Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 8011 - 8040 of 1737700

Full-Text Articles in Entire DC Network

Dosimetric Comparison Of Hybrid 3d Conformal Radiation Therapy And Volumetric Modulated Arc Therapy Versus Vmat-Only Planning For Accelerated Partial Breast Irradiation, Erjona Jusufi Aug 2026

Dosimetric Comparison Of Hybrid 3d Conformal Radiation Therapy And Volumetric Modulated Arc Therapy Versus Vmat-Only Planning For Accelerated Partial Breast Irradiation, Erjona Jusufi

Masters Projects

Abstract

Purpose: To compare dosimetric outcomes between volumetric modulated arc therapy (VMAT)-only and hybrid VMAT plus three-dimensional conformal radiotherapy (3D-CRT) techniques for accelerated partial breast irradiation (APBI) in patients with early-stage left-sided breast cancer.

Methods and Materials: Thirty patients treated with APBI at a single institution were retrospectively replanned using both VMAT-only and hybrid (VMAT + 3D-CRT) techniques. All plans were prescribed 26 Gy in 5 fractions. Each patient was planned using the same target volumes, optimization objectives, and evaluation criteria for both techniques. Planning target volume (PTV) coverage, conformity index (CI), homogeneity index (HI), hotspot control, organ-at-risk (OAR) doses, …


Info 7001: Technology Of Information, S E. Hackney Aug 2026

Info 7001: Technology Of Information, S E. Hackney

Open Educational Resources

BULLETIN DESCRIPTION INFO 7001. The Technology of Information. 3 hr.; 3cr. The course will introduce the conceptual and practical elements of visual and computer literacy for the library and information science profession. Particular attention will be paid to libraries and information centers.

EXPANDED COURSE DESCRIPTION The evolution into the age of information has created a requirement that professional librarians establish and steadily increase their understanding of four areas of literacy: oral, print, visual, and technology. Professional training has long been concentrated on the oral and printed aspects of information with some minor attention to the visual and technological. Library and …


Staff Education To Reduce Stress In Assisted Living Nursing Staff, Cherechi Onyenso Aug 2026

Staff Education To Reduce Stress In Assisted Living Nursing Staff, Cherechi Onyenso

Walden Dissertations and Doctoral Studies

In this staff education doctor of nursing practice (DNP) project, I addressed a practice gap associated with inadequate staff knowledge of workplace stress-management strategies in an assisted living facility. Workplace stress in nursing practice is a contributing factor to burnout, reduced job satisfaction, poor teamwork, and a decline in the quality of resident care. The practice-focused question for this project was about whether staff knowledge would be enhanced over an 8-week period in comparison to baseline knowledge as a result of their participation in a structured staff education program on workplace stress management. The purpose of the project was to …


Staff Education To Improve Staff Knowledge, Confidence, And Intent To Consistently Implement Medication-Assisted Treatment, Matilda Boachie Aug 2026

Staff Education To Improve Staff Knowledge, Confidence, And Intent To Consistently Implement Medication-Assisted Treatment, Matilda Boachie

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice staff education project addressed inconsistent medication-assisted treatment (MAT) implementation in a masked crisis stabilization unit. MAT was available, but staff education was informal and inconsistent, contributing to variation in knowledge, confidence, patient education, documentation, and discharge planning. The practice-focused question that was answered through this project was whether structured staff education would improve knowledge, confidence, and intent to consistently implement MAT. The purpose was to develop, implement, and evaluate structured education for interdisciplinary staff. De-identified pre- and post-education surveys were analyzed with descriptive statistics, and aggregate averages were compared because individual surveys were not matched. …


Staff Education To Standardize Chronic Pain Patient Education In Primary Care, Jessica Okpara Aug 2026

Staff Education To Standardize Chronic Pain Patient Education In Primary Care, Jessica Okpara

