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In Vitro Assessment Of The Antihistomonal Activity Of Methyl Jasmonate And Jasmonic Acid, Mckayla B. Williams

Poultry Science Undergraduate Honors Theses

Histomonas meleagridis is a protozoan parasite and the causative agent of histomonosis in gallinaceous birds. There are currently no approved prevention or treatment options available for histomonosis control in the United States. Mortality in affected turkey flocks can exceed 80% which highlights the urgent need for research investigating novel strategies to mitigate histomonosis in the field. The objective of this study was to evaluate the in vitro antihistomonal and antibacterial effects of of methyl jasmonate (MeJA) and jasmonic acid (JA), two plant-derived compounds, in a xenic culture of H. meleagridis. Assays were conducted using cultured H. meleagridis (PHL strain) treated …

The Black Bombers Of Ghana: Sport, Nation-Building And Pan-Africanism, 1958 To The 21st Century, Kenneth Tagoe

Graduate Theses and Dissertations

Ghana’s Amateur Boxing Team, known as the Black Bombers, has impacted the country’s political and socio-economic development since its formation in 1958. This thesis argues that amateur boxing was one of the sports that Kwame Nkrumah, Ghana’s first president, used to promote nation-building and, more broadly, a Pan-African agenda. The team’s success in international competitions has widely projected Ghana's sporting reputation and reinforced the Pan-African principles of Black pride and excellence in the global athletics arena, and beyond. This thesis traces the origins of amateur boxing and the formation of the Black Bombers, the squad’s participation in international athletics events …

A Grounded Theory Investigation Of The Experiences Of Rehabilitation Administrators, Counselors, And Supervisors Providing Services To Women With Disabilities Experiencing Intimate Partner Violence, Dana Posey

Graduate Theses and Dissertations

Abstract There is a noticeable gap in the literature as it relates to how rehabilitation and disability service providers have worked with women with disabilities who have experienced intimate partner violence. To address the dearth of knowledge, a qualitative grounded theory study was conducted with 12 rehabilitation administrators, counselors, and supervisors regarding their experiences providing services to women with disabilities who have been in or are in an intimate partner violence relationship. Semi-structured interviews were administered, recorded, and transcribed verbatim in an ongoing manner throughout the process. As data was collected, it was analyzed using NVIVO 15, which is a …

A Multicomponent Microneedle Patch For The Delivery Of Meloxicam For Veterinary Applications, Katherine Alejandra Miranda Munoz

Graduate Theses and Dissertations

Veterinary medicine requires innovative drug delivery strategies to enhance therapeutic efficacy while minimizing stress and handling. This dissertation explores the development and application of biodegradable microneedle patches for the transdermal delivery of meloxicam in livestock, offering a minimally invasive alternative to traditional administration methods. The research investigates the fabrication and characterization of microneedles using polyvinyl alcohol, collagen, and chitosan blends, demonstrating their mechanical strength, biocompatibility, and ability to facilitate sustained drug release. In vitro and in vivo evaluations confirm effective skin penetration, dissolution, and localized drug delivery. Pharmacokinetic studies highlight anatomical site-dependent variations in drug absorption, emphasizing the need for …

The Influence Of Retail Display Conditions On Ground Beef Quality And Palatability, Sarah Lynn Shoup

Graduate Theses and Dissertations

The objectives of these studies were to evaluate the impact of retail display case type and muscle type on meat quality attributes, including color, lipid oxidation, texture, and volatile compound profiles, as well as to assess economic implications based on retail color degradation. Case type effects were further evaluated by considering environmental factors such as temperature, air velocity, and relative humidity and their influence on the shelf life of beef patties. An economic analysis was also conducted to estimate the value of patties based on a* (redness) scores at different points during retail display. In Study 1, differences in L* …

End Times: American Mortality, Death Materiality, And Social Death In The 1990s, Jordan A. Savage

