Digital Commons Network^™

Hemodynamic Characteristics Of Dilated Ascending Aorta In Patients With Bicuspid Aortic Valve, Yu Xia, Xuehuan Zhang, Shuai Zhu, Suwei Chen, Wentao Dong, Zhuo Chen, Nan Zhang, Jiafu Ou, Junming Zhu, Duanduan Chen, Tie Zheng

2020-Current year OA Pubs

BACKGROUND: The aim of this study is to investigate the influence of aortic diameter on hemodynamic environment characteristics in patient with the bicuspid aortic valve (BAV) and dilated ascending aorta (AAo).

METHOD: In this study, an MRI of one BAV patient with 4.5 cm AAo was collected and numerical model was constructed. Based on the images, three additional anatomical models were constructed with different AAo sizes of 4.0 cm, 5.0 cm and 5.5 cm respectively, while the size and the geometry of other parts were fixed. Then hemodynamics in these four models was simulated numerically and the flow patterns and …

Real-World Dosing And Persistence Of Oral Treprostinil Initiation Strategies In Patients With Pulmonary Arterial Hypertension, Daniel J Lachant, Ali Ataya, H James Ford, Meredith Broderick, Scott Seaman, Benjamin Wu, Murali M Chakinala

2020-Current year OA Pubs

In patients with pulmonary arterial hypertension (PAH), limited real-world data are available on persistence to oral treprostinil therapy, particularly while transitioning from parenteral prostacyclins. We compared persistence to oral treprostinil and total daily dose (TDD) achieved among patients with PAH initiating oral treprostinil de novo or while transitioning from parenteral prostacyclins using two real-world datasets: specialty pharmacy shipment records (Analysis 1) and ADAPT registry (Analysis 2). In Analysis 1, patients receiving oral treprostinil in 2017, 2020, and 2023 were included. In Analysis 2, de-identified data of patients enrolled in ADAPT from July 2017 to January 2022 were included. We conducted …

Molecular Dynamics Of The Host Response To Streptococcus Pneumoniae Pneumonia In Baboons, Bryan D Kraft, Et Al.

2020-Current year OA Pubs

BACKGROUND: Bacterial pneumonia remains a leading cause of morbidity and mortality worldwide despite the widespread availability of antibiotics. Novel pneumonia therapies and biomarkers are urgently needed to improve outcomes and advance personalized therapy. Using an established baboon model of S. pneumoniae pneumonia, we sought to characterize the temporal dynamics of pneumonia host responses to identify novel potential diagnostic and therapeutic molecular targets.

METHODS: We performed whole blood transcriptomics, unbiased proteomics, and peripheral cytokine measurements serially in baboons inoculated with S. pneumoniae (n = 23) or saline (n = 10) and modeled the peripheral blood host response using principal components analysis …

Predicting Acute Postsurgical Pain In The Postanesthesia Care Unit: Risk Tool Development And Internal Validation, Nicholas Papadomanolakis-Pakis, Simon Haroutounian, Johan K. Sørensen, Charlotte Runge, Lone D. Brix, Christian F Christiansen, Lone Nikolajsen

2020-Current year OA Pubs

INTRODUCTION: Moderate-to-severe acute postsurgical pain (APSP) is experienced by approximately 30% of surgical patients.

OBJECTIVES: To improve early APSP management, we developed 2 pragmatic and generalizable point-of-care risk tools to preoperatively predict moderate-to-severe and severe APSP in the postanaesthesia care unit (PACU).

METHODS: This was a multicenter prospective cohort study of adult patients undergoing elective surgical procedures between May 2021 and May 2023. Candidate predictors were preidentified. Logistic regression was used to develop the models. Internal validation was conducted with bootstrap resampling. Model performance was assessed by discrimination and calibration. Decision curve analysis was conducted to evaluate clinical utility of …

Identification Of Surrogate Outcome Biomarkers In Lung Allograft Recipients With Bronchiolitis Obliterans: Implications For Randomized Controlled Trials, Derek E. Byers, Suresh Vedantham, Mary Clare Derfler, Paul Commean, Andrew Atkinson, Jeff Atkinson, Alexey Prokudin, John Mccarthy, George Despotis, Et Al.

2020-Current year OA Pubs

BACKGROUND: We developed a prospective, multicenter "registry" to evaluate the effect of extracorporeal photopheresis for lung transplant recipients who develop chronic lung allograft dysfunction (CLAD) with the bronchiolitis obliterans syndrome (BOS) phenotype (CLAD/BOS) and who are refractory to conventional standard-of-care therapy.

