Digital Commons Network^™

A Case Of Aqp4-Igg Neuromyelitis Optica Presenting With Orbital Inflammatory Syndrome, Lucy A Bailey, Roy F Riascos, Ore-Ofe O Adesina

Faculty, Staff and Student Publications

A 45-year-old healthy African-American man experienced 2 months of right-eye soreness followed by acute onset of right painful vision loss with binocular, oblique diplopia. Visual acuity was count fingers OD and 20/20 OS. He had a partial, right, pupil-involving cranial nerve III palsy with a right relative afferent pupillary defect and optic disc edema with tortuous vessels. Magnetic resonance imaging showed increased T2 signal with tortuosity and thickening of the retrobulbar right optic nerve with associated restricted diffusion and enhancement, enhancement of orbital fat adjacent to the optic nerve sheath, and relative right proptosis. Workup was positive for aquaporin-4 antibody …

The Effect Of Anterior Closing Wedge Slope-Reducing Osteotomy On Coronal Alignment-Effect Of Osteotomy Technique, Starting Point, And Degree Of Correction., James Matthew Helm, Mark Coggins, Brian Crowley, Maile Curbo, Jacob Siahaan, Alexis Aboulafia, Alfred A Mansour

Faculty, Staff and Student Publications

Background: Techniques for anterior closing wedge slope-reducing osteotomy (ACW-SRO) remain variable regarding management of the tibial tubercle and osteotomy starting point. Moreover, the potential unintended effect on coronal alignment has not yet been determined.

Purpose: To determine the effect of the ACW-SRO technique and starting point on coronal alignment in knees with an elevated posterior tibial slope (PTS).

Study design: Descriptive laboratory study.

Methods: Full-length lower extremity computed tomography scans were retrospectively reviewed in patients presenting to our level 1 trauma center to identify patients with an elevated PTS of ≥12° without secondary trauma to the lower extremity. Materialise software …

A Recipe For Disaster - Sodium Bicarbonate Overdose

Faculty, Staff and Student Publications

Audience: Emergency medicine residents post-graduate years 1-4.

Introduction: Sodium bicarbonate is a compound found commonplace in many households and in many products. It lends itself to countless everyday uses including cooking and cleaning. Physicians prescribe sodium bicarbonate regularly both on- and off-label regularly for various ailments.1 Due to the ubiquitous way both emergency physicians and the general public use and are exposed to sodium bicarbonate, we wanted to prepare learners to identify and appropriately manage sodium bicarbonate toxicity.Obtaining a thorough history not just of medications prescribed but of significant ingestions or infusions is critical in diagnosing this toxicity. Furthermore, acute …

Ten Practical Tips For A Successful Presentation At An Infectious Disease Clinical Case Conference

Faculty, Staff and Student Publications

This mini-review provides 10 practical tips for infectious disease trainees presenting at clinical case conferences. These tips, grounded in principles from education theory, aim to enhance the effectiveness of case presentations.

Cdemapper: Enhancing National Institutes Of Health Common Data Element Use With Large Language Models, Yujia Zhou, Xubing Hao, Pritham Ram, Lingfei Qian, Qianqian Xie, Ruey-Ling Weng, Fongci Lin, Yan Hu, Licong Cui, Xiaoqian Jiang, Hua Xu, Na Hong

Faculty, Staff and Student Publications

Objective: Common Data Elements (CDEs) standardize data collection and sharing across studies, enhancing data interoperability and improving research reproducibility. However, implementing CDEs presents challenges due to the broad range and variety of data elements. This study aims to develop a CDE mapping tool to bridge the gap between local data elements and National Institutes of Health (NIH) CDEs.

