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Articles 74491 - 74520 of 1738838
Full-Text Articles in Entire DC Network
Managing Covid-19-Related Stigma In Border Trade Communities: A Qualitative Study In Mae Hong Son, Thailand, Siwaporn Mahathamnuchock
Managing Covid-19-Related Stigma In Border Trade Communities: A Qualitative Study In Mae Hong Son, Thailand, Siwaporn Mahathamnuchock
Journal of Health Research
Background: In the border trade communities of Mae Hong Son Province, Thailand, misinformation and fear surrounding COVID-19 led to increased discrimination.
Method: This study aims to: (1) examine the different forms of stigma, (2) understand how affected individuals manage and cope with stigma, and (3) investigate community-based interventions to reduce stigma in border regions. An interpretative paradigm was used in a qualitative research design. A total of 18 participants—including local traders, housewives facing mobility challenges, a community leader, and healthcare workers were interviewed semi-structurally from August to December 2022. Key data patterns were identified by thematic analysis.
Results: There …
Classification Of Dental Adverse Events Using Iterative Qualitative Analysis, Kiti Siriwatana, Sathirakorn Pongpanich
Classification Of Dental Adverse Events Using Iterative Qualitative Analysis, Kiti Siriwatana, Sathirakorn Pongpanich
Journal of Health Research
Background: Effective incident reporting systems (IRS) are essential in dentistry for identifying and preventing adverse events (AEs), with standardized classifications ensuring consistent incident categorization. This study aimed to develop and validate a classification system for dental patient safety incidents based on a 5-year case study at the Dental Hospital at Chulalongkorn University, Thailand.
Methods: An iterative qualitative approach was used. A literature review explored existing accreditation standards and AE classification systems. Incident reports from 2018–2022 informed a draft classification system aligned with Thailand’s National Reporting and Learning System and accreditation standards. Reports from 2023 were used for validation. An expert …
Identifying Gaps In The Multidrug-Resistant Tuberculosis (Mdr-Tb) Cascade Of Care: Barriers And Improvement Opportunities In North Maluku, Indonesia, Eko Sudarmo Dahad Prihanto, Prayudi Santoso, Elsa Pudji Setiawati, Rovina Ruslami
Identifying Gaps In The Multidrug-Resistant Tuberculosis (Mdr-Tb) Cascade Of Care: Barriers And Improvement Opportunities In North Maluku, Indonesia, Eko Sudarmo Dahad Prihanto, Prayudi Santoso, Elsa Pudji Setiawati, Rovina Ruslami
Journal of Health Research
Background: The Multidrug-Resistant-Tuberculosis (MDR-TB) Cascade of Care includes MDR-TB treatments from suspicion to completion. Implementation gaps can lower treatment success. This study aimed to identify gap causes and opportunities to improve MDR-TB treatment in North Maluku, Indonesia
Methods: To identify gaps, we conducted in-depth interviews and focus group discussions with health workers at Puskesmas (Indonesian government's primary healthcare centers) and hospitals, MDR-TB patients, and patients’ families. Thematic analysis was conducted using the Consolidated Framework for Implementation Research (CFIR) for health workersand the health belief model (HBM) approach for patients and their families.
Results: Significant gaps were found …
Effects Of The Case Management With Community Support Program On Health Behaviors And Outcomes In Thai Buddhist Monks With Type 2 Diabetes And Early-Stage Chronic Kidney Disease, Napawadee Tangtrongvisolkit, Noppawan Piaseu, Porntip Malathum, Basia Belza
Effects Of The Case Management With Community Support Program On Health Behaviors And Outcomes In Thai Buddhist Monks With Type 2 Diabetes And Early-Stage Chronic Kidney Disease, Napawadee Tangtrongvisolkit, Noppawan Piaseu, Porntip Malathum, Basia Belza
Journal of Health Research
Background: Patient engagement and community support are vital for promoting self-care in monks with early-stage chronic kidney disease (CKD). This study investigated the impact of an 18-week Case Management with Community Support Program (CMCSP) on self-care activities and health outcomes (hemoglobin A1c, HbA1c), blood pressure, and estimated glomerular filtration rate (eGFR) in Thai Buddhist monks with type 2 diabetes mellitus (T2DM) and CKD.
