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October 2025 Library & Learning Newsletter, Minnesota State University, Mankato. Library & Learning Dean’S Office Communications Team

Library & Learning Newsletters

PDF version of the October 2025 (Volume 4, Issue 3) Library & Learning Newsletter.

Minority Farmer And Rancher Delinquency And Local Cultural Climate: Evidence From Farm Service Agency's County Office Committees, Lawson Connor, Bruce L. Ahrendsen, Charles B. Dodson, Logan Moss

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Farm delinquency is linked to many negative indicators of farm survival, including increased risk of bankruptcy and farm failure. Minority farmers and ranchers (MFR) have been found to exhibit higher rates of delinquency on U.S. Department of Agriculture (USDA) Farm Service Agency (FSA) loans compared to their non-Hispanic White male counterparts. These findings persist even after accounting for economic/financial factors expected to predict loan repayment performance. In this study, to further explore the existing discrepancy between loan default rates for MFR and White, non-Hispanic borrowers, we look more broadly than financial indicators and introduce MFR representation on the FSA County …

Relationship Between Dietary Probiotic Consumption And Cognitive Functioning In Older Adults: A 2011-2014 Nhanes Study, Lauren Weber, J. Gieng, Ashwini Wagle

Faculty Research, Scholarly, and Creative Activity

Background

Consumption of probiotics has recently been associated with a reduced risk of cognitive decline due to its anti-inflammatory effect on the brain, via the gut-brain-axis. Current studies with probiotic supplementation indicate that probiotics may play an important role in slowing the rate of cognitive decline and protecting memory. The purpose of this study was to evaluate a potential relationship between cognitive decline and dietary intake of probiotics.

Methods

This study utilized data from NHANES, both 2011-2012 and 2013-2014 cycles. Categorical variables were analyzed using chi-square tests, and continuous variables were analyzed using General Linear Models. Participants (n = 2,689) …

Comparative Analysis Of Mineral Content In Plant-Based Milk Alternatives: Implications For Renal Patient Education, K. Mitchell, A. Widaman, Ashwini Wagle

Faculty Research, Scholarly, and Creative Activity

The plant-based milk alternative (PBMA) market is expanding rapidly, offering a diverse range of options. However, the mineral composition of PBMA varies significantly across brands and milk types, posing challenges in educating individuals with renal disease. This study aimed to quantify and compare key minerals of concern for renal patients in commercially available PBMA using inductively coupled plasma optical emission spectrometry.

PBMA products available in the San Francisco Bay Area were purchased from chain grocery stores in spring 2023 and early January 2024. A total of 134 unique PBMA products from 28 brands and 11 different milk-alternative sources were analyzed. …

Effectiveness And Assessment Of A Culturally-Tailored Carbohydrate Counting Tool For South Asians With Diabetes: A Practitioner’S Evaluation, Ashwini Wagle

Faculty Research, Scholarly, and Creative Activity

South Asians are at a higher risk for type 2 diabetes compared to many other racial and ethnic groups. Dietary patterns play a significant role and are a modifiable risk factor. This study aimed to evaluate a South Asian carbohydrate counting tool developed by the researcher, assessed by Registered Dietitians Nutritionists and Certified Diabetes Care and Education Specialists. Using nutrition communication theory and the transtheoretical model, the tool included a comprehensive list of commonly consumed South Asian foods and sample vegetarian and non-vegetarian meals (1800e2100 kcal). Sixty-five participants received the tool and a training slide deck. A 40-item questionnaire assessed …

Developing Culturally-Tailored Diabetes Friendly And Heart Healthy Recipes For South Asians: Sensory Evaluation And Implications For Dietary Interventions, Ashwini Wagle, S. Starr, N. Goudarzi, G. Molina Martinez

Faculty Research, Scholarly, and Creative Activity

South Asians have a higher risk of developing type 2 diabetes than manyother racial or ethnic groups. Dietary patterns are a key, modifiable risk factor, and cultural influences strongly shape food choices and lifestyle decisions. Effective, long-term behavior change requires culturally meaningful interventions. This study aimed to develop culturally tailored recipes that comply with the American Diabetes Association (ADA) and American Heart Association (AHA) guidelines.