Walden Dissertations and Doctoral Studies

Inconsistent delivery and documentation of chronic pain patient education may contribute to variations in patient knowledge, treatment expectations, and engagement in self-management. This Doctor of Nursing Practice staff education and quality improvement project was designed to standardize chronic pain patient education in a primary care setting. The practice-focused question examined whether implementing standardized chronic pain education, compared with non-standardized education, would improve patient knowledge and use of self-management strategies over 10 weeks. Guided by the Johns Hopkins Evidence-Based Practice Model, the project included development of evidence-based education materials, staff preparation, workflow integration, and a standardized documentation process. Clinic staff identified …


Improving Glycemic Control And Self-Care Among Adult Patients With Type 2 Diabetes Mellitus At A Community Health Center, Lydia Asabea Lartey Aug 2026

Improving Glycemic Control And Self-Care Among Adult Patients With Type 2 Diabetes Mellitus At A Community Health Center, Lydia Asabea Lartey

Walden Dissertations and Doctoral Studies

Type 2 diabetes mellitus (T2DM) is a significant practice concern in community health settings, where adults often encounter barriers to effective self-management, including low health literacy, socioeconomic challenges, and limited access to Diabetes Self-Management Education and Support (DSMES). At the project site, inconsistent staff preparation, high patient volume, and limited standardized teaching resources contributed to gaps between evidence-based standards and routine diabetes education. To address these gaps, the project implemented a standardized, culturally responsive diabetes-education workflow to strengthen care quality, patient safety, and responsible resource use. The practice question guiding the project was: How does implementing a standardized, culturally responsive …


Reducing Nurse Burnout, Oluwarotimi Tunde Aborisade Aug 2026

Reducing Nurse Burnout, Oluwarotimi Tunde Aborisade

Walden Dissertations and Doctoral Studies

Nurse burnout is a severe job-related condition that significantly impacts nurses' well-being. Nurse burnout is a growing concern amid the increased demand for healthcare professionals. Research has been conducted to explore nurse burnout and how it affects the quality and safety of patients. Different research has also been conducted to review different interventions to address nurse burnout, including individual and organizational interventions. Some interventions include self-care, mindfulness and meditation, coping and resilience, as well as lifestyle adjustments. Some organizational interventions include workload management, psychological safety, and job redesign. This study was conducted to evaluate the effectiveness of individual interventions to …


An Interprofessional Organization Change Process To Reduce Catheter-Associated Urinary Tract Infections, Bolatito Owolabi Aug 2026

An Interprofessional Organization Change Process To Reduce Catheter-Associated Urinary Tract Infections, Bolatito Owolabi

Walden Dissertations and Doctoral Studies

This organization change process initiative addressed a critical safety practice gap regarding catheter-associated urinary tract infection (CAUTI) prevention in a 450-bed acute care facility. This gap was recognized based on evidence that the facility’s CAUTI Standardized Infection Ratio (SIR) was above the national benchmark—and daily necessity assessment compliance of only approximately 50%. This gap was attributed to an organizational interprofessional culture, which hindered timely device removal. Prolonged catheter dwell times increase patient morbidity, extend hospital stays, and expose the organization to severe financial penalties. The project aimed to safely reduce device dwell times by structurally empowering bedside nurses. I used …


Effective Strategies To Implement Energy-Efficient Practices In Enterprise Cloud Data Centers: A Qualitative Pragmatic Inquiry, Joshua Tremayne Campbell Aug 2026

Effective Strategies To Implement Energy-Efficient Practices In Enterprise Cloud Data Centers: A Qualitative Pragmatic Inquiry, Joshua Tremayne Campbell

Walden Dissertations and Doctoral Studies

Cloud computing has increased electricity use in data centers, leading to higher costs and a larger carbon footprint. Information Technology (IT) leaders need to address this, as such inefficiencies will increase operational costs, undermine sustainability commitments, and leave companies unprepared for future regulatory pressures. Energy-efficient technologies can reduce data center energy consumption by 40-60%, yet few studies examine the qualitative processes behind IT leaders' practices. The specific IT problem is that some IT leaders lack effective strategies to implement energy-efficient practices in enterprise cloud data centers. Grounded in the technology-organization-environment (TOE) framework, the purpose of this qualitative pragmatic inquiry was …


