And Life Course Theory To Understand The Lived Experiences Of Filipino Teenage Parents, Nina Linly D. Capulong, Liane Peña Alampay, Bernice Landoy Mamauag, Jennel Drezza Fe C. Reyes

Psychology Department Faculty Publications

Teenage parents face the unique challenge of simultaneously navigating adolescence and parenthood. Rising adolescent pregnancy rates in the Philippines necessitate urgent efforts to better understand and support them. Using Photovoice, Filipino teenage parents captured their lived experiences through photographs, resulting in eight themes: (1) Managing stresses and conflicts in partner relationships, (2) Peers as a source of emotional support, (3) Support and strain in family relationships, (4) Shifts in normative adolescent experiences and priorities, (5) Strain and agency in balancing roles, (6) Desire to enhance parenting knowledge and skills, (7) Environmental drivers of early sexual exposure, (8) Sexual knowledge from …

The Misinterpretation Of “Corporation” In Indonesia’S Penal Code No. 1 Of 2023: Ensuring Legal Certainty For Recognized Corporate Forms, Rizaldy Alif Syahrial

Indonesia Law Review

Abstract

Law No. 1 of 2023 on the Indonesian Penal Code expands criminal liability to include entities that do not possess legal personality, allowing informal entities such as commanditaire vennootschappen (CV), partnerships (firm), unincorporated business groups, and unregistered associations to be prosecuted as corporations. This expansion aims to close legal loopholes in addressing modern criminal activity and to align Indonesia with global developments in corporate criminal liability. However, extending criminal liability to non legal persons generates conceptual tension because Indonesian legal doctrine distinguishes between natural persons and legal persons, which possess legal personality, decision making organs, separate assets, and autonomous …

The Augmented Matching Law, Matias A. Avellaneda

All Graduate Theses and Dissertations, Fall 2023 to Present

Every living organism, including humans, has a finite amount of time available: 24 hours in a day, 365 days in a year, and a certain number of years in its life. At every moment, such an organism will be engaging in one of a multitude of possible activities, such as eating, sleeping, or reading this dissertation. We use the term choice to denote the way in which the organism distributes its time among all these activities, and some of these choice patterns are more beneficial to the organism than others, showcasing the importance of understanding the mechanisms underlying choice. A …

Cash, Cleats, And Carpools: A Multi-Method Investigation Of Resource Allocation In Families With Youth Athletes, Emily Susan Delisle

All Graduate Theses and Dissertations, Fall 2023 to Present

The current thesis is an investigation of time and financial resource allocation in families with youth athletes. Study 1 used a survey questionnaire to explore how the number of athletes in a family impacted the way parents allocated time and financial resources to their oldest child’s youth sport participation. Results indicate that an increase in the number of athletes in a family does not decrease parents’ time or financial commitments to their oldest child’s youth sport participation. Study 2 used interviews to explore how nine parents with multiple athletes experienced the intersecting demands of time, finances, and family life while …

"In Any Other Circumstance I Am Not In Work Mode. I Am Clocked Out": Chappell Roan And The Objectified Persona, Aubry Louise

All Graduate Theses and Dissertations, Fall 2023 to Present

It is known that celebrities have influence on their audience’s attitudes and behaviors. Within the last few decades, multiple celebrities have created distinctions between their public/stage self and their private self, however, less is known about the ways that they differentiate between the two. This paper looks at celebrity public persona’s and how these persona’s influence their audience. I use Kayleigh Amstutz, otherwise known as Chappell Roan, as my case study. This thesis offers an analysis of how Amstutz talks about Kayleigh differently than Chappell within social media posts, interviews, and commentary from media outlets. I use the concepts of …

Experimental And Numerical Investigation Of Flow Coefficients In Three-Way, T-Port, Ball Valve, Tyler A. Mindrum

All Graduate Theses and Dissertations, Fall 2023 to Present

Many systems that move fluids, like water distribution networks and heating, ventilation, and air conditioning (HVAC) systems, rely on valves to control flow. This study evaluates a three-way valve, which can direct flow in multiple directions, but has not been extensively researched. Testing included physical data collection and computer simulations to compare how the valves behaved under different valve openings and flow conditions. The results showed that computer simulations can predict the general flow behavior of three-way valves, but that physical testing is still important, especially for valves with complex internal geometries.