Methods: We propose CDEMapper, a large language model (LLM)-powered mapping tool designed to assist in mapping local data elements to NIH CDEs. CDEMapper has 3 core modules: (1) CDE indexing and embeddings. NIH CDEs were indexed and embedded to support semantic search; …

Evaluating Large Language Model Performance To Support The Diagnosis And Management Of Patients With Primary Immune Disorders, Cullen Dutmer, Jocelyn R Farmer, Kirk Roberts, Guergana Savova, Mei-Sing Ong

Faculty, Staff and Student Publications

Background: Generative artificial intelligence (GAI) is transforming health care in a variety of ways; however, the present utility of GAI for supporting clinicians who treat rare disease such as primary immune disorders (PIs) is not well studied. We evaluated the ability of 6 state-of-the-art large language models (LLMs) for providing clinical guidance about PIs.

Objective: To quantitatively and qualitatively measure the utility of current, open-source LLMs for diagnosing and providing helpful clinical decision support about PIs.

Methods: Five expert clinical immunologists each provided 5 real-world, anonymized PI case vignettes via multi-turn prompting to 6 LLMs (OpenAI GPT-4o, Llama-3.1-8B-Instruct, Llama-3.1-70B-Instruct, Mistral-7B-Instruct-v0.3, …

The Role Of Private Law In Promoting Building Safety: The Case Of Singapore, Edward S. W. Ti

Research Collection Yong Pung How School Of Law

Singapore is a tiny granite rock situated just north of the equator. Lacking land, and indeed any kind of natural resource, means that the trend for urban development in the city-state will always be densifi cation; 96 per cent of residents in Singapore already live in multi-owned housing, ie high-rise apartments. 1 Singapore is also a rapidly greying nation. 2 It has been observed that persons over 70 years old are four times more vulnerable in the event of a fi re, 3 and fi re safety is a critical aspect of building safety. Safety features and measures in the …

The Basic Structure In Malaysia: Less Than Meets The Eye, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

At first glance, studying the basic structure doctrine in Malaysia can be frustrating due to its inconsistent judicial treatment. While early cases such as Loh Kooi Choon and Phang Chin Hock rejected the doctrine, it was later accepted in landmark decisions like Sivarasa Rasiah, Semenyih Jaya, and Indira Gandhi. In 2020, scholars such as Jaclyn Neo and Yvonne Tew suggested a judicial embrace of the doctrine and its global trend toward constitutional unamendability. However, the Federal Court’s 2021 decision in Maria Chin Abdullah appeared to reject it once more, illustrating the doctrine’s precarious status. The resurgence seen in Dhinesh a/l …

Digital Economy Innovation In The Indo-Pacific: Towards A 'Singapore Effect'?, J.G. Allen, Qiu Xu Martin Liao

Research Collection Yong Pung How School Of Law

This paper examines the rise of Digital Economy Agreements (DEAs) in the Indo-Pacific as a strategic response to digital trade fragmentation and great power competition. Focusing on Singapore’s leadership, we introduce the ‘Singapore Effect’ – a model of regulatory influence distinct from others, such as the ‘Brussels Effect’ and ‘Beijing Effect.’ Unlike market-driven regulatory diffusion, the Singapore Effect emphasizes interoperability, norm entrepreneurship, and mini-lateralism, enabling middle powers to shape digital trade governance. We analyze DEA formation, implementation challenges in national law, and Singapore’s role as a bridge between diverse regulatory regimes. DEAs’ flexible, modular structure allows for incremental regulatory alignment …

Diaspora By Another Name: The Making Of Refugees In Cold War China, Jiaqi M. Liu, Clare Xiaoqian Wan

Research Collection School of Social Sciences

By examining China’s refugee policies from 1949 to 1982, this article demonstrates how the Chinese state redefined “return” and “refugee” to serve shifting political objectives. While China is often perceived as a source, rather than a host, of asylum seekers, it hosted over 320,000 displaced migrants—primarily ethnic Chinese from Southeast Asia—during the Cold War. Through a systematic discourse analysis of 382 People’s Daily articles, we identify four state narratives—diaspora, diplomatic tool, ideological sanctuary, and legal duty—that structured how China labeled displaced migrants, interpreted their sentiments, and determined their settlement. These models evolved dynamically: from the 1950s to the late 1970s, …