Comparing Non-Invasive Survey Methods For Southern Flying Squirrels (Glaucomys Volans) At The Western Edge Of Their Range, Jay E. Winfield, Jeremy A. White Aug 2026

Comparing Non-Invasive Survey Methods For Southern Flying Squirrels (Glaucomys Volans) At The Western Edge Of Their Range, Jay E. Winfield, Jeremy A. White

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

The southern flying squirrel (Glaucomys volans) is a threatened species in Nebraska that occurs along the Missouri River in the southeastern corner of the state. Recently, a population was discovered in the city of Lincoln, but it is unknown whether this population represents a natural range expansion from the Missouri River population or whether it is isolated and results from a human-assisted movement. A survey of southern flying squirrels in Nebraska is needed, but surveys of this elusive species are challenging. This study investigated and compared two noninvasive survey techniques for rapid detection of flying squirrels: acoustic detectors …


Sustaining Clabsi Prevention Through Central Line Bundle Compliance: A Focus On Iv Tubing Labeling, Visual Cues And Peer Support, See Elizabeth Vang Aug 2026

Sustaining Clabsi Prevention Through Central Line Bundle Compliance: A Focus On Iv Tubing Labeling, Visual Cues And Peer Support, See Elizabeth Vang

Master's Projects and Capstones

Abstract  

Problem: Inconsistent IV tubing labeling compliance on a telemetry unit was identified as a gap in central line maintenance practices that could affect adherence to the CLABSI prevention bundle.

Intervention: A quality improvement project reinforced existing IV tubing labeling practices through a visual job aid, staff education, and peer verification during Nursing Knowledge Exchange (NKE) bedside handoff.

Outcome Measure: The primary outcome measure was IV tubing labeling compliance, with a goal of increasing compliance from 86.5% to at least 95% on 24 bed Telemetry unit.

Results: The project did not achieve the desired improvement in compliance. Multiple concurrent quality …


Institute For Global Health And Development : Issue 14 - April-June 2026, Institute For Global Health And Development Aug 2026

Institute For Global Health And Development : Issue 14 - April-June 2026, Institute For Global Health And Development

IGHD Newsletters

  • Honours & Recognition
  • Research & Publications
  • In the Media
  • Events & Convenings
  • Training, Projects & Field Work
  • People & Milestones
  • Research Highlights & Knowledge Contributions
  • Publications from IGHD
  • Stay Connected


An Interdisciplinary Approach To Sampling Hard Rock Cores Of The Oceanic Crust For Microbiological And Biogeochemical Research, William J. Brazelton, Oscar Cavazos, Jordyn A. Robare, Gordon Southam, Johanna Suhonen, Fengping Wang, Susan Q. Lang, Andrew Mccaig, Peter Blum, Natsue Abe, Remi Coltat, Jeremy R. Deans, Kristin L. Dickerson, Marguerite Godard, Barbara E. John, Frieder Klein, Rebecca Kuehn, Kuan-Yu Lin, C. Johan Lissenberg, Haiyang Liu, Ethan L. Lopes, Toshio Nozaka, Andrew J. Parsons, Vamdev Pathak, Mark K. Reagan, C. Geoffrey Wheat Aug 2026

An Interdisciplinary Approach To Sampling Hard Rock Cores Of The Oceanic Crust For Microbiological And Biogeochemical Research, William J. Brazelton, Oscar Cavazos, Jordyn A. Robare, Gordon Southam, Johanna Suhonen, Fengping Wang, Susan Q. Lang, Andrew Mccaig, Peter Blum, Natsue Abe, Remi Coltat, Jeremy R. Deans, Kristin L. Dickerson, Marguerite Godard, Barbara E. John, Frieder Klein, Rebecca Kuehn, Kuan-Yu Lin, C. Johan Lissenberg, Haiyang Liu, Ethan L. Lopes, Toshio Nozaka, Andrew J. Parsons, Vamdev Pathak, Mark K. Reagan, C. Geoffrey Wheat