Recipes were selected from the published South Asian Carbohydrate Counting Tool, created by the researcher, and modified to enhance nutrient composition. Adjustments included ingredient substitutions, reduction or elimination of fat, salt, and sugar, and additions …

Machine Learning For Dissolved Oxygen Prediction In The Manawatu River Catchment, New Zealand, Imokhai T. Tenebe, Eunice O. Babatunde, Nkpa M. Ogarekpe, Egbe Etu Etu, Joshua Emakhu, Kindness E. Etu, Obiora B. Ezeudu, Oluwarotimi S. Oladele

Faculty Research, Scholarly, and Creative Activity

Uncontrolled anthropogenic activities have increased river pollution, resulting in poor water quality and a growing need for continuous monitoring, which is time-consuming and costly. This study evaluated the accuracy of machine learning (ML) models in predicting dissolved oxygen (DO) levels, aiming to reduce field monitoring efforts and minimize the number of measured parameters. Regression models (Huber, Linear, Ridge), Bagging methods (Extra Trees, Random Forest, Decision Trees), and Boosting techniques (Gradient Boosting, Light Gradient Boosting, AdaBoost) were tested using data from three sites in the Manawatu Catchment, New Zealand. Data spanning 1989–2014 included 12 water quality variables and was split into …

Better Digital Contracts With Prosocial Friction-In-Design, Brett Frischmann, Moshe Y. Vardi

Faculty Publications

Contract law is supposed to enable people to reach genuine agreements and cooperate. If this ideal was ever a reality, the rise of mass market contracts and boil­erplate rendered it pure fiction. Modern consumer contracts are incomprehensible to most people. No one reads them anyway.

Digital contracting involves design features that amplify traditional boilerplate harms and create others. For example, digital contracting is too cheap; low marginal costs lead to overexpansion in scale and scope. To make matters worse, the loss of autonomy from repeat engagement with digital contracting systems is pernicious. People become increasingly predictable and programmable as digital …

Plasma Proteome Correlations With Liver Stiffness In Pediatric Cholestasis Implicate Epithelial To Mesenchymal Transition, Benjamin L Shneider, Rupa S Kanchi, Sandra L Grimm, Sridevi Devaraj, Juliet Emamaullee, Jeremy Schraw, Philip J Lupo, Jorge A Bezerra, Kathleen M Loomes, John C Magee, Ronald J Sokol, Kasper S Wang, Alyssa Kriegmeier, Evelyn Hsu, Jean P Molleston, Philip Rosenthal, Rohit Kohli, Saul J Karpen, Simon P Horslen, M Kyle Jensen, Arianna Barbetta, Cristian Coarfa

Faculty, Staff and Students Publications

Background: Pediatric cholestatic liver diseases can be characterized by rapidly progressive fibrosis. A multicenter cross-sectional analysis of vibration-controlled elastography in biliary atresia (BA), alpha-1 antitrypsin deficiency (A1AT), and Alagille syndrome (ALGS) was leveraged to interrogate the plasma proteome relative to liver stiffness measurements (LSM).

Methods: Slow off-rate modified aptamer scanning profiling of >7000 proteins in plasma from 187 children with BA (n=93), A1AT (n=31), ALGS (n=46), and healthy pediatric controls (n=17) was performed, and correlations with LSM were undertaken.

Results: There was an abundance of LSM correlated proteins (BA n=2720, A1AT n=694, ALGS n=5968). Interestingly, a distinct plasma proteome was …

Examining The Relationship Between Dysphagia, Eating-Related Symptoms, And Diet Quality Among Oropharyngeal Cancer Patients During Critical Stages Of Cancer Survivorship: The U-Dine Study, Beatrice Manduchi, Vlad C Sandulache, Ji Yun Tark, Shreela Sharma, Ruosha Li, Emily Roller, Andrew Bevelhimer, Katherine A Hutcheson, Marcia C De Oliveira Otto

Faculty, Staff and Students Publications

Background: Diet quality is a modifiable factor impacting treatment outcomes in oropharyngeal cancer (OPC), yet the effect of dysphagia and self-reported eating-related symptoms remains unclear. This study examined their associations with diet quality in OPC patients.