Not Staying Regular?, Joshua Thong

Research Collection School of Social Sciences

Consider the following claims: 1. Rational credences are real-valued. 2. A rational agent is more confident in than in just in case appropriate set-theoretic relations between the relevant events and/or appropriate inequalities between her numerical credences, whether conditional or not, hold. 3. If a rational agent’s conditional credence in, given, is greater than her conditional credence in, given, then she is more confident in than in. 4. There are two distinct and particular ways of ordering the events in a lottery over the naturals, for each of which there exists a rational agent whose comparative confidence ordering corresponds to that …

Governing Migration, Producing Skills: Emigration And Education In The Philippines, Yasmin Y. Ortiga, Roderick. Galam

Research Collection School of Social Sciences

This article examines skill as an integral yet understudied aspect of emigration governance. To date, migration studies have mainly focused on how the demand for migrant skills drive people's movements across borders, shaping the conditions for entry into popular destinations in the West. In contrast, less is known as to how skills also shape the way governments manage emigration, pushing would-be migrants to acquire certain capacities well before they leave their countries of origin. Drawing from the case of the Philippines, this article discusses how state agencies have used skills training to dominate specific markets for migrant professionals and demand …

Stockpiling, Forecasting And Protecting Skills: Skilling As Technique Of Preparedness In Times Of Crises, Rebecca Ye, Yasmin Y. Ortiga

Research Collection School of Social Sciences

In this comparative and situational analysis, we examine how nation-states use skilling as a technique of preparedness during crisis moments. By analysing two strategically selected country cases, Singapore and Sweden, during a critical phase of a global pandemic, we identify three techniques: stockpiling, forecasting, and protecting skills, and how these were enacted as a means to perform preparedness. Stockpiling skills was observed to take place as a rapid response; forecasting skills was a technique enacted with a view on the longer-term horizon and protecting skills was mobilised as a short-term future technique, where boundaries were assembled around skilling. While there …

Language Brokering Conditions The Indirect Association Between Mexican‐Origin Adolescents' Academic Discrimination And Educational Expectations, Su Yeong Kim, Yayu Du, Chantal Alvarado, Wei Xiang Sim, Wen Wen, Tianlu Zhang, Jingyi Shen

Research Collection School of Social Sciences

Mexican-origin adolescents, a significant portion of the US Latino population, often experience a decline in educational expectations from early to late adolescence. Contextual factors such as academic discrimination and language brokering for parents may contribute to this decline. This study investigates the indirect effect of academic discrimination experienced in middle school on educational expectations in young adulthood through high school grades and engagement, and the moderating role of language brokering experiences in these relations. Data were collected from 604 Mexican-origin adolescents across four waves from 2012 to 2023. Academic discrimination experiences in middle school were negatively associated with school grades …

Religious Beliefs, Cooperation, And Evolutionary Mechanisms, Nicole Fellice Ko, Norman P. Li

Research Collection School of Social Sciences

Religion is an organized system of spiritual beliefs, practices, and rituals that often involve a sense of the divine (Schilbrack, 2022). An evolutionary mechanism is an evolved set of traits that interpret environmental inputs and generate behavioral responses that enhance survival or reproductive success (Li et al., 2018). Cooperation refers to the act of individuals or groups working together to achieve a shared goal or mutual benefit (Alós-Ferrer & Garagnani, 2020).

Artificial Insights Or Historical Fidelity? Crafting An Ethical Framework For The Use Of Genai In The Restoration, Reconstruction And Recreation Of Movable Cultural Heritage, David Ocón, Chunzhi Yin, Jose Luna

Research Collection School of Social Sciences

This article explores the ethical considerations surrounding using Generative Artificial Intelligence (GenAI) in preserving movable cultural heritage, focusing specifically on its application in restoration, reconstruction, and recreation. While GenAI offers innovative methods for preserving and recreating cultural heritage, it also presents significant ethical challenges. The article reviews current studies on the role of GenAI in heritage preservation alongside relevant ethical guidelines and proposes a tailored ethical framework for its application in movable heritage. The framework addresses several critical ethical concerns, including cultural integrity and sensitivity, accuracy and authenticity, intellectual property rights, sustainability and social impact, and governance and ethical accountability. …

