Digital Commons Network^™

Modeling The Importance Of Life Exposure Factors On Memory Performance In Diverse Older Adults: A Machine Learning Approach, Evan Fletcher, Marianne Chanti-Ketterl, Emily Hokett, Yi Lor, Umesh Venkatesan, Ruijia Chen, Omonigho M. Bubu, Rachel Whitmer, Paola Gilsanz, Zvinka Z. Zlatar

Moss-Magee Rehabilitation Papers

INTRODUCTION: Many health life exposure factors (LEFs) influence cognitive decline and dementia incidence, but their relative importance to episodic memory (an early indicator of cognitive decline) among diverse older adults is unclear. We used machine learning to rank LEFs for memory performance in a large and diverse US cohort.

METHODS: Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) and Study of Healthy Aging in African Americans (STAR), participants underwent neuropsychological testing and answered questionnaires about multiple LEFs. XGBoost and Shapley Additive exPlanation values ranked the importance of factors influencing cross-sectional episodic memory in the full sample and by sex and …

Association Of Obesity And Body Mass Index Classification With Glycemic Control In Adults Who Are Critically Ill Receiving Parenteral Nutrition: A Retrospective Study., Erika L Mackie, Melissa Dang, Kimberly Sharpe, Justin Delic, James M Hollands, Song Oh, Stacy Pasciolla, Laura Pontiggia, Diana Solomon, Angela Bingham

Ambulatory and Primary Care Articles

BACKGROUND: Hyperglycemia is a complication of parenteral nutrition (PN), which can be exacerbated in patients with obesity. Limited data exist on glycemic control in this population. This study aims to evaluate the association of obesity and body mass index (BMI) classification with glycemic control in patients who are critically ill initiated receiving PN.

METHODS: This is a retrospective study of patients who are critically ill receiving PN from January 2013 to February 2024. The primary outcome was glycemic control in patients with BMI ≥ 30 kg/m

RESULTS: The study included 220 patients with BMI ≥ 30 kg/m

CONCLUSION: Patients who …

Deep Phenotyping Of Obesity: Electronic Health Record-Based Temporal Modeling Study, Xiaoyang Ruan, Shuyu Lu, Liwei Wang, Andrew Wen, Sameer Murali, Hongfang Liu

Faculty, Staff and Student Publications

Background: Obesity affects approximately 40% of adults and 15%-20% of children and adolescents in the United States, and poses significant economic and psychosocial burdens. Currently, patient responses to any single antiobesity medication (AOM) vary significantly, making obesity deep phenotyping and associated precision medicine important targets of investigation.

Objective: This study aimed to evaluate the potential of electronic health records (EHR) as a primary data source for obesity deep phenotyping. We conducted an in-depth analysis of the data elements and quality available from obesity patients prior to pharmacotherapy and applied a multimodal longitudinal deep autoencoder to investigate the feasibility, data requirements, …

Ecological Drivers And Temporal Dynamics Of Daphnia In A Diverse Environmental And Spatial Landscape, Crysta A. Gantz

Dissertations and Theses

In the modern era, commonly referred to as the Anthropocene, human-caused changes to the environment are prevalent and complex. The study of impacts to biodiversity and ecosystem functioning requires multi-faceted approaches that encompass scales of organization from genes to ecosystems. It is often difficult to tease apart whether species responses to environmental change are due to phenotypic plasticity or genotypic variation. Therefore, it is important to try to understand where variation originated, that is, to link a phenotypic response to a genetic change or to gauge whether the response is from the environment. In addition, neutral genetic variation arising from …

First-Line Pd-1 +/- Ctla-4 Blockade In Patients With Deficient Mismatch Repair And/Or Microsatellite Instability-High Metastatic Colorectal Cancer, Vincenzo Nasca, Gabriele Tinè, Julien Taieb, Sara Lonardi, Ben Boursi, Ofer Margalit, Lisa Salvatore, Romain Cohen, Javier Ros, Margherita Ambrosini, Koen Zwart, Jeanine Roodhart, Priya Jayachandran, Michael J Overman, Maria Elena Elez, Chiara Cremolini, David Tougeron, Miriam Koopman, Thierry André, Rosalba Miceli, Filippo Pietrantonio