Methods: A cross-sectional analysis was conducted with two parallel cohorts from MD Anderson Cancer Center and Michael E. DeBakey Veterans Affairs Medical Center as part of the Uncovering the Long-Term Impact of OPC and Dysphagia on Dietary Quality and Nutrition Among Cancer Survivors (U-DINE) Study. Participants at varying survivorship stages (prediagnosis, 3-6 and 18+ months posttreatment) were assessed for dysphagia (DIGEST scale) and six …

Structure-Activity Relationships Of A–And B-Type Proanthocyanidins In Long-Term Dentin Biomodification And Biocompatibility, Yvette Alania, Mariana Reis-Havlat, Shu-Xi Jing, Fahimeh Tabatabaei, James B. Mcalpine, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objective

To explore the structure-activity relationships of plant-based proanthocyanidins (PACs) with dental pulp stem cells (DPSCs) and the long-term biomechanical stability of PAC-modified dentin extracellular matrix (ECM).

Methods

Mid-coronal dentin ECM (n= 8) was treated with eight PAC tetramers and trimers with varying A-/B-type linkages. Chemo-mechanical analyses included dynamic mechanical analysis and ATR-FTIR spectroscopy. Viscoelastic components were calculated after PAC biomodification, 18-month incubation, and protein destabilization. Collagen structure was assessed via IR amide absorbance ratios. DPSCs were cultured with PACs at different concentrations (100, 10, and 1 μg/mL) to measure proliferation. ANOVA and post-hoc tests were used for …

Effect Of Different Implant Abutment Materials On Optical Properties Of Translucent Monolithic Zirconia Crowns, Nisha Patel, Geoffrey A. Thompson, Carl Drago, Mohamed Elshewy, David W. Berzins, Hongseok An

School of Dentistry Faculty Research and Publications

Purpose

The use of translucent monolithic zirconia crowns in implant dentistry raises concerns about the underlying abutment color affecting esthetic outcomes. While abutment effects are documented for traditional ceramics, data are limited for modern monolithic zirconia. The purpose of this investigation is to evaluate how abutment material and zirconia brand influence the final color of translucent monolithic zirconia crowns.

Materials and Methods

Eighty monolithic zirconia crowns (four brands; n = 20 each) were fabricated in shade A2 and cemented onto five abutment types: titanium (Ti), gold-hued Ti, pink-hued Ti, zirconia, and a natural dentin-shaded control. Crowns were placed on abutments …

In Vitro Study To Analyze Reverse Torque Values Of Attachment Screws With Multiple Loosening/Tightening Preload Cycles, Amira Alhameed, Nikita Sinha, Geoffrey A. Thompson, Carl Drago, Hongseok An

School of Dentistry Faculty Research and Publications

Purpose

To determine the number of torque/reverse torque cycles attachment screws can withstand before fracture, and to record the magnitude of reverse torque values for each of the 10 cycles of screw tightening and loosening.

Materials and Methods

The testing assemblies consisted of 30 temporary cylinder/multiunit abutment/internal connection implants (10 each from Dentsply Sirona Astra, Biohorizons, and Zimmer Biomet Dental). The assemblies were inserted into resin blocks, and temporary cylinders were connected to the multiunit abutments with new attachment screws and torqued to the recommended preload (15 Ncm Dentsply Sirona Astra; 15 Ncm Biohorizons; 10 Ncm Zimmer Biomet Dental) using …

Measurement-Based Care For Depression In Youth: Practical Considerations For Selecting Measures To Assess Depression, Associated Features And Functioning, Cynthia Garza, Diana Chapa, Catherine Hernandez, Hayley Aramburu, Taryn L. Mayes, Graham J. Emslie

School of Medicine Publications

Identification and management of major depressive disorder (MDD) in children and adolescents remains a significant area of public health need. The process for identifying depression (e.g. screening) and management (e.g. measurement based care [MBC]) is substantially enhanced by utilization of clinical measures and rating scales. Measures can be self- or caregiver reported or clinician rated. They can aid recognition of at-risk individuals for future assessment and assist in clinical diagnosis and management of depression. In addition to assessing symptoms of depression, rating scales can be used to assess important associated features (e.g. anxiety, trauma) and functional outcomes (e.g. quality of …

Eat, Sleep, Console Care For Infants With Neonatal Abstinence Syndrome: A Multisite Evaluation, Amanda Fout

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Opioid use in pregnancy continues to rise, leading to increasing cases of neonatal abstinence syndrome (NAS). Traditional management with the Finnegan Neonatal Abstinence Scoring System (FNASS) often results in pharmacologic treatment, prolonged hospitalizations, and higher costs. Inconsistent FNASS scoring at the hospital system contributed to unnecessary NICU admissions and variable outcomes. Eat, Sleep, Console (ESC) was introduced as an alternative approach, but its effectiveness had not been formally evaluated.