Llm-As-A-Judge For Software Engineering: Literature Review, Vision, And The Road Ahead, Junda He, Jieke Shi, Terry Yue Zhuo, Christoph Treude, Jiamou Sun, Zhenchang Xing, Xiaoning Du, David Lo

Research Collection School Of Computing and Information Systems

The rapid integration of Large Language Models (LLMs) into software engineering (SE) has revolutionized tasks from code generation to program repair, producing a massive volume of software artifacts. This surge in automated creation has exposed a critical bottleneck: the lack of scalable and reliable methods to evaluate the quality of these outputs. Human evaluation, while effective, is very costly and time-consuming. Traditional automated metrics like BLEU rely on high-quality references and struggle to capture nuanced aspects of software quality, such as readability and usefulness. In response, the LLM-as-a-Judge paradigm, which employs LLMs for automated evaluation, has emerged. This approach leverages …

The Relationship Between Maintenance And Overhaul Employee Spending, Business Model, Geographic Region, And The Financial Performance Of Commercial Airlines, Naumaan Khalid Sheikh

Walden Dissertations and Doctoral Studies

After nearly 5 decades of deregulation, commercial airline leaders still lack the capability to improve financial performance by structuring their maintenance operations to gain competitive advantages in highly competitive global markets. Without an effective strategy, airline maintenance affects service and financial performance. Framed with Porter’s competitive advantage theory, this quantitative nonexperimental correlational project was to examine the relationships between airline in-house maintenance and overhaul employee spending, business model, geographic region, and financial performance of global commercial full-service carrier (FSC) and low-cost carrier (LCC) airlines. Longitudinal panel data were collected from 121 LCCs and FSCs operating from 2001 to 2019 in …

Exploring The Experiences Of Teacher Assistants Who Remain In A Rural Michigan Head Start Program, Melissa Thiebaut

Walden Dissertations and Doctoral Studies

The problem addressed in this study was the approximately 35% attrition rate of teacher assistants (TAs) in a rural Head Start program. Grounded in Bakker’s job resources and job demands theory, the purpose of this basic qualitative study was to explore the experiences of TAs who chose to remain working in a rural Head Start program and the factors that influenced their decisions to stay. Data were collected by conducting semistructured interviews with 12 TAs from one Head Start program. Data analysis involved a deductive data analysis method with two categories, job resources and job demands, being predetermined by the …

Measuring Health System Readiness In Saint Lucia Using International Health Regulations Capacity Indicators, Melissa Steele

Walden Dissertations and Doctoral Studies

Emerging infectious diseases continue to challenge national health systems, particularly in small island developing states with limited preparedness resources. Limited evidence comparing the International Health Regulations (2005) State Party Self-Assessment Annual Reporting (IHR SPAR) capacities of small island developing states with those of high-income countries limits efforts to identify preparedness gaps and strengthen health systems. The purpose of this quantitative comparative study was to evaluate Saint Lucia's preparedness using IHR SPAR indicators, compare its preparedness with the United States, and assess changes between 2023 and 2024. Guided by the World Health Organization Health System Framework, a quantitative cross-sectional design using …

Staff Education To Improve Provider Knowledge Of Marijuana Use And Mental Health In A Community Mental Health Setting, Kalubi Florence Muganguzi

Walden Dissertations and Doctoral Studies

This staff education doctoral project addressed a practice gap in provider knowledge, confidence, and consistency when assessing, educating, and documenting marijuana use among patients receiving mental health services. The practice-focused question was the following: For staff in a community mental health setting, does a structured staff education intervention on marijuana use and mental health improve knowledge and confidence related to assessment, patient education, documentation, and psychotropic treatment monitoring? The purpose was to translate current evidence into a practical education session, screening guidance, patient counseling points, and documentation prompts. The evidence base included 10 peer-reviewed articles addressing cannabis use, mental health …