Methods: A Randomized Controlled Trial (RCT) with pretest and post-test measures was employed. Eighty-two monks with T2DM and stage 1–2 CKD were recruited from 33 subdistricts in Thailand and randomly assigned into experimental (n = …
Mystical Epistemologies: Understanding Divine Love Through Ibn 'Arabi And Thomas Aquinas, Janai Wright
Mystical Epistemologies: Understanding Divine Love Through Ibn 'Arabi And Thomas Aquinas, Janai Wright
Undergraduate Honors Theses
This paper explores the epistemological role of love in the mystical frameworks of Muhyiddin Ibn ‘Arabi and Thomas Aquinas, two significant figures of medieval philosophy and theology. Though rooted in distinct monotheistic traditions—Islamic mysticism and Christian scholasticism—both thinkers share a foundation in Aristotelian thought, from which they derive skepticism regarding the intellect's capacity to fully comprehend or relate to the divine. Instead, they elevate love as the essential means to attaining knowledge of God. By comparing Ibn ‘Arabi’s concept of the heart with Aquinas’ notion of the will, the paper elucidates how each philosopher positions love as transcending the limitations …
Supporting Participation In Daily Occupations, Quality Of Life, And Well-Being For Individuals With Dementia In Nursing Homes, Julianne M. Sta.Ana
Supporting Participation In Daily Occupations, Quality Of Life, And Well-Being For Individuals With Dementia In Nursing Homes, Julianne M. Sta.Ana
Department of Occupational Therapy Entry-Level Capstone Projects
This capstone project aimed to enhance the quality of life, well-being, and occupational participation of individuals with dementia residing in nursing homes through the implementation of an eight-week occupational therapy-based program. By addressing unmet needs through personalized, meaningful activities such as cognitive stimulation, physical activities, and social engagement, this project seeks to reduce cognitive decline and improve emotional well-being. The SLUMS and GDS were used to evaluate the program’s effectiveness. Ultimately, this project sought to understand occupational therapy’s role in supporting dementia care in nursing homes.
Utilizing Wearable Technology To Improve Pots Diagnostic Testing, Monique Watson, Damen Wilson, Matthew Ward
Utilizing Wearable Technology To Improve Pots Diagnostic Testing, Monique Watson, Damen Wilson, Matthew Ward
Discovery Undergraduate Interdisciplinary Research Internship
Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia characterized by a heart rate (HR) increase ≥30 beats/minute (bpm) within 10 minutes of standing from a supine position, without a significant blood pressure drop. POTS can diminish quality of life with symptoms including tachycardia, headaches, and fatigue. Despite established diagnostic criteria, POTS is often underrecognized or misdiagnosed due to its episodic nature. Symptoms may not consistently be present during diagnostic testing, leading to false negatives during in-office testing. Wearables offer a promising solution through continuous physiological monitoring. Individuals with hypermobile Ehler-Danlos Syndrome (hEDS), a population in which POTS is …
Improving Anxiety Screening In Active-Duty Military: Policy Recommendation For Implementing Ham-A Alongside Gad-7, Alex Judkins
Improving Anxiety Screening In Active-Duty Military: Policy Recommendation For Implementing Ham-A Alongside Gad-7, Alex Judkins
Student Scholarly Projects
Practice Problem: Military personnel appear to be at increased risk for mood and stress-related conditions, such as anxiety and depression. These are frequently associated with traumatic brain injury (TBI), yet existing policies and practices may not fully capture this symptom complexity.
PICOT: For healthcare policymakers and providers (P), how does a policy review and recommendation for implementing the HAM-A screening tool for anxiety (I), compared to continued reliance on GAD-7 (C), impact the early identification and policy alignment for somatic and psychic anxiety management among active-duty military personnel (O)?