Faculty, Staff and Student Publications

Background: Patients with deficient mismatch repair (dMMR) and/or microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) show marked sensitivity to immune checkpoint inhibitors (ICIs). Dual PD-1/CTLA-4 blockade with nivolumab and ipilimumab showed superior progression-free survival (PFS) over chemotherapy and anti-PD-1 monotherapy, but data on treatment-naïve patients is not available yet.

Methods: This international multicenter study included patients with dMMR/MSI-H mCRC receiving either chemotherapy with or without biologics, or anti-PD-1 monotherapy, or dual PD-1/CTLA-4 blockade as a first-line treatment. Data were adjusted using inverse probability of treatment weighting (IPTW) to account for baseline imbalances. IPTW-adjusted survival and subgroup analyses were conducted.

Results: …

Fatal Facial Necrotizing Fasciitis: A Case Report Highlighting Diagnostic And Therapeutic Challenges, Muhammad Sheraz Hameed, Syed Rafay Hussain Zaidi, Ali Iqbal, Muhammad Ahsan, Austin Mitchell, Azka Asad Mirza, Joshiah Gordon, Rahmat Gul Omarzai

Department of Medicine Faculty Papers

BACKGROUND: Facial Necrotizing Fasciitis (FNF) is a rare but aggressive, life-threatening infection involving the face's subcutaneous tissues and underlying musculature. It can rapidly progress to septic shock and multi-organ failure if not promptly recognized and treated. The clinical course, including severe pain, disproportionate tenderness, and systemic signs, is often the most crucial factor in diagnosis. While computed tomography (CT) can aid in identifying early signs such as soft tissue swelling and gas formation, clinical suspicion remains paramount and should not be delayed by reliance on imaging alone. Without early intervention, FNF may lead to devastating outcomes, including disfigurement, blindness, or …

Multi-Ancestral Genome-Wide Association Study Of Clinically Defined Nicotine Dependence Reveals Strong Genetic Correlations With Other Substance Use Disorders And Health-Related Traits, Emma C Johnson, Jared V Balbona, Alexander S Hatoum, David A A Baranger, Louis Fox, Paul W Jeffries, Laura J Bierut, Andrew C Heath, Pamela A Madden, Elliot C Nelson, Arpana Agrawal, Et Al.

2020-Current year OA Pubs

BACKGROUND: Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement.

METHODS: We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry [EUR], 10,231 of African ancestry, and 3,746 of East Asian ancestry) and compared the results to other nicotine-related phenotypes.

RESULTS: We replicated the well-known association at the

CONCLUSIONS: Our results suggest that combining the wide availability of diagnostic EHR data with nuanced criterion-level analyses of DSM tobacco use disorder may produce new insights into the genetics …

Does Valve-Sparing Repair Improve Outcomes In Tetralogy Of Fallot? A Systematic Review, Jabez David John, Tirath Patel, Monica Kharat, Jeet Hansalkumar Patel, Jubran Al Hooti, Zoya Riyaz Syeda, Rohit Anil Khare, Sonya Bhatia, Amin Ibrahim, Arjun Bellamkonda, Nikhilesh Anand, Bharathi Gadad

School of Medicine Publications

Background: The systematic review determines whether valve-sparing surgeries improve patient outcomes compared with non valve-sparing surgeries for tetralogy of Fallot. Although previous studies have reported superior outcomes in valve-sparing surgery, no systematic review has compared these outcomes with those of nonsurgical surgical methods.