METHODS: Data from 258 lung transplant recipients enrolled in the Registry between April 2015 and April 2022 were included in this analysis. All recorded parameters (eg, demographics), including forced expiratory volume in 1 s (FEV

RESULTS: Mortality at 6 and 12 mo after CLAD/BOS diagnosis was 5% and 14%, whereas mortality at 6 and 12 mo after enrollment was …

Gut Complement System: A New Frontier In Microbiota-Host Communication And Intestinal Homeostasis, Xianbin Tian, Lan Zhang, Xinyang Qian, Yangqing Peng, Fengyixin Chen, Sarah Bengtson, Zhiqing Wang, Meng Wu

2020-Current year OA Pubs

The gut microbiota plays a crucial role in maintaining intestinal homeostasis and influencing various aspects of host physiology, including immune function. Recent advances have highlighted the emerging importance of the complement system, particularly the C3 protein, as a key player in microbiota-host interactions. Traditionally known for its role in innate immunity, the complement system is now recognized for its interactions with microbial communities within the gut, where it promotes immune tolerance and protects against enteric infections. This Review explores the gut complement system as a possibly novel frontier in microbiota-host communication and examines its role in shaping microbial diversity, modulating …

Recent Advances In The Identification And Quantification Of Xylazine And Medetomidine In Biological Specimens, Bridgit O Crews

2020-Current year OA Pubs

Xylazine is a veterinary sedative that is frequently detected in the illicit drug supply, often found mixed with illicitly manufactured fentanyl (IMF). It has been detected in the blood of overdose victims and patients who use illicit drugs. Xylazine is not approved for use in humans. It is an alpha-2-adrenergic receptor agonist that causes deep sedation that is non-responsive to naloxone, the antidote for opioid overdose. Chronic exposure to xylazine has been linked to severe wounds that can progress to amputation. Medetomidine is another related veterinary sedative that has more recently emerged as an adulterant in IMF. Medetomidine is also …

Chimeric Antigen Receptor Natural Killer (Car-Nk) Cells: From Preclinical Promise To Clinical Reality In Cancer Immunotherapy, Hunter Cassidy Cochran, Kevin Ashkan Ghobadi, Armin Ghobadi

2020-Current year OA Pubs

Chimeric antigen receptor (CAR) natural killer (NK) cell therapy represents an emerging frontier in cancer immunotherapy. CAR-NK cells offer the potential for "off-the-shelf" treatments with a favorable safety profile, due in part to their innate capacity for HLA-unrestricted tumor targeting and an absence of graft-versus-host disease. Landmark clinical studies using cord blood - derived CAR-NK cells and another employing iPSC-derived CAR-NK cells have reported impressive response rates, durable remissions, and minimal toxicity. Furthermore, a growing landscape of ongoing clinical trials is exploring innovative strategies to enhance persistence, overcome solid tumor challenges, and prevent antigen escape. These advances collectively underscore the …

A Modification To The Brand Transfer For Claw Hand: The Four-Tailed Extensor Carpi Radialis Brevis To Lateral Band Transfer, Lauren E Wessel, Nirbhay S Jain, Ambika E Paulson, Carrie Bettlach, Mitchell A Pet, Amy M Moore

2020-Current year OA Pubs

BACKGROUND: Claw deformity is a devastating consequence of low ulnar nerve palsy, resulting in loss of finger function. Traditionally, the Brand transfer is a favored intervention but requires lengthy grafts and bulky tenorrhaphies, risking adhesions in the lumbrical canal. We present a modified Brand tendon transfer, which extends the extensor carpi radialis brevis (ECRB) into 4 tails for individual grafting into the lateral band, decreasing adhesion risk and graft length need.

METHODS: Nine consecutive patients with claw hand were examined in detail to confirm the diagnosis and appropriateness for claw-correction surgery by the senior author. All patients underwent our modified …

Family Income And Polygenic Scores Are Independently But Not Interactively Associated With Cognitive Performance Among Youth Genetically Similar To European Reference Populations, S E Paul, N M Elsayed, S M C Colbert, R Bogdan, A S Hatoum, D M Barch

2020-Current year OA Pubs

Cognitive abilities are heritable and influenced by socioeconomic status (SES). It is critical to understand the association between SES and cognition beyond genetic propensity to inform potential benefits of SES-based interventions and to determine if such associations vary across (i) cognitive domains, (ii) facets of SES, and/or (iii) genetic propensity for different aspects of cognition. We examined the contributions of neighborhood socioeconomic advantage, family income, and polygenic scores (PGS) for domains of cognition (i.e., general cognitive ability, executive function, learning and memory, fluid reasoning) in a sample of children (ages 9-10;

Gender Trends In Professional Advancement Among Academic Pediatric Neurologists, Juliet K Knowles, Renée A Shellhaas, Et Al.