Graduate Theses and Dissertations

The United States in the 1990s was marked by pervasive representations of death in popular culture. As death imagery became increasingly visible in entertainment, there was a growing detachment from the embodied, biological realities of death, a tension intensified by the ongoing AIDS crisis. This project explores how death is politicized and how decisions about who lives and dies are shaped by power. I draw on a constellation of theoretical frameworks that collectively illuminate the operations of state-sanctioned death and social abandonment. These include Michel Foucault’s concept of biopolitics, which examines the management of life by state power; Giorgio Agamben’s …

Effect Of Marination And Storage Time On The Properties And Meat Quality Of Broiler Breast, Mayra Mabel Herrera Rivera

Graduate Theses and Dissertations

Abstract The poultry industry has implemented numerous methods, as marination and aging, to improve meat quality and satisfy consumer demands. Three experiments were developed to assess the effects of vacuum tumble marination and aging on the proteins of chicken breast. These experiments utilized 0.75 % sodium chloride, 0.45 % phosphate, and water in a marinade. In experiment one, 270 fillets were allocated into six treatment groups, each comprising 45 fillets. Six days of storage time were used, marinating and storing the fillets in each group at a temperature of 4°C. Following each day of storage period, the fillets underwent a …

Cultural Vibrations: Student Power, International Exchange, And Black America In Mai 1968, Noah Micheal Roberts

Graduate Theses and Dissertations

Abstract This thesis examines the prominence of Black Americans in the 68’ student movement in France. May 68’ incorporated a diverse and global network of social movements and political organizations, and had a notable connection to the American student movement. Black Americans had formed a large expatriate community in France which overlapped with many of the transnational connections forged by the student movements of 68’. This community was extremely notable in the French public sphere for popular works of literature and music, but its political contributions have been minimized or understudied. By utilizing student accounts, state and organizational records, and …

Minor League: The Journey To The Show, Collin Anderson

Graduate Theses and Dissertations

When thinking about the path an athlete takes to get to the major leagues, many think of the same process: High School, College, Professional. However, the professional level includes is more than just the MLB or NBA that people would assume. Almost all professional U.S. sports leagues have a minor league system associated with them that nearly all players pass through at one point or another. Through the lens of a documentary, this portion in an athlete’s journey will be spotlighted to show what these leagues do for them, how they help them improve, and how they prepare them to …

How To Do Things With Little Talking Tubes: Nonideal Speech Acts In The Digital Age, Anthony Holdier

Graduate Theses and Dissertations

In this work, I develop a view about what it means to share a social or conversational context with others, as well as what is normatively entailed by doing so. Working from a broadly Austinian perspective about the moral foundations of language use and how we use words to position ourselves within social space, as well as from a generally Stalnakerian social ontology (demarcating groups by dint of aligned or overlapping sets of commitments), I present three papers demonstrating how nonidealized, ordinary language philosophy can make sense of complex, real-world phenomena. Through analyses of heretical utterances, context collapse, and chatbot …

The Effects Of Background Child-Directed And Adult-Directed Singing On Reading Comprehension Performance, Agnes Yeboah Amfo-Adu

Graduate Theses and Dissertations

Although music features in speech, such as those found in child-directed speech and song, are known to enhance language processing, the underlying mechanism of this benefit remains unclear. Prior research has primarily compared verbal materials presented in a musical, child-directed style to those in a less musical, adult-directed style, leaving it uncertain whether the benefit stems from the music style of verbal presentation or mere exposure to musical features. This study examined whether the language benefits of child-directed input persist when it is presented as background auditory stimuli rather than the primary focus of cognitive tasks. Experiment 1 found that …

Empowerment Through The Sisters Lifting As We Climb Network: Examining The Organization’S Impact On Black Women, Sharnay Hearn Davis

Electronic Theses and Dissertations

This phenomenological case study examines the role of empowerment within the “Sisters Lifting as We Climb Network” through the experiences of Black women participants in Pittsburgh, Pennsylvania. Utilizing in-depth semi-structured interviews, the research investigates the organization's origins, evolution, and social support mechanisms that foster empowerment, as well as participants' experiences with programs and activities over the past nine years. Additionally, the study identifies areas for organizational improvement to further enhance participant empowerment.