School of Geography, Earth and Environmental Sciences

Studying life in the deep, rocky subseafloor involves many layers of technological and methodological challenges, and each drilling project or expedition must make a series of choices to address these challenges. We report on the workflow for sampling hard rock cores for microbiological and biogeochemical research that was developed and optimized during International Ocean Discovery Program (IODP) Expedition 399. All steps of the workflow, including selection of the sample and its shipboard homogenization and subsampling for specific analyses, were designed to maximize the potential for interdisciplinary collaborations and syntheses of results. Furthermore, multiple strategies to minimize and detect potential microbial …


Redefining Just Cause For Contract Termination In Fifa's Rstp: Striking A Fair Balance Between Player Rights And Club Interests In Light Of The Interim Regulatory Framework, Walid Ben Salah, Nayel Alomran, Noor Alhendi, Zouhaier Nouri Aug 2026

Redefining Just Cause For Contract Termination In Fifa's Rstp: Striking A Fair Balance Between Player Rights And Club Interests In Light Of The Interim Regulatory Framework, Walid Ben Salah, Nayel Alomran, Noor Alhendi, Zouhaier Nouri

All Works

Introduction This article examines the concept of just cause for the unilateral termination of professional football employment contracts under FIFA's Regulations on the Status and Transfer of Players (RSTP). It pays particular attention to the changes introduced by FIFA's 2025 Interim Regulatory Framework. The RSTP aims to protect contractual stability while safeguarding the rights of both players and clubs. However, the meaning and application of just cause continue to raise important legal questions.Methods The article uses a doctrinal legal approach. It examines the RSTP, the 2025 Interim Regulatory Framework, the FIFA Commentary on the RSTP, decisions of the FIFA Dispute …


Staff Education To Improve C-Ssrs Suicide Risk Screening Competency, Pearl Binka Aug 2026

Staff Education To Improve C-Ssrs Suicide Risk Screening Competency, Pearl Binka

Walden Dissertations and Doctoral Studies

This staff education doctoral project addressed inconsistent administration and documentation of the Columbia-Suicide Severity Rating Scale (C-SSRS) in an acute care mental health setting. The practice problem was important because inconsistent standardized screening could delay identification of patients who required timely safety interventions. The practice-focused question examined whether structured C-SSRS education improved nursing staff competency, screening consistency, and documentation compliance. The project was developed and implemented to strengthen nurses’ knowledge, confidence, and skill in applying the C-SSRS as part of routine suicide risk screening. Evaluation strategies included comparisons of pre- and posteducation knowledge scores, competency checklist completion, chart audit findings, …


Implementation Of An Evidence-Based, Standardized Hypertension Follow-Up Protocol To Improve Quality And Outcomes Among African American Females In A Primary Care Setting, Fausat Oluremi Ojo Aug 2026

Implementation Of An Evidence-Based, Standardized Hypertension Follow-Up Protocol To Improve Quality And Outcomes Among African American Females In A Primary Care Setting, Fausat Oluremi Ojo

Walden Dissertations and Doctoral Studies

Hypertension is a major modifiable risk factor for cardiovascular disease, stroke, kidney disease, and premature mortality. African American women experience a disproportionate burden of hypertension and hypertension-related complications, making timely follow-up and treatment intensification essential quality and equity priorities. This evidence-based practice project implemented a standardized hypertension follow-up protocol in a primary care setting to improve blood pressure (BP) control and follow-up reliability among African American females ages 18 to 65 with a hypertension diagnosis. The project population included 67 patients, numbered 1 to 67. Baseline BP report data showed that 47 patients had BP less than 140/90 mm Hg, …


A Program Proposal For An Evidence-Based Dietary Program To Support Spanish Speaking Diabetic Patients, Shaquetta Ann Mccloud-Petion Aug 2026