2020-Current year OA Pubs

No abstract provided.

A Word From The Writing Team (October 2025), Pam Walter, Mfa, Laura Deloretta, Phd

A Word From the Writing Team (Newsletter)

This issue includes:

• Publications Spotlight
• Wiley is Hosting Two Workshops
• Join us for the Launch Party of Evanescent Issue 6: Growing. Learning. Aging.
• Pam is Out of the Office until October 14^th!
• October 3rd is our First Friday Writing Retreat!

The Public Health Cost Of Online Behavioral Targeting, Arthi Annadurai

Vanderbilt Journal of Entertainment & Technology Law

Behavioral targeting is an increasingly popular marketing technique that utilizes users’ online activity to personalize advertisements aimed at consumers. However, since personalized advertisements aim to influence individual consumers, behavioral targeting can negatively impact vulnerable users. For instance, it may reinforce harmful behaviors—like showing alcohol advertisements to individuals with alcohol dependency—or worsen mental health struggles, such as prolonging grief by continuing to serve parenting advertisements to those mourning the loss of a child. These practices can perpetuate harmful behaviors, such as relapse or heightened psychological distress, and contribute to long-term health problems, such as addiction or other mental health problems, creating …

Agentizing Privacy Preferences Without Privatizing Data Protection Policy, Frank Pasquale, Vanna Carter

Cornell Law Faculty Publications

This essay explores how consumers might exercise newly restored agency in a digital environment increasingly shaped by generative AI. Rather than expecting consumers to read privacy-related terms of service, policymakers should encourage the emergence of Automated Consumer Agents (“ACAs”) capable of interpreting privacy provisions and acting on behalf of users according to their stated preferences. These systems could automatically reject objectionable forms of data extraction, translating consumer values into actionable decisions in online transactions.

Despite this promise, the rise of ACAs would also present new problems. Without supportive policy and legal frameworks, agentization of privacy preferences could itself reproduce or …

Cannabis Improves Metabolic Dysfunction And Macrophage Signatures In Obese Mice, Brandon N. Vanderveen, Thomas D. Cardaci, Christian A. Unger, Mitchell M. Nesmith, Jeffrey C. Freeman, Arianna V. Bastian, Kasie Roark, Mansi Upadhyay, Andrew G. Levy, Brooke M. Bullard, Sierra J. Mcdonald, Kandy T. Velázquez, Reilly T. Enos, Jason L. Kubinak, Lorne J. Hofseth Ph.D., James Hébert Scd, Daping Fan, E. Angela Murphy

Faculty Publications

Obesity rates continue to rise, highlighting the need for new treatments that are effective, safe, and widely accessible. Aligned with the easing of restrictions on cannabis use, interest in its therapeutic potential is evolving. As such, we examined the effects of the cannabis plant with high cannabidiol (CBD) content or high Δ9-tetrahydrocannabinol (THC) content on metabolic and immune dysregulation in obese mice. Briefly, female C57BL/6 mice were randomized into four groups (n = 15/group): 1) lean, 2) obese placebo, 3) obese CBD, and 4) obese THC. Lean mice consumed a low-fat diet for the study …

Analytical Solutions For Transitional Flow Around Hydrometeors: Implications For Particle Dynamics And Atmospheric Modeling, Ahmad Talaei, Timothy J. Garrett

Physics Student Research

Accurate modeling of hydrometeor dynamics is critical for advancing weather and climate predictions. However, this remains a long-standing challenge in atmospheric science, particularly within the transitional Reynolds number regime, due to the lack of analytical solutions to the Navier–Stokes equations. This study presents two analytical solutions for two-dimensional, incompressible, and viscous flow around a sphere, addressing the gap between low and high Reynolds number regimes. The first framework, an extension of classical expansion methods using hypergeometric, provides a direct analytical relation that characterizes separation angle across the transitional regime. To address post- separation dynamics, a second formulation based on a …

Tort Immunity Waiver For Vaccine Injuries: Ethical And Legal Perspectives, Tammy W. Cowart, Gregory L. Bock

Accounting, Finance, Information Systems, and Business-Law Faculty Publications and Presentations

The COVID pandemic highlighted the importance of vaccine development and availability worldwide. Operation Warp-Speed in the United States accelerated vaccine production by several major pharmaceutical manufacturers, averting some of the normal administrative processes. The result has been a financial windfall for those companies. Some recent data has shown that the COVID vaccine can cause negative side effects in some patients. There are provisions in U.S. law that allow victims of vaccine injuries to recover compensation through the court system. However, even then tort remedies are limited by federal law. Since the review process was rushed during the pandemic, should tort …