The findings of this research support the empowerment theory framework by clarifying the preconditions, processes, and outcomes of empowerment within the Network, which fosters sisterhood and enhances participants' …

Changes In Post-Transplant Serum Testosterone Levels In Men Undergoing Lung Transplantation: A Pilot Study Using The Trinetx Research Network, Austin Thompson, Danly Omil-Lima, Jaime Abraham Perez, Erin Jesse, Mohit Khera, Kenneth Chavin, Nannan Thirumavalavan

Faculty, Staff and Students Publications

Hypogonadism is understudied in men requiring solid organ transplants, particularly among lung transplant recipients. Improvement in serum testosterone levels has been reported in kidney and liver transplantation. Using the TriNetX Research Network, we performed a retrospective cohort study to evaluate the incidence of peri-transplant hypogonadism and the natural course of serum testosterone following successful lung transplantation. Men aged ≥ 18 with a lung transplant and total testosterone drawn within one year pre- and post-transplant were included. Men with receipt of testosterone therapy were excluded. A low testosterone (< 300 ng/dL) and normal testosterone (≥300 ng/dL) cohort was created before employing descriptive and analytic statistics to investigate the incidence of peri-transplant hypogonadism and the change in serum testosterone levels following lung transplantation. In our entire cohort, lung transplantation was not associated with a significant increase in post-transplant serum testosterone (329.86 ± 162.56 ng/dL pre-transplant and 355.13 ± 216.11 ng/dL post-transplant, p = 0.483). The number of men with low testosterone decreased by 9.8% following lung transplantation but was not significant, p = 0.404. In this pilot study, no significant change in the number of hypogonadal men nor serum testosterone levels was observed among men undergoing lung transplantation.

Examining Shock Wave Flow Past The Brim Of A Helmet Using Schlieren Imaging, Cody Thomas, Catherine E. Johnson

Mining Engineering Faculty Research & Creative Works

Increasing the protection a helmet provides the user from shock waves can help reduce the prevalence of blast induced traumatic brain injury (bTBI). Previous research has shown that air enters and gets trapped in the helmet-head cavity and can increase the overpressure experienced by the wearer. The brim design of the helmet has yet to be studied to understand how shock waves flow into the helmet. By studying a variety of brims, it is possible that the design can be modified to minimize shock wave flow into the helmet. This paper investigated a shock wave impacting interior and exterior facing …

Congestion And Sinonasal Illness In Outer Space: A Study On The International Space Station, Faizaan Khan, Koyal Ansingkar, Roshan Dongre, Zain Mehdi, Aatin K Dhanda, Kayla Powell, Tariq Syed, Samuel E Razmi, Isuru Somawardana, Jeffrey T Vrabec, David Hilmers, Omar G Ahmed, Masayoshi Takashima

Faculty, Staff and Students Publications

Objectives: This study aims to characterize quantitative data pertaining to sinonasal symptoms and their related medication use aboard the International Space Station (ISS). A secondary focus involves correlating these findings with mission parameters such as extravehicular activity (EVA) participation and mission duration.

Methods: This retrospective cohort study was conducted utilizing data requested from the National Aeronautics and Space Administration (NASA) Lifetime Surveillance of Astronaut Health (LSAH) program.

Results: Of 71 de-identified ISS astronauts beginning with Expedition 1 in the year 2000 through 62 in 2019, there were 754 logged medical events; 60 astronauts reported any type of sinonasal medical event …

Predicting Miner Localization In Underground Mine Emergencies Using A Hybrid Cnn-Lstm Model With Data From Delay-Tolerant Network Databases, Patrick Nonguin, Samuel Frimpong, Sanjay Madria

Mining Engineering Faculty Research & Creative Works

Underground mining environments are highly hazardous, often prone to gas explosions, cave-ins, and fires that may trap miners during emergencies. The accurate, real-time localization of miners is vital for effective self-escape and rescue operations. Although the Mine Improvement and New Emergency Response (MINER) Act of 2006 mandates communication and tracking systems, most current solutions rely on low-power devices and line-of-sight methods that are ineffective in GPS-denied, dynamic subsurface conditions. Delay-Tolerant Networking (DTN) has emerged as a promising alternative by supporting message relay through intermittent links. In this work, we propose a deep learning framework that combines Convolutional Neural Networks (CNNs) …