Aim of the Project: The aim of the quality improvement initiative was to evaluate the effectiveness of the ESC model in improving outcomes for infants with NAS across three hospitals …

Improving Patient Portal Messaging Workflow, Tanya M. Fitzpatrick

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Inefficiencies in patient portal secure messaging between providers and patients in a large primary care practice led to delayed resolution times, averaging 5.6 days per message. Most messages were closed by physicians or advanced practice providers, resulting in imbalanced workload distribution, increased provider burden, and reduced communication efficiency. The lack of standardized guidelines for message use, character limits, or triage processes contributed to workflow disruptions, a diminished patient experience, and unreimbursed provider time.

Aim of the Project: The aim of the project was to reduce average portal message closure times by at least 38% through the implementation of standardized …

Reducing Aspiration Pneumonia By Implementing An Enhanced Oral Care Toolkit, Jennifer London

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Oral care is essential for reducing bacteria and preventing aspiration pneumonia. The risk of aspiration pneumonia increases when protocols are not followed. In 2024, a regional hospital in the Midwest United States spent approximately one million dollars on the preventable healthcare-associated infection known as aspiration pneumonia. A pre-project chart audit of 100 random patient charts on a medical/surgical step-down unit revealed that only 1 of the 100 charts had oral care documented as completed.

Aim of the Project: The primary aims of this project were to increase nursing documentation of oral care by 50% and to decrease …

Decarbonising The Uk Pulp, Paper And Printing Sector: Balancing Sustainability And Global Competitiveness Through Insights From Lmdi And Mrio Analysis, T. Ibn-Mohammed, A. C. Serrenho, H. Fujii, A. Acquaye, A. Morrison-Saunders

Research outputs 2022 to 2026

The United Kingdom's pulp, paper, and printing sector (UKPPP) contributes ∼6 % of the nation's industrial CO2 emissions. While these emissions have declined since 2000, mainly because roughly half its paper mills closed due to global competitiveness challenges, other factors influencing emission dynamics (e.g., carbon intensity, energy intensity, fossil fuel dependency, economic structure, and activities) remain quantitatively unevaluated in comparison to other top global PPP countries (TGPPP). Additionally, the UKPPP relies on imports from TGPPP. Yet, a comprehensive modelling of the ecological CO2 emission exchanges and a comparison of sectoral production structures and emission dynamics between these entities have not …

Esg Ratings And Investment Returns At The Country Level: Does Higher Mean Better?, Ioannis Litsios, Dimitrios Asteriou, Keith Pilbeam, William Pouliot

Plymouth Business School

We examine whether U.S. dollar-based investors can do better investing in highly rated ESG countries than in medium andlower rated ESG countries using both cross sectional and panel data estimations. In general, we find evidence that investmentin ESGLow scoring countries leads to better returns than investing in ESGHigh scoring countries which in turn provide better returns than investing in ESGMedium scoring countries. We also examine the issue of risk-adjusted excess returns using a variety ofcountry risk-adjusted returns including the country-level Sharpe ratio, Treynor ratio and Alpha. In general, we find that ESGLowcountries still outperform ESGHigh countries who in turn outperform …

Otolith Microchemistry Reveals Contribution Of Hatchery-Origin Walleye In Lake Oahe, South Dakota, Mark J. Fincel, Cameron W. Goble, Gregory W. Whitledge, Katy Dawson, Jill A. Olin

Michigan Tech Publications

Objective: In Lake Oahe, South Dakota, recent stockings of fingerling Walleye Sander vitreus (every year from 2017 to 2019) have coincided with increased relative abundance of catchable-size Walleye. However, it is unknown if these fish originated from hatchery stockings or were produced naturally within Lake Oahe. Thus, we sought to use otolith microchemistry to delineate wild- versus hatchery-origin Walleye in Lake Oahe. Methods: In fall 2020, we collected age-0 through age-6 Walleye (n = 349) from Lake Oahe to determine fish origin during the standard gill-net survey. We used published water and otolith microchemical signatures to assign origin to collected …

Feasibility Study On Large-Scale Geologic Carbon Sequestration In Southern Colorado, Yanrui Ning, Ali Tura, David Herman, Jay Bridgeman, Dana Clark