Pandemic-Driven Healthcare Disruptions And Their Disproportionate Impact On Patients With Diabetes: Evidence From Texas, Meryem Saygili, Gultekin Gollu, Zehra Tekin

Economics Faculty Publications and Presentations

Background: Diabetic Ketoacidosis (DKA) is a life-threatening complication of uncontrolled diabetes. The COVID-19 pandemic may have increased DKA incidences and worsened outcomes both through the potential diabetogenic effects of SARS-CoV-2 infection (direct effect) and through pandemic-related disruptions in healthcare (indirect effects,) including delays in seeking or receiving care, reduced access to routine outpatient services, and strains on hospital capacity. The objective of this study is to examine changes in the frequency and outcomes of hospitalizations with DKA in Texas hospitals following the COVID-19 pandemic and to quantify the contributions of pandemic-related healthcare disruptions and SARS-CoV-2 infection. Comparisons to patients with …

Powering Up Clinical Scholarship In Pathology, Evelyn Wang

HSLIC Faculty and Staff Instructional Resources

This presentation is designed for pathology residents and covers clinical scholarship pathways including research question design, database/resource navigation, advanced literature searching (Boolean, proximity, MeSH), literature review, evidence appraisal, systematic review workflows (PRISMA), open access publishing, data management, and HSLIC educational/research support services.

Illuminated Magazine - Fall 2025, School Of Graduate Studies, East Tennessee State University

Illuminated: Graduate Student Research Magazine

• 2: Editorial Staff
• 5: Graduate Students and Advisors
• 6: ETSU’s First Master of Music Cohort Finds Its Voice on Campus
• 9: Where Are They Now? Jacob Mitchell
• 10: Characterizing and Enhancing Carotenoid Production in Tomato Plants
• 14: Where Are They Now? Jeremiah J. Flake
• 15: In the Gaps of the System: Centering BIPOC Mothers in Maternal Mental Health
• 18: Roles of Female Musicians in Appalachian Bluegrass
• 20: Where Are They Now? Alexis Moser
• 21: From Guyana to Tennessee: Bridging Gaps in Women’s Mental Health Care
• 24: Where Are They Now? Megan Roberts
• 26: Characterizing User Experience in AI Chatbots within …

Las Mujeres Que Tejen Su Poder A Través Del Turismo: Video Documental En La Comunidad De Huilloc (Cusco, Perú), Adina Veloz-Remis

Peru: Indigenous Peoples and Globalization

This research examines how tourism has transformed the lives of Indigenous women in Huilloc, Peru, specifically through the sale of woven textiles. Through a documentary, the study analyzes how the commercialization of their crafts has expanded the economic opportunities available to the weavers, supporting their financial autonomy. It also explores women’s empowerment, including new gender dynamics, greater independence within the household, and increased recognition from the community. The use of documentary film allows the women's voices to be amplified in their own language and cultural context, reinforcing their capacity and autonomy to narrate their stories from their own perspective.

Hilos Híbridos Las Formas Duales Del Tejido De Taquile, Entre El Uso Local Y El Mercado Turístico, Dean Mcmichael

Peru: Indigenous Peoples and Globalization

Para mi ISP del programa Perú: Indigenous Peoples and Globalization, realicé una investigación sobre los tejidos de la isla de Taquile, con el objetivo principal de entender cómo han cambiado los tejidos y la práctica de tejido en respuesta al desarrollo de la economía turística y cómo se refleja este proceso en el arte textil actual de la isla. Me quedé dos semanas en la isla, para recopilar datos, usando técnicas de observación participante y realizando entrevistas. A través de análisis de mis datos, he concluido que la coyuntura actual de los tejidos se define por una demarcación muy definida …

Tejedoras Indígenas Y La Política Económica Del Turismo En Chinchero, Perú: Centrales En La Economía, Marginales En La Política, Maria Herr

Peru: Indigenous Peoples and Globalization

This report is based on fieldwork carried out in Chinchero (Cusco, Peru) in November 2025 and examines the participation of women weavers in the local tourism economy and its relationship to municipal economic policy. It shows how Indigenous weavers, who are central to the district’s tourism, remain in a marginal position within formal spaces of economic decision-making. The study has four specific objectives: to describe the forms of participation of women weavers in Chinchero’s tourism economy; to analyze the mechanisms of collaboration between the Centro de Textiles Tradicionales del Cusco (CTTC) and other artisan associations with local public institutions; to …