Evidence: Investigating psychological illnesses and their physiological manifestations in isolation fails …
Artificial Intelligence-Based Digital Pathology Using H&E-Stained Whole Slide Images In Immuno-Oncology: From Immune Biomarker Detection To Immunotherapy Response Prediction., Jessica Zhang, Horyun Choi, Yeseul Kim, Jonghanne Park, Sukjoo Cho, Eugene Kim, Allen Cho, Ju Young Lee, Jaeyoun Choi, Christmann Low, Chan Mi Jung, Emma J Yu, Jeffrey Chuang, Lee Cooper, Young Kwang Chae
Artificial Intelligence-Based Digital Pathology Using H&E-Stained Whole Slide Images In Immuno-Oncology: From Immune Biomarker Detection To Immunotherapy Response Prediction., Jessica Zhang, Horyun Choi, Yeseul Kim, Jonghanne Park, Sukjoo Cho, Eugene Kim, Allen Cho, Ju Young Lee, Jaeyoun Choi, Christmann Low, Chan Mi Jung, Emma J Yu, Jeffrey Chuang, Lee Cooper, Young Kwang Chae
Faculty Research 2025
Immuno-oncology and the advent of immunotherapies, in particular immune checkpoint inhibitors (ICIs), have fundamentally altered the way we treat cancer. Yet only a small subset of patients actually responds to ICIs, and many face significant adverse effects, making the accurate selection of patients for ICIs essential to the work of immuno-oncology. Immune biomarkers, such as programmed death-ligand 1, microsatellite instability/defective mismatch repair, and tumor mutational burden have been developed for patient selection and stratification for ICIs, though their predictive abilities remain limited. This is due to several challenges: lack of adequate tissue sampling, the time-consuming and subjective nature of manual …
The Impact Of Cell Phones And Social Media On Social And Emotional Development Of High School Students, Laura Nash
The Impact Of Cell Phones And Social Media On Social And Emotional Development Of High School Students, Laura Nash
Masters Projects
Studies suggest that social media can have a negative impact on the social and emotional development of adolescents when overused or abused. This paper examines the benefits of social media and several of the adverse effects of problematic social media use. A few of the adverse effects can carry over into the school setting, resulting in students missing valuable instruction time and not being fully engaged in the learning environment. This project proposal is intended to educate parents and school employees about hazards of problematic social media use and the tools that are readily available to monitor the content that …
Comparative Dosimetric Evaluation Of Single-Beam And Two-Beam Grid Therapy In Head And Neck Cancers, Stephanie Scott Stinson
Comparative Dosimetric Evaluation Of Single-Beam And Two-Beam Grid Therapy In Head And Neck Cancers, Stephanie Scott Stinson
Masters Projects
This study aimed to evaluate whether a single-beam or two-beam configuration in GRID therapy offers superior tumor coverage to the Gross target volume(GTV) and organ-at-risk (OAR) sparing in head and neck cancer patients. Ten patients previously treated with GRID therapy to the left neck were retrospectively selected. For each patient, single-beam and two-beam plans were generated using consistent field size and energy. Dosimetric comparisons were performed using dose-volume histograms (DVHs), focusing on the highest dose received at any single point( dmax) and the average radiation dose delivered across an entire volume (dmean), and the volume covered by the 70% and …
Quality Improvement Project Impacting Healthcare Providers’ Knowledge And Self-Efficacy On Peripheral Artery Disease In An Outpatient Cardiovascular Clinic, Nikki Naphaphone Phanyoraj
Quality Improvement Project Impacting Healthcare Providers’ Knowledge And Self-Efficacy On Peripheral Artery Disease In An Outpatient Cardiovascular Clinic, Nikki Naphaphone Phanyoraj
Doctor of Nursing Practice Projects
Peripheral artery disease (PAD) affects over 200 million people worldwide and contributes to functional limitations, decline in quality of life, and increased risk of cardiovascular morbidity and mortality. Failure to effectively screen patients for PAD can lead to delayed treatment and poorer health outcomes. Early detection and intervention are key to altering the disease progression, reducing complications, and improving health outcomes. The purpose of the quality improvement project is to impact the knowledge and self-efficacy of the healthcare providers working in the outpatient cardiovascular clinic on PAD. A quasi-experimental design with pre- and post-test PAD knowledge exam and a pre- …
The Impact Of The Implementation Of A Code Lavender Stress Management Program On Post-Surgical Critical Care Nurses’ Stress, Solange Ngoundjou
The Impact Of The Implementation Of A Code Lavender Stress Management Program On Post-Surgical Critical Care Nurses’ Stress, Solange Ngoundjou
Student Scholarly Projects
Practice Problem: Post-surgical critical care nurses face a variety of stressful events when providing patient care. And there is a strong relationship between job stress, provision of patient care, patient satisfaction, and the overall well-being of the organization.