Methods: In the present research, we address this gap in the literature by comparing valve-sparing and non valve-sparing surgery outcomes. PubMed, PubMed Central, and Medline served as the databases for data collection; following the PRISMA guidelines, a comprehensive search strategy identified relevant articles for the review; the search strategy included Medical Subject heading (MeSH) terms and important …

Development Of Learning Tools For Manual Transmission Repair Competency Based On 4c Skills For Vocational High School Students, Reza Simatupang, Haris Abizar, Ikhsanudin Ikhsanudin

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This research attempts to test the feasibility of 4C-based manual transmission repair competency learning devices and determine the improvement of student learning outcomes with the developed learning devices. This kind of study employs a Research and Development strategy. This development research is designed by following the 4D development steps. The results of the development research showed a learning device product for manual transmission repair competency with a score of 96.75%. Based on the results of the analysis, it is known that there is a significant increase in student learning outcomes in the aspects of knowledge, skills, and attitudes of practice …

Makna Bekerja Sebagai Guru Honorer Di Sekolah Dasar Negeri Dalam Pendekatan Fenomenologi, Gde Dharma Putrawan, Sri Marmoah, Supianto Supianto

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The existence of honorary teachers is a reality that exists in the world of Indonesian education. This study examines the meaning of working as an honorary teacher in public elementary schools. The question asked in this study is what it means to work as an honorary teacher in public elementary schools. This research uses qualitative methods with a phenomenological approach. The data collection method in this study was semistructured interviews with open-ended questions. The informants of this study numbered fifteen people consisting of a school superintendent, two principals, and twelve honorary teachers. The results of this study are some people …

Strategies To Develop Professional Identity Of Teachers From Non-Education Faculty: A Case Study, Klara Tyas Sulistyawati, Paulus Kuswandono

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Nowadays, teachers do not always graduate from the education faculty. This phenomenon attracts researchers to conduct a study about the strategies to develop teacher professional identity, specifically for teachers from non-education faculty. In this study, the researchers implemented a case study method. To collect the data, the researchers distributed a closed-ended questionnaire to six teachers from the non-education faculty and did interview sessions. The researchers concluded the three major findings, namely (1) perceiving oneself, (2) gaining valuable insight through the teacher community, and (3) doing reflection on previous teaching experiences.

Validated Hots-Based Worksheets Enhance Higher-Order Thinking Skills And Impact Geometry Learning Outcomes, Aulia Al Tsani Izzati, Siti Faizah, Mardhatillah Mardhatillah

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to develop and evaluate worksheets that promote higher-order thinking skills (HOTS) in teaching perimeter and area to primary school students. The worksheets were highly valid, with a score of 94.63%, and were shown to be well aligned with learning objectives through extensive validity and reliability testing. They contain various question types, including multiple-choice, short-answer and essay questions, which encourage students to think critically and creatively. While many students improved their analytical skills, 39% needed to meet the minimum competency standard (KKM). This underscores the necessity for supplementary strategies to support all learners and enhance learning outcomes.

Ekologi Dan Tinjauan Filsafat Sains Pendidikan Islam, Baharuddin Baharuddin, Darmawati Jufri, Ambo Dalle, Asmiatin Asmiatin, Abdul Halik

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Learning local content builds national character, because it pays attention to environmental characteristics and local culture. This study aims to determine the application of character education to students based on local wisdom in the Riau Malay learning process. This research is ethnographic and qualitative with the principal, 7 class teachers, and students as subjects. The research instrument consists of observation, interviews, documentation. The results of this study have been carried out well based on local wisdom in Malay culture learning at SDN 183 Pekanbaru including being religious, honest, disciplined, social care, responsibility, environmental care, independent and respectful.

