Digital Commons Network^™

Editorial: Disclosure In Sexual And Reproductive Health, Pooja Chitneni, Shan Qiao Ph.D., Simon M. Manga, Janet M. Turan

Faculty Publications

No abstract provided.

Changes In Self-Reported Excessive Daytime Sleepiness Are Associated With 5-Year All-Cause Mortality Risk Among Veterans, Katherine G Bay, Arash Maghsoudi, Amin Ramezani, Drew A Helmer, Amir Sharafkhaneh, Javad Razjouyan

Faculty, Staff and Students Publications

Excessive daytime sleepiness (EDS) is linked to adverse clinical outcomes. This study evaluated changes in a validated tool to assess EDS, the Epworth Sleepiness Scale (ESS) and mortality risk. This retrospective cohort study included Veterans receiving sleep-related services in the Department of Veterans Affairs (VA) from October 4, 1999 to August 18, 2018, with two qualifying ESS measures. ESS values were extracted from patient notes using a validated natural language processing (NLP) pipeline (96% accuracy). ESS scores were categorised as Normal (0-10) or Abnormal (11-24). Patients were grouped based on ESS changes: Normal-Normal, Normal-Abnormal, Abnormal-Abnormal and Abnormal-Normal. Cox proportional hazards …

Revisiting The Effect Of Udenafil On Exercise Performance In Patients With Fontan Circulation: Results Of A Post Hoc Analysis Of The Fuel Trial, David J Goldberg, William B Orr, Et Al.

2020-Current year OA Pubs

BACKGROUND: In the FUEL (Fontan Udenafil Exercise Longitudinal) trial, a positive treatment effect was identified for outcomes at the ventilatory anaerobic threshold but not for the primary outcome, oxygen consumption (Vo

METHODS: Participants were divided into subgroups by baseline predicted peak Vo

RESULTS: Of the 379 participants with paired exercise data, 302 (80%) had a baseline peak Vo

CONCLUSIONS: In this post hoc subgroup analysis, after exclusion of patients with Fontan circulation with near-normal baseline peak Vo

REGISTRATION: URL: https://clinicaltrials.gov; Unique identifier: NCT0274115.

Echocardiographic Assessment Of Pulmonary Hemodynamics And Right Ventricular Performance In Neonatal Murine Hypoxia, Kel Vin Woo, Philip T Levy, Carla J Weinheimer, Amanda L Hauck, Aaron Hamvas, David M Ornitz, Attila Kovacs, Gautam K Singh

2020-Current year OA Pubs

No abstract provided.

Heart Failure And Death In Older Adults With Elevated Cardiac Biomarkers But Without Risk Factors: The Atherosclerosis Risk In Communities Study, Xiaoming Jia, Mahmoud Al Rifai, Chiadi Ndumele, Amil Shah, Elizabeth Selvin, Salim S Virani, Ron C Hoogeveen, Biykem Bozkurt, Christie M Ballantyne, Vijay Nambi

Faculty, Staff and Students Publications

No abstract provided.

Global Drivers And Local Management Of Groundwater Stress: A High-Resolution Economic Analysis Of Land, Water, And Food Systems, Iman Haqiqi, Thomas Hertel, Kavitha Srikanth

Department of Agricultural Economics Faculty Publications

Groundwater stress, a critical challenge for global water security and food production, has intensified due to the interaction of global change drivers and rapidly evolving local conditions. This paper investigates the individual and combined impacts of water availability, heat, population growth, income dynamics, and technological advancements on global groundwater stress over a historical period from 1997 to 2017. Utilizing the gridded Simplified International Model of agricultural Prices, Land use, and the Environment (SIMPLE-G), the study attributes local changes in water and land use patterns to these key global drivers. Furthermore, it evaluates an alternative, counterfactual scenario in which sustainable management …

Putting Genai On Notice: Genai Exceptionalism And Contract Law, David Atkinson

NULR Online

No abstract provided.

Strategies To Improve Psychiatrist Understaffing In Psychiatric Hospitals In Rural And Underserved Communities: Addressing Administrative Challenges, Carla Aramouni

Walden Dissertations and Doctoral Studies

Psychiatric hospitals across the United States face a worsening shortage of psychiatrists, particularly in rural and underserved communities, which limits timely mental health care, increases wait times, and places unsustainable strain on the psychiatric workforce. The purpose of this integrative review was to identify administrative strategies that can mitigate psychiatrist understaffing and support sustainable care delivery in psychiatric hospitals. An integrative review methodology was used to explore both empirical and nonempirical literature, resulting in 92 articles, including 32 peer-reviewed sources and several supporting studies selected through a systematic search, screening, and critical appraisal. Thematic analysis of the evidence revealed five …