A Program Proposal For An Evidence-Based Dietary Program To Support Spanish Speaking Diabetic Patients, Shaquetta Ann Mccloud-Petion

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) executive leadership system improvement project addresses provider-identified gaps in dietary education for Spanish-speaking patients with diabetes, which may contribute to suboptimal glycemic control and diabetes self-management. A comprehensive review of evidence from CINAHL Complete, PubMed/MEDLINE, and Cochrane supports the use of culturally tailored, evidence-based dietary education to improve diabetes knowledge, self-management behaviors, and health outcomes. The project proposes the development and implementation of a standardized dietary education program using culturally appropriate dietary exchange tools within an outpatient clinic. The initiative aims to improve staff confidence, adoption, and consistency in delivering culturally responsive diabetes education …


Staff Education On Psychoeducation Delivery To Enhance Medication-Adherence Education For Adults With Bipolar Disorder In An Outpatient Psychiatric Mental Health Facility, Bibiana Chinwe Ndula Aug 2026

Staff Education On Psychoeducation Delivery To Enhance Medication-Adherence Education For Adults With Bipolar Disorder In An Outpatient Psychiatric Mental Health Facility, Bibiana Chinwe Ndula

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) staff education project addressed inconsistent delivery of evidence-based medication-adherence psychoeducation for adults with bipolar disorder (BD) in an outpatient psychiatric mental health facility. The project question was whether an 8-week structured module, in relation to existing staff education practices, would increase staff knowledge and confidence. The intervention was guided by the Johns Hopkins evidence-based practice (JHEBP) model and comprised a PowerPoint presentation, a facilitator guide, a handout, a checklist, a toolkit, and anonymous pre- and post-training assessments. Eight out of ten invited staff completed the project. The mean knowledge rose from 6.1 to 8.9 …


Influence Of National Policies In Addressing Intimate Partner Violence In Sierra Leone, Yatta Matilda Musa Aug 2026

Influence Of National Policies In Addressing Intimate Partner Violence In Sierra Leone, Yatta Matilda Musa

Walden Dissertations and Doctoral Studies

Intimate partner violence (IPV) has been shown to be a critical public health and human rights crisis in Sierra Leone driven by patriarchal sociocultural norms. However, despite legislative frameworks like the Domestic Violence Act of 2007, IPV incidents continue to rise, revealing a gap in policy implementation and real-world enforcement. Past research has documented IPV prevalence, yet an empirical evaluation assessing how stakeholders viewed the impact of national policies on prevention and response had not been conducted. The purpose of this study was to explore frontline stakeholders' perceptions regarding the operational influence of existing IPV policies. Grounded in the narrative …


Staff Education To Improve Depression Screening Adherence Using The Patient Health Questionnaire-2/Patient Health Questionnaire-9, Jeremiah Umeh Aug 2026

Staff Education To Improve Depression Screening Adherence Using The Patient Health Questionnaire-2/Patient Health Questionnaire-9, Jeremiah Umeh

Walden Dissertations and Doctoral Studies

Depression is a common mental health condition that frequently goes undetected in primary care because of inconsistent screening and follow-up practices. The purpose of this Doctor of Nursing Practice quality improvement project was to develop, implement, and evaluate an evidence-based staff education program to improve adherence to standardized depression screening using the Patient Health Questionnaire-2 (PHQ-2) and Patient Health Questionnaire-9 (PHQ-9) in a primary care clinic. Eighteen clinical staff members, including registered nurses, medical assistants, and primary care providers, participated in a structured educational intervention focused on standardized screening, documentation, scoring, and referral procedures. Project outcomes were evaluated using pre- …


Implementation Of A Nightshift Sleep Promotion Bundle To Support Delirium Prevention In A Neurosurgical Intensive Care Unit, Pamella Simpson Aug 2026