Integrasi Nilai-Nilai Pembelajaran Islam Pada Seni Kaligrafi Di Mts, Maya Risa, Ajahari Ajahari, Saiful Lutfi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The art of Islamic calligraphy has great potential in integrating Islamic values in learning, but has not been fully utilized optimally in formal education. Phenomena in the field show that most students have an interest in the art of calligraphy, but have not fully understood the relationship between the practice of calligraphy with Islamic values contained in it. This study aims to analyze the process of integration of Islamic learning values through calligraphy art media and identify Islamic learning values that are integrated through calligraphy art learning at MTS Terpadu Berkah Palangka Raya. This study used a descriptive qualitative approach …

Enhancing Student Engagement And Cognitive Development Through Game-Based Learning (Gbl), Kusuma Rani, Putri Dwi Lestari, Saenab Ka-Lupae

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Elementary school students are classified as playing-age children, they like to do activities while playing. This research aims to determine the influence of the Game-Based Learning (GBL) learning model on students' cognitive activities and abilities. This type of research is quasi-experimental, one-group pre-test and post-test design. The population of this study were Madrasah Ibtidaiyah students at Darussalam Seuksa School, Thepa, Southern Thailand. The research sample for grade 5 students was 28 students. Student activity is measured using an observation sheet with indicators measured using a 1-5 Likert scale. Cognitive abilities are measured by tests. The results of data analysis showed …

Analisis Swot Dalam Implementasi Manajemen Berbasis Sekolah Di Sekolah Dasar Islam Terpadu, Ainul Mardhiyah, Muhamad Sofian Hadi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Riset ini dilakukan untuk mencermati analisis SWOT dalam pengelolaan manajemen berbasis sekolah. Kemampuan Analisis SWOT sangat diperlukan untuk menjawab tantangan sekolah di Era Globalisasi. Metode yang digunakan adalah metode kualitatif deskriptif. Subjek penelitian yaitu guru dan kepala lembaga pendidikan. Data yang terkumpul dianalisis lalu diinterpretasi dalam bentuk deskripsi. Hasil Penelitian menunjukkan: (1) Strengths 80% (2) Weakness 64% (3) Opportunities 74% (4) Threaths 66%. Dapat disimpulkan bahwa Analisis SWOT dalam Implementasi MBS di SDIT Bintang telah dilaksanakan dengan cukup baik (71%) meskipun terdapat kelemahan yaitu adakalanya program sekolah yang terkendala manajemen keuangan sekolah yang sentralistik. Strategi sekolah adalah fokus pada kekuatan …

Pembelajaran Berbasis Proyek Dalam Pembelajaran Ilmu Pengetahuan Alam Untuk Meningkatkan Hasil Belajar Siswa, Agustinus Tanggu Daga, Matias Hota Heli, Petrus Lende

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Penerapan Ilmu Pengetahuan Alam di sekolah dasar sebagai salah satu mata pelajaran mendukung pelaksanaan pendidikan abad 21. Masalah yang sering ditemui adalah pengetahuan yang kirang pada siswa tentang esensi keilmuan Ilmu Pengetahuan Alam yang berdampak pada kinerja, baik dalam proses pembelajaran maupun dalam hasil belajar. Penelitian ini mengkaji secara ilmiah dampak terhadap hasil belajar dalam pembelajaran berbasis proyek (PjBL). Untuk itu diambil 18 siswa kelas V sebagai subyek penelitian. Penelitian ini menggunakan pendekatan kuantitatif dan metode kuasi eksperimen. Tes hasil belajar digunakan sebagai instrument pengumpulan data yang diterapkan sebelum dan sesudah intervensi. Analisis data mencakup beberapa pendekatan yaitu analisis deskriptif, …

Analyzing The Necessities For Blended Learning In Higher Education: A Pathway To Flexible Learning, Faznah Faznah, Khaerudin Khaerudin, Indina Tarjiah

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Rapidly developing educational technology innovations require educational institutions to provide innovation in creating effective and efficient learning to achieve optimal educational goals. Blended learning is an alternative for institutions that still implement conventional learning to integrate technology into learning and overcome the problem of learning duration so that students can learn actively and flexibly. This study aims to collect information about student needs in designing a flexible blended learning model to optimize learning in learning media courses. Needs analysis is used to explore information about gaps, student needs, and the readiness of lecturers and institutions in creating a blended learning …