Canada’S Indigenous Social Workers’ Medicinal Plant Knowledge: A Land-Based Way Of Knowing For Indigenous Practice, Iris Kim Plain Eagle

Walden Dissertations and Doctoral Studies

Canada’s Indigenous people of Treaty 7 region have experienced intergenerational trauma resulting from colonization perpetrated by the Canadian government. While the use of medicinal plants, are employed by Indigenous social workers, their integration into mainstream human services organizations remains limited. The gaps in Indigenous social work practice hinders client culturally competent care and the acknowledgement of Indigneous knowledge systems in colonial systems. This generic qualitative study explored the experiences of participants who integrate medicinal plant healing and ancestral knowledge into practice. Informed by indigenous wholistic theory, the study aimed to understand how Indigenous social workers navigate the challenges and opportunities …

Gm-Csf Production By Immune Cells In Steady State And Autoimmune Neuroinflammation Mapped Using Fate Reporting Mice, Gholamreza Azizi, Javad Rasouli, Hamed Naziri, Michael V. Gonzalez, James Garifallou, Guang-Xian Zhang, Bogoljub Ciric, Abdolmohamad M. Rostami

Department of Neurology Faculty Papers

INTRODUCTION: GM-CSF is a pro-inflammatory cytokine that promotes an inflammatory phenotype in myeloid cells. The extent and pattern of GM-CSF expression in immune cells have not been fully elucidated. Our goal was to advance this topic using novel GM-CSF reporter/fate reporter transgenic mice.

METHODS: We tracked ongoing and past GM-CSF expression in various immune cells from multiple organs, in steady-state and autoimmune inflammation of the central nervous system (CNS).

RESULTS: The GM-CSF expression patterns varied by cell type and organ, with CD4

DISCUSSION: These findings identified distinct GM-CSF cellular sources across organs, highlighting the transient nature of GM-CSF expression and …

Dissatisfaction And Residual Symptoms In Younger And Older Adult Patients After Total Knee Arthroplasty, Nicholas Pohl, Parker Brush, Adrian Santana, Sebastian Fras, Eleanor Jenkins, Arjun Saxena

Department of Orthopaedic Surgery Faculty Papers

INTRODUCTION: Total knee arthroplasty (TKA) is an increasingly used treatment option for younger patients with osteoarthritis. Previous research has found only 66% patients < 60 years who underwent TKA postoperatively reported that their knees felt normal. However, the prior studies did not compare underlying causes for dissatisfaction based on age. This study compared the satisfaction and residual symptom rates between patients ages < 60 and ≥60 years and identified specific reasons for their dissatisfaction between the age groups.

METHODS: Patients who underwent unilateral TKA for osteoarthritis from 2014 to 2016 were electronically sent a 15-question survey pertaining to surgery satisfaction. Following patient identification and survey completion, patient demographics, medical history, surgical time, and length of stay were collected through manual review of medical records. Patients who completed surveys were grouped by age (< 60 years or ≥60 years) for analysis.

RESULTS: In total, 1189 ≥ 60-year-old patients and 388 < 60-year-old patients were included. Most patients in both cohorts reported satisfaction with overall knee function (< 60: 68.6%; ≥60: 71.8%; P = 0.175). Fewer < 60-year patients reported normal knee function (66.5% vs. 75.2%; P < 0.001). The most common residual symptom in both cohorts was continued pain.

CONCLUSION: Patients younger than 60 years reported less satisfaction with performing normal activities …

Effect Of Bond Strength Variation And Ionizing Radiation On Mutations In Cytosine-Guanine Islands, Joshua Robert Bedwell, Yan Poniatovskyi, Vola Andrianarijaona

Achieve

Ionizing radiation produces free electrons within cells which then ionizes DNA and has the potential to cause carcinogenic mutations. Cytosine-Guanine (CpG) islands are regions that are rich in cytosine and guanine bases and are common sites of single point mutations and strand breaks. In this study, density function theory (DFT) is used to calculate the potential energy of DNA nucleotide dimers varying bond lengths in five different ionized states. Crossing between two ionized states can be seen in the potential energy curves, indicating the possibility of natural transition between the two states. Potential energy curves are used to determine bond …

Analyzing The Strength Of The Amine Bond Of Guanine Via Potential Curve Analysis: A Computational Approach, Yan Poniatovskyi, Joshua Robert Bedwell, Vola Andrianarijaona