Distinctive Transpassivation Behavior And Characteristics Of Passive Films Of Laser Powder Bed Fusion Produced And Annealed Ti–6al–4v In Hank's Solution, Yi Fan Zhang, Liang Yu Chen, Ze Xin Wang, Hong Yu Yang, Maksym Bobrov, Dobuvyy Oleksandr, Yong Liu, Lai Chang Zhang

Research outputs 2022 to 2026

Passivated Ti alloys typically demonstrate enhanced corrosion resistance due to the formation of passive films. Intriguingly, in comparison to the annealed Ti–6Al–4V, laser powder bed fusion (LPBF) produced Ti–6Al–4V exhibits significantly attenuated transpassivation behavior in Hank's solution. This work investigated the electrochemical responses of both samples before and after the transpassivation region to illustrate the underlying mechanism for the phenomenon. In the passivation region, both samples displayed analogous passivation behavior, with the annealed and LPBF-produced Ti–6Al–4V having the current densities of 6.64 × 10⁻⁶ and 8.14 × 10⁻⁶ A cm⁻² at 1 V, respectively. Between 1.5 V …

How Emotions In Online Reviews Affect Movie Sales: Evidence From Hollywood, Rahat Ullah, Muhammad Aftab Alam, Atya Zeb

Research outputs 2022 to 2026

Movies evoke strong human emotions that resonate in the content of online reviews, known as electronic word of mouth (eWOM). Existing literature suggests that positive content enhances, and negative content reduces movie sales, with negative content having a stronger effect. We demonstrate that there is a limit to the negative emotional content's impact on sales, beyond which it boosts sales. We extract positive and negative emotional content from 80 Hollywood movie reviews (N = 23,046) and empirically examine their influence on movie sales. Results indicate that for high eWOM volume, the effect of positive content increases progressively, while negative content …

Postoperative Care Pathways For Patients Following Coronary Artery Bypass Grafting Surgery: An Observational Study, Dima Nasrawi, Sharon Latimer, Debbie Massey, Brigid M. Gillespie

Research outputs 2022 to 2026

Aims: The aim of this study was to describe the postoperative care pathway, with phase 1 cardiac rehabilitation (CR) delivery, for adult patients following coronary artery bypass grafting (CABG) surgery at one large hospital in Queensland, Australia. Design and methods: This observational study involved structured observations, patient electronic medical record audits, and field notes to gather postoperative data. Four continuous hours of patient and healthcare professional (HCP) observations gathered at 30-min intervals occurred on 12 separate days over a 1-month period (February–March 2023). We observed post-CABG patients and HCPs involved in delivering direct care. Data were gathered on the clinical …

Recruitment And Retention Of Intensive Care Unit Survivors In Follow-Up Studies: A Systematic Review, Beverley Ewens, Vivien Kemp, Yvonne Middlewick, Amanda Towell-Barnard, Lisa Whitehead

Research outputs 2022 to 2026

Background: Engaging intensive care unit survivors in research is challenging. Studies have reported recruitment and attrition rates; details are lacking on retention strategies and attrition. Objective: The aim of this study was to explore barriers and enablers to recruitment and retention in research of people post intensive care discharge. Methods: A convergent mixed-method review using the Joanna Briggs Institute (JBI) methodology considered studies that reported on recruitment, retention, and attrition rates of adult post–intensive care survivors in longitudinal studies. CINAHL Ultimate (CINAHL+), PubMed, Excerpta Medica Database (EMBASE), PsycINFO, Scopus, Proquest Health, and Medical Collection were searched in March 2024 using …