PICOT Question: For post-surgical critical nurses who are part of a stressful event (P), do evidence-based stress management strategies (I) compared to the current practice (C), reduce stress (O) within 8 weeks (T)?
Evidence: The evidence that guided this project change is based on John Hopkins’ nursing evidence-based practice model, and Lewin’s Change theory.
Intervention: The Code Lavender …
The Multiband Imaging Survey For High-Alpha Planets (Mishaps). I. Preliminary Constraints On The Occurrence Rate Of Hot Jupiters In 47 Tucanae, Alison L. Crisp, Jonas Klüter, Marz L. Newman, Matthew T. Penny, Thomas G. Beatty, L. Ilsedore Cleeves, Karen A. Collins, Jennifer A. Johnson, Marshall C. Johnson, Michael B. Lund, Clara E. Martínez-Vázquez, Melissa K. Ness, Joseph E. Rodriguez, Robert Siverd, Daniel J. Stevens, Steven Villanueva, Carl Ziegler
The Multiband Imaging Survey For High-Alpha Planets (Mishaps). I. Preliminary Constraints On The Occurrence Rate Of Hot Jupiters In 47 Tucanae, Alison L. Crisp, Jonas Klüter, Marz L. Newman, Matthew T. Penny, Thomas G. Beatty, L. Ilsedore Cleeves, Karen A. Collins, Jennifer A. Johnson, Marshall C. Johnson, Michael B. Lund, Clara E. Martínez-Vázquez, Melissa K. Ness, Joseph E. Rodriguez, Robert Siverd, Daniel J. Stevens, Steven Villanueva, Carl Ziegler
Faculty Publications
The first generation of transiting planet searches in globular clusters yielded no detections, and in hindsight only placed occurrence rate limits slightly higher than the measured occurrence rate in the higher-metallicity Galactic thick disk. To improve these limits, we present the first results of a new wide-field search for transiting hot Jupiters in the globular cluster 47 Tucanae (47 Tuc). We have observed 47 Tuc as part of the Multiband Imaging Survey for High-Alpha PlanetS. Using 24 partial and full nights of observations taken with the Dark Energy Camera on the 4 m Blanco telescope at Cerro-Tololo Interamerican Observatory, we …
Proceedings Of Nordes 2025: Relational Design, Andrew Morrison, Alma Culén, Laurence Habib
Proceedings Of Nordes 2025: Relational Design, Andrew Morrison, Alma Culén, Laurence Habib
DRS Conference Volumes
This volume is the proceedings of the 11th biennial Nordes conference, hosted by OsloMet - Oslo Metropolitan University, 6 – 8 August 2025. All contributions relate in different ways to the overall theme, ‘Relational Design’.