Developing Culturally Centered Outreach Materials For Rural Native Veterans, Alexandra B Caloudas, Kelley Arredondo, Gail Beauchamp, Sharon Anastas, Kathy Marchant-Miros, Kristen Frosio, Giselle Day, Katherine Bay, Stephanie Day, Jan Lindsay, Jay Shore

Faculty, Staff and Students Publications

Native Americans serve in the U.S. military at the highest rate per capita of any ethnoracial group and have elevated rates of mental health (MH) difficulties compared to other ethnoracial groups, including posttraumatic stress disorder, alcohol use disorders, and suicide. Almost half of Native Veterans live in rural areas; rurality is associated with significant barriers to MH services. Engaging in outreach with Native Veterans is an important pathway for connecting them with MH care, but the outreach process and educational materials must be culturally aligned to be more effective. We collaborated with partners at a rural Department of Veterans Affairs …

Child Abuse In Colonial America, Brian Allen

Graduate Masters Theses

Child Abuse in Colonial America is an investigation of the extent to which colonial societies were aware of child abuse and how they responded. Historians often assert that awareness of the problem did not exist in America until the mid-nineteenth century; however, the evidence uncovered suggests that cases of child abuse were recognized during the colonial period and that the societal responses differed widely. Historians of childhood document myriad social, economic, political, religious, and other cultural influences that dictate how children were treated at different times and locations, and this framework is used to interpret why the responses to child …

Radio Emission As A Probe Of Astrophysical Sources And Ionized Media, Olivia R. Young

Theses

Broadband radio emission originates from a wide range of astronomical sources, such as the hot plasma of the middle solar corona and the exotic environments found around objects such as radio pulsars. For many of these sources, radio emission mechanisms and regions are not well understood, as they are complex and obscured from direct observation by the ionized media that the emission must traverse as it radiates outward toward the observer. Broadband radio waves from galactic astrophysical sources are delayed and distorted on their paths toward the Earth as they pass through the free electrons that compose a variety of …

Global Trail: Interactive Travel Memory System For Unesco Sites, Anne Sophie Beatrice Min Fa

Theses

Global Trail is an interactive mobile app designed for travellers or culture seekers to reimagine how they discover new places, engage with cultural sites and remember their travel experiences. In this digital world, photos get easily lost in phone galleries and sometimes lack an organized way to find specific memories to places visited. Through design, the app experience addresses three core objectives: Discover — users explore Unesco sites represented by badges through an interactive world map; Engage — they unlock and earn those badges when they visit those sites where they can post their memories on a community platform; and …

Impact Of Hereditary Angioedema Attacks On Health-Related Quality Of Life And Work Productivity, Maeve O'Connor, Paula J Busse, Timothy J Craig, Cristine Radojicic, H James Wedner, Sherry Danese, Julie Ulloa, Vibha Desai, Tomas Andriotti, Paul K Audhya, Sandra Christiansen

2020-Current year OA Pubs

BACKGROUND: Hereditary angioedema (HAE) negatively impacts health-related quality of life (HRQoL). Few studies have characterized impairments to HRQoL, work productivity, and well-being during and following HAE attacks.

METHODS: Patients with ≥1 HAE attack in the previous 3 months were recruited by the United States (US) HAE Association (HAEA) to complete an online survey. Respondents were categorized into those who did (Treated Cohort) and did not (Untreated Cohort) manage their last attack with on-demand treatment (OD). Adapted versions of the EuroQol-Five Dimensions-Five Levels (EQ-5D-5L), EuroQol Visual Analogue Scale (EQ VAS), and Work Productivity and Activity Impairment-General Health assessments were used.