The Effect Of Oral Colchicine And Vitamin K1 On Bone Metabolism In Patients With Diabetes Mellitus: A Post-Hoc Analysis Of A 2 × 2 Factorial Randomized Controlled Trial With 18F-Sodium Fluoride Positron Emission Tomography, Jamie W. Bellinge, Marc Sim, Roslyn J. Francis, Sing Ching Lee, Dick C. Chan, Christian M. Girgis, Gerald F. Watts, Joshua R. Lewis, Carl J. Schultz

Research outputs 2022 to 2026

Purpose: Diabetes mellitus (DM) confers an increased risk of fracture. Fracture risk stratification techniques are imperfect, and preventative therapies are sparse. We aimed to describe features associated with a dysfunctional bone metabolism determined by 18F-Sodium Fluoride Positron Emission Tomography (18F-NaF PET) in patients with DM and test the effects of vitamin K1 and colchicine therapy on vertebral 18F-NaF activity. Methods: This is a post-hoc analysis of a 2 × 2 factorial randomized double-blind placebo-controlled trial. Participants aged 50–80 with DM underwent 18F-NaF PET/CT imaging at baseline, 3 months of therapy with vitamin K1 (10mg/daily) or placebo, and colchicine (0.5 mg/day) …

Performance Of Interrupted Minichannel Heat Sink Using Various Coolant Fluids, Ernie Mat Tokit, Mohd Zamri Yusoff, Hussein A. Mohammed

Research outputs 2022 to 2026

The advancement in the micro electro mechanical system, MEMS, had been utilized for several years before. This embarked on the compact and high density of power generation for tiny devices. This led to the development of a heat dissipating system for high-power-density devices. Hence, the work intends to simulate the fluid flow performance of interrupted minichannel heat sinks due to the redeveloping and interrupting of the boundary layer merging in previous work that augments the heat dissipation. The study is conducted through numerical work of laminar steady flow, by governing the Navier-Stokes and energy equation. Three interrupted minichannel heat sinks …

The Artichoke Model: A Conceptual Framework For Positive Food Environments In Early Childhood Education And Care (Ecec) Settings, Ros Sambell, Audrey Elford, Tori Overstone, Rebecca Byrne, Kirsty Elliott, Sandra Vale, Penelope Love, Lisa Vincze, Leanne Elliston, Fiona Nave, Janny Goris, Emma Esdaile, Amanda Devine

Research outputs 2022 to 2026

The Artichoke Model is a conceptual framework developed to support the understanding of the breadth and influence of food environments in Early Childhood Education and Care (ECEC) settings. It identifies twelve interrelated components spanning food provision, mealtime practices, curriculum integration, staff capacity, family engagement, and systemic enablers such as policy, equity, and environmental sustainability. Represented visually as an artichoke with the child at its centre, the model encourages holistic analysis, recognising that sustainable change requires the interconnected operation of all components, rather than isolated interventions. The Artichoke Model is intended as a tool for researchers, policymakers, and advocates to guide …

A Perspective Or Review Based Entirely On Low-Quality Evidence Is Simply An Opinion, Matthew S. Tenan, Sophia Nimphius

Research outputs 2022 to 2026

No abstract provided.

Navigating Child Oral Health In Western Australia: A Caregiver's Perspective, Lesley Andrew, Elizabeth Wenden, Mohamed Estai, Ruth Wallace

Research outputs 2022 to 2026

Background: Early childhood caries (ECC) is the most common chronic health condition among Australian preschool-aged children. Untreated, ECC can affect children's physical and emotional health and future social opportunities. ECC is largely preventable through primary caregivers' correct understanding of oral health promoting diets, oral hygiene practices and dental service engagement. The study aim is to explore Western Australian (WA) primary caregivers' child oral health knowledge, experience and practices. The Fisher-Owens socioecological model of child oral health was applied across the study to structure and interpret the findings across the complex, interactive sociocultural influences on child oral health. Methods: The mixed-methods …

Relational History: Correcting Temporal Myopia In Social Network Research, Julia Brennecke, Gianluca Carnabuci, Gokhan Ertug