Nemvaleukin Alfa Monotherapy In Patients With Advanced Melanoma And Renal Cell Carcinoma: Results From The Phase 1/2 Non-Randomized Artistry-1 Trial, Emiliano Calvo, Valentina Boni, Olivier Dumas, Sang Joon Shin, Seth D Rosen, Arvind Chaudhry, Philip R Debruyne, Xiaomin He, Ulka N Vaishampayan, David F Mcdermott
Nemvaleukin Alfa Monotherapy In Patients With Advanced Melanoma And Renal Cell Carcinoma: Results From The Phase 1/2 Non-Randomized Artistry-1 Trial, Emiliano Calvo, Valentina Boni, Olivier Dumas, Sang Joon Shin, Seth D Rosen, Arvind Chaudhry, Philip R Debruyne, Xiaomin He, Ulka N Vaishampayan, David F Mcdermott
School of Nursing and Midwifery
BACKGROUND: Despite improved outcomes with immune checkpoint inhibitors (ICIs) and their combinations in advanced solid tumors, a subset of patients remains unresponsive or progresses, highlighting an unmet need for novel treatments with durable benefit. Nemvaleukin alfa (nemvaleukin, ALKS 4230) demonstrated manageable safety and antitumor activity, alone and in combination with pembrolizumab, across heavily pretreated advanced solid tumors in the ARTISTRY-1 study. We report in-depth antitumor activity, safety, pharmacokinetics, and pharmacodynamics of nemvaleukin monotherapy at the recommended phase 2 dose (RP2D) in advanced melanoma and renal cell carcinoma (RCC) cohorts from ARTISTRY-1.
METHODS: ARTISTRY-1 was a three-part (A, B, and C), …
My A-T Pack: A Qualitative Study Of The Utility, Acceptability, Design, And Content Of A Family-Designed And Owned Information Pack Relevant To The Lives Of Children And Young People Living With Ataxia Telangiectasia, Lisa Bunn, Joanne Paton
My A-T Pack: A Qualitative Study Of The Utility, Acceptability, Design, And Content Of A Family-Designed And Owned Information Pack Relevant To The Lives Of Children And Young People Living With Ataxia Telangiectasia, Lisa Bunn, Joanne Paton
School of Health Professions
BackgroundAtaxia Telangiectasia (A-T) is a rare genetic and progressive condition, primarily affecting the neurological, immunological, and pulmonary systems. In the absence of a cure, people living with A-T require co-ordinated multidisciplinary care to manage their complex needs. This often leads to families working with a range of different professionals and feeling burdened by the amount of information and coordination of care that they manage.With the aim to inform the co-production of a family-owned healthcare pack to promote person-centered care and self-management, this study explored the views of children with A-T and parents of children and young people with A-T about …
Yo Soy Minnesota: Bridging Health Equity Gaps With Culturally And Linguistically Inclusive Resources For Hispanics In Central Minnesota, Liz Damaris Vincente Berrios
Yo Soy Minnesota: Bridging Health Equity Gaps With Culturally And Linguistically Inclusive Resources For Hispanics In Central Minnesota, Liz Damaris Vincente Berrios
DNP Projects
Health disparities are preventable yet persist due to systemic inequities in social, economic, and healthcare structures. Rooted in historical injustices and social determinants of health, these disparities disproportionately impact minority communities, including Hispanics in Central Minnesota. Barriers such as limited English proficiency (LEP), provider biases, and inadequate health literacy further exacerbate inequitable health outcomes. Culturally and Linguistically Appropriate Services (CLAS) offer a modifiable solution to mitigate these disparities by ensuring healthcare resources align with diverse beliefs, practices, and linguistic needs. This project focuses on CLAS as a modifiable factor affecting Hispanics in Central Minnesota and explores the impact of "Yo …
Artificial Ignorance: Understanding The Role Of Ai In Modern Agnotology, Amit Ray, Michael Nolan
Artificial Ignorance: Understanding The Role Of Ai In Modern Agnotology, Amit Ray, Michael Nolan
Articles
This paper explores the concept of agnotology, the deliberate production of ignorance, within the context of modern scientific endeavors, particularly in the corporate and technological sectors. It examines how industries use various tactics to manipulate public understanding of scientific issues, often to protect profits and limit liability. The rise of private sector funding and the increasing reliance on technologies like AI and machine learning have exacerbated this process by making scientific inquiry more opaque and less accountable. Ultimately, we argue that as knowledge production becomes more entangled with corporate interests and technological systems, traditional methods of oversight and regulation are …