The Multicultural Social Fabric And Its Impact On The Assimilation Of The French And British Education Systems In Cameroon, Fatima Zohra Gueddouda Mekhanet

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This article examines the impact of Cameroon's diverse social fabric on the successful adoption of the French and British colonial educational systems. Relying on the descriptive analytical approach, the historical and social contexts that contributed to local communities’ acceptance of colonial education were studied, with a focus on cultural values, ethnic, and religious diversity. The research aims to provide a comprehensive view on how education and educational policies are affected by cultural and social diversity in Cameroon. The research began with a historical background on ethnic and cultural diversity in pre-colonial Cameroon, pointing to the nature of the diverse social …

Leading And Learning From Inside Out: Insights From Meditative Inquiry, Jody L. Rebek

Journal of Contemplative and Holistic Education

This article explores our modern world and our role in shaping collective experiences. By our thoughts, choices and behaviours (our character), we influence our shared reality. Higher education has an imperative responsibility to engage students ethically and develop their character. I offer a teaching metaphor and case study to meaningfully develop students’ self-awareness of character via an undergraduate leadership course. I employed the ‘seed’ metaphor to illustrate how nurturing students’ self-awareness and agency mirrors the growth of a seed within a carefully cultivated ecosystem. Each contemplative practice (character development) intertwined with leadership content (competence and confidence), serves as essential nourishment, …

Students' Attitudes Towards Cooperative Learning In Offline And Online Language Cl, Muhammad Bayu Aji Putra Harianto, Suharyadi Suharyadi, Shinta Tresnadewi

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This research investigated the perspectives of English as a Foreign Language (EFL) students on their experiences with group work (GW) in both online and offline environments. The results indicated that most students who participated in GW in both settings held a positive perception. Implementing a Collaborative Learning (CL) approach can enhance students’ self-confidence, motivation, engagement in a studentcentered environment, and sense of responsibility. However, some students reported negative experiences with online GW due to issues such as unstable internet connections, limited prior experience with GW, and unfamiliarity with relevant applications and software. Consequently, the findings of this study offer valuable …

Synthesis And Characterization Of Near-Infrared Fluorescent Dye Cy7-2 For Targeted Cancer Imaging, Eleanor Yerkin

Summer Research Showcase

The growing demand for real-time, precise, cancer diagnostics and treatment has driven the development of targeted near-infrared (NIR) fluorescent biosensors. Traditional visible-range fluorophores, such as Boron-dipyrromethene (BODIPY) dyes are well-known for their high quantum yields, photostability, biocompatibility, and sharp absorption and emission peaks, making them widely used in fluorescence imaging (Nisar and Sui). However, Cyanine dyes offer some advantages over visible-range dyes, such as deeper tissue penetration due to their near-infrared (NIR) absorption and emission, significantly reduced background autofluorescence, and improved signal-to- noise ratios in vivo (Zhang et al.). This project explores the synthesis and characterization of the NIR fluorescent …

Comprehensive Fitness Assessment In A Professional Military Education Cohort: A Cross-Sectional Study, Daniel J. Lawson, Russell K. Lowell, C. Brooks Mobley, Katherine Frick, Nicholas C. Bordonie, Kaitlyn G. Clouse, Cameron D. Ott, Harrison C. Dimick, Nicholas R. Mauldin, Joellen M. Sefton

International Journal of Exercise Science

International Journal of Exercise Science 18(8): 811-835, 2025. Military personnel face rigorous physical and cognitive demands critical for operational readiness and long-term health. This study evaluated body composition, cognitive performance, and physical fitness metrics in non-entry-level service members to inform tailored fitness interventions. This cross-sectional study analyzed data from Air Command Staff College personnel (N = 307; 89 females, 218 males; age: 37 ± 5 years) at Air University, Maxwell Air Force Base. Participants completed assessments for body composition (body mass index [BMI], body fat percentage [%BF], fat mass index [FMI], fat-free mass index [FFMI]), flexibility (sit-and-reach test, functional reach …