Efficient Test-Time Retrieval Augmented Generation, Hailong Yin, Bin Zhu, Jingjing Chen, Chong-Wah Ngo

Research Collection School Of Computing and Information Systems

Although Large Language Models (LLMs) demonstrate significant capabilities, their reliance on parametric knowledge often leads to inaccuracies. Retrieval Augmented Generation (RAG) mitigates this by incorporating external knowledge, but these methods may introduce irrelevant retrieved documents, leading to inaccurate responses. While the integration methods filter out incorrect answers from multiple responses, but lack external knowledge like RAG methods, and their high costs require balancing overhead with performance gains. To address these issues, we propose an Efficient Test-Time Retrieval-Augmented Generation Framework named ET2RAG to improve the performance of LLMs while maintaining efficiency. Specifically, ET2RAG is a training-free method, that first retrieves the …

Continuous Query For Top-K Maximal Sum Intervals Over Streaming Data, Zhongshuai Zhang, Xiaochun Yang, Baihua Zheng, Rui Zhu, Haomin Li, Bin Wang

Research Collection School Of Computing and Information Systems

The continuous identification of top-k maximal sum intervals using a sliding window over a data stream is a critical operation for applications in IoT and beyond. A maximal sum interval is a non-overlapping, contiguous subsequence with the maximal sum in a sequence of signed values. Existing algorithms are ill-suited for streaming contexts: they either exhaustively enumerate all intervals even for small k values, or depend on indexes that require frequent and costly restructuring. We propose a novel partition-based strategy. Our core insight is a partitioning scheme that guarantees that any maximal sum interval is fully contained within a single partition, …

Success Of New Ideas In Online Platforms: An Idea Network Perspective, Yimei Zhou, Qian Tang, Vincent Z.W. Mack Mack, Shao Yi Liaw

Research Collection School Of Computing and Information Systems

On online platforms, new ideas often emerge by recombining existing ones within idea networks. Unlike traditional knowledge networks, idea networks represent curated, meaning-based associations among ideas, offering a distinct lens on recombination. Drawing upon a hypergraph perspective, we investigate how new idea success depends on their structural and content attributes, and how collaborative participation shapes these attributes. Using data from an ideation platform, we find that both structural embeddedness and bridging benefit new idea success. Content diversity has no direct effect, but it amplifies the benefits of bridging while constraining those of embeddedness. Both crowd contributions and ideator expertise strengthen …

Final Master's Portfolio On Writing Transfer, Clarence Snell

Master of Arts in English Plan II Graduate Projects

This final portfolio shows how gauging student interest can help to transfer their knowledge from subject to subject, whether it be by using Resident Evil to help with ethics or creative writing to help with grammar. The first essay goes into detail on the ethics of Resident Evil: The Official Strategy Guide, written for the original 1996 game. It elaborates on the guide and the game itself, using framing systems like that of Kant to gain a deeper understanding of the source material. Then, the second essay explains how creative writing can help students learn grammar, showing how both …

A Practical Guide To Science Writing & Publishing, Ryan W. Mcewan

Department of Biology Open Educational Resources

This document contains advice that I developed for students working in my research lab and represents an approach to science writing that is in some ways very basic, and in others, quite idiosyncratic.

Writing is a creative process and as you advance as a science writer you will get stronger, and stronger, and you will develop your own process. At some point, someone might give you different advice about science writing than what you find here. If you join a research lab your PI might have their own program. You should absorb all of the good advice you can find. …

At Risk Students: Ensuring A Successful Transition Into High School, Angela Espada

Education Theses and Dissertations

This Improvement Science Dissertation in Practice concentrated on the persistent problem of freshman course failure at a large, diverse, Title I high school serving a military-connected community in Central Texas. Although intervention programs existed, an increasing number of ninth-grade students were consistently failing one or more courses during their first year of high school, which revealed several gaps in the campus’s system of support. The Improvement Science framework and two Plan-Do-Study-Act (PDSA) cycles were used to examine the factors contributing to freshman course failure and to assess the interventions implemented to improve academic success as students transitioned into high school. …