Achieve

The deamination of guanine can be a cause of single point DNA mutations. In this study, the strength of the amine bond was examined using DFT and B3LYP to map out the bond’s potential curves under conditions of various charges being imposed on the molecule. Such an approach yielded a few potential curves that do not exhibit the expected behavior and rather, show crossings in potential energy curves. Discussions regarding the suspected causes of these unexpected behaviors are included in the poster presentation. The Mulliken charge analysis of guanine under these conditions is coherent with the proposition that the deamination …

Conceptual Model And Design Of An Initiative To Build Nurses’ Resilience And Ethical Practice, Cynda Hylton Rushton, Sandra M. Swoboda, Nancy Reller, Laura C. Sarver, Erin M. Wright, Krysia Warren Hudson, Robie Victoria Hughes, Ginger C. Hanson, Rita D’Aoust

College of Nursing Faculty Papers & Presentations

Background: Healthcare faces a nursing crisis with high turnover, burnout, and faculty shortages, which requires innovative educational approaches that bridge the gap between education and practice. Purpose: To present the conceptual model and design of a statewide, trans-institutional academic-practice collaboration that holistically builds nurses' resilience and ethical practice across the education-to-practice continuum. Method: Development of the Renewal, Resilience, and Retention (R³) Initiative based on adaptation of the Mindful Ethical Practice and Resilience Academy (MEPRA), social ecological framework, and stakeholder input across eight schools of nursing and five hospitals in Maryland. Results: The R³ Initiative created a scalable …

An Educational Intervention Focused On Identifying Adverse Childhood Experiences, Laconia Bacon

Walden Dissertations and Doctoral Studies

Adverse childhood experiences (ACEs) refer to traumatic childhood experiences that individuals may have been exposed to during their youth, such as child maltreatment, domestic violence, or interparental violence. Research has demonstrated that experiencing ACEs in childhood may result in physical and mental illnesses that led to dangerous lifestyle patterns in adulthood. In the local organization, several patients with ACEs presented in the emergency department (ED). The nurses, unaware of ACEs, were unable to detect and respond to the consequences of ACEs. Thus, the purpose of this Doctor of Nursing Practice (DNP) project was to determine whether an educational intervention focused …

Strategies For Volunteer Firefighter Recruitment And Retention, Teddy Gene Abbey

Walden Dissertations and Doctoral Studies

Volunteer fire departments (VFDs) provide essential services in rural areas that cannot afford full-time staff, and they are negatively impacted by declining recruitment and retention. VFD administrators who lack strategies to recruit and retain volunteer firefighters risk reduced emergency services and increased costs for hiring paid firefighters. Grounded in Herzberg’s two-factor theory, the purpose of this qualitative pragmatic inquiry project was to identify and explore strategies some VFD administrators use to recruit and retain members and maintain necessary emergency services. Participants were six administrators from VFDs in Oklahoma and Arkansas with community populations of 1,500 citizens or fewer residents who …

The Perceived Impact Of Officer-Involved Domestic Violence On Law Enforcement Administrators, Victoria Smith

Walden Dissertations and Doctoral Studies

The frequency of officer-involved domestic violence (OIDV) is a serious problem in the law enforcement profession. This qualitative phenomenological study aimed to determine what measures and specific domestic violence policies are working well and what is working poorly in Florida. This study is critical because it can aid upcoming law enforcement administrators (LEAs) and current LEAs in improving the policies and measures they use in their agency to combat OIDV among their officers and recruits. Jacques’s organizational culture theory (OCT) provided a framework for this study. I used purposeful snowball sampling methods to recruit participants for this study. Six law …

Women Veterans' Use Of Gender-Specific, Online, Social Support Systems For Social Identity After Military Service, Katie M. Baillio

Walden Dissertations and Doctoral Studies

The number of women veterans serving in the military is growing. This qualitative study explored women veterans' perspectives and experiences with gender-specific online social support services, and how that contributes to their social identity after military service. A generic qualitative design was used, and data were collected through semistructured interviews for 10 women veterans who had transitioned out of the military within the last 5 years. Five themes emerged: (a) big picture: connecting with other women veterans was helpful; (b) veteran forums were used for federal or state benefits, but women used gender-specific forums for questions specific to women's issues; …

Educating Nurses On The Agency Of Healthcare Research And Quality Pressure Ulcer Prevention Program To Reduce The Rate Of Pressure Ulcers, Marie France Destaul

Walden Dissertations and Doctoral Studies

A staff development project was conducted to address the practice problem encountered in a healthcare setting. The identified gap in practice was related to a lack of knowledge of pressure ulcer injury prevention among inpatient staff. Leadership deemed it essential to address this practice problem in nursing care because the prevalence of pressure ulcer injuries in hospitalized patients was high. The following practice-focused question guided the project: For staff in an inpatient setting, will education on the Agency of Healthcare Research and Quality (AHRQ) Pressure Ulcer Prevention Program increase knowledge toward the goal of decreasing the incidence of pressure ulcers? …