RESULTS: …

The Ccjr® Charles A. Engh, Sr, Md. Excellence In Hip Research Award: Pelvic Tilt And Cup Position Change Significantly In Most Young Patients 10 Years After Hip Arthroplasty, Joseph J Kromka, William A Zuke, Caroline J Granger, John C Clohisy, Robert L Barrack

2020-Current year OA Pubs

BACKGROUND: Acetabular cup position is fundamental to total hip arthroplasty (THA) and surface replacement arthroplasty (SRA). Even if initial cup placement is adequate, changes in spinopelvic relationships alter functional acetabular position over time. This can lead to late complications. The purpose of this study was to examine changes in pelvic tilt and acetabular position in patients with at least 10 years of follow-up after THA or SRA.

METHODS: A retrospective review was conducted of patients from one academic practice who underwent THA or SRA and had at least 10 years of follow-up. Pelvic ratio was measured and converted to pelvic …

High-Density Lipoprotein-Associated Cholesterol Abnormalities In A Clinical Outcomes Study Of Dysferlin-Deficient Limb-Girdle Muscular Dystrophy Type R2, Zoe White, Alan Pestronk, Et Al.

2020-Current year OA Pubs

BACKGROUND: Limb-girdle muscular dystrophy (MD) type R2 (LGMDR2, formerly LGMD2B) is an autosomal recessive form of MD caused by variants in the dysferlin gene, DYSF. It leads to slow proximal and distal muscle weakening that generally results in loss of ambulation around early adulthood but without the lethal cardiorespiratory dysfunction observed in the more severe Duchenne MD. How loss of dysferlin causes muscle fibre death is poorly understood, but recent evidence suggests a link between muscle wasting and loss of muscle cholesterol homeostasis with circulating lipoprotein abnormalities in many forms of MD.

METHODS: Cross-sectional circulating total cholesterol (CHOL), high-density lipoprotein-associated …

Sex-Related Variability In The Perception Of Symptoms Associated With Common Otolaryngologic Complaints, Sabrina K Wagner, Jakob L Fischer, Alvaro Navarro, Lily Trinh, Waleed M Abuzeid, Ian M Humphreys, Nadeem A Akbar, Sharan Shah, Jivianne T Lee, Tara Wu, John S Schneider, Edward D Mccoul, Charles A Riley, Anthony M Tolisano

2020-Current year OA Pubs

OBJECTIVE: To assess the differences in the symptoms associated with common otolaryngology complaints between male and female patients.

METHODS: Between June 2020 and July 2023, a multi-institutional cross-sectional study was performed at six tertiary academic otolaryngology practices using semantics-based questionnaires to assess the symptoms patients associate with the complaints of sinus infection, reflux, congestion, and dizziness. Patients selected symptoms from lists of proposed terms to describe the various conditions. The primary outcome measure was sex-related differences in respondent symptom selection.

RESULTS: Four separate questionnaires were completed by a total of 1495 patients (46.0% male, 54.0% female). Female patients more often …

Autism And Intellectual Disability Due To A Novel Gain-Of-Function Mutation In Ube3a, Anna M Gunelson, Kwang-Soo Kim, Connolly G Steigerwald, Devorah Segal, Nicolas J Abreu, Jason J Yi

2020-Current year OA Pubs

The loss of maternal UBE3A causes Angelman syndrome whereas its duplication is associated with a heterogeneous neurodevelopmental disorder. Here, we describe two affected brothers who possess a novel UBE3A

Characteristics Of Responders To Interventions For Parkinson Disease: A Scoping Systematic Review, Sidney T. Baudendistel, Gammon M Earhart

2020-Current year OA Pubs

AIMS: The purpose of this review is to identify the characteristics of responders in interventions targeting motor function for individuals with Parkinson disease.

MATERIALS & METHODS: The primary search included, 'Parkinson' + 'responder.' A second, broader, search further included 'response' + 'responsiveness' + 'responsive.' Records were sorted by intervention: neuromodulation, pharmaceutical, physical, and placebo.