Research Collection Lee Kong Chian School Of Business

Scholars have used network concepts and methods to explain a wide range of organizational phenomena. Despite this broad interest, prevalent approaches tend to neglect a critical constitutive dimension of network ties: their history. We invoke the concept of relational history to signify the temporal path and biography of a network tie. We argue that a network tie’s history shapes what the relationship means to the parties involved, what can be accomplished in and through the relationship, and how the relationship might further evolve. In directing the attention of organizational network researchers to the relational history of network ties, we aim …

Effect Of Rainfall Reduction And Competition On The Phenology Of The Mediterranean Forage Perennial Legume Bituminaria Bituminosa Var. Albomarginata Cv. Lanza, Jesus Fernandez-Habas, Daniel Real, Tom Vanwalleghem, Jose Ramon Leal-Murillo, Jesus Fernandez-Rebollo

Grain and Other Field Crops Research Articles

Tedera (Bituminaria bituminosa (L.) C.H. Stirt.) is a Mediterranean drought-tolerant species that shows potential as a forage perennial legume for Mediterranean livestock systems. This three-year study investigated the phenology of the newly developed variety of tedera (Lanza) in response to an annual 24% rainfall reduction and competition compared to alfalfa (Medicago sativa L.) in a typical Mediterranean environment of the Iberian Peninsula. Tedera showed early phenology for the reproductive stages from inflorescence emergence to ripening compared to alfalfa, with a long flowering period from early April to mid-May, overlapping with mature fruits. In general, tedera responded to a …

Work-Integrated Learning In Business And Management: Gauging Impact And Opportunities For Growth, Denise Jackson

Research outputs 2022 to 2026

Work-Integrated Learning's (WIL) widely heralded role in developing future-capable graduates has boosted growth in diverse WIL offerings in Australia. Yet comparatively low participation among certain student groups and ongoing talent shortages highlight the need for further expansion, particularly in disciplines where WIL is optional. This study explores student engagement in different types of WIL and the impact it has on student employability and graduate labour force outcomes. Survey data were gathered from over 60,000 graduates of bachelor and postgraduate Business and Management degrees across Australia and compared to other disciplines where WIL is traditionally elective. Despite recent rises in student …

Institute For Global Health And Development : Issue 11 - July 2025, Institute For Global Health And Development

IGHD Newsletters

• Climate Change, Water, And the Way Forward
• Dr. Zulfiqar Bhutta Joins Global Panel on CGTN America For World Health Day 2025
• IGHD Welcomes New Associate Faculty Members
• Dr. Zulfiqar A. Bhutta Named American Society For Nutrition (ASN) Distinguished Fellow 2025
• IGHD’s Dr. Ammad Qazi Delivers Keynote Address at AKU Climate Change Event
• New IGHD Research Project to Develop Sustainable Health Infrastructure in LMICS

CLIMATE CHANGE, WATER, AND THE WAY FORWARD

Translating Advocacy Into Action: Exploring Oncology Healthcare Professionals’ Awareness And Use Of The Clinical Oncology Society Of Australia Position Statement On Exercise In Cancer Care, Jack Dalla Via, Francesca Cehic, Carolyn J. Peddle-Mcintyre, Christopher R. Andrew, David Mizrahi, Yvonne Zissiadis, Nigel A. Spry, Robert U. Newton, Mary A. Kennedy

Research outputs 2022 to 2026

Purpose: The Clinical Oncology Society of Australia (COSA) position statement on exercise in cancer care encourages all healthcare professionals to discuss, recommend, and refer people with cancer to exercise; however, use of these recommendations in practice is unknown. Methods: Oncology healthcare professionals working in Australia were invited to complete a cross-sectional online survey that assessed contextual factors that influence implementation of COSA exercise guidance in cancer care, based on the Consolidated Framework for Implementation Research. Results: We received 133 survey responses. Most were women (74%), nurses (35%), or oncologists (26%), involved in cancer care for > 10 years (63%), and in …