A Qualitative Study On The Experiences Of Burnout Among Mental Health Practitioners Rendering Clinical Care During Covid-19, Mykiyaa Marvella Walker-Sanchez

Walden Dissertations and Doctoral Studies

Prior to the COVID-19 pandemic, between 21% and 67% of mental health practitioners in the United States experienced signs of burnout. The pandemic exacerbated these challenges, with an increased demand for mental health services. By 2022, 45% of practitioners reported burnout, and the APA’s 2023 Practitioner Pulse Survey noted that psychologists were working at the limits of their capacity, with high levels of burnout. While research on COVID-19 and burnout has expanded for physicians and nurses, less focus has been placed on mental health practitioners' experiences. The purpose of this generic qualitative study aimed to understand how mental health practitioners …

Effects Of Social Influences On Adult Male Politicians Who Engage In Sexually-Exploitative Behaviors, Rodshana M. Ulery

Walden Dissertations and Doctoral Studies

Sexually-exploitative behaviors by adult male politicians is a significant societal concern that reflects deeper issues involving power misuse, gender inequality, and institutional failure. This qualitative research involved examining societal factors that were linked with this type of misconduct. Guided by the status characteristics theory, the study involved examining how status-related traits such as political power, public image, and institutional affiliation shaped social dynamics and fostered environments that enabled these behaviors. Using NVIVO, thematic content analysis was applied to 24 adult male politician cases. Five key themes emerged: early life and family influences, position and power, opportunity expectations, cultural and institutional …

Collaborative Research: Bocp-Implementation: Us-China: Multi-Scale, Multi- Proxy, Integrative Investigation Of Functional Biodiversity On A Changing Proterozoic Planet, Carol Dehler

Funded Research Records

No abstract provided.

Efficient Decontamination Of Organophosphate-Based Pesticides And Nerve Agent Simulants Mediated By N-Containing Nucleophiles, Emmanuel Kingsley Darkwah, Puspa Aryal, Saidulu Todeti, Jared Kenik, Samuel Insall, V. Prakash Reddy, Chariklia Sotiriou-Leventis

Chemistry Faculty Research & Creative Works

There is a growing interest in developing safer and more effective decontaminating agents for organophosphate-based pesticides and nerve agents. In this study, we present an effective method for the nonaqueous decontamination of these compounds using small-molecule-based decontaminating agents under ambient conditions. Our approach utilizes aryl and heteroaryl carboxaldehyde hydrazones and hydrazides to effectively hydrolyze nerve agent simulants into their nontoxic degradation products. The effectiveness of this method was evaluated using a range of nerve agent simulants, including dimethyl 4-nitrophenyl phosphate (DMNP), dimethyl methyl phosphonate (DMMP), and triphenyl phosphate (TPhP). In the presence of the heteroaryl hydrazone, the rate of hydrolysis …

Three Essays In Gamification, Innovation, And Cybersecurity, Eduard Yelagin

Electronic Theses and Dissertations Archive

This dissertation consists of three essays on Gamification, Innovation, and Cyber Security. The first essay investigates gamified stock trading. Gamification of stock trading is a novel practice by brokers to incorporate game-like features to increase clients’ engagement with trading. This study examines how the market reacts to the introduction of 142 gamification features in the mobile trading apps of 17 major U.S. brokers. I find that the gamification of trading can be viewed as a double-edged sword. It alters and worsens retail traders’ strategy by reducing their returns and increasing return volatility. However, it also reduces costs and risks for …

Enhanced Meropenem Activity And Stability Following Load In Polyvinyl Alcohol Nanofiber Scaffolds With Sitagliptin As Quorum Sensing Inhibitor On Pseudomonas Aeruginosa, Samar A. Salim, Abdelrhman Mohsen, Mohamed Emara, Taghrid Elmahdy

Nanotechnology Research Centre

Background The increasing resistance of bacteria to conventional antibiotics poses a significant health challenge. Innovative strategies, such as combining antibiotics with agents like quorum sensing inhibitors (QSIs), have been developed to combat this issue. QSIs enhance antibiotic efficacy without inhibiting bacterial growth, minimizing the risk of resistance. Aims Evaluate the combined effect of Sitagliptin (STG) as a QSI with Meropenem (MER), fabricate drug-loaded Polyvinyl Alcohol (PVA) nanofibers, and investigate their antimicrobial activity against standard Pseudomonas aeruginosa (PAO1) and carbapenem-resistant P. aeruginosa (CRPA). Methods The combinatorial effect was assessed using a checkerboard assay. PVA/STG, PVA/MER, and PVA/STG/ MER nanofibers were fabricated …

Predictability And The Pleasure Of Music, Amy M. Belfi

Psychological Science Faculty Research & Creative Works

No abstract provided.