Same But Different: The Survivability Of Arctic-Based Russian Second-Strike Capability, July Decarpentrie

Space and Defense

This article analyzes the survivability of Russia’s second-strike capability in the Arctic through the lens of classical nuclear deterrence theory. Despite heavy commitments in Ukraine, Moscow continues to modernize its Northern Fleet and reinforce bastion defenses, underscoring the Arctic’s role as the cornerstone of its retaliatory deterrent. While these strategies mirror Cold War practices, they face unprecedented challenges from NATO expansion, multipolar competition, and advances in anti-submarine detection technologies. The study concludes that safeguarding Russia’s second-strike capability not only shapes regional security dynamics but also has broader implications for global strategic stability.

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Atomic Offsets: Nuclear Policy Shifts For Arctic States In The Wake Of Moscow’S Special Military Operation, Molly Wise, Lillian Hussong

Space and Defense

This article examines how Russia’s 2022 invasion of Ukraine has intensified nuclear reliance among Arctic states. Applying a new framework of “conventional-nuclear vulnerability,” it analyzes the nuclear policy shifts of Sweden, Finland, and Russia. The findings show that Finland and Sweden pursued NATO membership to secure nuclear guarantees, while Russia adopted riskier nuclear signaling and lowered thresholds for nuclear use. These developments highlight the growing centrality of nuclear deterrence in Arctic security, underscoring the challenges for U.S. and NATO policymakers in balancing assurance and deterrence in a volatile regional environment.

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Russian Strategic Culture And Deterrence In The Arctic, Lana Obradovic, Bethany Vailliant

Space and Defense

This study analyzes Russia’s evolving strategic culture to assess its implications for deterrence in the Arctic. It argues that Western deterrence frameworks insufficiently account for Russia’s integration of military, economic, informational, and political tools into a holistic strategy. Rooted in a siege mentality and aspirations for great power status, Russia perceives the Arctic as central to its security, economic modernization, and geopolitical influence. By situating Arctic policy within this cultural framework, the analysis highlights the need for U.S. and NATO practitioners to reassess assumptions and develop more culturally attuned deterrence strategies.

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Front Matter, Editors Space And Defense

Space and Defense

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Space And Defense Vol. 16 No. 1 Summer 2025 Special Issue On Arctic Security (Whole Issue), Editors Space And Defense

Space and Defense

Articles that cover issues on Artic Security.

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Summary Of The 2024 Brano Heart Failure Forum, Igor D. Gregoric, Milovan Bojic, Bojan Vrtovec, Rajko Radovancevic

The VAD Journal

Since 2007, the Branislav “Brano” Radovancevic Heart Failure Forum (BHFF) has been held annually to provide a venue for experts to present and discuss “Innovations and New Treatment Strategies in Heart Failure.” Clinicians and researchers gather yearly in a different Eastern European city to discuss the latest in heart failure diagnostics and therapeutics. The 2024 BHHF was held on the 18^th through the 20^th of September 2024 in Belgrade, Serbia. It was attended by over 100 faculty from 16 countries. In addition, participation through online streaming was available. Throughout the forum, 17 sessions focused on challenges and solutions …

Interplanetary Rail Launcher: Open Architecture And Free Technology Bricks (Magseal, Mhd, Hts) – Full Report And Associated Data, Xavier Pillet

Defensive Publications Series

This document, produced with the assistance of ChatGPT o3 and ChatGPT 5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes: EPC Art. 54(2) (European Patent Convention), French IPC Art. L 611-11 (French Intellectual Property Code), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). It discloses 140+ enabling inventions for an interplanetary rail-launcher: MagSeal liquid-metal gates, large-Ø plasma windows, staged MHD vacuum pumps, deployable ReBCO shields, adaptive MHD …