Optimization Of Light Spectrum During The Early Grow-Out Of Caribbean Corals, Liam A. Abrams
Optimization Of Light Spectrum During The Early Grow-Out Of Caribbean Corals, Liam A. Abrams
All HCAS Student Capstones, Theses, and Dissertations
For at least half a century, numerous direct and indirect anthropogenic stressors have led to the decline of coral populations globally. To minimize this decline and preserve genetic diversity, land-based nurseries have been sexually propagating corals to repopulate reefs. While the techniques to induce corals to spawn and rear their larvae are relatively well-established, the grow-out, i.e. rearing from newly settled to a size suitable for outplanting, remains yet to be fully optimized. Specifically, light spectrum, food quantity and quality and algal control require optimization. This study investigated the post-settlement survival and growth of the Caribbean reef building corals Colpophyllia …
Dyadic And Multiparty Turn-Taking In Two Deaf Preschool Classrooms, Savannah Tellander
Dyadic And Multiparty Turn-Taking In Two Deaf Preschool Classrooms, Savannah Tellander
Theses
Conversational turn-taking skills are needed to succeed in most conversational interactions. Timing of turn-taking is crucial for young deaf signers, who need early, accessible, and consistent input in a signed and/or spoken language. For deaf children who acquire a language in either modality, they must acquire appropriate turn-taking skills. Without these abilities, children may miss critical language input, and in a cascading effect–they may miss opportunities both for input (and thus new knowledge) and expressive language. In addition to documenting deaf children’s turn-taking skills across development, it is important to also document timing data for further understanding of cognitive language …
Open And Timely Public Access To Final, Citable U.S. Case Law: A Progress Report, Peter W. Martin
Open And Timely Public Access To Final, Citable U.S. Case Law: A Progress Report, Peter W. Martin
Cornell Law Faculty Publications
By the early 1990s, numerous advantages of disseminating legal information electronically instead of in print had become widely recognized. These included the potential for faster and wider access and increased competition. To maximize those gains, the American Association of Law Libraries and American Bar Association recommended that the nation’s court systems adopt public (non-proprietary) systems of case citation that could function readily regardless of medium. A few had already headed down that path. In the years since, others have followed.
This article traces the progress of that movement and describes a less conspicuous alternative more recently implemented in a number …
Chemists Explore 'Super Alcohol' That May Point To Cosmic Life, Clara Turnage
Chemists Explore 'Super Alcohol' That May Point To Cosmic Life, Clara Turnage
University of Mississippi News
OXFORD, Miss. – Researchers have for the first time isolated a compound that could open new doors to discovering the chemistry that supports life in space.
Resurgent Education In Native American Catholic Schools: The Stories Of Indigenous Educators Who Attended Boarding Schools, William Newkirk
Resurgent Education In Native American Catholic Schools: The Stories Of Indigenous Educators Who Attended Boarding Schools, William Newkirk
LMU Theses and Dissertations
Although news coverage has discussed the history of Native American boarding schools with more attention, a problematic lack of Native voice has continued to remain in these discussions. In particular, the perspectives of former students of boarding schools are too often missing. Further, there are former residential school students teaching in Native American Catholic schools whose stories and experiences have not yet been documented. This research was not meant to strictly learn from their time as students in the schools, but also their perspectives and successes found within their time as educators. They are teachers with deeply important historical experiences, …
Ada News - 08/04/2025, American Dental Association, Publishing Division
Ada News - 08/04/2025, American Dental Association, Publishing Division
ADA News
Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.