RESULTS: Thirteen studies were identified in the primary and 19 studies in the secondary search, culminating in 120 characteristics. For neuromodulation interventions, responders were younger at onset, more responsive to levodopa, and had more difficulties with activities of daily living. Responders to pharmaceuticals were younger at …

Muscle Biopsy Findings In Valosin-Containing Protein Multisystem Proteinopathy, Marianela Schiava, Manouela V. Valtcheva, Conrad Weihl, Et Al.

2020-Current year OA Pubs

BACKGROUND AND OBJECTIVES: Valosin Containing Protein-associated multisystem proteinopathy (VCP-MSP) is a progressive, autosomal dominant disorder caused by pathogenic variants in the VCP gene, resulting in a heterogeneous clinical presentation. Muscle biopsy findings are characteristic but not pathognomonic. This study aimed to comprehensively analyse VCP-related myopathology and explore correlations with clinical phenotypes, genetic variants, and disease progression.

METHODS: Muscle biopsy images and data were collected retrospectively from adults (≥18 years) with pathogenic or likely pathogenic VCP variants enrolled in the VCP Multicentre International Study. Biopsy data were standardized using the "Common Data Elements for Muscle Biopsy Reporting." Variations in biopsy findings …

Barriers And Facilitators To Accessing Healthcare For People With Parkinson's Disease In Latin America: A Qualitative Study, Christine Jeyachandran, Catherine Spooner, Ana Margarita Rodriguez Salgado, Matthew Prina, Joel Rhee, Jorge Jesus Llibre-Guerra, Dani Kim, Juan J Llibre-Rodriguez, Mark F Harris

2020-Current year OA Pubs

AIMS: The aim of the study was to identify the barriers and facilitators to healthcare access for people with Parkinson's disease (PWP) in Spanish-speaking Latin American countries (LAC) in Central and South America, to understand their drivers and consider the implications for health systems in LAC.

METHODS: Four online semi-structured focus groups were conducted with 25 PWP who provide education and/or support to PWP. The study was designed and implemented by a person with lived experience of PD. Data were mapped to an existing model of access to healthcare that incorporates provider and consumer abilities.

FINDINGS: There were multiple provider …

Genetic Diversity And Expanded Phenotypes In Dystonia: Insights From Large-Scale Exome Sequencing, Mirja Thomsen, Joel S Perlmutter, Et Al.

2020-Current year OA Pubs

OBJECTIVE: Dystonia is one of the most prevalent movement disorders, characterized by significant clinical and etiological heterogeneity. Despite considerable heritability (~25%), the etiology in most patients remains elusive. Moreover, understanding correlations between clinical manifestations and genetic variants has become increasingly complex.

METHODS: Exome sequencing was conducted on 1924 genetically unsolved, mainly late-onset isolated dystonia patients, recruited primarily from two dystonia registries (DysTract and the Dystonia Coalition). Rare variants in genes previously linked to dystonia (n = 406) were examined, confirmed via Sanger sequencing, and analyzed for segregation when possible.

RESULTS: We identified 137 distinct likely pathogenic/pathogenic variants (according to ACMG …

Left Atrial And Ventricular Remodeling In Chronic Mitral Regurgitation, Jack J Yi, Martha Mcgilvray, Tari-Ann Yates, Samantha Procasky, Jakraphan Yu, Caleb Berberet, Nicholas Banull, Jie Zheng, Jonathan K Zoller, Matthew R Schill, Christian Zemlin, Ralph J Damiano Jr

2020-Current year OA Pubs

OBJECTIVE: This study describes the structural and mechanical changes in the left atrium and left ventricle in a canine model of chronic mitral regurgitation in an attempt to identify markers linked to the onset of atrial tachyarrhythmias or left ventricle dysfunction.

METHODS: Animals underwent baseline and terminal echocardiography and cardiac magnetic resonance imaging. Under echocardiographic guidance, chordae tendinae were avulsed until there was severe mitral regurgitation, defined by regurgitant jet area to left atrium area more than 70%. At terminal surgery, rapid atrial pacing was performed to test inducibility of atrial tachyarrhythmias.

RESULTS: Twelve canines underwent mitral valve chordae avulsion …