“Il N’Y A Plus De Monstres”: A Case Study On Trans And Gender-Diverse Health In Switzerland, Sophie Lin

Switzerland: Global Health and Development Policy

Transgender and gender-diverse (TGD) populations experience significant health disparities, particularly in regards to mental health outcomes and quality of life. This case study employs a qualitative approach to elucidate barriers and enablers to TGD health and gender-affirming care in Switzerland. Evidence collected from semi-structured interviews with health professionals working with Swiss TGD communities provides a thorough understanding of contemporary resources and obstacles regarding gender-affirming treatment. This research seeks to contribute to scholarship by synthesizing health literature with critical queer theory. Drawing from Butler’s theory of gender performativity, a framework of gender self-determination is advanced as a core principle of health, …

Nutrition In Context: How Cultural Beliefs, Gender Norms, Social Environments, And Interventions Shape Maternal Nutrition In Nepal, Rebecca Fan

Switzerland: Global Health and Development Policy

Maternal nutrition is recognized as one of the most significant and modifiable determinants of persistent inequities in maternal and neonatal health. In Nepal, what women are able to eat and how they experience pregnancy are all shaped by a complex interplay of cultural beliefs, gendered expectations, household dynamics, structural barriers, and nutrition intervention efforts. This study examines these intersecting factors through ethnographic accounts, peer-reviewed scientific literature, expert interviews, and an analysis of current interventions operating across different levels. Specifically, to understand the social environments shaping maternal nutrition, the paper explores cultural beliefs and misconceptions surrounding food, women’s limited control over …

Chapter 1: A Brief History Of Archival Appraisal. In Selecting And Appraising Archives And Manuscripts, Michelle Light

Library Staff Publications

This chapter traces the evolution of archival appraisal theory and practice in the United States, situating it within shifting technological, social, and intellectual contexts from the late nineteenth century to the present. In this roughly chronological account, the chapter underscores continuity and disruption in selecting and appraising archival records. It highlights the influence and ongoing critiques of Theodore Schellenberg’s evidential and informational values, as well as subsequent expansions by Maynard Britchford and others. It explores transformative moments such as F. Gerald Ham’s call for coordinated documentation, the development of the Black Box model, the rise of documentation strategy, and the …

Not Born A Democracy: Constitutional Preconditions, Martha Minow

William & Mary Law Review

Beneath growing perceptions of constitutional crisis and democratic fragility in the United States lies a fundamental conundrum. Critical preconditions for effective self-government are either weak or missing in action, and our constitutional system, at least for now, stands in the way of actions to strengthen or build those preconditions. This Article focuses on three essential predicates for constitutional democracy that face jeopardy: education, reliable news, and security against lethal violence. As basic as these elements may be, repeated efforts to secure a federal constitutional right to education have failed in the courts. Because of a confluence of legal, technological, and …

Anterior Cingulate Cortex Connectivity And The Role In Neuroticism: A Diffusion-Weighted-Imaging-Based Investigation Of Limbic And Prefrontal Circuits., Jake Cox Ii

College of Arts & Sciences Senior Theses

Neuroticism is a trait which has been shown to significantly predict psychopathology. Investigating its neurobiological underpinnings may uncover a brain-based relationship that allows clinicians to conceptualize a shared predispositional factor across multiple psychopathologies, implicating treatment protocols. Inter-connectivity network and structural variation has been shown to be implicated in neuroticism, more specifically the frontoparietal network, default mode network, salience networks, and limbic networks. These networks tackle executive, salience, and emotional information, respectively. The anterior cingulate cortex (ACC) is a brain region nested between and functionally related to various networks stated above that are implicated in neuroticism. As such, it was hypothesized …

Mckee Minute October 2025, Southern Adventist University

McKee Minute – McKee Library This Month

The October 2025 edition of McKee Minute includes information on International Open Access Week, National Book Month, course reserves, and the library's mid-semester break hours.

Cybersecurity Risk Disclosure And Regulatory Compliance: Evaluating Market Sensitivity And Disclosure Effectiveness In U.S. Public Companies, Kingsford Brakye, Abdul Basit Karim Adam

Research & Publications

This paper analyzes disclosing cybersecurity risk and regulatory compliance by the U.S. public companies, with reference to the sensitivity of the information in the market and the effectiveness of disclosure. With rising cyber threats, there is mounting pressure on firms to safeguard their financial systems and adhere to rules such as the 2011, 2018, and 2023 guidelines issued by the SEC, which require firms to report incidents in time and to disclose detailed risk management. However, the disclosure is often done in generic, boilerplate terms, and this limits its use by investors and raises the question of transparency. The study …