A Quality Improvement Project Cultural Competency: A Project For Improving Culturally Competent Care Among Mental Health Providers, Lanre Olanrewaju
A Quality Improvement Project Cultural Competency: A Project For Improving Culturally Competent Care Among Mental Health Providers, Lanre Olanrewaju
Doctor of Nursing Practice Projects
Cultural competence, knowledge, and awareness are essential for improving mental healthcare outcomes in diverse populations. Despite the need, the absence of structured cultural competence training contributes to reduced quality of care and health disparities. The purpose of this quality improvement project is to improve cultural awareness and knowledge among mental health providers at an outpatient clinic by implementing structured staff training. A needs assessment identified gaps in cultural competence knowledge, inconsistent practices, and limited provider confidence in addressing diverse patient needs. In the methodology, the model used to answer the PICOT question is Purnell’s Model, guided by a structured process …
The Place Speaks: Sacred & Artistic Genealogies Of Appalachia, The Reece Museum, East Tennessee State University
The Place Speaks: Sacred & Artistic Genealogies Of Appalachia, The Reece Museum, East Tennessee State University
The Reece Museum Exhibition Publications
Jimmy Morrow was born March 6, 1955 in Raven Branch, a population area in rural Del Rio, Tennessee. His father, Albert Morrow, is remembered as a very devout man who raised his seven children in the church, and young Jimmy Morrow began preaching there when he was just six years old, soon after he received his first vision. Throughout his career, in which the Rev. Morrow was the founder and pastor of the Edwina Church of God in Jesus Christ’s Name, Morrow also preached at churches in Tennessee, Alabama, Georgia, South Carolina, and Kentucky. Alongside his work as a spiritual …
Feasibility Of A Novel Combined Treatment For Apraxia Of Speech, Claire Evans Jensen
Feasibility Of A Novel Combined Treatment For Apraxia Of Speech, Claire Evans Jensen
Theses and Dissertations
Apraxia of speech (AOS) is a disorder of articulation and prosody interrupting the spatial and temporal planning and/or programming of speech movements and commonly co-occurs with aphasia. Most AOS treatment research has used single case experimental designs (SCEDS) to document the effects of treatment. The strength of SCEDs is that they can demonstrate clear causal relations between intervention and behavior change. The most studied AOS treatment is an articulatory-kinematic treatment called Sound Production Treatment (SPT). This study was designed to examine the effects of a novel treatment, Sound Production Treatment in a Metrical- Paced Frame (SPTMF), on the speech production …
Predicting The Yield Strength Of Aluminum Alloys Based On Composition, Clinton K. Waite
Predicting The Yield Strength Of Aluminum Alloys Based On Composition, Clinton K. Waite
Theses and Dissertations
This work describes a model to predict the yield strength of aluminum alloys, in either an annealed or T6 (peak aged) state, based solely on its composition. This is accomplished through the analyses of strengthening mechanisms common to aluminum, of which a novel semi-empirical model to predict precipitation strengthening is discussed. Solid solution strengthening and grain boundary strengthening are more simplistically considered but with significant accuracy. It is shown that by combining the strength contributions of each strengthening mechanism, the overall yield strength can be predicted by its composition in any of the 1xxx-7xxx series alloys. This allows the model …
Upregulating Ankhd1 In Ps19 Mice Reduces Tau Phosphorylation And Mitigates Tau Toxicity-Induced Cognitive Deficits, Xiaolin Tian, Nathan Le, Yuhai Zhao, Dina Alawamleh, Andrew Schwartz, Lauren Meyer, Elizabeth Helm, Chunlai Wu
Upregulating Ankhd1 In Ps19 Mice Reduces Tau Phosphorylation And Mitigates Tau Toxicity-Induced Cognitive Deficits, Xiaolin Tian, Nathan Le, Yuhai Zhao, Dina Alawamleh, Andrew Schwartz, Lauren Meyer, Elizabeth Helm, Chunlai Wu
School of Graduate Studies Faculty Publications
Using the fly eye as a model system, we previously demonstrated that upregulation of the fly gene mask protects against FUS- and Tau-induced photoreceptor degeneration. Building upon this finding, we investigated whether the protective role of mask is conserved in mammals. To this end, we generated a transgenic mouse line carrying Cre-inducible ANKHD1, the human homolog of mask. Utilizing the TauP301S-PS19 mouse model for Tau-related dementia, we found that expressing ANKHD1 driven by CamK2a-Cre reduced hyperphosphorylated human Tau in 6-month-old mice. Additionally, ANKHD1 expression was associated with a trend toward reduced gliosis and preservation of the presynaptic marker Synaptophysin, suggesting …