“I Feel Like A Lot Of Times Women Are The Ones Who Are Problem-Solving For All The People That They Know”: The Gendered Impacts Of The Pandemic On Women In Alaska, Marya Rozanova-Smith, Andrey N. Petrov

Faculty Publications

The impacts of the COVID-19 pandemic and post-pandemic recovery in urban communities in the Arctic have been substantial, but their gendered aspects remain largely unknown. The goal of this study was to enhance the understanding of the gender-based impact on women in the urban areas of Alaska by exploring strengths and constraints to resilience in the social and economic domains of gender equality during and in the aftermath of the COVID-19 pandemic. Drawing on grounded theory methodology, this study is based on 29 in-depth, semi-structured interviews. The study methodology utilized a conceptual framework that integrated deficit-based and strength-based analytical perspectives. …

Teaching Bilingual Learners With Dysgraphia, Angela Gonzalez-Urbina

Masters Projects

With the push for legislation on the Dyslexia law in Michigan and elsewhere, teachers need to understand what dyslexia and dysgraphia are to support all students. An extra understanding is necessary in bilingual education and reading challenges because they use two language systems in and out of the classroom. Reading and writing are already areas that impact the working memory of the learner; adding dysgraphia to that proves to be more of a challenge. Dysgraphia can coexist with dyslexia, and individuals with dysgraphia often experience difficulties with spelling and writing speed. This project introduces dysgraphia as one of the reading …

A Brief History Of Circadian Time In The Heart, Martin E Young, Vanya Khanna, Mallory Metcalfe, Niruththaan Rameshkumar, Sarah Harington, Leo H Li, Janan Shoja Doost, Heinrich Taegtmeyer, Tami A Martino

Faculty, Staff and Student Publications

This review tracks the discovery of circadian biology in cardiovascular science, starting with early clinical observations of daily changes in heart rate, blood pressure, and cardiovascular events. These patterns suggested that time of day matters, but it was not until the past two decades that the mechanisms and knowledge translation of these rhythms were uncovered. We describe the heart's intrinsic circadian properties and importantly how this leads to regulation of cardiac gene and protein expression, neuroendocrine and vascular rhythms, metabolism, cellular electrophysiology, and cell signaling pathways. Next, we explore emerging themes, including the impact of circadian timing on ischemic injury, …

Revisiting The Effect Of Udenafil On Exercise Performance In Patients With Fontan Circulation: Results Of A Post Hoc Analysis Of The Fuel Trial., David J. Goldberg, Victor Zak, Chenwei Hu, Adam M. Lubert, Rahul H. Rathod, Daniel J. Penny, Robert Whitehill, Kurt R. Schumacher, Salil Ginde, Michelle Ploutz, Gi Beom Kim, Todd T. Nowlen, Michael V. Dimaria, Benjamin P. Frischhertz, Jonathan B. Wagner, Kimberly E. Mchugh, Brian W. Mccrindle, Mark J. Cartoski, Jon Detterich, Anji T. Yetman, Anitha S. John, Marc E. Richmond, Matthew Files, R Mark Payne, Andrew S. Mackie, Christopher K. Davis, William B. Orr, Ruchira Garg, Kevin D. Hill, Jennifer S. Yauck, Michael G. Mcbride, James Yeager, Gail D. Pearson, Stephen M. Paridon, Bryan H. Goldstein

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: In the FUEL (Fontan Udenafil Exercise Longitudinal) trial, a positive treatment effect was identified for outcomes at the ventilatory anaerobic threshold but not for the primary outcome, oxygen consumption (Vo₂ in participants with near-normal baseline exercise performance.

METHODS: Participants were divided into subgroups by baseline predicted peak Vo₂ (< 80% versus ≥80%). Treatment effect was evaluated in those with a baseline peak Vo2 < 80% predicted and linear regression was performed to examine the interaction between subgroup and response to therapy for the primary and secondary outcomes.

RESULTS: Of the 379 participants with paired exercise data, 302 (80%) had a baseline peak Vo₂ < 80% predicted. In this subgroup, the primary outcome of peak Vo₂ improved significantly after 6 months of udenafil treatment, when compared with placebo (0.23±4.17 mL/kg per min versus -0.90±3.74 mL/kg per min; P=0.021). Secondary outcome measures, including Vo₂ at …