Implementation Of A Nightshift Sleep Promotion Bundle To Support Delirium Prevention In A Neurosurgical Intensive Care Unit, Pamella Simpson

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) quality improvement project aimed to identify the need for a consistent sleep-promotion protocol in an adult neurosurgical intensive care unit (NSICU). Disrupted sleep is a frequent problem for patients who are seriously ill and can lead to delirium, longer hospital stays, higher health care expenses, diminished cognitive function, and death. While there was evidence supporting nonpharmacological sleep-promotion and delirium-risk-reduction interventions, they were not consistently implemented at the project site, creating a gap between evidence and clinical practice. The purpose of this project was to implement and evaluate an evidence-based night-shift sleep-promotion bundle. The practice-focused …


Staff Education To Improve Knowledge On Accurate Administration Of Medication, Deepu Pudasaini Aug 2026

Staff Education To Improve Knowledge On Accurate Administration Of Medication, Deepu Pudasaini

Walden Dissertations and Doctoral Studies

Medication errors have been a significant problem, primarily due to a lack of continuous monitoring and inadequate training for personnel involved in managing or administering medications in non-healthcare settings. These errors often go undetected or unreported. This Doctor of Nursing Practice (DNP) project was a staff education project to improve staff knowledge of accurate medication administration of medication in a group home. The practice-focused question was: Will a staff education program on the accurate administration of medication improve certified medication technicians’ (CMTs) knowledge about the association between the medication administration process and medication error? The purpose of this DNP staff …


Hypnotherapists’ Perspectives On Using Hypnosis To Address Somatic Symptoms In Clients With Psychological Distress, Tina Wilkerson Aug 2026

Hypnotherapists’ Perspectives On Using Hypnosis To Address Somatic Symptoms In Clients With Psychological Distress, Tina Wilkerson

Walden Dissertations and Doctoral Studies

Somatic symptoms accompany psychological distress and can affect well-being. Hypnosis has demonstrated effectiveness in reducing psychological distress and related somatic symptoms, but limited research has explored hypnotherapists’ perspectives on its clinical application. The purpose of this qualitative phenomenological study was to explore the experiences of licensed hypnotherapists with 3 years of experience using hypnosis to treat adults experiencing somatic symptoms associated with psychological distress. Guided by Engel’s biopsychosocial model and Hilgard’s neodissociation theory, data were collected through semistructured interviews with 10 licensed hypnotherapists and analyzed using phenomenological reduction and thematic analysis. Analysis resulted in four primary themes: (a) mind–body connection …


Improving Identification And Initial Management Of Perimenopause In Primary Care, Yewande Banire Aug 2026

Improving Identification And Initial Management Of Perimenopause In Primary Care, Yewande Banire

Walden Dissertations and Doctoral Studies

Perimenopause is a common but frequently underrecognized stage of reproductive aging that can significantly affect women's physical, psychological, cognitive, and sexual well-being. In primary care, inconsistent provider education and the absence of standardized screening and assessment processes often contribute to delayed recognition and fragmented management. The purpose of this Doctor of Nursing Practice quality improvement project was to develop, implement, and evaluate an evidence-based clinical practice guideline to improve the identification and initial management of perimenopause in a primary care setting. Guided by the Johns Hopkins Evidence-Based Practice Model, the project involved synthesizing and critically appraising the literature to develop …


Educating Psychiatric Mental Health Nurse Practitioners On Long-Acting Injectable Antipsychotic Medication Management, Omonzua Mabel Eromosele Aug 2026

Educating Psychiatric Mental Health Nurse Practitioners On Long-Acting Injectable Antipsychotic Medication Management, Omonzua Mabel Eromosele

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) staff education project addressed the underutilization of long-acting injectable (LAI) antipsychotic medications in an outpatient mental health center. Although LAI antipsychotics improve medication adherence, reduce relapse, and decrease psychiatric hospitalization, provider knowledge deficits and inconsistent prescribing practices lead to their underuse. The practice-focused question was: Among psychiatric-mental health nurse practitioners (PMHNPs) in an outpatient mental health center, what is the impact of an educational program on the application of LAI antipsychotic medication management on the improvement of staff knowledge? The purpose of this project was to implement and evaluate evidence-based educational intervention to improve …