Michigan Tech Publications

This study evaluates the feasibility of storing over 50 million metric tons of CO2 within a 30-year period in southern Colorado. The target for injection is the 7000 ft (2134 m)-deep Lyons saline aquifer formation, with the overlying alternating layers of anhydrite and shale serving as seals. Geological static models were constructed using seismic, well log and core data, followed by fluid flow modeling to understand the CO2 injection strategy, saturation distribution and plume size. The results indicate that approximately 60 million metric tons of CO2 can be injected with 2 wells into the formation over 30 years, with 85 …

Machine Learning Classification Of Eeg Responses To Pain-Related Vs Non-Pain-Related Stimulus In Preterm Infants, Lojain Hamwi, Hang Du, Sara Jasim, Xiaogang Wang, Vibhuti Shah, Carol Cheng, Lorenzo Fabrizi, Maria Fitzgerald, Judith Meek, Nicole Racine, Ian Stedman, Rebecca Pillai Riddell

Michigan Tech Publications

INTRODUCTION: Unmanaged pain in preterm infants can lead to long-term developmental consequences. Current pain assessment methods lack specificity, resulting in possible pain mismanagement in Neonatal Intensive Care Units (NICUs). This study explores the application of machine learning (ML) to differentiate between pain-related and non-pain-related cortical activity in preterm infants. OBJECTIVE: To evaluate the performance of ML models in distinguishing cortical EEG activity during a painful procedure in preterm infants across different postmenstrual ages (PMAs). METHODS: This observational study was conducted from June 2015 to May 2024 at Mount Sinai Hospital in Toronto, Canada, and University College London Hospital, United Kingdom. …

Alberta, Mi (Nrhp Initial Submission), Steven Walton

Michigan Tech Publications

This is the full initial submission for Alberta Village (the Ford Center) to be listed on the National Register of Historic Places. This application was submitted to the State Historic Preservation Office in August 2025. This application document was developed to support the consideration of Alberta Village (the Ford Center) as a historic site.

From the summary paragraph of the application:

The Village of Alberta in the Upper Peninsula of Michigan was originally built as a Ford company town and lumber mill in 1935. In 1954 the village and approx. 1,800 acres of surrounding timber lands were donated to Michigan …

Endoscopic Submucosal Dissection For Previously Attempted Colorectal Lesions: An International Multicenter Experience., Suchapa Arayakarnkul, Hiroyuki Aihara, Alessandro Repici, Roberta Maselli, Antonio Capogreco, Leonardo Da Rio, Fabio Shiguehissa Kawaguti, Fauze Maluf-Filho, Makoto Nishimura, Sera Satoi, Sayaka Nagao, Shai Friedland, Robert Bechara, Norio Fukami, Sonmoon Mohapatra, Amit Bhatt, Abel Joseph, Alex Schlachterman, Anand Kumar, Andrew Y Wang, Ross C D Buerlein, Louis M Wong Kee Song, Fnu Deepali, Dennis Yang, Muhammad K Hasan, Nikhil A Kumta, David L Diehl, Edward J Despott, Alberto Murino, Alessandro Rimondi, Laura Lucaciu, Neil R Sharma, Christina Zelt, Ashley Rumple Rn, Bsn, David Leslie Carr-Locke, Reem Z Sharaiha, Srihari Mahadev, Kamal M Hassan, Mohamad-Noor Abu-Hammour, Carlos Robles-Medranda, Martha Arevalo-Mora, Juan Alcivar-Vasquez, Vivek Kumbhari, Jongkyu Park, Salmaan Jawaid, Mai A Khalaf, Kasenee Tiankanon, Sarah S Al Ghamdi, Mohamed O Othman, Saowanee Ngamruengphong

PCI Publications and Projects

BACKGROUND & AIMS: Salvage endoscopic submucosal dissection (ESD) has been proposed for previously attempted colorectal lesions (PACLs), yet the extensive submucosal fibrosis impacts procedural difficulty and resection outcomes. The aim of this study was to evaluate the efficacy and safety of salvage ESD for the treatment of PACLs.

METHODS: This international, multicenter study enrolled consecutive patients who underwent ESD to manage PACLs. Rates of en bloc, R0 resection, and local recurrence were assessed for efficacy. Safety was assessed by adverse events (AEs), procedure-related mortality, and the need for surgical management.

RESULTS: Of 415 lesions, en bloc rate was 83.4%, the …

Associations Of High Attenuation Area-Related Proteomic Biomarkers With Fibrotic Or Subpleural Interstitial Lung Abnormalities, John S Kim, Catherine L Debban, Daniel E Guzman, Riley T Hannan, Mary Salvatore, Claire Mcgroder, David Zhang, Anna J Podolanczuk, Daniel A Duprez, Shwu-Fan Ma, Yong Huang, Jeffrey M Sturek, Stephen S Rich, Jerome I Rotter, Rajat Deo, Ruth F Dubin, Janelle Vu Pugashetti, Jennifer M Wang, Meilan K Han, Justin M Oldham, Imre Noth, Prescott G Woodruff, Victor E Ortega, Julie C Fanburg-Smith, Edward B Stelow, Christopher A Moskaluk, Eric A Hoffman, Christine Kim Garcia, Russell P Bowler, Peter Ganz, R Graham Barr, Ani Manichaikul

Faculty, Staff and Student Publications

No abstract provided.

Refining The Utility Of Late Amniocentesis In High-Risk Pregnancies, Roni Zemet, Ronald J Wapner, Ignatia B Van Den Veyver

Duncan NRI Faculty and Staff Publications

No abstract provided.

Enhancing Nursing Documentation Accuracy For Female External Urinary Collection Devices Through Structured Documentation Huddles, Tiffany Ealy

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Accurate documentation of female external urinary collection devices (EUCDs), such as the PureWick, is crucial for maintaining continuity of care and ensuring efficient resource utilization. However, inconsistent nursing documentation practices have led to gaps in regulatory compliance and communication among healthcare teams. Baseline data revealed frequent omissions and inaccuracies in female EUCD charting, indicating a significant practice gap that requires targeted improvement.

Aim of the Project: The purpose of the evidence-based practice (EBP) project was to improve nursing documentation accuracy for female EUCDs by implementing structured documentation huddles, thereby enhancing organizational compliance.

Review of the Evidence: A …

Reducing Hospital-Acquired Pressure Injuries In Critical Care Using A Preventing Pressure Ulcers Data Tool, Elizabeth Appiah-Caslin

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem: Hospital-acquired pressure injuries (HAPIs) are preventable yet remain a significant source of patient harm, especially in high-acuity settings like the Neurocritical Care (NCC) unit. HAPIs increase morbidity, length of stay, and healthcare costs. Despite having a prevention bundle, the NCC unit exceeded national benchmarks due to inconsistent adherence, delayed consultations, and variable documentation. Addressing this issue supports the organization's goals for safety and quality, aligning with CMS and Joint Commission standards.

Aim of the Project: This 12-week quality improvement project aimed to reduce HAPI incidence in the NCC unit by implementing the AHRQ Preventing Pressure Ulcers Data Tool. The …

Inhibition Of Ros1 Activity With Lorlatinib Reversibly Suppresses Fertility In Male Mice, Yuki Oyama, Kentaro Shimada, Haruhiko Miyata, Rie Iida-Norita, Chihiro Emori, Maki Kamoshita, Seiya Oura, Ryohei Katayama, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

Background: Inhibition of sperm maturation in the epididymis is a promising post-testicular strategy for short-acting male contraceptives. It has been shown that ROS1, a receptor tyrosine kinase expressed in the epididymis, is essential for epididymal differentiation, sperm maturation, and male fertility in mice. However, it is unknown if inhibition of ROS1 suppresses male fertility reversibly.

Objectives: Our study aimed to investigate the effects of ROS1 inhibitor administration in male mice on sperm function and fertility.

Materials and methods: We used lorlatinib, an anti-cancer drug that inhibits ROS1. We treated 10-week-old sexually mature male mice with lorlatinib for 3 weeks and …

Nonexposed Endoscopic Full Thickness Resection Of Residual Disease After Definitive Chemoradiation For Locally Advanced Gastric Cancer, Brennan W Gioe, Bryan C Luu, Michael M Ittmann, George Chen, Yvonne H Sada, Wasseem Skef

Faculty, Staff and Students Publications

Salvage endoscopic resection of residual esophageal neoplasia for patients that prefer to avoid surgery or are poor surgical candidates has been reported. We report a case of gastric signet ring cell carcinoma with residual disease after definitive chemoradiotherapy, that was treated with nonexposed endoscopic full thickness resection. This endoscopic resection achieved negative margins, with postresection surveillance endoscopy and imaging showing no evidence of disease. This case highlights the potential use of salvage endoscopic resection as a therapy for residual gastric cancer after chemoradiation in patients where surgery is not an option.