Reducing Copd Readmissions Through An Evidenced-Based Clinical Practice Guideline, Courtney Rye Aug 2026

Reducing Copd Readmissions Through An Evidenced-Based Clinical Practice Guideline, Courtney Rye

Walden Dissertations and Doctoral Studies

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and hospital readmissions, with rural critical access hospitals (CAHs) facing unique challenges in delivering consistent, evidence-based care. At the pilot CAH medical–surgical unit, local chart review and practice observation revealed an approximately 18% 30-day COPD readmission rate and significant variation in discharge education, written action plans, inhaler technique assessment, and structured post‑discharge follow‑up. The purpose of this Doctor of Nursing Practice project was to develop and appraise an evidence‑based, Appraisal of Guidelines Research and Evaluation II (AGREE II) and Institute of Medicine–compliant COPD clinical practice guideline (CPG) to …


The Defining Role Of Ago4 And Its Catalytic Activity During De Novo Rna-Directed Dna Methylation, Tianyi Li Aug 2026

The Defining Role Of Ago4 And Its Catalytic Activity During De Novo Rna-Directed Dna Methylation, Tianyi Li

Arts & Sciences Graduate Student Theses and Dissertations

Plant transposable elements and transgenes are continuously targeted for transcriptional repression via the pathway of RNA-directed DNA methylation (RdDM). Although perpetual RdDM of the endogenous genomic loci has been well studied in the field, much less is known about the de novo RdDM pathway, the pioneering round of DNA methylation responsible for triggering and initiating silencing of new transgenes. Despite being two distinct pathways, both perpetual and de novo mechanisms of RdDM require the production of small interfering RNAs (siRNAs) and the key proteins of the ARGONAUTE4 (AGO4) clade. However, the order and likely mechanism of recruitment of AGO4 to …


Pdf Full Issue, Rosalind L. Raby Aug 2026

Pdf Full Issue, Rosalind L. Raby

Journal of Comparative & International Higher Education

No abstract provided.


Miconazole As A Repurposed Anticancer Candidate For Prostate Cancer, Eswara Naga Hanuma Kumar Ghali, Lindsey Shim, Rajasekhar Baru, Anupam Dhasmana, Ryan Chang, Sung Yun Jung, Rahul Tiwari, Neeraj Chauhan, Vivek K. Kashyap, Sheema Khan, Diane Nguyen, Subhash C. Chauhan, Murali Mohan Yallapu Aug 2026

Miconazole As A Repurposed Anticancer Candidate For Prostate Cancer, Eswara Naga Hanuma Kumar Ghali, Lindsey Shim, Rajasekhar Baru, Anupam Dhasmana, Ryan Chang, Sung Yun Jung, Rahul Tiwari, Neeraj Chauhan, Vivek K. Kashyap, Sheema Khan, Diane Nguyen, Subhash C. Chauhan, Murali Mohan Yallapu

School of Medicine Publications

Prostate cancer is one of the major health concerns, with increasing incidence and persistent therapeutic resistance worldwide. Despite various available treatments (radiation therapy, chemotherapy, hormone therapy, cryotherapy, biological therapy, and high-intensity focused ultrasound), patients still show treatment-related side effects over many years. These challenges highlight the urgent need for novel and safe therapeutic strategies. In the present study, we repurposed five FDA-approved antifungal agents, namely natamycin (NM), terbinafine hydrochloride (TH), ketoconazole (KZ), miconazole (MZ), and clotrimazole (CZ), as they can modulate conserved cellular processes, including sterol metabolism and mitochondrial function, which are increasingly recognized as critical determinants of cancer cell …


Full Issue Aug 2026

Full Issue

The Thetean: A Student Journal for Scholarly Historical Writing

No abstract provided.